-
1
-
-
84890569395
-
SIRT6, a protein with many faces
-
Gertler, A.A. et al. (2013) SIRT6, a protein with many faces. Biogerontology, 14, 629-639.
-
(2013)
Biogerontology
, vol.14
, pp. 629-639
-
-
Gertler, A.A.1
-
2
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry, J. et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA, 97, 5807-5811.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
-
3
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein, M. et al. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev., 13, 2570-2580.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
-
4
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S. et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature, 403, 795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
-
5
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R.H. et al. (2012) Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol., 13, 225-238.
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
-
6
-
-
26244436281
-
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
-
Michishita, E. et al. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell, 16, 4623-4635.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
-
7
-
-
84890547679
-
The contentious history of sirtuin debates
-
Naiman, S. et al. (2012) The contentious history of sirtuin debates. Rambam Maimonides Med. J., 3, e0022.
-
(2012)
Rambam Maimonides Med. J
, vol.3
-
-
Naiman, S.1
-
8
-
-
81555226055
-
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription
-
Rajendran, R. et al. (2011) Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J. Biomed. Biotechnol., 2011, 368276.
-
(2011)
J. Biomed. Biotechnol
, vol.2011
-
-
Rajendran, R.1
-
9
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis, M.C. et al. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol., 5, 253-295.
-
(2010)
Annu. Rev. Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
-
10
-
-
84875881601
-
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
-
Jiang, H. et al. (2013) SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature, 496, 110-113.
-
(2013)
Nature
, vol.496
, pp. 110-113
-
-
Jiang, H.1
-
11
-
-
79954581231
-
Structure and biochemical functions of SIRT6
-
Pan, P.W. et al. (2011) Structure and biochemical functions of SIRT6. J. Biol. Chem., 286, 14575-14587.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 14575-14587
-
-
Pan, P.W.1
-
12
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R. et al. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell, 124, 315-329.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
-
13
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi, Y. et al. (2012) The sirtuin SIRT6 regulates lifespan in male mice. Nature, 483, 218-221.
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
-
14
-
-
84888198135
-
Insulin, IGF-1 and longevity
-
van Heemst, D. (2010) Insulin, IGF-1 and longevity. Aging Dis., 1, 147-157.
-
(2010)
Aging Dis
, vol.1
, pp. 147-157
-
-
van Heemst, D.1
-
15
-
-
77953244349
-
SIRT6 protects against pathological damage caused by diet-induced obesity
-
Kanfi, Y. et al. (2010) SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell, 9, 162-173.
-
(2010)
Aging Cell
, vol.9
, pp. 162-173
-
-
Kanfi, Y.1
-
16
-
-
84895127938
-
SIRT1 metabolic actions: Integrating recent advances from mouse models
-
Boutant, M. et al. (2014) SIRT1 metabolic actions: Integrating recent advances from mouse models. Mol. Metab., 3, 5-18.
-
(2014)
Mol. Metab
, vol.3
, pp. 5-18
-
-
Boutant, M.1
-
17
-
-
39649100868
-
Regulation of SIRT6 protein levels by nutrient availability
-
Kanfi, Y. et al. (2008) Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett., 582, 543-548.
-
(2008)
FEBS Lett
, vol.582
, pp. 543-548
-
-
Kanfi, Y.1
-
18
-
-
45549102566
-
Regulation of SIRT1 protein levels by nutrient availability
-
Kanfi, Y. et al. (2008) Regulation of SIRT1 protein levels by nutrient availability. FEBS Lett., 582, 2417-2423.
-
(2008)
FEBS Lett
, vol.582
, pp. 2417-2423
-
-
Kanfi, Y.1
-
19
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng, H.L. et al. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA, 100, 10794-10799.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
-
20
-
-
84889053953
-
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease
-
Etchegaray, J.P. et al. (2013) The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease. Curr. Top. Med. Chem., 13, 2991-3000.
-
(2013)
Curr. Top. Med. Chem
, vol.13
, pp. 2991-3000
-
-
Etchegaray, J.P.1
-
21
-
-
77956315551
-
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
-
Kim, H.S. et al. (2010) Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab., 12, 224-236.
-
(2010)
Cell Metab
, vol.12
, pp. 224-236
-
-
Kim, H.S.1
-
22
-
-
84940451498
-
SIRT3 regulates progression and development of diseases of aging
-
McDonnell, E. et al. (2015) SIRT3 regulates progression and development of diseases of aging. Trends Endocrinol. Metab., 26, 486-492.
