메뉴 건너뛰기




Volumn 11, Issue 20, 2012, Pages 3792-3800

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation

Author keywords

BRCT; CDK; Dpb11; Mec1; Rad53; Rad9

Indexed keywords


EID: 84868034800     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.21987     Document Type: Article
Times cited : (22)

References (35)
  • 1
    • 0036948433 scopus 로고    scopus 로고
    • Toward maintaining the genome: DNA damage and replication checkpoints
    • DOI 10.1146/annurev.genet.36.060402.113540
    • Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 2002;36:617-56; PMID:12429704; http://dx.doi.org/10.1146/annurev. genet.36.060402.113540. (Pubitemid 36109200)
    • (2002) Annual Review of Genetics , vol.36 , pp. 617-656
    • Nyberg, K.A.1    Michelson, R.J.2    Putnam, C.W.3    Weinert, T.A.4
  • 2
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • PMID:11100718; http://dx.doi.org/10.1038/35044005
    • Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-9; PMID:11100718; http://dx.doi.org/10.1038/ 35044005.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 3
    • 33751419716 scopus 로고    scopus 로고
    • Surviving the breakup: The DNA damage checkpoint
    • DOI 10.1146/annurev.genet.40.051206.105231
    • Harrison JC, Haber JE. Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 2006;40:209-35; PMID:16805667; http://dx.doi.org/10.1146/annurev. genet.40.051206.105231. (Pubitemid 44956785)
    • (2006) Annual Review of Genetics , vol.40 , pp. 209-235
    • Harrison, J.C.1    Haber, J.E.2
  • 4
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
    • PMID:3291120; http://dx.doi.org/10.1126/science.3291120
    • Weinert TA, Hartwell LH. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 1988;241:317-22; PMID:3291120; http://dx.doi.org/10.1126/science.3291120.
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 6
    • 0037112212 scopus 로고    scopus 로고
    • 53BP1, a mediator of the DNA damage checkpoint
    • DOI 10.1126/science.1076182
    • Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science 2002;298:1435-8; PMID:12364621; http://dx.doi.org/10.1126/science.1076182. (Pubitemid 35346146)
    • (2002) Science , vol.298 , Issue.5597 , pp. 1435-1438
    • Wang, B.1    Matsuoka, S.2    Carpenter, P.B.3    Elledge, S.J.4
  • 7
    • 76349099135 scopus 로고    scopus 로고
    • 53BP1 promotes ATM activity through direct interactions with the MRN complex
    • PMID:20010693; http://dx.doi.org/10.1038/emboj.2009.372
    • Lee JH, Goodarzi AA, Jeggo PA, Paull T T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J 2010;29:574-85; PMID:20010693; http://dx.doi.org/10.1038/emboj.2009.372.
    • (2010) EMBO J , vol.29 , pp. 574-585
    • Lee, J.H.1    Goodarzi, A.A.2    Jeggo, P.A.3    Paull, T.T.4
  • 8
    • 47849125967 scopus 로고    scopus 로고
    • A multidimensional chromatography technology for in-depth phosphoproteome analysis
    • DOI 10.1074/mcp.M700468-MCP200
    • Albuquerque C P, Smolka MB, Payne SH, Bafna V, Eng J, Zhou H. A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics 2008;7:1389-96; PMID:18407956; http://dx.doi.org/10.1074/mcp. M700468-MCP200. (Pubitemid 352038280)
    • (2008) Molecular and Cellular Proteomics , vol.7 , Issue.7 , pp. 1389-1396
    • Albuquerque, C.P.1    Smolka, M.B.2    Payne, S.H.3    Bafna, V.4    Eng, J.5    Zhou, H.6
  • 9
    • 0032189952 scopus 로고    scopus 로고
    • The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
    • DOI 10.1093/emboj/17.19.5679
    • Vialard JE, Gilbert CS, Green CM, Lowndes N F. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J 1998;17:5679-88; PMID:9755168; http://dx.doi.org/10.1093/emboj/17.19.5679. (Pubitemid 28445979)
    • (1998) EMBO Journal , vol.17 , Issue.19 , pp. 5679-5688
