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Volumn 13, Issue 3, 2016, Pages 286-300

Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

Author keywords

IL 23R gene; immune mediated diseases; R381Q (rs11209026) polymorphism

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 23 RECEPTOR; IL23R PROTEIN, HUMAN; INTERLEUKIN 23; INTERLEUKIN RECEPTOR;

EID: 84962476854     PISSN: 1547691X     EISSN: 15476901     Source Type: Journal    
DOI: 10.3109/1547691X.2015.1115448     Document Type: Review
Times cited : (49)

References (91)
  • 1
    • 84938856326 scopus 로고    scopus 로고
    • Association between lower frequency of R381Q variant (rs11209026) in IL-23 receptor gene and increased risk of recurrent spontaneous abortion (RSA)
    • E.Abdollahi, F.Tavasolian, N.Ghasemi, S.A.Mirghanizadeh, M.Azizi, M.Ghoryani, M.Samadi. 2015. Association between lower frequency of R381Q variant (rs11209026) in IL-23 receptor gene and increased risk of recurrent spontaneous abortion (RSA). J Immunotoxicol. 12:317–321
    • (2015) J Immunotoxicol. , vol.12 , pp. 317-321
    • Abdollahi, E.1    Tavasolian, F.2    Ghasemi, N.3    Mirghanizadeh, S.A.4    Azizi, M.5    Ghoryani, M.6    Samadi, M.7
  • 2
    • 67449147595 scopus 로고    scopus 로고
    • H17 pathways and inflammatory bowel disease
    • H17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 15:1090–1100.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1090-1100
    • Abraham, C.1    Cho, J.2
  • 3
    • 34548125305 scopus 로고    scopus 로고
    • IL-1β and -6, but not TGFβ are essential for the differentiation of IL-17-producing human T-helper cells
    • E.V.Acosta-Rodriguez, G.Napolitani, A.Lanzavecchia, F.Sallusto. 2007. IL-1β and -6, but not TGFβ are essential for the differentiation of IL-17-producing human T-helper cells. Nat Immunol. 8:942–949.
    • (2007) Nat Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 5
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • D.Altshuler, M.J.Daly, E.S.Lander. 2008. Genetic mapping in human disease. Science. 322:881–888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 7
    • 84953284717 scopus 로고    scopus 로고
    • Association of 14-bp insertion/deletion polymorphism of HLA-G gene with idiopathic recurrent miscarriages in infertility center patients in Yazd, Iran
    • F.Arjmand, M.Samadi. 2016. Association of 14-bp insertion/deletion polymorphism of HLA-G gene with idiopathic recurrent miscarriages in infertility center patients in Yazd, Iran. J Immunotoxicol. 13:249–254.
    • (2016) J Immunotoxicol. , vol.13 , pp. 249-254
    • Arjmand, F.1    Samadi, M.2
  • 17
    • 0242299624 scopus 로고    scopus 로고
    • The IL‐25 gene located in the inflammatory bowel disease (IBD) 4 region: No association with inflammatory bowel disease
    • C.Büning, J.Genschel, R.Weltrich, H.Lochs, H.Schmidt. 2003. The IL‐25 gene located in the inflammatory bowel disease (IBD) 4 region: No association with inflammatory bowel disease. Eur J Immunogen. 30:329–333.
    • (2003) Eur J Immunogen , vol.30 , pp. 329-333
    • Büning, C.1    Genschel, J.2    Weltrich, R.3    Lochs, H.4    Schmidt, H.5
  • 27
    • 84863634453 scopus 로고    scopus 로고
    • IL-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
    • Z.Duan, F.Pan, Z.Zeng, T.Zhang, S.Wang, G.Li, S.Xu, J.Xu, L.Zhang. 2012. IL-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis. Rheumatol Intl. 32:1209–1214.
    • (2012) Rheumatol Intl , vol.32 , pp. 1209-1214
    • Duan, Z.1    Pan, F.2    Zeng, Z.3    Zhang, T.4    Wang, S.5    Li, G.6    Xu, S.7    Xu, J.8    Zhang, L.9
  • 30
    • 43849103451 scopus 로고    scopus 로고
    • Relation of an IL-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation
    • A.Elmaagacli, M.Koldehoff, O.Landt, D.Beelen. 2008. Relation of an IL-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation. Bone Marrow Transplant. 41:821–826.
    • (2008) Bone Marrow Transplant , vol.41 , pp. 821-826
    • Elmaagacli, A.1    Koldehoff, M.2    Landt, O.3    Beelen, D.4
  • 31
