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Volumn 22, Issue 5, 2016, Pages 506-515

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

(25)  Peuker, Kenneth a,b   Muff, Stefanie a   Wang, Jun c,d   Künzel, Sven c,d   Bosse, Esther a   Zeissig, Yvonne a,e   Luzzi, Giuseppina a,b   Basic, Marijana f   Strigli, Anne b   Ulbricht, Andrea a   Kaser, Arthur g   Arlt, Alexander a   Chavakis, Triantafyllos b   Van Den Brink, Gijs R h   Schafmayer, Clemens a   Egberts, Jan Hendrik a   Becker, Thomas a   Bianchi, Marco E i   Bleich, André f   Röcken, Christoph a   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CALCINEURIN; GREEN FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR NFAT; RNA 16S;

EID: 84962130477     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4072     Document Type: Article
Times cited : (100)

References (92)
  • 2
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell cycle progression during colitis-associated tumorigenesis
    • Bollrath, J. et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell cycle progression during colitis-associated tumorigenesis. Cancer Cell 15, 91-102 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1
  • 3
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R. et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (2004).
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 4
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 5
    • 84868613705 scopus 로고    scopus 로고
    • Adenoma-linked barrier defects and microbial products drive IL-23- and IL-17-mediated tumor growth
    • Grivennikov, S.I. et al. Adenoma-linked barrier defects and microbial products drive IL-23- and IL-17-mediated tumor growth. Nature 491, 254-258 (2012).
    • (2012) Nature , vol.491 , pp. 254-258
    • Grivennikov, S.I.1
  • 6
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem cell-like properties
    • Schwitalla, S. et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem cell-like properties. Cell 152, 25-38 (2013).
    • (2013) Cell , vol.152 , pp. 25-38
    • Schwitalla, S.1
  • 7
    • 79151468994 scopus 로고    scopus 로고
    • Interaction of calcineurin with substrates and targeting proteins
    • Li, H., Rao, A. & Hogan, P.G. Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol. 21, 91-103 (2011).
    • (2011) Trends Cell Biol. , vol.21 , pp. 91-103
    • Li, H.1    Rao, A.2    Hogan, P.G.3
  • 8
    • 0242361191 scopus 로고    scopus 로고
    • Cancer risk following organ transplantation: A nationwide cohort study in Sweden
    • Adami, J. et al. Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br. J. Cancer 89, 1221-1227 (2003).
    • (2003) Br. J. Cancer , vol.89 , pp. 1221-1227
    • Adami, J.1
  • 9
    • 0032574187 scopus 로고    scopus 로고
    • Effect of long-term immunosuppression in kidney graft recipients on cancer incidence: Randomized comparison of two cyclosporin regimens
    • Dantal, J. et al. Effect of long-term immunosuppression in kidney graft recipients on cancer incidence: randomized comparison of two cyclosporin regimens. Lancet 351, 623-628 (1998).
    • (1998) Lancet , vol.351 , pp. 623-628
    • Dantal, J.1
  • 10
    • 15744397205 scopus 로고    scopus 로고
    • Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: Involvement in the regulation of cyclooxygenase-2
    • Duque, J., Fresno, M. & Iñiguez, M.A. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. J. Biol. Chem. 280, 8686-8693 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 8686-8693
    • Duque, J.1    Fresno, M.2    Iñiguez, M.A.3
  • 11
    • 0036308285 scopus 로고    scopus 로고
    • The role of NFAT transcription factors in integrin-mediated carcinoma invasion
    • Jauliac, S. et al. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat. Cell Biol. 4, 540-544 (2002).
    • (2002) Nat. Cell Biol. , vol.4 , pp. 540-544
    • Jauliac, S.1
  • 13
    • 84864752366 scopus 로고    scopus 로고
    • Nuclear factor of activated T cell-c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells
    • Zhou, Y., Wang, Q., Guo, Z., Weiss, H.L. & Evers, B.M. Nuclear factor of activated T cell-c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells. Mol. Biol. Cell 23, 2963-2972 (2012).
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2963-2972
    • Zhou, Y.1    Wang, Q.2    Guo, Z.3    Weiss, H.L.4    Evers, B.M.5
  • 14
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser, A.R., Pitot, H.C. & Dove, W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324 (1990).
