Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

PLoS Computational Biology

Volumn 12, Issue 3, 2016, Pages

  Cvicek, Vaclav ^a,b   Goddard, William A ^a   Abrol, Ravinder ^a,c  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALIGNMENT; PHYLOGENETIC; PHYSIOLOGY;

CONSERVED RESIDUES; EXPERIMENTAL DETERMINATION; G PROTEIN COUPLED RECEPTORS; HOTSPOTS; PHYLOGENETICS; SEQUENCE ALIGNMENTS; SEQUENCE SPACE; STRUCTURE-BASED; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE DOMAIN;

CHEMICAL ACTIVATION;

G PROTEIN COUPLED RECEPTOR; PHEROMONE; RHODOPSIN; TASTE RECEPTOR 2; UNCLASSIFIED DRUG; VOMERONASAL RECEPTOR 1;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; MUTATION; PHYLOGENETIC TREE; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ALGORITHM; BIOLOGY; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR MODEL; PHYLOGENY; PROCEDURES; PROTEIN DATABASE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

ALGORITHMS; AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; HUMANS; MODELS, MOLECULAR; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

EID: 84962045982     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004805     Document Type: Article

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