-
1
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., and Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 75 (1993) 817-825
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
2
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
3
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K., and Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7 (2001) 683-694
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
4
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E., Ohki R., Murasawa H., Nemoto J., Shibue T., Yamashita T., Tokino T., Taniguchi T., and Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288 (2000) 1053-1058
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
5
-
-
33845193134
-
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis
-
Jiang P., Du W., Heese K., and Wu M. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol. Cell Biol. 26 (2006) 9071-9082
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 9071-9082
-
-
Jiang, P.1
Du, W.2
Heese, K.3
Wu, M.4
-
6
-
-
34548014527
-
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
-
Olsson A., Manzl X., Strasser A., and Villunger A. How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?. Cell Death Differ. 14 (2007) 1561-1575
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1561-1575
-
-
Olsson, A.1
Manzl, X.2
Strasser, A.3
Villunger, A.4
-
7
-
-
0030973579
-
Transcription factors of the NFAT family: regulation and function
-
Rao A., Luo C., and Hogan P.C. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15 (1997) 707-747
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 707-747
-
-
Rao, A.1
Luo, C.2
Hogan, P.C.3
-
8
-
-
0031034051
-
Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells
-
Rincon M., and Flavell R.A. Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells. Mol. Cell Biol. 17 (1997) 1522-1534
-
(1997)
Mol. Cell Biol.
, vol.17
, pp. 1522-1534
-
-
Rincon, M.1
Flavell, R.A.2
-
9
-
-
15844416253
-
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
-
Loh C., Shaw K.T., Carew J., Viola J.P., Luo C., Perrino B.A., and Rao A. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271 (1996) 10884-10891
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10884-10891
-
-
Loh, C.1
Shaw, K.T.2
Carew, J.3
Viola, J.P.4
Luo, C.5
Perrino, B.A.6
Rao, A.7
-
10
-
-
0036234543
-
NFAT signaling: choreographing the social lives of cells
-
Crabtree G.R., and Olson E.N. NFAT signaling: choreographing the social lives of cells. Cell 109 Suppl. (1999) S67-S79
-
(1999)
Cell
, vol.109
, Issue.SUPPL
-
-
Crabtree, G.R.1
Olson, E.N.2
-
11
-
-
0030930366
-
A model for p53-induced apoptosis
-
Polyak K., Xia Y., Zweier J.L., Kinzler K.W., and Vogelstein B. A model for p53-induced apoptosis. Nature 389 (1997) 300-305
-
(1997)
Nature
, vol.389
, pp. 300-305
-
-
Polyak, K.1
Xia, Y.2
Zweier, J.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
12
-
-
0034700139
-
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines
-
Maxwell S.A., and Davis G.E. Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Proc. Natl. Acad. Sci. USA 97 (2000) 13009-13014
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13009-13014
-
-
Maxwell, S.A.1
Davis, G.E.2
-
13
-
-
44849109711
-
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species
-
Cooper S.K., Pandhare J., Donald S.P., and Phang J.M. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. J. Biol. Chem. 283 (2008) 10485-10492
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10485-10492
-
-
Cooper, S.K.1
Pandhare, J.2
Donald, S.P.3
Phang, J.M.4
-
14
-
-
23844477888
-
The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
-
Rivera A., and Maxwell S.A. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J. Biol. Chem. 280 (2005) 29346-29354
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29346-29354
-
-
Rivera, A.1
Maxwell, S.A.2
-
15
-
-
33748671329
-
Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling
-
Liu Y., Borchert G.L., Surazynski A., Hu C.-A., and Phang J.M. Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. Oncogene 25 (2006) 5640-5647
-
(2006)
Oncogene
, vol.25
, pp. 5640-5647
-
-
Liu, Y.1
Borchert, G.L.2
Surazynski, A.3
Hu, C.-A.4
Phang, J.M.5
-
16
-
-
33747616250
-
2+/calcineurin signaling pathway
-
2+/calcineurin signaling pathway. EMBO J. 25 (2006) 3714-3724
-
(2006)
EMBO J.
, vol.25
, pp. 3714-3724
-
-
Buchholz, M.1
Schatz, A.2
Wagner, M.3
Michl, P.4
Linhart, T.5
Adler, G.6
Gress, T.M.7
Ellenrieder, V.8
-
17
-
-
0025040233
-
Suppression of human colorectal carcinoma cell growth by wild-type p53
-
Baker S.J., Markowitz S., Fearon E.R., Willson J.K.V., and Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249 (1990) 912-915
-
(1990)
Science
, vol.249
, pp. 912-915
-
-
Baker, S.J.1
Markowitz, S.2
Fearon, E.R.3
Willson, J.K.V.4
Vogelstein, B.5
-
18
-
-
0025021281
-
Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells
-
Hiwasa T., Sawada T., and Sakiyama S. Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells. Carcinogenesis 11 (1990) 75-80
-
(1990)
Carcinogenesis
, vol.11
, pp. 75-80
-
-
Hiwasa, T.1
Sawada, T.2
Sakiyama, S.3
-
19
-
-
33745034073
-
Enhancement of chemosensitivity toward peplomycin by calpastatin-stabilized NF-κB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism
-
Liu T.-L., Shimada H., Ochiai T., Shiratori T., Lin S.E., Kitagawa M., Harigaya K., Maki M., Oka M., Abe T., Takiguchi M., and Hiwasa T. Enhancement of chemosensitivity toward peplomycin by calpastatin-stabilized NF-κB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism. Apoptosis 11 (2006) 1025-1037
-
(2006)
Apoptosis
, vol.11
, pp. 1025-1037
-
-
Liu, T.-L.1
Shimada, H.2
Ochiai, T.3
Shiratori, T.4
Lin, S.E.5
Kitagawa, M.6
Harigaya, K.7
Maki, M.8
Oka, M.9
Abe, T.10
Takiguchi, M.11
Hiwasa, T.12
-
20
-
-
0034033569
-
r-1 cells derived from ultraviolet-sensitive human RSa cells
-
r-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ. 7 (2000) 531-537
-
(2000)
Cell Death Differ.