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 15
    • 0032849010 scopus 로고    scopus 로고
    • Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
    • Aramburu, J. et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285, 2129-2133 (1999).
    • (1999) Science , vol.285 , pp. 2129-2133
    • Aramburu, J.1
  • 16
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • Rivera, A. & Maxwell, S.A. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J. Biol. Chem. 280, 29346-29354 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 17
    • 67349172713 scopus 로고    scopus 로고
    • K120R mutant
    • K120R mutant. FEBS Lett. 583, 1916-1922 (2009).
    • (2009) FEBS Lett. , vol.583 , pp. 1916-1922
    • Shinmen, N.1
  • 18
    • 0027331410 scopus 로고
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178, 1517-1522 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1517-1522
    • Woodrow, M.1    Clipstone, N.A.2    Cantrell, D.3
  • 19
    • 0033019518 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: A role for tissue factor gene expression
    • Armesilla, A.L. et al. Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. Mol. Cell. Biol. 19, 2032-2043 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2032-2043
    • Armesilla, A.L.1
  • 20
    • 77249176619 scopus 로고    scopus 로고
    • NFAT-induced histone acetylation relay switch promotes c-Myc- dependent growth in pancreatic cancer cells
    • Köenig, A. et al. NFAT-induced histone acetylation relay switch promotes c-Myc- dependent growth in pancreatic cancer cells. Gastroenterology 138, 1189-1199 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1189-1199
    • Köenig, A.1
  • 21
    • 0037118064 scopus 로고    scopus 로고
    • The Wnt-calcium pathway activates NFAT and promotes ventral cell fate in Xenopus embryos
    • Saneyoshi, T., Kume, S., Amasaki, Y. & Mikoshiba, K. The Wnt-calcium pathway activates NFAT and promotes ventral cell fate in Xenopus embryos. Nature 417, 295-299 (2002).
    • (2002) Nature , vol.417 , pp. 295-299
    • Saneyoshi, T.1    Kume, S.2    Amasaki, Y.3    Mikoshiba, K.4
  • 22
    • 80755132231 scopus 로고    scopus 로고
    • Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
    • Wang, J.Y. et al. Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells. Cell. Signal. 24, 162-169 (2012).
    • (2012) Cell. Signal , vol.24 , pp. 162-169
    • Wang, J.Y.1
  • 23
    • 84856534859 scopus 로고    scopus 로고
    • Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
    • Castellarin, M. et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 22, 299-306 (2012).
    • (2012) Genome Res. , vol.22 , pp. 299-306
    • Castellarin, M.1
  • 24
    • 84919884555 scopus 로고    scopus 로고
    • Microbiota organization is a distinct feature of proximal colorectal cancers
    • Dejea, C.M. et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc. Natl. Acad. Sci. USA 111, 18321-18326 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 18321-18326
    • Dejea, C.M.1
  • 25
    • 84863022950 scopus 로고    scopus 로고
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
    • Kostic, A.D. et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22, 292-298 (2012).
    • (2012) Genome Res. , vol.22 , pp. 292-298
    • Kostic, A.D.1
  • 26
    • 77649272127 scopus 로고    scopus 로고
    • High expression of toll-like receptor 4 and myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer
    • Wang, E.L. et al. High expression of toll-like receptor 4 and myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br. J. Cancer 102, 908-915 (2010).
    • (2010) Br. J. Cancer , vol.102 , pp. 908-915
    • Wang, E.L.1
  • 27
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • Arthur, J.C. et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338, 120-123 (2012).
    • (2012) Science , vol.338 , pp. 120-123
    • Arthur, J.C.1
  • 28
    • 0030614675 scopus 로고    scopus 로고
    • Min mouse: Independence from the microbial and natural killer (beige locus) status
    • Min mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res. 57, 812-814 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 812-814
    • Dove, W.F.1
  • 29
    • 84882354326 scopus 로고    scopus 로고
    • Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment
    • Kostic, A.D. et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14, 207-215 (2013).
    • (2013) Cell Host Microbe , vol.14 , pp. 207-215
    • Kostic, A.D.1
  • 30
    • 77953196709 scopus 로고    scopus 로고
    • Min/+ mice
    • Min/+ mice. Nat. Med. 16, 665-670 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 665-670
    • Lee, S.H.1
  • 31
    • 84864298078 scopus 로고    scopus 로고
    • Min/+ mice
    • Min/+ mice. Carcinogenesis 33, 1231-1238 (2012).
    • (2012) Carcinogenesis , vol.33 , pp. 1231-1238
    • Li, Y.1
  • 32
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum, S. & Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (2007).
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 33
    • 84925286089 scopus 로고    scopus 로고
    • A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis
    • Scheeren, F.A. et al. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat. Cell Biol. 16, 1238-1248 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 1238-1248
    • Scheeren, F.A.1
  • 34
    • 84892476369 scopus 로고    scopus 로고
    • Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
    • Song, X. et al. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40, 140-152 (2014).
    • (2014) Immunity , vol.40 , pp. 140-152
    • Song, X.1
  • 35
    • 67650500800 scopus 로고    scopus 로고
    • CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
    • Zanoni, I. et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460, 264-268 (2009).
    • (2009) Nature , vol.460 , pp. 264-268
    • Zanoni, I.1
  • 36
    • 84877753124 scopus 로고    scopus 로고
    • TLR4 activates the β-catenin pathway to cause intestinal neoplasia
    • Santaolalla, R. et al. TLR4 activates the β-catenin pathway to cause intestinal neoplasia. PLoS One 8, e63298 (2013).
    • (2013) PLoS One , vol.8
    • Santaolalla, R.1
  • 37
    • 40449114489 scopus 로고    scopus 로고
    • Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: Combined effects of lipid A acylation state and TLR4 polymorphisms on signaling
    • Rallabhandi, P. et al. Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. J. Immunol. 180, 1139-1147 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 1139-1147
    • Rallabhandi, P.1
  • 38
    • 77954167202 scopus 로고    scopus 로고
    • Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways
    • Liu, S. & Kielian, T. Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. J. Immunol. 183, 5537-5547 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5537-5547
    • Liu, S.1    Kielian, T.2
  • 39
    • 33747616250 scopus 로고    scopus 로고
    • 2+-calcineurin signaling pathway
    • 2+-calcineurin signaling pathway. EMBO J. 25, 3714-3724 (2006).
    • (2006) EMBO J , vol.25 , pp. 3714-3724
    • Buchholz, M.1
  • 40
    • 77952716949 scopus 로고    scopus 로고
    • Opposing roles for calcineurin and ATF3 in squamous skin cancer
    • Wu, X. et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465, 368-372 (2010).
    • (2010) Nature , vol.465 , pp. 368-372
    • Wu, X.1
  • 41
    • 34548214756 scopus 로고    scopus 로고
    • The NFAT1 transcription factor is a repressor of cyclin A2 gene expression
    • Carvalho, L.D. et al. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle 6, 1789-1795 (2007).
    • (2007) Cell Cycle , vol.6 , pp. 1789-1795
    • Carvalho, L.D.1
  • 42
    • 84865734269 scopus 로고    scopus 로고
    • Transcription factor NFAT1 activates the Mdm2 oncogene independent of p53
    • Zhang, X. et al. Transcription factor NFAT1 activates the Mdm2 oncogene independent of p53. J. Biol. Chem. 287, 30468-30476 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 30468-30476
    • Zhang, X.1
  • 43
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 44
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 45
    • 0028131614 scopus 로고
    • Colorectal cancer prognosis and expression of exon v6-containing CD44 proteins
    • Mulder, J.W. et al. Colorectal cancer prognosis and expression of exon v6-containing CD44 proteins. Lancet 344, 1470-1472 (1994).
    • (1994) Lancet , vol.344 , pp. 1470-1472
    • Mulder, J.W.1
  • 46
    • 45549109525 scopus 로고    scopus 로고
    • Min/+ mice attenuates intestinal tumorigenesis
    • Min/+ mice attenuates intestinal tumorigenesis. Cancer Res. 68, 3655-3661 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3655-3661
    • Zeilstra, J.1
  • 47
    • 84896115102 scopus 로고    scopus 로고
    • CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis
    • Todaro, M. et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell 14, 342-356 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 342-356
    • Todaro, M.1
  • 48
    • 84893328640 scopus 로고    scopus 로고
    • min mice downstream of Wnt signaling
    • min mice downstream of Wnt signaling. Oncogene 33, 665-670 (2014).
