Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line

Cell Death and Differentiation

Volumn 8, Issue 1, 2001, Pages 51-62

  Duquesne, F ^a   Florent, M ^a   Roue G ^a   Troussard, X ^a   Sola, B ^a  

^a CHU CÔTE DE NACRE   (France)

Author keywords

Apoptosis; Cell cycle; Cyclin; Kinase; Lymphocyte; Retinoblastoma protein

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; GROWTH FACTOR; HORMONE; MURISTERONE A; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER; CELL CYCLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE OVEREXPRESSION; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; LYMPHOID CELL LINE; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROLYMPHOCYTE; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; STIMULUS;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL SURVIVAL; CLONE CELLS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECDYSTERONE; ETOPOSIDE; GENETIC VECTORS; INTERLEUKIN-3; MICE; NUCLEIC ACID SYNTHESIS INHIBITORS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STEM CELLS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 0035138069     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400768     Document Type: Article

References (51)

1. G1 phase progression: Cycling on cue
2. The retinoblastoma protein and cell cycle control
3. Cancer cell cycles
4. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
5. The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas
6. D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1
7. Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and the neck
8. Identificationand cloning of two overexpressed genes U21B31/PRAD1 and EMS1, within the amplifiedchromosome 11q13regioninhumancarcinomas
9. A novel cyclin encoded by a bcl1-linked candidate oncogene
10. Amplification and expression of the human cyclin D gene in esophageal cancer
11. Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium
12. Mammary hyperplasia and carcinoma in MMTY-cyclin D1 transgenic mice
13. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
14. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression
15. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
16. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system
17. Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit
18. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth
19. KIP1, inhibits growth, and enhances apoptosis
20. Regulation of G1/S transition by cyclins D2 and D3 in hematopoïetic cells
21. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines
22. Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma
23. Mantle cell lymphoma - An entity comes of age
24. Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation
25. IL-3-dependent mouse clones that express B-220 surface antigen, contain lg genes in germ-line configuration, and generate B lymphocytes in vivo
26. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
27. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
28. Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores
29. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
30. p53, the cellular gatekeeper for growth and division
31. A matter of life and death
32. Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts
33. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-Cdk2 and cyclin D1-cdk2 complexes
34. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
35. Nerve growth factor-induced accumulation of PC12 cells expressing cyclin D1: Evidence for a G1 phase block
36. NGF regulates the PC12 cell cycle machinery trough specific inhibition of the cdk kinases and induction of cyclin D1
37. Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 without altering cell cycle progression
38. Effects of cyclin D1 overexpression on G1 progression-related events
39. Different roles for cyclins D1 and E in regulation of the G1-to-S transition
40. Cyclin D1 is an essential mediator of apoptotic neuronal cell death
41. Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E
42. Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line
43. Role for cyclin D1 in UVC-induced and p53-mediated apoptosis
44. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
45. p53 and E2F-1 cooperate to mediate apoptosis
46. E2F-1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
47. ARF links the tumour suppressors RB and p53
48. E2F-1-induced p53-independent apoptosis in transgenic mice
49. Increased E2F-1 activity induces skin tumors in mice heterozygous and nullizygous for p53
50. E2F-1 potentiates cell death by blocking antiapoptotic signalling pathways
51. E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis