Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

Nature Medicine

Volumn 19, Issue 12, 2013, Pages 1643-1648

  Thrane, Vinita Rangroo ^a,b,c   Thrane, Alexander S ^a,b,c   Wang, Fushun ^a   Cotrina, Maria L ^a   Smith, Nathan A ^a,d   Chen, Michael ^a   Xu, Qiwu ^a   Kang, Ning ^a   Fujita, Takumi ^a   Nagelhus, Erlend A ^a,b,e   Nedergaard, Maiken ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d The Brain Institute at the University of Utah   (United States)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; AMMONIA; BUMETANIDE; GLUTAMATE AMMONIA LIGASE; ORNITHINE CARBAMOYLTRANSFERASE; POTASSIUM; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN EDEMA; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DETERIORATION; GENE DELETION; HYPERAMMONEMIA; IN VIVO STUDY; INHIBITION KINETICS; MICROELECTRODE; MOTOR DYSFUNCTION; MOUSE; MYOCLONUS SEIZURE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; ORNITHINE TRANSCARBAMYLASE DEFICIENCY; PHENOTYPE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SEIZURE; SWELLING; SYNAPTIC POTENTIAL; TONIC CLONIC SEIZURE; WAKEFULNESS; WILD TYPE;

MUS;

EID: 84889887369     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3400     Document Type: Article

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