-
(2015)
Trends Endocrinol. Metab
, vol.26
, pp. 486-492
-
-
McDonnell, E.1
-
23
-
-
82455212901
-
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
-
Hirschey, M.D. et al. (2011) SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol. Cell, 44, 177-190.
-
(2011)
Mol. Cell
, vol.44
, pp. 177-190
-
-
Hirschey, M.D.1
-
24
-
-
74049094817
-
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim, H.S. et al. (2010) SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell, 17, 41-52.
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
-
25
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization
-
Finley, L.W. et al. (2011) SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization. Cancer Cell, 19, 416-428.
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
-
26
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita, E. et al. (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature, 452, 492-496.
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
-
27
-
-
69249221533
-
Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
-
Michishita, E. et al. (2009) Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle, 8, 2664-2666.
-
(2009)
Cell Cycle
, vol.8
, pp. 2664-2666
-
-
Michishita, E.1
-
28
-
-
69249229772
-
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
-
Yang, B. et al. (2009) The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle, 8, 2662-2663.
-
(2009)
Cell Cycle
, vol.8
, pp. 2662-2663
-
-
Yang, B.1
-
29
-
-
30544442161
-
Histone acetylation increases chromatin accessibility
-
Görisch, S.M. et al. (2005) Histone acetylation increases chromatin accessibility. J. Cell Sci., 118(Pt 24), 5825-5834.
-
(2005)
J. Cell Sci
, vol.118
, pp. 5825-5834
-
-
Görisch, S.M.1
-
30
-
-
84885913409
-
SIRT6 exhibits nucleosome-dependent deacetylase activity
-
Gil, R. et al. (2013) SIRT6 exhibits nucleosome-dependent deacetylase activity. Nucleic Acids Res., 41, 8537-8545.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 8537-8545
-
-
Gil, R.1
-
31
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi, A. et al. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science, 329, 1348-1353.
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
-
32
-
-
84871676013
-
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis
-
Dominy, J.E. Jr et al. (2012) The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol. Cell, 48, 900-913.
-
(2012)
Mol. Cell
, vol.48
, pp. 900-913
-
-
Dominy, J.E.1
-
33
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong, L. et al. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell, 140, 280-293.
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
-
34
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
-
Seagroves, T.N. et al. (2001) Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol. Cell. Biol., 21, 3436-3444.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
-
35
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden, M.G. et al. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
-
36
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell, 151, 1185-1199.
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastián, C.1
-
37
-
-
84872858887
-
The guardian: metabolic and tumour-suppressive effects of SIRT6
-
Lerrer, B. et al. (2013) The guardian: metabolic and tumour-suppressive effects of SIRT6. EMBO J., 32, 7-8.
-
(2013)
EMBO J
, vol.32
, pp. 7-8
-
-
Lerrer, B.1
-
38
-
-
77949920493
-
MYC as a regulator of ribosome biogenesis and protein synthesis
-
van Riggelen, J. et al. (2010) MYC as a regulator of ribosome biogenesis and protein synthesis. Nat. Rev. Cancer, 10, 301-309.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 301-309
-
-
van Riggelen, J.1
-
39
-
-
84939182991
-
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
-
Choe, M. et al. (2015) The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. J. Cell. Biochem., 116, 2210-2226.
-
(2015)
J. Cell. Biochem
, vol.116
, pp. 2210-2226
-
-
Choe, M.1
-
40
-
-
84912137237
-
Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder
-
Wu, M. et al. (2014) Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder. Int. J. Clin. Exp. Pathol., 7, 6504-6513.
-
(2014)
Int. J. Clin. Exp. Pathol
, vol.7
, pp. 6504-6513
-
-
Wu, M.1
-
41
-
-
84929628771
-
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells
-
Wu, M. et al. (2015) E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells. Oncotarget, 6, 11252-11263.
-
(2015)
Oncotarget
, vol.6
, pp. 11252-11263
-
-
Wu, M.1
-
42
-
-
84904687584
-
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion
-
Zhang, P. et al. (2014) Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proc. Natl. Acad. Sci. USA, 111, 10684-10689.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 10684-10689
-
-
Zhang, P.1
-
43
-
-
77954974215
-
Obesity and cancer
-
Wolin, K.Y. et al. (2010) Obesity and cancer. Oncologist, 15, 556-565.
-
(2010)
Oncologist
, vol.15
, pp. 556-565
-
-
Wolin, K.Y.1
-
44
-
-
52949130217
-
Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers
-
Polednak, A.P. (2008) Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers. Cancer Detect. Prev., 32, 190-199.