    • 79952214058 scopus 로고    scopus 로고
    • IL23R and IL12B SNPs and haplotypes strongly associate with Crohn's disease risk in a New Zealand population
    • L.R.Ferguson, D.Y.Han, A.G.Fraser, C.Huebner, W.J.Lam, A.R.Morgan. 2010. IL23R and IL12B SNPs and haplotypes strongly associate with Crohn's disease risk in a New Zealand population. Gastroenterol Res Practice. 2010:1–12.
    • (2010) Gastroenterol Res Practice , vol.2010 , pp. 1-12
    • Ferguson, L.R.1    Han, D.Y.2    Fraser, A.G.3    Huebner, C.4    Lam, W.J.5    Morgan, A.R.6
  • 33
    • 0037039582 scopus 로고    scopus 로고
    • IL-23: a cytokine that acts on memory T-cells
    • D.M.Frucht. 2002. IL-23: a cytokine that acts on memory T-cells. Science Signaling. 2002:pe1.
    • (2002) Science Signaling , vol.2002 , pp. pe1
    • Frucht, D.M.1
  • 34
    • 29744450121 scopus 로고    scopus 로고
    • Both IL‐12p70 and IL‐23 are synthesized during active Crohn's disease and down‐regulated by treatment with anti‐IL‐12 p40 monoclonal antibody
    • I.J.Fuss, C.Becker, Z.Yang, C.Groden, R.L.Hornung, F.Heller, M.F.Neurath, W.Strober, P.J.Mannon. 2006. Both IL‐12p70 and IL‐23 are synthesized during active Crohn's disease and down‐regulated by treatment with anti‐IL‐12 p40 monoclonal antibody. Inflamm Bowel Dis. 12:9–15.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3    Groden, C.4    Hornung, R.L.5    Heller, F.6    Neurath, M.F.7    Strober, W.8    Mannon, P.J.9
  • 36
    • 39649106413 scopus 로고    scopus 로고
    • rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: Combined analysis of IL23R, CARD15, and OCTN1/2 variants
    • J.Glas, J.Seiderer, M.Wetzke, A.Konrad, H.Torok-P, S.Schmechel, L.Tonenchi, C.Grassl, J.Dambacher, S.Pfennig. 2007. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: Combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS One. 2:e819.
    • (2007) PLoS One , vol.2 , pp. e819
    • Glas, J.1    Seiderer, J.2    Wetzke, M.3    Konrad, A.4    Torok, H.5    Schmechel, S.6    Tonenchi, L.7    Grassl, C.8    Dambacher, J.9    Pfennig, S.10
  • 37
    • 84925403090 scopus 로고    scopus 로고
    • ATG16L1 and IL23R variants and genetic susceptibility to Crohn's Disease: Mode of inheritance based on meta-analysis of genetic association studies
    • C.A.Grigoras, P.D.Ziakas, E.Jayamani, E.Mylonakis. 2015. ATG16L1 and IL23R variants and genetic susceptibility to Crohn's Disease: Mode of inheritance based on meta-analysis of genetic association studies. Inflamm Bowel Dis. 21:768–776.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 768-776
    • Grigoras, C.A.1    Ziakas, P.D.2    Jayamani, E.3    Mylonakis, E.4
  • 38
    • 84865547366 scopus 로고    scopus 로고
    • Targeting IL‐23 by employing a p40 peptide‐based vaccine ameliorates murine allergic skin and airway inflammation
    • Q.Guan, Y.Ma, L.Aboud, C.Weiss, G.Qing, R.Warrington, Z.Peng. 2012. Targeting IL‐23 by employing a p40 peptide‐based vaccine ameliorates murine allergic skin and airway inflammation. Clin Exp Allergy. 42:1397–1405.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1397-1405
    • Guan, Q.1    Ma, Y.2    Aboud, L.3    Weiss, C.4    Qing, G.5    Warrington, R.6    Peng, Z.7
  • 39
    • 84930486427 scopus 로고    scopus 로고
    • Evidence of association of IL-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients
    • G.Hamdy, H.Darweesh, E.A.Khattab, S.Fawzy, E.Fawzy, M.Sheta. 2015. Evidence of association of IL-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients. Human Immunol. 76:417–420.
    • (2015) Human Immunol , vol.76 , pp. 417-420
    • Hamdy, G.1    Darweesh, H.2    Khattab, E.A.3    Fawzy, S.4    Fawzy, E.5    Sheta, M.6
  • 41
    • 84859887556 scopus 로고    scopus 로고
    • IL-23R rs11209026 poly-morphism modulates IL-17A expression in patients with rheumatoid arthritis
    • J.Hazlett, L.Stamp, T.Merriman, J.Highton, P.Hessian. 2012. IL-23R rs11209026 poly-morphism modulates IL-17A expression in patients with rheumatoid arthritis. Genes Immun. 13:282–287.
    • (2012) Genes Immun , vol.13 , pp. 282-287
    • Hazlett, J.1    Stamp, L.2    Merriman, T.3    Highton, J.4    Hessian, P.5
  • 43
    • 77953245440 scopus 로고    scopus 로고
    • The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease
    • O.Hradsky, P.Dusatkova, M.Lenicek, et al. 2010. The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease. BMC Med Genet. 11:91.
    • (2010) BMC Med Genet , vol.11 , pp. 91
    • Hradsky, O.1    Dusatkova, P.2    Lenicek, M.3
  • 52
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human IL-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomized double-blind placebo-controlled trial (PHOENIX 1)
    • C.L.Leonardi, A.B.Kimball, K.A.Papp, N.Yeilding, C.Guzzo, Y.Wang, S.Li, L.T.Dooley, K.B.Gordon, P.S.Investigators. 2008. Efficacy and safety of ustekinumab, a human IL-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomized double-blind placebo-controlled trial (PHOENIX 1). Lancet. 371:1665–1674.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6    Li, S.7    Dooley, L.T.8    Gordon, K.B.9    Investigators, P.S.10
  • 53
    • 41949125627 scopus 로고    scopus 로고
    • Contribution of positively charged flanking residues to the insertion of trans-membrane helices into the endoplasmic reticulum
    • M.Lerch-Bader, C.Lundin, H.Kim, I.Nilsson, G.von Heijne. 2008. Contribution of positively charged flanking residues to the insertion of trans-membrane helices into the endoplasmic reticulum. Proc Natl Acad Sci USA. 105:4127–4132.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4127-4132
    • Lerch-Bader, M.1    Lundin, C.2    Kim, H.3    Nilsson, I.4    von Heijne, G.5
  • 55
    • 60749086043 scopus 로고    scopus 로고
    • Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients
    • L.Magyari, G.Melyaregu, B.Melegh. 2008. Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients. Orvosi Hetilap. 150:81–88.
    • (2008) Orvosi Hetilap , vol.150 , pp. 81-88
    • Magyari, L.1    Melyaregu, G.2    Melegh, B.3
  • 56
    • 44049104564 scopus 로고    scopus 로고
    • H17 cells requires TGFβ and induction of the nuclear receptor RORγt
    • H17 cells requires TGFβ and induction of the nuclear receptor RORγt. Nat Immunol. 9:641–649.
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 58
    • 34948840330 scopus 로고    scopus 로고
    • The IL23 axis plays a key role in the pathogenesis of IBD
    • D.McGovern, F.Powrie. 2007. The IL23 axis plays a key role in the pathogenesis of IBD. Gut. 56:1333–1336.
    • (2007) Gut. , vol.56 , pp. 1333-1336
    • McGovern, D.1    Powrie, F.2
  • 63
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • B.Oppmann, R.Lesley, B.Blom, J.C.Timans, Y.Xu, B.Hunte, F.Vega, N.Yu, J.Wang, K.Singh. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:715–725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7    Yu, N.8    Wang, J.9    Singh, K.10
  • 64
    • 41549135632 scopus 로고    scopus 로고
    • H17 cell effector cytokines in inflammation
    • H17 cell effector cytokines in inflammation. Immunity. 28:454–467.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 68
    • 84921473604 scopus 로고    scopus 로고
    • The human IL-23 Receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA apecies
    • Y.Y.Raymond, J.Brazaitis, G.Gallagher. 2015. The human IL-23 Receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA apecies. J Immunol. 194:1062–1068.
    • (2015) J Immunol , vol.194 , pp. 1062-1068
    • Raymond, Y.Y.1    Brazaitis, J.2    Gallagher, G.3
  • 71
    • 70450200633 scopus 로고    scopus 로고
    • Functional variants of the IL-23 receptor gene in non-gastrointestinal autoimmune diseases
    • E.Safrany, B.Melegh. 2009. Functional variants of the IL-23 receptor gene in non-gastrointestinal autoimmune diseases. Cur Med Chem. 16:3766–3774.
    • (2009) Cur Med Chem , vol.16 , pp. 3766-3774
    • Safrany, E.1    Melegh, B.2
  • 75
    • 13944281011 scopus 로고    scopus 로고
    • Expression of IL‐12‐related cytokine transcripts in inflammatory bowel disease: elevated IL‐23p19 and IL‐27p28 in Crohn's disease but not in ulcerative colitis