, vol.7
, pp. 531-537
-
-
Hiwasa, T.1
Arase, Y.2
Kikuno, K.3
Hasegawa, R.4
Sugaya, S.5
Kita, K.6
Saido, T.7
Yamamori, H.8
Maki, M.9
Suzuki, N.10
-
21
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammolott U., Lukacs C., Klein C., Fotouhi N., and Liu E.A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammolott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
22
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
23
-
-
0032475878
-
Signaling to p53: breaking the MDM2-p53 circuit
-
Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell 95 (1998) 5-8
-
(1998)
Cell
, vol.95
, pp. 5-8
-
-
Prives, C.1
-
24
-
-
1542350145
-
Regulation of p53 stability and function in HCT116 colon cancer cells
-
Kaeser M.D., Pebernard S., and Iggo R.D. Regulation of p53 stability and function in HCT116 colon cancer cells. J. Biol. Chem. 279 (2004) 7598-7605
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7598-7605
-
-
Kaeser, M.D.1
Pebernard, S.2
Iggo, R.D.3
-
25
-
-
0032518917
-
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
-
Roth J., Dobbelstein M., Freedman D.A., Shenk T., and Levine A.J. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17 (1998) 554-564
-
(1998)
EMBO J.
, vol.17
, pp. 554-564
-
-
Roth, J.1
Dobbelstein, M.2
Freedman, D.A.3
Shenk, T.4
Levine, A.J.5
-
26
-
-
43049163953
-
Acetylation is indispensable for p53 activation
-
Tang Y., Zhao W., Chen Y., Zhao Y., and Gu W. Acetylation is indispensable for p53 activation. Cell 133 (2008) 612-626
-
(2008)
Cell
, vol.133
, pp. 612-626
-
-
Tang, Y.1
Zhao, W.2
Chen, Y.3
Zhao, Y.4
Gu, W.5
-
27
-
-
33845656738
-
Acetylation of the p53 DNA-binding domain regulates apoptosis induction
-
Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., and McMahon S.B. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24 (2006) 841-851
-
(2006)
Mol. Cell
, vol.24
, pp. 841-851
-
-
Sykes, S.M.1
Mellert, H.S.2
Holbert, M.A.3
Li, K.4
Marmorstein, R.5
Lane, W.S.6
McMahon, S.B.7
-
28
-
-
33746012703
-
Mutational analysis of the p53 core domain L1 loop
-
Zupnick A., and Prives C. Mutational analysis of the p53 core domain L1 loop. J. Biol. Chem. 281 (2006) 20464-20473
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 20464-20473
-
-
Zupnick, A.1
Prives, C.2
-
29
-
-
0027050648
-
Wild-type p53 binds to the TATA-binding protein and represses transcription
-
Seto E., Usheva A., Zambetti G.P., Momand J., Horikoshi N., Weinmann R., Levine A.J., and Shenk T. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA 89 (1992) 12028-12032
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 12028-12032
-
-
Seto, E.1
Usheva, A.2
Zambetti, G.P.3
Momand, J.4
Horikoshi, N.5
Weinmann, R.6
Levine, A.J.7
Shenk, T.8
-
30
-
-
0028979005
-
II31 protein is a transcriptional coactivator of the p53 protein
-
II31 protein is a transcriptional coactivator of the p53 protein. Proc. Natl. Acad. Sci. USA 92 (1995) 5154-5158
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5154-5158
-
-
Lu, H.1
Levine, A.J.2
-
31
-
-
0030996361
-
Synergistic activation of transcription by CBP and p53
-
Gu W., Shi X.L., and Roeder R.G. Synergistic activation of transcription by CBP and p53. Nature 387 (1997) 819-823
-
(1997)
Nature
, vol.387
, pp. 819-823
-
-
Gu, W.1
Shi, X.L.2
Roeder, R.G.3
-
32
-
-
35648997922
-
Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications
-
Batta K., and Kundu T.K. Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. Mol. Cell Biol. 27 (2007) 7607-7614
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 7607-7614
-
-
Batta, K.1
Kundu, T.K.2
-
33
-
-
33845345621
-
LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation
-
Zeng P.Y., and Berger S.L. LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res. 66 (2006) 10701-10718
-
(2006)
Cancer Res.
, vol.66
, pp. 10701-10718
-
-
Zeng, P.Y.1
Berger, S.L.2
|