메뉴 건너뛰기




Volumn 189, Issue 12, 2012, Pages 5659-5666

Cyclin-dependent kinase 2 controls peripheral immune tolerance

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GAMMA INTERFERON; INTERLEUKIN 2; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FOXP3;

EID: 84871150208     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202313     Document Type: Article
Times cited : (54)

References (51)
  • 1
    • 67649160608 scopus 로고    scopus 로고
    • New insights into the molecular basis of T cell anergy: Anergy factors, avoidance sensors, and epigenetic imprinting
    • Wells, A. D. 2009. New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting. J. Immunol. 182: 7331-7341.
    • (2009) J. Immunol. , vol.182 , pp. 7331-7341
    • Wells, A.D.1
  • 2
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak, K., M.-H. Lee, H. Erdjument-Bromage, A. Koff, J. M. Roberts, P. Tempst, and J. Massagué. 1994. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.-H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massagué, J.7
  • 3
    • 0033621780 scopus 로고    scopus 로고
    • p27(kip1) functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes
    • DOI 10.1038/73144
    • Boussiotis, V. A., G. J. Freeman, P. A. Taylor, A. Berezovskaya, I. Grass, B. R. Blazar, and L. M. Nadler. 2000. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat. Med. 6: 290-297. (Pubitemid 30148621)
    • (2000) Nature Medicine , vol.6 , Issue.3 , pp. 290-297
    • Boussiotis, V.A.1    Freeman, G.J.2    Taylor, P.A.3    Berezovskaya, A.4    Grass, I.5    Blazar, B.R.6    Nadler, L.M.7
  • 4
    • 14844353313 scopus 로고    scopus 로고
    • + T cell proliferation and effector function
    • Rowell, E. A., M. C. Walsh, and A. D. Wells. 2005. Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function. J. Immunol. 174: 3359-3368. (Pubitemid 40354040)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3359-3368
    • Rowell, E.A.1    Walsh, M.C.2    Wells, A.D.3
  • 5
    • 33749521081 scopus 로고    scopus 로고
    • kip1 is required for transplantation tolerance induced by costimulatory blockade
    • Rowell, E. A., L. Wang, W. W. Hancock, and A. D. Wells. 2006. The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade. J. Immunol. 177: 5169-5176. (Pubitemid 44527589)
    • (2006) Journal of Immunology , vol.177 , Issue.8 , pp. 5169-5176
    • Rowell, E.A.1    Wang, L.2    Hancock, W.W.3    Wells, A.D.4
  • 6
    • 33750123428 scopus 로고    scopus 로고
    • Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance
    • DOI 10.1038/ni1398, PII NI1398
    • Li, L., Y. Iwamoto, A. Berezovskaya, and V. A. Boussiotis. 2006. A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nat. Immunol. 7: 1157-1165. (Pubitemid 44594311)
    • (2006) Nature Immunology , vol.7 , Issue.11 , pp. 1157-1165
    • Li, L.1    Iwamoto, Y.2    Berezovskaya, A.3    Boussiotis, V.A.4
  • 7
    • 1942466518 scopus 로고    scopus 로고
    • Kip1 modulates cell migration through the regulation of RhoA activation
    • DOI 10.1101/gad.1185504
    • Besson, A., M. Gurian-West, A. Schmidt, A. Hall, and J. M. Roberts. 2004. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18: 862-876. (Pubitemid 38529656)
    • (2004) Genes and Development , vol.18 , Issue.8 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 8
    • 0033545636 scopus 로고    scopus 로고
    • Degradation of the cyclin-dependentkinase inhibitor p27Kip1 is instigated by Jab1
    • Tomoda, K., Y. Kubota, and J. Kato. 1999. Degradation of the cyclin-dependentkinase inhibitor p27Kip1 is instigated by Jab1. Nature 398: 160-165.
    • (1999) Nature , vol.398 , pp. 160-165
    • Tomoda, K.1    Kubota, Y.2    Kato, J.3
  • 10
    • 0037177386 scopus 로고    scopus 로고
    • Kip1 on serine 10 is required for its binding to CRM1 and nuclear export
    • DOI 10.1074/jbc.C100762200
    • Ishida, N., T. Hara, T. Kamura, M. Yoshida, K. Nakayama, and K. I. Nakayama. 2002. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J. Biol. Chem. 277: 14355-14358. (Pubitemid 34952496)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.17 , pp. 14355-14358
    • Ishida, N.1    Hara, T.2    Kamura, T.3    Yoshida, M.4    Nakayama, K.5    Nakayama, K.I.6
  • 11
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: Several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana, A., and P. Kaldis. 2009. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28: 2925-2939.
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 13
    • 33846016948 scopus 로고    scopus 로고
    • Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
    • DOI 10.1074/jbc.M608848200
    • Chen, C., E. A. Rowell, R. M. Thomas, W. W. Hancock, and A. D. Wells. 2006. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281: 36828-36834. (Pubitemid 46042151)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.48 , pp. 36828-36834
    • Chen, C.1    Rowell, E.A.2    Thomas, R.M.3    Hancock, W.W.4    Wells, A.D.5
  • 15
    • 0035863825 scopus 로고    scopus 로고
    • Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question
    • Suchin, E. J., P. B. Langmuir, E. Palmer, M. H. Sayegh, A. D. Wells, and L. A. Turka. 2001. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J. Immunol. 166: 973-981. (Pubitemid 32060253)
    • (2001) Journal of Immunology , vol.166 , Issue.2 , pp. 973-981
    • Suchin, E.J.1    Langmuir, P.B.2    Palmer, E.3    Sayegh, M.H.4    Wells, A.D.5    Turka, L.A.6
  • 18
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie, F., R. Correa-Oliveira, S. Mauze, and R. L. Coffman. 1994. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179: 589-600.
    • (1994) J. Exp. Med. , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 19
    • 33749132566 scopus 로고    scopus 로고
    • Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN
    • Buckler, J. L., P. T. Walsh, P. M. Porrett, Y. Choi, and L. A. Turka. 2006. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J. Immunol. 177: 4262-4266. (Pubitemid 44469752)
    • (2006) Journal of Immunology , vol.177 , Issue.7 , pp. 4262-4266
    • Buckler, J.L.1    Walsh, P.T.2    Porrett, P.M.3    Choi, Y.4    Turka, L.A.5
  • 20
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27 (Kip1)-deficient mice
    • Fero, M. L., M. Rivkin, M. Tasch, P. Porter, C. E. Carow, E. Firpo, K. Polyak, L. H. Tsai, V. Broudy, R. M. Perlmutter, et al. 1996. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27 (Kip1)-deficient mice. Cell 85: 733-744.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3    Porter, P.4    Carow, C.E.5    Firpo, E.6    Polyak, K.7    Tsai, L.H.8    Broudy, V.9    Perlmutter, R.M.10
  • 21
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama, K., N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I. Horii, D. Y. Loh, and K. Nakayama. 1996. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-720.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6    Horii, I.7    Loh, D.Y.8    Nakayama, K.9
  • 23
    • 14044252169 scopus 로고    scopus 로고
    • + T lymphocytes
    • Wolfraim, L. A., and J. J. Letterio. 2005. Cutting edge: p27Kip1 deficiency reduces the requirement for CD28-mediated costimulation in naive CD8+ but not CD4+ T lymphocytes. J. Immunol. 174: 2481-2484. (Pubitemid 40279658)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 2481-2484
    • Wolfraim, L.A.1    Letterio, J.J.2
  • 24
    • 77957824896 scopus 로고    scopus 로고
    • Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1
    • Singh, A., A. Jatzek, E. H. Plisch, R. Srinivasan, J. Svaren, and M. Suresh. 2010. Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1. Mol. Cell. Biol. 30: 5145-5159.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 5145-5159
