Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide

Gut

Volumn 64, Issue 2, 2015, Pages 222-232

  Dupont, Aline ^a   Kaconis, Yani ^b   Yang, Ines ^a   Albers, Thorben ^a   Woltemate, Sabrina ^a   Heinbockel, Lena ^b   Andersson, Mats ^c   Suerbaum, Sebastian ^a   Brandenburg, Klaus ^b   Hornef, Mathias W ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTDIN 2; DEFENSIN; ENDOTOXIN; PEP19-2.5 PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; PEPTIDE FRAGMENT; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CELL; BINDING AFFINITY; CONTROLLED STUDY; DNA SEQUENCE; DRUG BINDING; DRUG DISTRIBUTION; FEMALE; HIGH THROUGHPUT SEQUENCING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; INTESTINE MUCOSA; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN LOCALIZATION; SALMONELLOSIS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; DRUG SCREENING; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; MICROBIOLOGY; MICROFLORA; MUCUS; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PROCEDURES; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA INFECTIONS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; INTESTINAL MUCOSA; MICE, INBRED C57BL; MICROBIOTA; MUCUS; PEPTIDE FRAGMENTS; PROTEINS; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM;

EID: 84920992524     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307150     Document Type: Article

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