메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages

TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; BETA CATENIN; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 4; TUMOR PROMOTER; VILLIN;

EID: 84877753124     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063298     Document Type: Article
Times cited : (104)

References (67)
  • 4
    • 33748180713 scopus 로고    scopus 로고
    • Celecoxib for the prevention of colorectal adenomatous polyps
    • Arber N, Eagle CJ, Spicak J, Racz I, Dite P, et al. (2006) Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 355: 885-895.
    • (2006) N Engl J Med , vol.355 , pp. 885-895
    • Arber, N.1    Eagle, C.J.2    Spicak, J.3    Racz, I.4    Dite, P.5
  • 6
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman TA, Itzkowitz SH, (2011) Intestinal inflammation and cancer. Gastroenterology 140: 1807-1816.
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1    Itzkowitz, S.H.2
  • 7
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • Fukata M, Shang L, Santaolalla R, Sotolongo J, Pastorini C, et al. (2011) Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis 17: 1464-1473.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1464-1473
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5
  • 9
    • 36549082403 scopus 로고    scopus 로고
    • Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    • Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, et al. (2007) Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133: 1869-1881.
    • (2007) Gastroenterology , vol.133 , pp. 1869-1881
    • Fukata, M.1    Chen, A.2    Vamadevan, A.S.3    Cohen, J.4    Breglio, K.5
  • 10
    • 81855176234 scopus 로고    scopus 로고
    • Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer
    • Eyking A, Ey B, Runzi M, Roig AI, Reis H, et al. (2011) Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer. Gastroenterology.
    • (2011) Gastroenterology
    • Eyking, A.1    Ey, B.2    Runzi, M.3    Roig, A.I.4    Reis, H.5
  • 12
    • 78049484534 scopus 로고    scopus 로고
    • The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
    • Cammarota R, Bertolini V, Pennesi G, Bucci EO, Gottardi O, et al. (2010) The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker. J Transl Med 8: 112.
    • (2010) J Transl Med , vol.8 , pp. 112
    • Cammarota, R.1    Bertolini, V.2    Pennesi, G.3    Bucci, E.O.4    Gottardi, O.5
  • 13
    • 77649272127 scopus 로고    scopus 로고
    • High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer
    • Wang EL, Qian ZR, Nakasono M, Tanahashi T, Yoshimoto K, et al. (2010) High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer 102: 908-915.
    • (2010) Br J Cancer , vol.102 , pp. 908-915
    • Wang, E.L.1    Qian, Z.R.2    Nakasono, M.3    Tanahashi, T.4    Yoshimoto, K.5
  • 14
    • 62149131898 scopus 로고    scopus 로고
    • Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis
    • Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, et al. (2009) Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. Ann Surg Oncol 16: 1043-1050.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1043-1050
    • Earl, T.M.1    Nicoud, I.B.2    Pierce, J.M.3    Wright, J.P.4    Majoras, N.E.5
  • 15
    • 33845373278 scopus 로고    scopus 로고
    • Colorectal cancer and genetic alterations in the Wnt pathway
    • Segditsas S, Tomlinson I, (2006) Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 25: 7531-7537.
    • (2006) Oncogene , vol.25 , pp. 7531-7537
    • Segditsas, S.1    Tomlinson, I.2
  • 17
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5
  • 19
    • 79953679891 scopus 로고    scopus 로고
    • Enteric Bacteria and Cancer Stem Cells
    • Sun J, (2010) Enteric Bacteria and Cancer Stem Cells. Cancers (Basel) 3: 285-297.
    • (2010) Cancers (Basel) , vol.3 , pp. 285-297
    • Sun, J.1
  • 20
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of [beta]-catenin
    • Valenta T, Hausmann G, Basler K, (2012) The many faces and functions of [beta]-catenin. EMBO J 31: 2714-2736.
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 21
    • 48549103766 scopus 로고    scopus 로고
    • Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
    • Shang L, Fukata M, Thirunarayanan N, Martin AP, Arnaboldi P, et al. (2008) Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology 135: 529-538.
    • (2008) Gastroenterology , vol.135 , pp. 529-538
    • Shang, L.1    Fukata, M.2    Thirunarayanan, N.3    Martin, A.P.4    Arnaboldi, P.5
  • 22
    • 77956138914 scopus 로고    scopus 로고
    • Phosphoinositide 3-Kinase Signaling Mediates [beta]-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
    • Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, et al. (2010) Phosphoinositide 3-Kinase Signaling Mediates [beta]-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis. Gastroenterology 139: 869-881.e869.
