Evidence of association of interleukin-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients

Human Immunology

Volumn 76, Issue 6, 2015, Pages 417-420

  Hamdy, Gehan ^a   Darweesh, Hanan ^a   Khattab, Enas A ^b   Fawzy, Samar ^a   Fawzy, Esmat ^c   Sheta, Marwa ^a  

^a Cairo University   (Egypt)

^b Fayoum University   (Egypt)

^c ZAGAZIG UNIVERSITY   (Egypt)

Author keywords

IL23; IL23 gene polymorphism; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; HYDROXYCHLOROQUINE; INTERLEUKIN 23 RECEPTOR; LEFLUNAMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; RHEUMATOID FACTOR; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; IL23R PROTEIN, HUMAN; INTERLEUKIN RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ACTIVITY SCORE; DISEASE DURATION; DISEASE PREDISPOSITION; EGYPTIAN; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MORNING STIFFNESS; ONSET AGE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; URINALYSIS; VISUAL ANALOG SCALE; ADOLESCENT; ALLELE; CASE CONTROL STUDY; EGYPT; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADOLESCENT; ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; BIOMARKERS; CASE-CONTROL STUDIES; EGYPT; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN;

EID: 84930486427     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2015.03.020     Document Type: Article

References (30)

1. Silman A.J., Pearson J.E. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res. 2002, 4(3):S265-S272.
2. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361.
3. Bowes J., Barton A. Recent advances in the genetics of RA susceptibility. Rheumatology 2008, 47:399-402.
4. Hollis-Moffat J.E., Merriman M.E., Rodger R.A., Rowley K.A., Chapman P.T., Dalbeth N., et al. Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Ann Rheum Dis. 2009, 68(8):1340-1344.
5. Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12R beta 1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 2002, 168:5699-5708.
6. Zhang X.Y., Zhang H.J., Zhang Y., Fu Y.J., He J., Zhu L.P., et al. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics 2006, 57:934-943.
7. Safrany E., Melegh B. Functional Variants of the Interleukin-23 Receptor Gene in Non-Gastrointestinal Autoimmune Diseases. Current Medicinal Chemistry 2009, 16:3766-3774.
8. Lankford C.S., Frucht D.M. A unique role for IL-23 in promoting cellular immunity. J. Leukoc. Biol. 2003, 73:49-56.
9. Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., Gurney A.L., et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. The Journal of Biological Chemistry 2003, 278:1910-1914.
10. Iwakura Y., Ishigame H. The IL-23/IL-17 axis in inflammation. The Journal of Clinical Investigation 2006, 116:1218-1222.
11. Kim H.R., Cho M.L., Kim K.W., Juhn J.Y., Hwang S.Y., Yoon C.H., et al. Up-regulation of IL23-p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3- kinase-NFkB- and p38 MAPK-dependent signaling pathways. Rheumatology 2007, 46:57-64.
12. Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., et al. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen induced arthritis in rats. Arthritis research & therapy. 2007, 9(5):R96.
13. Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Itoh K., Ishiyama S., et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999, 103:1345-1352.
14. Yago T., Nanke Y., Furuya T., Kobashigawa T., Kamatani N., Kotake S. Infliximab potently inhibits osteoclastogenesis from human monocytes alone induced by IL-17 in the absence of osteoblasts. Arthritis Rheum. 2004, 50:S289.
15. Lubberts E, Koenders M I, van den Berg W B. The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res. Ther. 7 (2005) 29-37.
16. Miossec P. Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum. 2003, 48:594-601.
17. McGovern D., Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut 2007, 56:1333-1336.
18. Rueda B.G., Orozco E., Raya J.L., Fernandez S., Mulero J., Blanco F.J., et al. The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Annals of the Rheumatic Diseases 2008, 67:1451-1454.
19. Huber A K, Jacobson E M, Jazdzewski K, Concepcion E S, Tomer Y l. Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. The Journal of Clinical Endocrinology and Metabolism 2008; 93: 1077-1081.
20. Safrany E, Szell M, Csongei V, Jaromi L, Sipeky C, Szabo T et al. Polymorphisms of the IL23R Gene Are Associated with Psoriasis but not with Immunoglobulin a Nephropathy in a Hungarian Population. Inflammation. 2010; 27.
21. Daniel a, Tuhina N, Alan J S, Julia F, David T F, Clifton O, Bingham, Neal S B et al.: 2010 Rheumatoid Arthritis Classification Criteria. Arthritis & Rheumatism. 2010; 62(9): 2569-2581.
22. Jaap F., Gerold S. Piet L C M van Rie: Rheumatoid Arthritis Measures Disease Activity Score (DAS), Disease Activity Score-28 (DAS28), Rapid Assessment of Disease Activity in Rheumatology (RADAR), and Rheumatoid Arthritis Disease Activity Index (RADAI). Arthritis & Rheumatism. 2003, 49(5S):S214-S224.
23. Thasia W., Veena R., Daniel E. Rheumatoid arthritis in the elderly recent advances in understanding the pathogenesis, risk factors, co morbidities and risk-benefit of treatments. Aging Health 2013, 9(2):167-178.
24. Jiang Z., Yang P., Hou S., Li F., Zhou H. Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population. Human Immunology. 2010, 71:4141-4147.
25. Filer C., Ho P., Smith R.L., Griffiths C., Young H.S., Worthington J., et al. Investigation of Association of the IL12B and IL23R Genes with Psoriatic Arthritis. Arthritis and Rheumatism. 2008, 58:3705-3709.
26. Orozco G., Rueda B., Robledo G., García A., Martín J. Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort. Hum Immunol. 2007, 68:681-684.
27. Chang M., Saiki R.K., Cantanese J.J., Lew D., van der Helm van Mil, Toes R.E.M., et al. The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis. Arthritis Rheum. 2008, 58:1877-1881.
28. Park J.H., Kim Y.J., Park B.L., Bae J.S., Shin H.D., Bae S.C. Lack of association between interleukin 23 receptor (IL23R) gene Polymorphisms and rheumatoid arthritis susceptibility. Arthritis and Rheumatism 2008, 58:S214.
29. Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006, 314:1461-1463.
30. Farago B., Magyari L., Safrany E., Csongei V., Jaromi L., Horvatovich K., et al. Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis. Ann Rheum Dis. 2008, 67:248-250.