-
1
-
-
0028856130
-
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
-
Adachi M., Suematsu S., Kondo T., Ogasawara J., Tanaka T., Yoshida N., Nagata S. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat. Genet. 1995, 11:294-300.
-
(1995)
Nat. Genet.
, vol.11
, pp. 294-300
-
-
Adachi, M.1
Suematsu, S.2
Kondo, T.3
Ogasawara, J.4
Tanaka, T.5
Yoshida, N.6
Nagata, S.7
-
2
-
-
81255205373
-
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
-
Anders L., Ke N., Hydbring P., Choi Y.J., Widlund H.R., Chick J.M., Zhai H., Vidal M., Gygi S.P., Braun P., Sicinski P. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 2011, 20:620-634.
-
(2011)
Cancer Cell
, vol.20
, pp. 620-634
-
-
Anders, L.1
Ke, N.2
Hydbring, P.3
Choi, Y.J.4
Widlund, H.R.5
Chick, J.M.6
Zhai, H.7
Vidal, M.8
Gygi, S.P.9
Braun, P.10
Sicinski, P.11
-
3
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R., Mermel C.H., Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm J.S., Dobson J., Urashima M., et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010, 463:899-905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
-
4
-
-
0041666539
-
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
-
Caserta T.M., Smith A.N., Gultice A.D., Reedy M.A., Brown T.L. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 2003, 8:345-352.
-
(2003)
Apoptosis
, vol.8
, pp. 345-352
-
-
Caserta, T.M.1
Smith, A.N.2
Gultice, A.D.3
Reedy, M.A.4
Brown, T.L.5
-
5
-
-
72449178334
-
Division and apoptosis of E2f-deficient retinal progenitors
-
Chen D., Pacal M., Wenzel P., Knoepfler P.S., Leone G., Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. Nature 2009, 462:925-929.
-
(2009)
Nature
, vol.462
, pp. 925-929
-
-
Chen, D.1
Pacal, M.2
Wenzel, P.3
Knoepfler, P.S.4
Leone, G.5
Bremner, R.6
-
6
-
-
84875798688
-
Unexpected outcomes of CDK4/6 inhibition
-
Choi Y.J., Sicinski P. Unexpected outcomes of CDK4/6 inhibition. Oncotarget 2013, 4:176-177.
-
(2013)
Oncotarget
, vol.4
, pp. 176-177
-
-
Choi, Y.J.1
Sicinski, P.2
-
7
-
-
84867618851
-
The requirement for cyclin D function in tumor maintenance
-
Choi Y.J., Li X., Hydbring P., Sanda T., Stefano J., Christie A.L., Signoretti S., Look A.T., Kung A.L., von Boehmer H., Sicinski P. The requirement for cyclin D function in tumor maintenance. Cancer Cell 2012, 22:438-451.
-
(2012)
Cancer Cell
, vol.22
, pp. 438-451
-
-
Choi, Y.J.1
Li, X.2
Hydbring, P.3
Sanda, T.4
Stefano, J.5
Christie, A.L.6
Signoretti, S.7
Look, A.T.8
Kung, A.L.9
von Boehmer, H.10
Sicinski, P.11
-
8
-
-
72449177341
-
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells
-
Chong J.L., Wenzel P.L., Sáenz-Robles M.T., Nair V., Ferrey A., Hagan J.P., Gomez Y.M., Sharma N., Chen H.Z., Ouseph M., et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 2009, 462:930-934.
-
(2009)
Nature
, vol.462
, pp. 930-934
-
-
Chong, J.L.1
Wenzel, P.L.2
Sáenz-Robles, M.T.3
Nair, V.4
Ferrey, A.5
Hagan, J.P.6
Gomez, Y.M.7
Sharma, N.8
Chen, H.Z.9
Ouseph, M.10
-
9
-
-
33750920705
-
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis
-
DeGregori J., Johnson D.G. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr. Mol. Med. 2006, 6:739-748.
-
(2006)
Curr. Mol. Med.
, vol.6
, pp. 739-748
-
-
DeGregori, J.1
Johnson, D.G.2
-
10
-
-
18344372831
-
Cyclins and cdks in development and cancer: a perspective
-
Deshpande A., Sicinski P., Hinds P.W. Cyclins and cdks in development and cancer: a perspective. Oncogene 2005, 24:2909-2915.
-
(2005)
Oncogene
, vol.24
, pp. 2909-2915
-
-
Deshpande, A.1
Sicinski, P.2
Hinds, P.W.3
-
11
-
-
0013439945
-
Cycling to cancer with cyclin D1
-
Diehl J.A. Cycling to cancer with cyclin D1. Cancer Biol. Ther. 2002, 1:226-231.