    • (2010) Gastroenterology , vol.139 , pp. 869-881
    • Lee, G.1    Goretsky, T.2    Managlia, E.3    Dirisina, R.4    Singh, A.P.5
  • 23
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    • Abreu MT, (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 10: 131-144.
    • (2010) Nat Rev Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 24
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, et al. (2001) Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 167: 1609-1616.
    • (2001) J Immunol , vol.167 , pp. 1609-1616
    • Abreu, M.T.1    Vora, P.2    Faure, E.3    Thomas, L.S.4    Arnold, E.T.5
  • 25
    • 1842583729 scopus 로고    scopus 로고
    • Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    • Otte JM, Cario E, Podolsky DK, (2004) Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126: 1054-1070.
    • (2004) Gastroenterology , vol.126 , pp. 1054-1070
    • Otte, J.M.1    Cario, E.2    Podolsky, D.K.3
  • 26
    • 0033525861 scopus 로고    scopus 로고
    • Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines
    • Pinto D, Robine S, Jaisser Fdr, Marjou FE, Louvard D, (1999) Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines. Journal of Biological Chemistry 274: 6476-6482.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 6476-6482
    • Pinto, D.1    Robine, S.2    Jaisser, F.3    Marjou, F.E.4    Louvard, D.5
  • 27
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    van Es, J.H.2    Kuipers, J.3    Kujala, P.4    van den Born, M.5
  • 28
    • 34548162712 scopus 로고    scopus 로고
    • An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    • Neufert C, Becker C, Neurath MF, (2007) An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protocols 2: 1998-2004.
    • (2007) Nat Protocols , vol.2 , pp. 1998-2004
    • Neufert, C.1    Becker, C.2    Neurath, M.F.3
  • 29
    • 77955525325 scopus 로고    scopus 로고
    • Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
    • Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, et al. (2010) Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis. Cancer Cell 18: 135-146.
    • (2010) Cancer Cell , vol.18 , pp. 135-146
    • Bennecke, M.1    Kriegl, L.2    Bajbouj, M.3    Retzlaff, K.4    Robine, S.5
  • 30
    • 76349089749 scopus 로고    scopus 로고
    • Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3
    • Meunier C, Cai J, Fortin A, Kwan T, Marquis JF, et al. (2009) Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3. Oncogene 29: 647-661.
    • (2009) Oncogene , vol.29 , pp. 647-661
    • Meunier, C.1    Cai, J.2    Fortin, A.3    Kwan, T.4    Marquis, J.F.5
  • 31
    • 27944437061 scopus 로고    scopus 로고
    • Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet
    • Bissahoyo A, Pearsall RS, Hanlon K, Amann V, Hicks D, et al. (2005) Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet. Toxicological Sciences 88: 340-345.
    • (2005) Toxicological Sciences , vol.88 , pp. 340-345
    • Bissahoyo, A.1    Pearsall, R.S.2    Hanlon, K.3    Amann, V.4    Hicks, D.5
  • 32
    • 77953288698 scopus 로고    scopus 로고
    • Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin
    • Fan X-S, Wu H-Y, Yu H-P, Zhou Q, Zhang Y-F, et al. (2010) Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin. International Journal of Colorectal Disease 25: 583-590.
    • (2010) International Journal of Colorectal Disease , vol.25 , pp. 583-590
    • Fan, X.-S.1    Wu, H.-Y.2    Yu, H.-P.3    Zhou, Q.4    Zhang, Y.-F.5
  • 34
    • 0017412603 scopus 로고
    • One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh J, Fogh JM, Orfeo T, (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59: 221-226.
    • (1977) J Natl Cancer Inst , vol.59 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 35
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, et al. (1991) Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669.
    • (1991) Science , vol.253 , pp. 665-669
    • Nishisho, I.1    Nakamura, Y.2    Miyoshi, Y.3    Miki, Y.4    Ando, H.5
  • 36
    • 0018394382 scopus 로고
    • Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria
    • Quaroni A, Wands J, Trelstad RL, Isselbacher KJ, (1979) Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 80: 248-265.
    • (1979) J Cell Biol , vol.80 , pp. 248-265
    • Quaroni, A.1    Wands, J.2    Trelstad, R.L.3    Isselbacher, K.J.4
  • 37
    • 0035849796 scopus 로고    scopus 로고
    • Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells
    • Soubeyran P, Haglund K, Garcia S, Barth BU, Iovanna J, et al. (2001) Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells. Oncogene 20: 4180-4187.
