Quantifying conformational changes in GPCRs: Glimpse of a common functional mechanism

BMC Bioinformatics

Volumn 16, Issue 1, 2015, Pages

  Dalton, James A R ^a   Lans, Isaias ^a   Giraldo, Jesús ^a  

^a INSTITUT DE NEUROCIÈNCIES   (Spain)

Author keywords

Conformational change; Dihedral angle; GPCR; Interhelical interaction; Quantify; Receptor activation

Indexed keywords

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; PROTEINS; VAN DER WAALS FORCES;

CONFORMATIONAL CHANGE; GPCR; INTERHELICAL INTERACTIONS; QUANTIFY; RECEPTOR ACTIVATION; ACTIVE STATE; BINDING-SITES; CLASS A; FUNCTIONAL MECHANISMS; G PROTEIN COUPLED RECEPTORS; H-BONDING;

DIHEDRAL ANGLE;

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN BINDING;

BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; HUMAN; HYDROGEN BOND; METABOLISM; PROTEIN CONFORMATION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84964698897     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/s12859-015-0567-3     Document Type: Article

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