Association between lower frequency of R381Q variant (rs11209026) in IL-23 receptor gene and increased risk of recurrent spontaneous abortion (RSA)

Journal of Immunotoxicology

Volumn 12, Issue 4, 2015, Pages 317-321

  Abdollahi, Elham ^a   Tavasolian, Fataneh ^a   Ghasemi, Nasrin ^a   Mirghanizadeh, Seyed Ali ^a   Azizi, Mohammdareza ^b   Ghoryani, Mohsen ^c   Samadi, Morteza ^a  

^a SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Research and Clinical Center for Infertility   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

IL 23R; R381Q; recurrent spontaneous abortion

Indexed keywords

INTERLEUKIN 23 RECEPTOR; IL23R PROTEIN, HUMAN; INTERLEUKIN RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT ABORTION; RECURRENT SPONTANEOUS ABORTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; ALLELE; AMINO ACID SUBSTITUTION; CLINICAL TRIAL; GENETICS; MISSENSE MUTATION; MULTICENTER STUDY; PREGNANCY; RISK FACTOR;

ABORTION, HABITUAL; ADULT; ALLELES; AMINO ACID SUBSTITUTION; FEMALE; GENE FREQUENCY; HUMANS; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RECEPTORS, INTERLEUKIN; RISK FACTORS;

EID: 84938856326     PISSN: 1547691X     EISSN: 15476901     Source Type: Journal    
DOI: 10.3109/1547691X.2014.978056     Document Type: Article

References (36)

1. Dehghani Firoozabadi, R., Klantar, S. M., Seyed-Hasani, S. M., et al. 2006. Cytogenetic analysis in couples with recurrent spontaneous abortion. Iran. J. Reprod. Med. 4:13-17.
2. Duan, Z., Pan, F., Zeng, Z., et al. 2012. IL-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: A metaanalysis. Rheumatol. Intl. 32:1209-1214.
3. Duerr, R. H., Taylor, K. D., Brant, S. R., et al. 2006. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314:1461-1463.
4. Duvallet, E., Semerano, L., Assier, E., et al. 2011. IL-23: A key cytokine in inflammatory diseases. Ann. Med. 43:503-511.
5. H17 cell response by IL-21. Gastroenterology 134:1038-1048.
6. Ghasemi, N., Karimi-Zarchi, M., Mortazavi-Zadeh, M. R., and Atash-Afza, A. 2010. Evaluation of the frequency of TP53 gene codon 72 polymorphisms in Iranian patients with endometrial cancer. Cancer Genet. Cytogenet. 196:167-170.
7. Guan, Q., Ma, Y., Aboud, L., et al. 2012. Targeting IL-23 by employing a p40 peptide-based vaccine ameliorates murine allergic skin and airway inflammation. Clin. Exp. Allergy 42:1397-1405.
8. H17 polarization during CNS-inflammation in vivo. Eur. J. Immunol. 39:1864-1869.
9. Hazlett, J., Stamp, L., Merriman, T., et al. 2012. IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis. Genes Immunity 13:282-287.
10. Hedrick, M. N., Lonsdorf, A. S., Shirakawa, A. K., et al. 2009. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J. Clin. Invest. 119:2317-2329.
11. Hradsky, O., Dusatkova, P., Lenicek, M., et al. 2011. Two independent genetic factors responsible for associations of IBD5 locus with Crohn's disease in the Czech population. Inflamm. Bowel Dis. 17:1523-1529.
12. Kwak-Kim, J., Yang, K. M., and Gilman-Sachs, A. 2009. Recurrent pregnancy loss: A disease of inflammation and coagulation. J. Obstet. Gynecol. Res. 35:609-622.
13. Larid, S., Tucherman, E., Cork, B., et al. 2003. A review of immune cells and molecules in women with recurrent miscarriage. Human Reprod. Update 9:163-174.
14. Lakatos, P., Szamosi, T., Szilvasi, A., et al. 2008. ATG16L1 and IL-23 receptor (IL-23R) genes are associated with disease susceptibility in Hungarian CD patients. Digest. Liver Dis. 40:867-873.
15. H17 and regulatory T-cells in women with recurrent pregnancy loss. Am. J. Reprod. Immunol. 67:311-318.
16. Liu, C., Wang, J., Zhou, S., et al. 2010. Association between-238 but not-308 polymorphism of TNF and unexplained recurrent spontaneous abortion (URSA) in Chinese population. Reprod. Biol. Endocrinol. 8:114-118.
17. H17 cells and unexplained recurrent spontaneous abortion. Am. J. Reprod. Immunol. 65:503-511.
18. H17 cells. Brain Behav. Immun. 25:863-871.
19. Miller, S., Dykes, D., and Polesky, H. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
20. H2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am. J. Reprod. Immunol. 48:77-86.
21. Numasaki, M., Fukushi, J.-I., Oni, M., et al. 2003. Interleukin-17 promotes angiogenesis and tumor growth. Blood 101:2620-2627.
22. H2 polarization and regulates allergic airway inflammation. Cell Res. 20:62-71.
23. Piccinni, M. P. 2006. T-Cells in normal pregnancy and recurrent pregnancy loss. Reprod. Biomed. Online 13:840-844.
24. Pidasheva, S., Trifari, S., Phillips, A., et al. 2011. Functional studies on the IBD susceptibility gene IL-23R implicate reduced receptor function in the protective genetic variant R381Q. PLoS One 6:e25038.
25. Pongcharoen, S., Somran, J., Sritippayawan, S., et al. 2007. IL-17 expression in the human placenta. Placenta 28:59-63.
26. Raghupathy, R. 2003. The immunology of unexplained recurrent spontaneous abortion: Cytokines as key mediators. Bull. Kuwait Inst. Med. Spec. 2:32-38.
27. Rahman, P., Inman, R. D., Gladman, D. D., et al. 2008. Association of IL-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 58:1020-1025.
28. Safrany, E., Szabo, M., Szell, M., et al. 2013. Difference of IL-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis. Inflamm. Res. 62:195-200.
29. high regulatory T-cells in human pregnancy. J. Reprod. Immunol. 65:111-120.
30. + T-cells in healthy pregnancy but not in pre-eclampsia. J. Immunol. 183:7023-7030.
31. + human T-cell functional responses. Proc. Natl. Acad. Sci. USA 108:9560-9565.
32. 2 exacer-bates collagen-induced arthritis in mice through the inflammatory IL-23/IL-17 axis. Arthritis Rheum. 56:2608-2619.
33. Soares, M. J. 2004. The prolactin and growth hormone families: Pregnancy-specific hormones/cytokines at maternal-fetal interface. Reprod. Biol. Endocrinol. 2:1477-7827.
34. Venegas, M., Beltrán, C. J., Álvarez, L., et al. 2008. IL-23R Arg381Gln polymorphism in Chilean patients with inflammatory bowel disease. Eur. Cytokine Network 19:190-195.
35. Wang, W. J., Hao, C. F., Qu, Q. L., et al. 2010a. The de-regulation of regulatory T-cells on IL-17-producing T-helper cells in patients with unexplained early recurrent miscarriage. Human Reprod. 25:2591-2596.
36. H17 cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J. Reprod. Immunol. 84:164-170.