    • Vialard, J.E.1    Gilbert, C.S.2    Green, C.M.3    Lowndes, N.F.4
  • 10
    • 75749130721 scopus 로고    scopus 로고
    • A mitotic phos-phorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G (2)/M DNA damage checkpoint
    • PMID:20126263; http://dx.doi.org/10.1371/journal. pbio.1000287
    • van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, et al. A mitotic phos-phorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G (2)/M DNA damage checkpoint. PLoS Biol 2010;8:e1000287; PMID:20126263; http://dx.doi.org/10.1371/journal. pbio.1000287.
    • (2010) PLoS Biol , vol.8
    • Van Vugt, M.A.1    Gardino, A.K.2    Linding, R.3    Ostheimer, G.J.4    Reinhardt, H.C.5    Ong, S.E.6
  • 12
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • DOI 10.1016/j.molcel.2008.03.023, PII S1097276508002943
    • Bonilla CY, Melo JA, Toczyski D P. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 2008;30:267-76; PMID:18471973; http://dx.doi.org/10.1016/j.molcel.2008.03. 023. (Pubitemid 351615321)
    • (2008) Molecular Cell , vol.30 , Issue.3 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 13
    • 77957368466 scopus 로고    scopus 로고
    • Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity
    • PMID:20700441; http://dx.doi.org/10.1371/journal.pgen. 1001047
    • Granata M, Lazzaro F, Novarina D, Panigada D, Puddu F, Abreu CM, et al. Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet 2010;6:6; PMID:20700441; http://dx.doi.org/10.1371/journal.pgen. 1001047.
    • (2010) PLoS Genet , vol.6 , pp. 6
    • Granata, M.1    Lazzaro, F.2    Novarina, D.3    Panigada, D.4    Puddu, F.5    Abreu, C.M.6
  • 14
    • 83555168211 scopus 로고    scopus 로고
    • Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment
    • PMID:21946560; http://dx.doi.org/10.1038/emboj.2011.345
    • Pfander B, Diffley J F. Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J 2011;30:4897-907; PMID:21946560; http://dx.doi.org/10.1038/emboj.2011.345.
    • (2011) EMBO J , vol.30 , pp. 4897-4907
    • Pfander, B.1    Diffley, J.F.2
  • 15
    • 33745137149 scopus 로고    scopus 로고
    • Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks
    • DOI 10.1101/gad.1422606
    • Du LL, Nakamura TM, Russell P. Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev 2006;20:1583-96; PMID:16778077; http://dx.doi.org/10.1101/gad.1422606. (Pubitemid 43901098)
    • (2006) Genes and Development , vol.20 , Issue.12 , pp. 1583-1596
    • Du, L.-L.1    Nakamura, T.M.2    Russell, P.3
  • 16
    • 77956692119 scopus 로고    scopus 로고
    • BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint
    • PMID:20679485; http://dx.doi.org/10.1128/MCB.00413-10
    • Sofueva S, Du LL, Limbo O, Williams JS, Russell P. BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint. Mol Cell Biol 2010;30:4732-43; PMID:20679485; http://dx.doi.org/10.1128/MCB.00413-10.
    • (2010) Mol Cell Biol , vol.30 , pp. 4732-4743
    • Sofueva, S.1    Du, L.L.2    Limbo, O.3    Williams, J.S.4    Russell, P.5
  • 17
    • 3042793923 scopus 로고    scopus 로고
    • Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
    • DOI 10.1128/MCB.24.14.6215-6230.2004
    • Nakamura TM, Du LL, Redon C, Russell P. Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol 2004;24:6215-30; PMID:15226425; http://dx.doi.org/10.1128/MCB.24.14.6215-6230.2004. (Pubitemid 38891124)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.14 , pp. 6215-6230
    • Nakamura, T.M.1    Du, L.-L.2    Redon, C.3    Russell, P.4
  • 18
    • 28544439936 scopus 로고    scopus 로고
    • Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast
    • DOI 10.1128/MCB.25.24.10721-10730.2005