    • (2001) Oncogene , vol.20 , pp. 4180-4187
    • Soubeyran, P.1    Haglund, K.2    Garcia, S.3    Barth, B.U.4    Iovanna, J.5
  • 38
    • 33748271299 scopus 로고    scopus 로고
    • Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    • Fukata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, et al. (2006) Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology 131: 862-877.
    • (2006) Gastroenterology , vol.131 , pp. 862-877
    • Fukata, M.1    Chen, A.2    Klepper, A.3    Krishnareddy, S.4    Vamadevan, A.S.5
  • 39
    • 77956245973 scopus 로고    scopus 로고
    • Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury
    • Hsu D, Fukata M, Hernandez YG, Sotolongo JP, Goo T, et al. (2010) Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Lab Invest.
    • (2010) Lab Invest
    • Hsu, D.1    Fukata, M.2    Hernandez, Y.G.3    Sotolongo, J.P.4    Goo, T.5
  • 40
    • 0030861128 scopus 로고    scopus 로고
    • Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus
    • Miller JR, Moon RT, (1997) Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus. J Cell Biol 139: 229-243.
    • (1997) J Cell Biol , vol.139 , pp. 229-243
    • Miller, J.R.1    Moon, R.T.2
  • 41
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B, Wu W, Li Y, Hoppe D, Stannek P, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411: 321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5
  • 42
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA, (2001) Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 3: 683-686.
    • (2001) Nat Cell Biol , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 43
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 11: 951-961.
    • (2001) Curr Biol , vol.11 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5
  • 44
    • 70449105185 scopus 로고    scopus 로고
    • Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
    • Kaler P, Augenlicht L, Klampfer L, (2009) Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene 28: 3892-3902.
    • (2009) Oncogene , vol.28 , pp. 3892-3902
    • Kaler, P.1    Augenlicht, L.2    Klampfer, L.3
  • 45
    • 73449139396 scopus 로고    scopus 로고
    • The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta
    • Kaler P, Godasi BN, Augenlicht L, Klampfer L (2009) The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. Cancer Microenviron.
    • (2009) Cancer Microenviron
    • Kaler, P.1    Godasi, B.N.2    Augenlicht, L.3    Klampfer, L.4
  • 46
    • 0030978351 scopus 로고    scopus 로고
    • [beta]-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R, (1997) [beta]-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16: 3797-3804.
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 47
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, et al. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5
  • 48
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ, (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 49
    • 0029143388 scopus 로고
    • Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase
    • Kohn AD, Kovacina KS, Roth RA, (1995) Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14: 4288-4295.
    • (1995) EMBO J , vol.14 , pp. 4288-4295
    • Kohn, A.D.1    Kovacina, K.S.2    Roth, R.A.3
  • 50
    • 0035313040 scopus 로고    scopus 로고
    • Lipopolysaccharide Activates Akt in Human Alveolar Macrophages Resulting in Nuclear Accumulation and Transcriptional Activity of Î2-Catenin
    • Monick MM, Carter AB, Robeff PK, Flaherty DM, Peterson MW, et al. (2001) Lipopolysaccharide Activates Akt in Human Alveolar Macrophages Resulting in Nuclear Accumulation and Transcriptional Activity of Î2-Catenin. The Journal of Immunology 166: 4713-4720.
    • (2001) The Journal of Immunology , vol.166 , pp. 4713-4720
    • Monick, M.M.1    Carter, A.B.2    Robeff, P.K.3    Flaherty, D.M.4    Peterson, M.W.5
  • 51
    • 79952236601 scopus 로고    scopus 로고
    • LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases Beta1-Integrin-Mediated Cell Adhesion and Liver Metastasis
    • Hsu RYC, Chan CHF, Spicer JD, Rousseau MC, Giannias B, et al. (2011) LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases Beta1-Integrin-Mediated Cell Adhesion and Liver Metastasis. Cancer Research 71: 1989-1998.
    • (2011) Cancer Research , vol.71 , pp. 1989-1998
    • Hsu, R.Y.C.1    Chan, C.H.F.2    Spicer, J.D.3    Rousseau, M.C.4    Giannias, B.5
  • 53
    • 79955580889 scopus 로고    scopus 로고
    • Epithelial Phosphatidylinositol-3-Kinase Signaling Is Required for {beta}-Catenin Activation and Host Defense against Citrobacter rodentium Infection
    • Brown JB, Cheresh P, Goretsky T, Managlia E, Grimm GR, et al. (2011) Epithelial Phosphatidylinositol-3-Kinase Signaling Is Required for {beta}-Catenin Activation and Host Defense against Citrobacter rodentium Infection. Infect Immun 79: 1863-1872.