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 226-231
-
-
Diehl, J.A.1
-
12
-
-
39749178390
-
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal invivo
-
Fleming H.E., Janzen V., Lo Celso C., Guo J., Leahy K.M., Kronenberg H.M., Scadden D.T. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal invivo. Cell Stem Cell 2008, 2:274-283.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 274-283
-
-
Fleming, H.E.1
Janzen, V.2
Lo Celso, C.3
Guo, J.4
Leahy, K.M.5
Kronenberg, H.M.6
Scadden, D.T.7
-
13
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry D.W., Harvey P.J., Keller P.R., Elliott W.L., Meade M., Trachet E., Albassam M., Zheng X., Leopold W.R., Pryer N.K., Toogood P.L. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther. 2004, 3:1427-1438.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1427-1438
-
-
Fry, D.W.1
Harvey, P.J.2
Keller, P.R.3
Elliott, W.L.4
Meade, M.5
Trachet, E.6
Albassam, M.7
Zheng, X.8
Leopold, W.R.9
Pryer, N.K.10
Toogood, P.L.11
-
14
-
-
9444236895
-
Minireview: cyclin D1: normal and abnormal functions
-
Fu M., Wang C., Li Z., Sakamaki T., Pestell R.G. Minireview: cyclin D1: normal and abnormal functions. Endocrinology 2004, 145:5439-5447.
-
(2004)
Endocrinology
, vol.145
, pp. 5439-5447
-
-
Fu, M.1
Wang, C.2
Li, Z.3
Sakamaki, T.4
Pestell, R.G.5
-
15
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
Gurumurthy S., Xie S.Z., Alagesan B., Kim J., Yusuf R.Z., Saez B., Tzatsos A., Ozsolak F., Milos P., Ferrari F., et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010, 468:659-663.
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
Tzatsos, A.7
Ozsolak, F.8
Milos, P.9
Ferrari, F.10
-
16
-
-
0030850752
-
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
-
Hsieh J.-K., Fredersdorf S., Kouzarides T., Martin K., Lu X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 1997, 11:1840-1852.
-
(1997)
Genes Dev.
, vol.11
, pp. 1840-1852
-
-
Hsieh, J.-K.1
Fredersdorf, S.2
Kouzarides, T.3
Martin, K.4
Lu, X.5
-
17
-
-
36749050812
-
Life and death decisions by the E2F transcription factors
-
Iaquinta P.J., Lees J.A. Life and death decisions by the E2F transcription factors. Curr. Opin. Cell Biol. 2007, 19:649-657.
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 649-657
-
-
Iaquinta, P.J.1
Lees, J.A.2
-
18
-
-
4444307411
-
Mouse development and cell proliferation in the absence of D-cyclins
-
Kozar K., Ciemerych M.A., Rebel V.I., Shigematsu H., Zagozdzon A., Sicinska E., Geng Y., Yu Q., Bhattacharya S., Bronson R.T., et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 2004, 118:477-491.
-
(2004)
Cell
, vol.118
, pp. 477-491
-
-
Kozar, K.1
Ciemerych, M.A.2
Rebel, V.I.3
Shigematsu, H.4
Zagozdzon, A.5
Sicinska, E.6
Geng, Y.7
Yu, Q.8
Bhattacharya, S.9
Bronson, R.T.10
-
19
-
-
0029155706
-
Inducible gene targeting in mice
-
Kühn R., Schwenk F., Aguet M., Rajewsky K. Inducible gene targeting in mice. Science 1995, 269:1427-1429.
-
(1995)
Science
, vol.269
, pp. 1427-1429
-
-
Kühn, R.1
Schwenk, F.2
Aguet, M.3
Rajewsky, K.4
-
20
-
-
0029054399
-
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
-
Lukas J., Parry D., Aagaard L., Mann D.J., Bartkova J., Strauss M., Peters G., Bartek J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 1995, 375:503-506.
-
(1995)
Nature
, vol.375
, pp. 503-506
-
-
Lukas, J.1
Parry, D.2
Aagaard, L.3
Mann, D.J.4
Bartkova, J.5
Strauss, M.6
Peters, G.7
Bartek, J.8
-
21
-
-
60749109846
-
Cell cycle, CDKs and cancer: a changing paradigm
-
Malumbres M., Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 2009, 9:153-166.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
22
-
-
4444247138
-
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
-
Malumbres M., Sotillo R., Santamaría D., Galán J., Cerezo A., Ortega S., Dubus P., Barbacid M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004, 118:493-504.
