Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Pidasheva, Svetlana ^a   Trifari, Sara ^a,d   Phillips, Anne ^a,e   Hackney, Jason A ^a   Ma, Yan ^a   Smith, Ashley ^a   Sohn, Sue J ^a   Spits, Hergen ^a,c   Little, Randall D ^b   Behrens, Timothy W ^a   Honigberg, Lee ^a   Ghilardi, Nico ^a   Clark, Hilary F ^a  

^a GENENTECH INC   (United States)

^b Genizon BioSciences Inc   (Canada)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6; JANUS KINASE 2; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; IL23R PROTEIN, HUMAN; INTERLEUKIN RECEPTOR; STAT PROTEIN;

ADULT; AGED; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA POLYMORPHISM; DONOR; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIGAND BINDING; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PSORIASIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ULCERATIVE COLITIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BIOLOGICAL MODEL; CELL CLONE; CELL LINE; CHEMISTRY; DRUG EFFECT; GENETIC PREDISPOSITION; GENETICS; LYMPHOCYTE COUNT; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; CELL LINE, TRANSFORMED; CLONE CELLS; CONSERVED SEQUENCE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-23; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COUNT; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; SPECIES SPECIFICITY; STAT TRANSCRIPTION FACTORS; T-LYMPHOCYTES; TISSUE DONORS;

EID: 80053991071     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025038     Document Type: Article

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