Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5702-5707

  Isom, Daniel G ^a   Dohlman, Henrik G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

7 Transmembrane receptor; Buried charge; G protein coupled receptor; Molecular evolution; Structural bioinformatics

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND; RHODOPSIN; ADRENALIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ARCHAEAL PROTEIN; BACTERIAL PROTEIN; BACTERIORHODOPSIN; ION; NORADRENALIN; OPSIN; PROTEIN BINDING;

ARTICLE; EUKARYOTE; ION TRANSPORT; LIGAND BINDING; LIGHT; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURAL BIOINFORMATICS; ALGORITHM; ARCHAEON; BACTERIUM; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PH; PROTEIN DATABASE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALIA; EUKARYOTA; PROKARYOTA;

ALGORITHMS; ARCHAEA; ARCHAEAL PROTEINS; BACTERIA; BACTERIAL PROTEINS; BACTERIORHODOPSINS; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; EPINEPHRINE; EVOLUTION, MOLECULAR; HYDROGEN-ION CONCENTRATION; IONS; LIGANDS; MODELS, MOLECULAR; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; OPSINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN;

EID: 84929001600     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417888112     Document Type: Article

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