Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 23, 2011, Pages 9560-9565

  Sarin, Ritu ^a   Wu, Xingxin ^a   Abraham, Clara ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; Cytokines; Psoriasis; Ulcerative colitis

Indexed keywords

ARGININE; GLUTAMINE; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; STAT3 PROTEIN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TH17 CELL;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; INFLAMMATORY BOWEL DISEASES; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; LUCIFERASES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS;

EID: 79959335758     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017854108     Document Type: Article

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