    • Nakamura TM, Moser BA, Du LL, Russell P. Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast. Mol Cell Biol 2005;25:10721-30; PMID:16314498; http://dx.doi.org/10.1128/MCB.25.24.10721-10730.2005. (Pubitemid 41747118)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.24 , pp. 10721-10730
    • Nakamura, T.M.1    Moser, B.A.2    Du, L.-L.3    Russell, P.4
  • 19
    • 0031438163 scopus 로고    scopus 로고
    • Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
    • Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev 1997;11:3387-400; PMID:9407031; http://dx.doi.org/10.1101/gad.11.24.3387. (Pubitemid 28023961)
    • (1997) Genes and Development , vol.11 , Issue.24 , pp. 3387-3400
    • Saka, Y.1    Esashi, F.2    Matsusaka, T.3    Mochida, S.4    Yanagida, M.5
  • 20
    • 1542320701 scopus 로고    scopus 로고
    • Regulation of checkpoint kinases through dynamic interaction with Crb2
    • DOI 10.1038/sj.emboj.7600018
    • Mochida S, Esashi F, Aono N, Tamai K, O'Connell MJ, Yanagida M. Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J 2004;23:418-28; PMID:14739927; http://dx.doi.org/10.1038/sj.emboj.7600018. (Pubitemid 38294506)
    • (2004) EMBO Journal , vol.23 , Issue.2 , pp. 418-428
    • Mochida, S.1    Esashi, F.2    Aono, N.3    Tamai, K.4    O'Connell, M.J.5    Yanagida, M.6
  • 21
    • 33846328709 scopus 로고    scopus 로고
    • Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
    • DOI 10.1038/nature05432, PII NATURE05432
    • Zegerman P, Diffley J F. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007;445:281-5; PMID:17167417; http://dx.doi.org/10.1038/nature05432. (Pubitemid 46122811)
    • (2007) Nature , vol.445 , Issue.7125 , pp. 281-285
    • Zegerman, P.1    Diffley, J.F.X.2
  • 22
    • 0036281710 scopus 로고    scopus 로고
    • Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
    • DOI 10.1016/S1097-2765(02)00532-4
    • Schwartz MF, Duong JK, Sun Z, Morrow JS, Pradhan D, Stern D F. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 2002;9:1055-65; PMID:12049741; http://dx.doi.org/10.1016/ S1097-2765 (02) 00532-4. (Pubitemid 34626674)
    • (2002) Molecular Cell , vol.9 , Issue.5 , pp. 1055-1065
    • Schwartz, M.F.1    Duong, J.K.2    Sun, Z.3    Morrow, J.S.4    Pradhan, D.5    Stern, D.F.6
  • 23
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    • DOI 10.1126/science.281.5374.272
    • Sun Z, Hsiao J, Fay DS, Stern DF. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 1998;281:272-4; PMID:9657725; http://dx.doi.org/10.1126/sci-ence.281.5374.272. (Pubitemid 28334513)
    • (1998) Science , vol.281 , Issue.5374 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, D.F.4
  • 24
    • 33847767159 scopus 로고    scopus 로고
    • Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae
    • DOI 10.1074/jbc.M609322200
    • Chen SH, Smolka MB, Zhou H. Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. J Biol Chem 2007;282:986-95; PMID:17114794; http://dx.doi.org/10.1074/jbc. M609322200. (Pubitemid 47076565)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.2 , pp. 986-995
    • Chen, S.-H.1    Smolka, M.B.2    Zhou, H.3
  • 25
    • 0035736486 scopus 로고    scopus 로고
    • Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
    • DOI 10.1038/ncb1101-966
    • Tanaka K, Russell P. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat Cell Biol 2001;3:966-72; PMID:11715017; http://dx.doi.org/10.1038/ncb1101-966. (Pubitemid 34428741)
    • (2001) Nature Cell Biology , vol.3 , Issue.11 , pp. 966-972
    • Tanaka, K.1    Russell, P.2
  • 26
    • 0038506000 scopus 로고    scopus 로고
    • Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
    • DOI 10.1101/gad.1098303
    • Osborn AJ, Elledge SJ. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 2003;17:1755-67; PMID:12865299; http://dx.doi.org/10.1101/gad.1098303. (Pubitemid 36870338)
