Inhibition of astrocytic energy metabolism by d-lactate exposure impairs memory

Neurochemistry International

Volumn 52, Issue 6, 2008, Pages 1012-1018

  Gibbs, Marie E ^a   Hertz, Leif ^b  

^a MONASH UNIVERSITY   (Australia)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Acetate; Astrocytes; Energy metabolism; Learning; Monocarboxylate transporter; Pyruvate carboxylation

Indexed keywords

2,4 DINITROPHENOL; ACETIC ACID; ASPARTIC ACID; DEXTRO LACTIC ACID; GLUTAMIC ACID; GLYCOGEN; LACTIC ACID; PYRUVIC ACID; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN CORTEX; CARBOXYLATION; CHICKEN; CONTROLLED STUDY; DISCRIMINATION LEARNING; ENANTIOMER; ENERGY METABOLISM; ENERGY YIELD; MEMORY DISORDER; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RIGHT HEMISPHERE; TRAINING;

ACETIC ACID; ANIMALS; ASTROCYTES; BRAIN; CHICKENS; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUTAMIC ACID; ISOMERISM; LACTIC ACID; MALE; MEMORY; MEMORY DISORDERS; MITOCHONDRIA; NEURONS; PYRUVIC ACID;

MAMMALIA;

EID: 40949125201     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.10.014     Document Type: Article

References (34)

1. Baker K.D., and Edwards T.M. d-Lactate inhibition of memory in a single trial discrimination avoidance task in the young chick. Neurobiol. Learn. Mem. 88 (2007) 269-276
2. 2 in rat tissues. Proc. Soc. Exp. Biol. Med. 175 (1984) 328-335
3. Carpenter L., and Halestrap A.P. The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF. Biochem. J. 304 (1994) 751-760
4. Cassady C.J., Phillis J.W., and O'Regan M.H. Further studies on the effects of topical lactate on amino acid efflux from the ischemic rat cortex. Brain Res. 901 (2001) 30-37
5. Dahlquist N.R., Perrault J., Callaway C.W., and Jones J.D. d-Lactic acidosis and encephalopathy after jejunoileostomy: response to overfeeding and to fasting in humans. Mayo Clin. Proc. 59 (1984) 141-145
6. Daisley J.N., Gruss M., Rose S.P., and Braun K. Passive avoidance training and recall are associated with increased glutamate levels in the intermediate medial hyperstriatum ventrale of the day-old chick. Neural Plast. 6 (1998) 53-61
7. de Bari L., Atlante A., Guaragnella N., Principato G., and Passarella S. d-Lactate transport and metabolism in rat liver mitochondria. Biochem. J. 365 (2002) 391-403
8. Gibbs M.E., Anderson D.G., and Hertz L. Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chicks. Glia 54 (2006) 214-222
9. Gibbs M.E., Andrew R.J., and Ng K.T. Hemispheric lateralization of memory stages for discriminated avoidance learning in the chick. Behav. Brain Res. 139 (2003) 157-165
10. Gibbs M.E., and Hertz L. Importance of glutamate-generating metabolic pathways for memory consolidation in chick. J. Neurosci. Res. 81 (2005) 293-300
11. Gibbs M.E., Lloyd H.G.E., Santa T., and Hertz L. Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence. J. Neurosci. Res. 85 (2007) 3326-3333
12. Gibbs M.E., and Summers R.J. Role of adrenoceptor subtypes in memory consolidation. Prog. Neurobiol. 67 (2002) 345-391
13. 2-adrenoceptors on glycogenolysis. Neuropsychopharmacology, in press.
14. Giesecke D., and von Wallenberg P. Metabolism of d(-)lactic acid in rats given high intragastral doses. Comp. Biochem. Physiol. B: Comp. Biochem. 82 (1985) 255-258
15. Halestrap A.P., and Denton R.M. Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate. Biochem. J. 138 (1974) 313-316
16. Harmon D.L., Britton R.A., and Prior R.L. In vitro rates of oxidation and gluconeogenesis from l(+)- and d(-)lactate in bovine tissues. Comp. Biochem. Physiol. B: Comp. Biochem. 77 (1984) 365-368
17. Hertz L., and Dienel G.A. Lactate transport and transporters: general principles and functional roles in brain cells. J. Neurosci. Res. 79 (2005) 11-18
18. Hertz L., O'Dowd B.S., Ng K.T., and Gibbs M.E. Reciprocal changes in forebrain contents of glycogen and of glutamate/glutamine during early memory consolidation in the day-old chick. Brain Res. 994 (2003) 226-233
19. Hertz L., Peng L., and Dienel G.A. Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J. Cereb. Blood Flow Metab. 27 (2007) 219-249
20. Jackson V.N., and Halestrap A.P. The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2′,7′-bis(carboxyethyl)-5(6)-carboxyfluorescein. J. Biol. Chem. 271 (1996) 861-868
21. Jarvis E.D., Gunturkun O., Bruce L., Csillag A., Karten H., Kuenzel W., Medina L., Paxinos G., Perkel D.J., Shimizu T., Striedter G., Wild J.M., Ball G.F., Dugas-Ford J., Durand S.E., Hough G.E., Husband S., Kubikova L., Lee D.W., Mello C.V., Powers A., Siang C., Smulders T.V., Wada K., White S.A., Yamamoto K., Yu J., Reiner A., and Butler A.B. Opinion: avian brains and a new understanding of vertebrate brain evolution. Nat. Rev. Neurosci. 6 (2005) 151-159
22. Magistretti P.J., Pellerin L., Rothman D.L., and Shulman R.G. Energy on demand. Science 283 (1999) 496-497
23. Manning Fox J.E., Meredith D., and Halestrap A.P. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J. Physiol. 529 (2000) 285-293
24. Muir D., Berl S., and Clarke D.D. Acetate and fluoroacetate as possible markers for glial metabolism in vivo. Brain Res. 380 (1986) 336-340
25. Narula R.K., El Shafei A., Ramaiah D., and Schmitz P.G. d-Lactic acidosis 23 years after jejuno-ileal bypass. Am. J. Kidney Dis. 36 (2000) E9
26. Oh M.S., Phelps K.R., Traube M., Barbosa-Saldivar J.L., Boxhill C., and Carroll H.J. d-Lactic acidosis in a man with the short-bowel syndrome. N. Engl. J. Med. 301 (1979) 249-252
27. Peng L., Zhang X., and Hertz L. High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes, but have no stimulatory effect in a GABAergic neuronal culture. Brain Res. 663 (1994) 168-172
28. Petersen C. d-Lactic acidosis. Nutr. Clin. Pract. 20 (2005) 634-645
29. Poole R.C., Cranmer S.L., Halestrap A.P., and Levi A.J. Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriers. Biochem. J. 269 (1990) 827-829
30. Scully T.B., Kraft S.C., Carr W.C., and Harig J.M. d-Lactate-associated encephalopathy after massive small-bowel resection. J. Clin. Gastroenterol. 11 (1989) 448-451
31. Tekkök S.B., Brown A.M., Westenbroek R., Pellerin L., and Ransom B.R. Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity. J. Neurosci. Res. 81 (2005) 644-652
32. Uribarri J., Oh M.S., and Carroll H.J. d-Lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine 77 (1998) 73-82
33. Wibrand F., and Juel C. Reconstitution of the lactate carrier from rat skeletal-muscle sarcolemma. Biochem. J. 299 (1994) 533-537
34. Waniewski R.A., and Martin D.L. Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 18 (1998) 5225-5233