Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 13, 2013, Pages 5211-5216

  Wootten, Denise ^a   Simms, John ^a   Miller, Laurence J ^b   Christopoulos, Arthur ^a   Sexton, Patrick M ^a  

^a MONASH UNIVERSITY   (Australia)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; LIGAND; OXYNTOMODULIN;

ARTICLE; LIGAND BINDING; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING;

ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; OXYNTOMODULIN; PEPTIDES; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; VENOMS;

EID: 84875533946     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221585110     Document Type: Article

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