    • (2003) Genes and Development , vol.17 , Issue.14 , pp. 1755-1767
    • Osborn, A.J.1    Elledge, S.J.2
  • 28
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao X, Muller EG, Rothstein R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 1998;2:329-40; PMID:9774971; http://dx.doi.org/10.1016/S1097-2765 (00) 80277-4. (Pubitemid 128379273)
    • (1998) Molecular Cell , vol.2 , Issue.3 , pp. 329-340
    • Zhao, X.1    Muller, E.G.D.2    Rothstein, R.3
  • 29
    • 0036237806 scopus 로고    scopus 로고
    • Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
    • Wang H, Elledge SJ. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 2002;160:1295-304; PMID:11973288. (Pubitemid 34454356)
    • (2002) Genetics , vol.160 , Issue.4 , pp. 1295-1304
    • Wang, H.1    Elledge, S.J.2
  • 30
    • 47949109008 scopus 로고    scopus 로고
    • Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
    • PMID:18541674; http://dx.doi.org/10.1128/MCB.00330-08
    • Puddu F, Granata M, Di Nola L, Balestrini A, Piergiovanni G, Lazzaro F, et al. Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 2008;28:4782-93; PMID:18541674; http://dx.doi.org/10.1128/MCB.00330- 08.
    • (2008) Mol Cell Biol , vol.28 , pp. 4782-4793
    • Puddu, F.1    Granata, M.2    Di Nola, L.3    Balestrini, A.4    Piergiovanni, G.5    Lazzaro, F.6
  • 31
    • 79451472566 scopus 로고    scopus 로고
    • Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination
    • PMID:21130053; http://dx.doi.org/10.1016/j.dnarep. 2010.11.001
    • Germann SM, Oestergaard VH, Haas C, Salis P, Motegi A, Lisby M. Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination. DNA Repair (Amst) 2011;10:210-24; PMID:21130053; http://dx.doi.org/10.1016/j.dnarep. 2010.11.001.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 210-224
    • Germann, S.M.1    Oestergaard, V.H.2    Haas, C.3    Salis, P.4    Motegi, A.5    Lisby, M.6
  • 32
    • 0037034048 scopus 로고    scopus 로고
    • S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
    • DOI 10.1038/nature713
    • Masumoto H, Muramatsu S, Kamimura Y, Araki H. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 2002;415:651-5; PMID:11807498; http://dx.doi.org/10.1038/ nature713. (Pubitemid 34136393)
    • (2002) Nature , vol.415 , Issue.6872 , pp. 651-655
    • Masumoto, H.1    Muramatsu, S.2    Kamimura, Y.3    Araki, H.4
  • 33
    • 77957149919 scopus 로고    scopus 로고
    • Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
    • PMID:20835227; http://dx.doi.org/10.1038/nature09373
    • Zegerman P, Diffley J F. Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 2010;467:474-8; PMID:20835227; http://dx.doi.org/10.1038/nature09373.
    • (2010) Nature , vol.467 , pp. 474-478
    • Zegerman, P.1    Diffley, J.F.2
  • 34
    • 0035969559 scopus 로고    scopus 로고
    • Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
    • DOI 10.1038/35107009
    • Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 2001;414:514-21; PMID:11734846; http://dx.doi.org/10. 1038/35107009. (Pubitemid 33131529)
    • (2001) Nature , vol.414 , Issue.6863 , pp. 514-521
    • Nash, P.1    Tang, X.2    Orlicky, S.3    Chen, Q.4    Gertler, F.B.5    Mendenhall, M.D.6    Sicheri, F.7    Pawson, T.8    Tyers, M.9
  • 35
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
    • Longtine MS, McKenzie A 3rd, Demarini DJ, Shah NG, Wach A, Brachat A, et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cere-visiae. Yeast 1998;14:953-61; PMID:9717241; http://dx.doi.org/10.1002/(SICI) 1097-0061 (199807) 14:10<953::AID- YEA293>3.0. CO;2-U. (Pubitemid 28328001)
    • (1998) Yeast , vol.14 , Issue.10 , pp. 953-961
    • Longtine, M.S.1    McKenzie III, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.