Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

EMBO Journal

Volumn 19, Issue 17, 2000, Pages 4783-4795

  Macián, Fernando ^a   García Rodríguez, Carmen ^b   Rao, Anjana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

Author keywords

Activation induced cell death; AP 1; Cytokine expression; Nuclear factor of activated T cells; Transcriptional regulation

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; NUCLEAR FACTOR;

ARTICLE; BINDING SITE; CELL DEATH; COMPLEX FORMATION; DIMERIZATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

EID: 0034283018     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.17.4783     Document Type: Article

References (56)

1. Cell type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
2. Cellular interactions in thymocyte development
3. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
4. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
5. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
6. Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp
7. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
8. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer
9. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c
10. 2+, calcineurin, and NF-AT
11. Autocrine T-cell suicide mediated by Apo-1/(Fas/CD95)
12. Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31
13. Abnormal differentiation of thymocytes in mice treated with cyclosporin A
14. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)
15. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
16. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter
17. Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element
18. Functional analysis of a growth factor-responsive transcription factor complex
19. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system
20. Nuclear factor of activated T cells contains Fos and Jun
21. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
22. Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells
23. A similar DNA-binding motif in NFAT family proteins and the Rel homology region
24. Transcriptional regulation of the IL-2 gene
25. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
26. The regulation of AP-1 activity by mitogen-activated protein kinases
27. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB
28. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells
29. Manipulating immune responses with immunosuppressive agents that target NFAT
30. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
31. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells
32. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
33. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1
34. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-α gene transcription
35. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression
36. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
37. Structure of the NF-κB p50 homodimer bound to DNA
38. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1
39. Impaired negative selection in CD28-deficient mice
40. The transcription factor NFAT4 is involved in the generation and survival of T cells
41. A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1
42. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
43. Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies
44. Transcription factors of the NFAT family: Regulation and function
45. Sequential involvement of NFAT and EGR transcription factors in FasL regulation
46. The JNK pathway regulates the in vivo deletion of immature CD4(+)CD8(+) thymocytes
47. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
48. B7 blockade prevents activation-induced cell death of thymocytes
49. Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1
50. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
51. Transcriptional activation: A complex puzzle with few easy pieces
52. Tumor necrosis factor α gene regulation in activated T cells involves Atf-2/Jun and NFATp
53. Cell-type-specific regulation of the human tumor necrosis factor α gene in B cells and T cells by NFATp, and ATF-2/Jun
54. T cell antigen-receptor signal transduction
55. Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
56. Solution structure of the core NFATC1/DNA complex