Replication of an Association Between IL23R Gene Polymorphism With Inflammatory Bowel Disease

Clinical Gastroenterology and Hepatology

Volumn 5, Issue 8, 2007, Pages

  Oliver, Javier ^a   Rueda, Blanca ^a   López Nevot, Miguel A ^b   Gómez García, María ^b   Martín, Javier ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLYCINE; INTERLEUKIN 23; SPACER DNA;

ARTICLE; CONTROLLED STUDY; ENTERITIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; HUMAN TISSUE; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN;

EID: 34547126695     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2007.05.002     Document Type: Article

References (27)

1. Podolsky D.K. Inflammatory bowel disease. N Engl J Med 347 (2002) 417-429
2. Bouma G., and Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3 (2003) 521-533
3. Vermeire S., and Rutgeerts P. Current status of genetics research in inflammatory bowel disease. Genes Immun 6 (2005) 637-645
4. Gaya D.R., Russell R.K., Nimmo E.R., et al. New genes in inflammatory bowel disease: lessons for complex diseases?. Lancet 367 (2006) 1271-1284
5. Langrish C.L., McKenzie B.S., Wilson N.J., et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 202 (2004) 96-105
6. Trinchieri G., Pflanz S., and Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19 (2003) 641-644
7. Oppmann B., Lesley R., Blom B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
8. Parham C., Chirica M., Timans J., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168 (2002) 5699-5708
9. Cua D.J., Sherlock J., Chen Y., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
10. Murphy C.A., Langrish C.L., Chen Y., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198 (2003) 1951-1957
11. Becker C., Wirtz S., Blessing M., et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 112 (2003) 693-706
12. Hue S., Ahern P., Buonocore S., et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 203 (2006) 2473-2483
13. Kullberg M.C., Jankovic D., Feng C.G., et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 203 (2006) 2485-2494
14. Yen D., Cheung J., Scheerens H., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 (2006) 1310-1316
15. McKenzie B.S., Kastelein R.A., and Cua D.J. Understanding the IL-23-IL-17 immune pathway. Trends Immunol 27 (2006) 17-23
16. Fuss I.J., Becker C., Yang Z., et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 12 (2006) 9-15
17. Schmidt C., Giese T., Ludwig B., et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis 11 (2005) 16-23
18. Duerr R.H., Taylor K.D., Brant S.R., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
19. Lennard-Jones J.E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170 (1989) 2-6 discussion 16-19
20. Oliver J., Marquez A., Gómez-Garcia M., et al. Association of the macrophage inhibitory factor gene polymorphisms with inflammatory bowel disease. Gut 56 (2007) 150-151
21. Ioannidis J.P., Trikalinos T.A., Ntzani E.E., et al. Genetic associations in large versus small studies: an empirical assessment. Lancet 361 (2003) 567-571
22. Lohmueller K.E., Pearce C.L., Pike M., et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33 (2003) 177-182
23. Zhang X.Y., Zhang H.J., Zhang Y., et al. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics 57 (2006) 934-943
24. Zwiers A., Seegers D., Heijmans R., et al. Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease. Genes Immun 5 (2004) 675-677
25. Sanchez E., Morales S., Paco L., et al. Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. Rheumatology (Oxford) 44 (2005) 1136-1139
26. Orozco G., Gonzalez-Gay M.A., Paco L., et al. Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis. Hum Immunol 66 (2005) 710-715
27. Uhlig H.H., McKenzie B.S., Hue S., et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25 (2006) 309-318