-
(2004)
Cell
, vol.118
, pp. 493-504
-
-
Malumbres, M.1
Sotillo, R.2
Santamaría, D.3
Galán, J.4
Cerezo, A.5
Ortega, S.6
Dubus, P.7
Barbacid, M.8
-
23
-
-
79960836823
-
Cyclin D as a therapeutic target in cancer
-
Musgrove E.A., Caldon C.E., Barraclough J., Stone A., Sutherland R.L. Cyclin D as a therapeutic target in cancer. Nat. Rev. Cancer 2011, 11:558-572.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
24
-
-
0028136903
-
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
-
Neuman E., Flemington E.K., Sellers W.R., Kaelin W.G. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 1994, 14:6607-6615.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6607-6615
-
-
Neuman, E.1
Flemington, E.K.2
Sellers, W.R.3
Kaelin, W.G.4
-
25
-
-
77954279920
-
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
-
Puyol M., Martín A., Dubus P., Mulero F., Pizcueta P., Khan G., Guerra C., Santamaría D., Barbacid M. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 2010, 18:63-73.
-
(2010)
Cancer Cell
, vol.18
, pp. 63-73
-
-
Puyol, M.1
Martín, A.2
Dubus, P.3
Mulero, F.4
Pizcueta, P.5
Khan, G.6
Guerra, C.7
Santamaría, D.8
Barbacid, M.9
-
26
-
-
35848943667
-
Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
-
Rossi D.J., Seita J., Czechowicz A., Bhattacharya D., Bryder D., Weissman I.L. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle 2007, 6:2371-2376.
-
(2007)
Cell Cycle
, vol.6
, pp. 2371-2376
-
-
Rossi, D.J.1
Seita, J.2
Czechowicz, A.3
Bhattacharya, D.4
Bryder, D.5
Weissman, I.L.6
-
27
-
-
34250215990
-
INK4a-independent mechanisms
-
INK4a-independent mechanisms. Mol. Cell. Biol. 2007, 27:4273-4282.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 4273-4282
-
-
Ruas, M.1
Gregory, F.2
Jones, R.3
Poolman, R.4
Starborg, M.5
Rowe, J.6
Brookes, S.7
Peters, G.8
-
28
-
-
8644219655
-
Living with or without cyclins and cyclin-dependent kinases
-
Sherr C.J., Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 2004, 18:2699-2711.
-
(2004)
Genes Dev.
, vol.18
, pp. 2699-2711
-
-
Sherr, C.J.1
Roberts, J.M.2
-
29
-
-
10544256183
-
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
-
Sicinski P., Donaher J.L., Geng Y., Parker S.B., Gardner H., Park M.Y., Robker R.L., Richards J.S., McGinnis L.K., Biggers J.D., et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 1996, 384:470-474.
-
(1996)
Nature
, vol.384
, pp. 470-474
-
-
Sicinski, P.1
Donaher, J.L.2
Geng, Y.3
Parker, S.B.4
Gardner, H.5
Park, M.Y.6
Robker, R.L.7
Richards, J.S.8
McGinnis, L.K.9
Biggers, J.D.10
-
30
-
-
60149085396
-
The many roles of FAS receptor signaling in the immune system
-
Strasser A., Jost P.J., Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity 2009, 30:180-192.
-
(2009)
Immunity
, vol.30
, pp. 180-192
-
-
Strasser, A.1
Jost, P.J.2
Nagata, S.3
-
31
-
-
79953010469
-
E2f1-3 are critical for myeloid development
-
Trikha P., Sharma N., Opavsky R., Reyes A., Pena C., Ostrowski M.C., Roussel M.F., Leone G. E2f1-3 are critical for myeloid development. J.Biol. Chem. 2011, 286:4783-4795.
-
(2011)
J.Biol. Chem.
, vol.286
, pp. 4783-4795
-
-
Trikha, P.1
Sharma, N.2
Opavsky, R.3
Reyes, A.4
Pena, C.5
Ostrowski, M.C.6
Roussel, M.F.7
Leone, G.8
-
33
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
Wilson A., Laurenti E., Oser G., van der Wath R.C., Blanco-Bose W., Jaworski M., Offner S., Dunant C.F., Eshkind L., Bockamp E., et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008, 135:1118-1129.
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
van der Wath, R.C.4
Blanco-Bose, W.5
Jaworski, M.6
Offner, S.7
Dunant, C.F.8
Eshkind, L.9
Bockamp, E.10
-
34
-
-
0037112178
-
Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
-
Zou X., Ray D., Aziyu A., Christov K., Boiko A.D., Gudkov A.V., Kiyokawa H. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 2002, 16:2923-2934.
-
(2002)
Genes Dev.
, vol.16
, pp. 2923-2934
-
-
Zou, X.1
Ray, D.2
Aziyu, A.3
Christov, K.4
Boiko, A.D.5
Gudkov, A.V.6
Kiyokawa, H.7
|