    • (2014) Oncogene , vol.33 , pp. 665-670
    • Zeilstra, J.1
  • 49
    • 84890834283 scopus 로고    scopus 로고
    • Nfatc1 orchestrates aging in hair follicle stem cells
    • Keyes, B.E. et al. Nfatc1 orchestrates aging in hair follicle stem cells. Proc. Natl. Acad. Sci. USA 110, E4950-E4959 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E4950-E4959
    • Keyes, B.E.1
  • 50
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologs associate with Wnt receptors and mediate R-spondin signaling
    • de Lau, W. et al. Lgr5 homologs associate with Wnt receptors and mediate R-spondin signaling. Nature 476, 293-297 (2011).
    • (2011) Nature , vol.476 , pp. 293-297
    • De Lau, W.1
  • 52
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 33-337 (2012).
    • (2012) Nature , vol.487 , pp. 33-337
    • Cancer Genome Atlas Network1
  • 53
    • 84865459654 scopus 로고    scopus 로고
    • Recurrent R-spondin fusions in colon cancer
    • Seshagiri, S. et al. Recurrent R-spondin fusions in colon cancer. Nature 488, 660-664 (2012).
    • (2012) Nature , vol.488 , pp. 660-664
    • Seshagiri, S.1
  • 54
    • 0026632557 scopus 로고
    • FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
    • O'Keefe, S.J., Tamura, J., Kincaid, R.L., Tocci, M.J. & O'Neill, E.A. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357, 692-694 (1992).
    • (1992) Nature , vol.357 , pp. 692-694
    • O'Keefe, S.J.1    Tamura, J.2    Kincaid, R.L.3    Tocci, M.J.4    O'Neill, E.A.5
  • 55
    • 84896078883 scopus 로고    scopus 로고
    • Microbes, microbiota and colon cancer
    • Sears, C.L. & Garrett, W.S. Microbes, microbiota and colon cancer. Cell Host Microbe 15, 317-328 (2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 317-328
    • Sears, C.L.1    Garrett, W.S.2
  • 56
    • 84863989936 scopus 로고    scopus 로고
    • A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects
    • Tjalsma, H., Boleij, A., Marchesi, J.R. & Dutilh, B.E. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat. Rev. Microbiol. 10, 575-582 (2012).
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 575-582
    • Tjalsma, H.1    Boleij, A.2    Marchesi, J.R.3    Dutilh, B.E.4
  • 57
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med. 15, 1016-1022 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1016-1022
    • Wu, S.1
  • 58
    • 0042815050 scopus 로고    scopus 로고
    • Canonical analysis of principal coordinates: A useful method of constrained ordination for ecology
    • Anderson, M.J. & Willis, T.J. Canonical analysis of principal coordinates: a useful method of constrained ordination for ecology. Ecology 84, 511-525 (2003).
    • (2003) Ecology , vol.84 , pp. 511-525
    • Anderson, M.J.1    Willis, T.J.2
  • 59
    • 84966552899 scopus 로고
    • Controlling the false-discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false-discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Stat. Methodol. 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. Series B Stat. Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 60
    • 84924405610 scopus 로고    scopus 로고
    • Caspase-8 controls the gut response to microbial challenges by TNF-α-dependent and independent pathways
    • Günther, C. et al. Caspase-8 controls the gut response to microbial challenges by TNF-α-dependent and independent pathways. Gut 64, 601-610 (2015).
    • (2015) Gut , vol.64 , pp. 601-610
    • Günther, C.1
  • 61
    • 84868261605 scopus 로고    scopus 로고
    • Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis
    • Neal, M.D. et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis. J. Biol. Chem. 287, 37296-37308 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 37296-37308
    • Neal, M.D.1
  • 62
    • 84920992524 scopus 로고    scopus 로고
    • Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide
    • Dupont, A. et al. Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide. Gut 64, 222-232 (2015).
    • (2015) Gut , vol.64 , pp. 222-232
    • Dupont, A.1
  • 63
    • 79956359184 scopus 로고    scopus 로고
    • Toward the human colorectal cancer microbiome
    • Marchesi, J.R. et al. Toward the human colorectal cancer microbiome. PLoS One 6, e20447 (2011).