    • (2011) Infect Immun , vol.79 , pp. 1863-1872
    • Brown, J.B.1    Cheresh, P.2    Goretsky, T.3    Managlia, E.4    Grimm, G.R.5
  • 55
    • 79851502476 scopus 로고    scopus 로고
    • Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis
    • Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, et al. (2011) Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Anticancer Res 31: 263-270.
    • (2011) Anticancer Res , vol.31 , pp. 263-270
    • Takeda, K.1    Kinoshita, I.2    Shimizu, Y.3    Matsuno, Y.4    Shichinohe, T.5
  • 56
    • 84860165742 scopus 로고    scopus 로고
    • P53 Gene Mutation Increases Progastrin Dependent Colonic Proliferation and Colon Cancer Formation in Mice
    • Ramanathan V, Jin G, Westphalen CB, Whelan A, Dubeykovskiy A, et al. (2012) P53 Gene Mutation Increases Progastrin Dependent Colonic Proliferation and Colon Cancer Formation in Mice. Cancer Invest.
    • (2012) Cancer Invest
    • Ramanathan, V.1    Jin, G.2    Westphalen, C.B.3    Whelan, A.4    Dubeykovskiy, A.5
  • 57
    • 84868261605 scopus 로고    scopus 로고
    • Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis
    • Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, et al. (2012) Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis. Journal of Biological Chemistry 287: 37296-37308.
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 37296-37308
    • Neal, M.D.1    Sodhi, C.P.2    Jia, H.3    Dyer, M.4    Egan, C.E.5
  • 59
    • 77956471611 scopus 로고    scopus 로고
    • Convergence between Wnt-beta-catenin and EGFR signaling in cancer
    • Hu T, Li C, (2010) Convergence between Wnt-beta-catenin and EGFR signaling in cancer. Mol Cancer 9: 236.
    • (2010) Mol Cancer , vol.9 , pp. 236
    • Hu, T.1    Li, C.2
  • 60
    • 0028170977 scopus 로고
    • Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
    • Hoschuetzky H, Aberle H, Kemler R, (1994) Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 127: 1375-1380.
    • (1994) J Cell Biol , vol.127 , pp. 1375-1380
    • Hoschuetzky, H.1    Aberle, H.2    Kemler, R.3
  • 61
    • 77954559878 scopus 로고    scopus 로고
    • The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
    • Hernandez Y, Sotolongo J, Breglio K, Conduah D, Chen A, et al. (2010) The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterol 10: 82.
    • (2010) BMC Gastroenterol , vol.10 , pp. 82
    • Hernandez, Y.1    Sotolongo, J.2    Breglio, K.3    Conduah, D.4    Chen, A.5
  • 62
    • 77953196709 scopus 로고    scopus 로고
    • ERK activation drives intestinal tumorigenesis in Apcmin/+ mice
    • Lee SH, Hu L-L, Gonzalez-Navajas J, Seo GS, Shen C, et al. (2010) ERK activation drives intestinal tumorigenesis in Apcmin/+ mice. Nat Med 16: 665-670.
    • (2010) Nat Med , vol.16 , pp. 665-670
    • Lee, S.H.1    Hu, L.-L.2    Gonzalez-Navajas, J.3    Seo, G.S.4    Shen, C.5
  • 63
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum S, Medzhitov R, (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317: 124-127.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 64
    • 20444432334 scopus 로고    scopus 로고
    • Toll-like receptors on tumor cells facilitate evasion of immune surveillance
    • Huang B, Zhao J, Li H, He KL, Chen Y, et al. (2005) Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 65: 5009-5014.
    • (2005) Cancer Res , vol.65 , pp. 5009-5014
    • Huang, B.1    Zhao, J.2    Li, H.3    He, K.L.4    Chen, Y.5
  • 65
    • 72249103413 scopus 로고    scopus 로고
    • Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis
    • Sodhi CP, Shi XH, Richardson WM, Grant ZS, Shapiro RA, et al. (2010) Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology 138: 185-196.
    • (2010) Gastroenterology , vol.138 , pp. 185-196
    • Sodhi, C.P.1    Shi, X.H.2    Richardson, W.M.3    Grant, Z.S.4    Shapiro, R.A.5
  • 66
    • 20244372724 scopus 로고    scopus 로고
    • Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
    • Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, et al. (2005) Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 288: G1055-1065.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Fukata, M.1    Michelsen, K.S.2    Eri, R.3    Thomas, L.S.4    Hu, B.5
  • 67
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R, (2004) Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis. Cell 118: 229-241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.