    • Singh, A.1    Jatzek, A.2    Plisch, E.H.3    Srinivasan, R.4    Svaren, J.5    Suresh, M.6
  • 25
    • 27544470656 scopus 로고    scopus 로고
    • Mammalian cyclin-dependent kinases
    • DOI 10.1016/j.tibs.2005.09.005, PII S0968000405002768
    • Malumbres, M., and M. Barbacid. 2005. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30: 630-641. (Pubitemid 41540083)
    • (2005) Trends in Biochemical Sciences , vol.30 , Issue.11 , pp. 630-641
    • Malumbres, M.1    Barbacid, M.2
  • 28
    • 34249657416 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Molecular switches controlling anergy and potential therapeutic targets for tolerance
    • DOI 10.1016/j.smim.2007.02.009, PII S1044532307000152, Molecular Mechanisms Supporting Peripheral T cell Tolerance: Potential Therapeutic Approaches to Autoimmunity and Allograft Rejection
    • Wells, A. D. 2007. Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance. Semin. Immunol. 19: 173-179. (Pubitemid 46824072)
    • (2007) Seminars in Immunology , vol.19 , Issue.3 , pp. 173-179
    • Wells, A.D.1
  • 31
    • 84863116170 scopus 로고    scopus 로고
    • STAT5 is a potent negative regulator of TFH cell differentiation
    • Johnston, R. J., Y. S. Choi, J. A. Diamond, J. A. Yang, and S. Crotty. 2012. STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 209: 243-250.
    • (2012) J. Exp. Med. , vol.209 , pp. 243-250
    • Johnston, R.J.1    Choi, Y.S.2    Diamond, J.A.3    Yang, J.A.4    Crotty, S.5
  • 32
    • 44649178270 scopus 로고    scopus 로고
    • Janus-Kinase-3-Dependent Signals Induce Chromatin Remodeling at the Ifng Locus during T Helper 1 Cell Differentiation
    • DOI 10.1016/j.immuni.2008.04.016, PII S1074761308002331
    • Shi, M., T. H. Lin, K. C. Appell, and L. J. Berg. 2008. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28: 763-773. (Pubitemid 351778407)
    • (2008) Immunity , vol.28 , Issue.6 , pp. 763-773
    • Shi, M.1    Lin, T.H.2    Appell, K.C.3    Berg, L.J.4
  • 33
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper, M., A. J. Pagán, B. Z. Igyártó, J. J. Taylor, and M. K. Jenkins. 2011. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35: 583-595.
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagán, A.J.2    Igyártó, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 34
    • 79956085895 scopus 로고    scopus 로고
    • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    • Liao, W., J.-X. Lin, L. Wang, P. Li, and W. J. Leonard. 2011. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol. 12: 551-559.
    • (2011) Nat. Immunol. , vol.12 , pp. 551-559
    • Liao, W.1    Lin, J.-X.2    Wang, L.3    Li, P.4    Leonard, W.J.5
  • 36
    • 33846923124 scopus 로고    scopus 로고
    • + regulatory T cells and for expansion of these cells
    • Zheng, S. G., J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz. 2007. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 178: 2018-2027. (Pubitemid 46233398)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2018-2027
    • Song, G.Z.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 38
    • 79955781017 scopus 로고    scopus 로고
    • CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation
    • Vanden Bush, T. J., and G. A. Bishop. 2011. CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation. PLoS ONE 6: e19468.
    • (2011) PLoS ONE , vol.6
    • Vanden Bush, T.J.1    Bishop, G.A.2
  • 39
    • 33749643800 scopus 로고    scopus 로고
    • AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex
    • DOI 10.1128/MCB.00597-06
    • Biggs, J. R., L. F. Peterson, Y. Zhang, A. S. Kraft, and D.-E. Zhang. 2006. AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol. Cell. Biol. 26: 7420-7429. (Pubitemid 44547694)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.20 , pp. 7420-7429
    • Biggs, J.R.1    Peterson, L.F.2    Zhang, Y.3    Kraft, A.S.4    Zhang, D.-E.5
  • 40
    • 78650941326 scopus 로고    scopus 로고
    • Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3
    • Guo, H., and A. D. Friedman. 2011. Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3. J. Biol. Chem. 286: 208-215.