    • (2011) PLoS One , vol.6
    • Marchesi, J.R.1
  • 64
    • 1642264751 scopus 로고    scopus 로고
    • Calcineurin B1 is essential for positive but not negative selection during thymocyte development
    • Neilson, J.R., Winslow, M.M., Hur, E.M. & Crabtree, G.R. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity 20, 255-266 (2004).
    • (2004) Immunity , vol.20 , pp. 255-266
    • Neilson, J.R.1    Winslow, M.M.2    Hur, E.M.3    Crabtree, G.R.4
  • 65
    • 55849088412 scopus 로고    scopus 로고
    • NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
    • Aliprantis, A.O. et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J. Clin. Invest. 118, 3775-3789 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 3775-3789
    • Aliprantis, A.O.1
  • 66
    • 34250849587 scopus 로고    scopus 로고
    • Selective role of NFATc3 in positive selection of thymocytes
    • Canté-Barrett, K., Winslow, M.M. & Crabtree, G.R. Selective role of NFATc3 in positive selection of thymocytes. J. Immunol. 179, 103-110 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 103-110
    • Canté-Barrett, K.1    Winslow, M.M.2    Crabtree, G.R.3
  • 67
    • 0037031856 scopus 로고    scopus 로고
    • Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    • Madison, B.B. et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277, 33275-33283 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 33275-33283
    • Madison, B.B.1
  • 68
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193 (2004).
    • (2004) Genesis , vol.39 , pp. 186-193
    • El Marjou, F.1
  • 69
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the Myd88 gene results in loss of IL-1- and IL-18-mediated function
    • Adachi, O. et al. Targeted disruption of the Myd88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998).
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1
  • 70
    • 84874691073 scopus 로고    scopus 로고
    • Rage signaling promotes intestinal tumorigenesis
    • Heijmans, J. et al. Rage signaling promotes intestinal tumorigenesis. Oncogene 32, 1202-1206 (2013).
    • (2013) Oncogene , vol.32 , pp. 1202-1206
    • Heijmans, J.1
  • 71
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph, T.E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1
  • 72
    • 34347262689 scopus 로고    scopus 로고
    • Chemically induced mouse models of intestinal inflammation
    • Wirtz, S., Neufert, C., Weigmann, B. & Neurath, M.F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546 (2007).
    • (2007) Nat. Protoc , vol.2 , pp. 541-546
    • Wirtz, S.1    Neufert, C.2    Weigmann, B.3    Neurath, M.F.4
  • 73
    • 77249163771 scopus 로고    scopus 로고
    • Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis
    • Hill, D.A. et al. Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Mucosal Immunol. 3, 148-158 (2010).
    • (2010) Mucosal Immunol. , vol.3 , pp. 148-158
    • Hill, D.A.1
  • 74
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228 (1998).
    • (1998) Cell , vol.93 , pp. 215-228
    • Molkentin, J.D.1
  • 75
    • 0347320747 scopus 로고    scopus 로고
    • Calcineurin-NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy
    • Wilkins, B.J. et al. Calcineurin-NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ. Res. 94, 110-118 (2004).
    • (2004) Circ. Res. , vol.94 , pp. 110-118
    • Wilkins, B.J.1
  • 76
    • 0033982992 scopus 로고    scopus 로고
    • Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure
    • De Windt, L.J. et al. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure. Circ. Res. 86, 255-263 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 255-263
    • De Windt, L.J.1
  • 77
    • 52049094598 scopus 로고    scopus 로고
    • Interleukin-1β-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin-NFAT activity
    • Sama, M.A. et al. Interleukin-1β-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin-NFAT activity. J. Biol. Chem. 283, 21953-21964 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 21953-21964
    • Sama, M.A.1
  • 78
    • 84863707404 scopus 로고    scopus 로고
    • Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity
    • Zeissig, S. et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat. Med. 18, 1060-1068 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1060-1068
    • Zeissig, S.1
  • 79
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 80
    • 0029670841 scopus 로고    scopus 로고
    • min and an activated ras mutation is sufficient to induce colon carcinomas
    • min and an activated ras mutation is sufficient to induce colon carcinomas. Mol. Cell. Biol. 16, 884-891 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 884-891
    • D'Abaco, G.M.1    Whitehead, R.H.2    Burgess, A.W.3
  • 81
    • 0027367116 scopus 로고
    • Immortalization of mouse intestinal epithelial cells by the SV40 large T gene. Phenotypic and immune characterization of the MODE-K cell line
    • Vidal, K., Grosjean, I., evillard, J.P., Gespach, C. & Kaiserlian, D. Immortalization of mouse intestinal epithelial cells by the SV40 large T gene. Phenotypic and immune characterization of the MODE-K cell line. J. Immunol. Methods 166, 63-73 (1993).