    • C.Schmidt, T.Giese, B.Ludwig, I.Mueller-Molaian, T.Marth, S.Zeuzem, S.C.Meuer, A.Stallmach. 2005. Expression of IL‐12‐related cytokine transcripts in inflammatory bowel disease: elevated IL‐23p19 and IL‐27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis. 11:16–23.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 16-23
    • Schmidt, C.1    Giese, T.2    Ludwig, B.3    Mueller-Molaian, I.4    Marth, T.5    Zeuzem, S.6    Meuer, S.C.7    Stallmach, A.8
  • 77
    • 84911489363 scopus 로고    scopus 로고
    • Pilot study of variants of the IL-23R and STAT3 genes reveals no association with Hashimoto’s thyroiditis in the Croatian population
    • M.S.Stevic, M.Stefanic, S.Tokic, L.Glavas-Obrovac, S.Mihaljevic, I.Karner. 2014. Pilot study of variants of the IL-23R and STAT3 genes reveals no association with Hashimoto’s thyroiditis in the Croatian population. Endocrine Res. 39:164–167.
    • (2014) Endocrine Res , vol.39 , pp. 164-167
    • Stevic, M.S.1    Stefanic, M.2    Tokic, S.3    Glavas-Obrovac, L.4    Mihaljevic, S.5    Karner, I.6
  • 78
    • 84904392521 scopus 로고    scopus 로고
    • Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA)
    • F.Tavasolian, E.Abdollahi, M.Samadi. 2014. Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA). J Assisted Repro Genet. 31:851–856.
    • (2014) J Assisted Repro Genet , vol.31 , pp. 851-856
    • Tavasolian, F.1    Abdollahi, E.2    Samadi, M.3
  • 80
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12, interleukin-23, and psoriasis: current prospects
    • D.C.Torti, S.R.Feldman. 2007. Interleukin-12, interleukin-23, and psoriasis: current prospects. J Am Acad Dermatol. 57:1059–1068.
    • (2007) J Am Acad Dermatol , vol.57 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 82
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: new players in the regulation of T-cell responses
    • G.Trinchieri, S.Pflanz, R.A.Kastelein. 2003. The IL-12 family of heterodimeric cytokines: new players in the regulation of T-cell responses. Immunity. 19:641–644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 83
    • 9644265521 scopus 로고    scopus 로고
    • Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae
    • E.van de Vosse, M.A.Hoeve, T.H.Ottenhoff. 2004. Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae. Lancet Infect Dis. 4:739–749.
    • (2004) Lancet Infect Dis , vol.4 , pp. 739-749
    • van de Vosse, E.1    Hoeve, M.A.2    Ottenhoff, T.H.3
  • 86
    • 69049103047 scopus 로고    scopus 로고
    • Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis
    • X.Wang, Z.Lin, Q.Wei, Y.Jiang, J.Gu. 2009. Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis. Rheumatol Intl. 29:1343–1347.
    • (2009) Rheumatol Intl , vol.29 , pp. 1343-1347
    • Wang, X.1    Lin, Z.2    Wei, Q.3    Jiang, Y.4    Gu, J.5
  • 90
    • 34347357508 scopus 로고    scopus 로고
    • Association analysis of genetic variants in IL23R, ATG16L1 and 5p13. 1 loci with Crohn’s disease in Japanese patients
    • K.Yamazaki, Y.Onouchi, M.Takazoe, M.Kubo, Y.Nakamura, A.Hata. 2007. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13. 1 loci with Crohn’s disease in Japanese patients. J Human Genet. 52:575–583.
    • (2007) J Human Genet , vol.52 , pp. 575-583
    • Yamazaki, K.1    Onouchi, Y.2    Takazoe, M.3    Kubo, M.4    Nakamura, Y.5    Hata, A.6
  • 91
    • 84866272883 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms of IL23R and IL-17 with ulcerative colitis risk in a Chinese Han population
    • P.Yu, F.Shen, X.Zhang, R.Cao, X.Zhao, P.Liu, H.Tu, X.Yang, R.Shi, H.Zhang. 2012. Association of single nucleotide polymorphisms of IL23R and IL-17 with ulcerative colitis risk in a Chinese Han population. PLoS One. 7:e44380.
    • (2012) PLoS One , vol.7 , pp. e44380
    • Yu, P.1    Shen, F.2    Zhang, X.3    Cao, R.4    Zhao, X.5    Liu, P.6    Tu, H.7    Yang, X.8    Shi, R.9    Zhang, H.10


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