    • (2011) J. Biol. Chem. , vol.286 , pp. 208-215
    • Guo, H.1    Friedman, A.D.2
  • 41
    • 0035895420 scopus 로고    scopus 로고
    • Modulation of SP1 activity by a cyclin A/CDK complex
    • DOI 10.1006/jmbi.2000.4406
    • Haidweger, E., M. Novy, and H. Rotheneder. 2001. Modulation of Sp1 activity by a cyclin A/CDK complex. J. Mol. Biol. 306: 201-212. (Pubitemid 33032874)
    • (2001) Journal of Molecular Biology , vol.306 , Issue.2 , pp. 201-212
    • Haidweger, E.1    Novy, M.2    Rotheneder, H.3
  • 42
    • 4544305468 scopus 로고    scopus 로고
    • Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase a regulation during the S phase of the cell cycle
    • DOI 10.1074/jbc.M406468200
    • Banchio, C., L. M. Schang, and D. E. Vance. 2004. Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle. J. Biol. Chem. 279: 40220-40226. (Pubitemid 39258298)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 40220-40226
    • Banchio, C.1    Schang, L.M.2    Vance, D.E.3
  • 43
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • DOI 10.1038/nature02650
    • Matsuura, I., N. G. Denissova, G. Wang, D. He, J. Long, and F. Liu. 2004. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430: 226-231. (Pubitemid 38902433)
    • (2004) Nature , vol.430 , Issue.6996 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 44
    • 0030614504 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator
    • DOI 10.1126/science.275.5299.523
    • Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523-527. (Pubitemid 27051906)
    • (1997) Science , vol.275 , Issue.5299 , pp. 523-527
    • Perkins, N.D.1    Felzien, L.K.2    Betts, J.C.3    Leung, K.4    Beach, D.H.5    Nabel, G.J.6
  • 46
    • 33744548700 scopus 로고    scopus 로고
    • Phosphorylation of the Linker Histone H1 by CDK Regulates Its Binding to HP1a
    • DOI 10.1016/j.molcel.2006.04.016, PII S1097276506002644
    • Hale, T. K., A. Contreras, A. J. Morrison, and R. E. Herrera. 2006. Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1alpha. Mol. Cell 22: 693-699. (Pubitemid 43817599)
    • (2006) Molecular Cell , vol.22 , Issue.5 , pp. 693-699
    • Hale, T.K.1    Contreras, A.2    Morrison, A.J.3    Herrera, R.E.4
  • 48
    • 0030498092 scopus 로고    scopus 로고
    • A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle
    • DOI 10.1016/S1074-7613(00)80272-1
    • Li, Z., D. I. Dordai, J. Lee, and S. Desiderio. 1996. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity 5: 575-589. (Pubitemid 27062067)
    • (1996) Immunity , vol.5 , Issue.6 , pp. 575-589
    • Li, Z.1    Dordai, D.I.2    Lee, J.3    Desiderio, S.4
  • 50
    • 66749113138 scopus 로고    scopus 로고
    • The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD
    • Li, L., H. Wang, J. S. Kim, G. Pihan, and V. Boussiotis. 2009. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle 8: 1794-1802.
    • (2009) Cell Cycle , vol.8 , pp. 1794-1802
    • Li, L.1    Wang, H.2    Kim, J.S.3    Pihan, G.4    Boussiotis, V.5
  • 51
    • 0031437624 scopus 로고    scopus 로고
    • Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cells receptor and CD28 differentially regulate the induction and duration of a proliferative response
    • Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100: 3173-3183. (Pubitemid 28022856)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.12 , pp. 3173-3183
    • Wells, A.D.1    Gudmundsdottir, H.2    Turka, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.