    • (1993) J. Immunol. Methods , vol.166 , pp. 63-73
    • Vidal, K.1    Grosjean, I.2    Evillard, J.P.3    Gespach, C.4    Kaiserlian, D.5
  • 82
    • 33846253247 scopus 로고    scopus 로고
    • Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional upregulation of epithelial sodium channels
    • Zeissig, S. et al. Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional upregulation of epithelial sodium channels. Gastroenterology 132, 236-248 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 236-248
    • Zeissig, S.1
  • 83
    • 0034283018 scopus 로고    scopus 로고
    • Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
    • Macián, F., García-Rodríguez, C. & Rao, A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19, 4783-4795 (2000).
    • (2000) EMBO J , vol.19 , pp. 4783-4795
    • Macián, F.1    García-Rodríguez, C.2    Rao, A.3
  • 84
    • 0344373791 scopus 로고    scopus 로고
    • Zebrafish prickle, a modulator of noncanonical Wnt-Fz signaling, regulates gastrulation movements
    • Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H. & Moon, R.T. Zebrafish prickle, a modulator of noncanonical Wnt-Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680-685 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 680-685
    • Veeman, M.T.1    Slusarski, D.C.2    Kaykas, A.3    Louie, S.H.4    Moon, R.T.5
  • 85
    • 77955294460 scopus 로고    scopus 로고
    • Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function
    • Zeissig, S. et al. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J. Clin. Invest. 120, 2889-2899 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2889-2899
    • Zeissig, S.1
  • 86
    • 77956515952 scopus 로고    scopus 로고
    • Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients
    • Rehman, A. et al. Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients. J. Med. Microbiol. 59, 1114-1122 (2010).
    • (2010) J. Med. Microbiol. , vol.59 , pp. 1114-1122
    • Rehman, A.1
  • 87
    • 84884251320 scopus 로고    scopus 로고
    • Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform
    • Kozich, J.J., Westcott, S.L., Baxter, N.T., Highlander, S.K. & Schloss, P.D. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl. Environ. Microbiol. 79, 5112-5120 (2013).
    • (2013) Appl. Environ. Microbiol. , vol.79 , pp. 5112-5120
    • Kozich, J.J.1    Westcott, S.L.2    Baxter, N.T.3    Highlander, S.K.4    Schloss, P.D.5
  • 88
    • 80054913451 scopus 로고    scopus 로고
    • FLASH: Fast length adjustment of short reads to improve genome assemblies
    • Magoč, T. & Salzberg, S.L. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27, 2957-2963 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 2957-2963
    • Magoč, T.1    Salzberg, S.L.2
  • 89
    • 84884904719 scopus 로고    scopus 로고
    • UPARSE: Highly accurate OTU sequences from microbial amplicon reads
    • Edgar, R.C. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat. Methods 10, 996-998 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 996-998
    • Edgar, R.C.1
  • 90
    • 34548293679 scopus 로고    scopus 로고
    • Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
    • Wang, Q., Garrity, G.M., Tiedje, J.M. & Cole, J.R. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl. Environ. Microbiol. 73, 5261-5267 (2007).
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 5261-5267
    • Wang, Q.1    Garrity, G.M.2    Tiedje, J.M.3    Cole, J.R.4
  • 91
    • 77957244650 scopus 로고    scopus 로고
    • Search and clustering orders of magnitude faster than BLAST
    • Edgar, R.C. Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26, 2460-2461 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2460-2461
    • Edgar, R.C.1
  • 92
    • 1142306112 scopus 로고    scopus 로고
    • VEGAN, a package of R functions for community ecology
    • Dixon, P. VEGAN, a package of R functions for community ecology. J. Veg. Sci. 14, 927-930 (2003).
    • (2003) J. Veg. Sci. , vol.14 , pp. 927-930
    • Dixon, P.1


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