-
(2008)
Cancer Detect. Prev
, vol.32
, pp. 190-199
-
-
Polednak, A.P.1
-
45
-
-
84884150671
-
Multiple regulatory layers of SREBP1/2 by SIRT6
-
Elhanati, S. et al. (2013) Multiple regulatory layers of SREBP1/2 by SIRT6. Cell Rep., 4, 905-912.
-
(2013)
Cell Rep
, vol.4
, pp. 905-912
-
-
Elhanati, S.1
-
46
-
-
0036864411
-
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
-
Horton, J.D. (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem. Soc. Trans., 30(Pt 6), 1091-1095.
-
(2002)
Biochem. Soc. Trans
, vol.30
, pp. 1091-1095
-
-
Horton, J.D.1
-
47
-
-
0032892175
-
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis
-
Horton, J.D. et al. (1999) Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr. Opin. Lipidol., 10, 143-150.
-
(1999)
Curr. Opin. Lipidol
, vol.10
, pp. 143-150
-
-
Horton, J.D.1
-
48
-
-
0032793068
-
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism
-
Fajas, L. et al. (1999) Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol., 19, 5495-5503.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5495-5503
-
-
Fajas, L.1
-
49
-
-
0037144604
-
Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target
-
Le Lay, S. et al. (2002) Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. J. Biol. Chem., 277, 35625-35634.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 35625-35634
-
-
Le Lay, S.1
-
50
-
-
0028987126
-
Concerted participation of NF-kappa B and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liver
-
Ray, A. et al. (1995) Concerted participation of NF-kappa B and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liver. J. Biol. Chem., 270, 7365-7374.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 7365-7374
-
-
Ray, A.1
-
51
-
-
79952032653
-
Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats
-
Yang, S.J. et al. (2011) Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS One, 6, e17057.
-
(2011)
PLoS One
, vol.6
-
-
Yang, S.J.1
-
52
-
-
84905731719
-
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal
-
Sounni, N.E. et al. (2014) Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal. Cell Metab., 20, 280-294.
-
(2014)
Cell Metab
, vol.20
, pp. 280-294
-
-
Sounni, N.E.1
-
53
-
-
13944249618
-
DNA repair, genome stability, and aging
-
Lombard, D.B. et al. (2005) DNA repair, genome stability, and aging. Cell, 120, 497-512.
-
(2005)
Cell
, vol.120
, pp. 497-512
-
-
Lombard, D.B.1
-
54
-
-
3242881500
-
The cellular response to general and programmed DNA double strand breaks
-
Bassing, C.H. et al. (2004) The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst)., 3, 781-796.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 781-796
-
-
Bassing, C.H.1
-
55
-
-
69249217081
-
Sirtuins at the breaking point: SIRT6 in DNA repair
-
Lombard, D.B. (2009) Sirtuins at the breaking point: SIRT6 in DNA repair. Aging, 1, 12-16.
-
(2009)
Aging
, vol.1
, pp. 12-16
-
-
Lombard, D.B.1
-
56
-
-
66049150672
-
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord, R.A. et al. (2009) SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging, 1, 109-121.
-
(2009)
Aging
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
-
57
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao, Z. et al. (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science, 332, 1443-1446.
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
-
58
-
-
84882630603
-
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling
-
Toiber, D. et al. (2013) SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol. Cell, 51, 454-468.
-
(2013)
Mol. Cell
, vol.51
, pp. 454-468
-
-
Toiber, D.1
-
59
-
-
80052908853
-
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
-
Van Meter, M. et al. (2011) SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle, 10, 3153-3158.
-
(2011)
Cell Cycle
, vol.10
, pp. 3153-3158
-
-
Van Meter, M.1
-
60
-
-
84918592495
-
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
-
Van Meter, M. et al. (2014) SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat. Commun., 5, 5011.
-
(2014)
Nat. Commun
, vol.5
, pp. 5011
-
-
Van Meter, M.1
-
61
-
-
0942290423
-
Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells
-
Liu, T. et al. (2004) Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene, 23, 39-48.
-
(2004)
Oncogene
, vol.23
, pp. 39-48
-
-
Liu, T.1
-
62
-
-
0034700154
-
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
-
O'Connor, D.S. et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA, 97, 13103-13107.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13103-13107
-
-
O'Connor, D.S.1
-
63
-
-
0035969963
-
An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7
-
Shin, S. et al. (2001) An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7. Biochemistry, 40, 1117-1123.
-
(2001)
Biochemistry
, vol.40
, pp. 1117-1123
-
-
Shin, S.1
-
64
-
-
34047273890
-
Survivin does not inhibit caspase-3 activity
-
Banks, D.P. et al. (2000) Survivin does not inhibit caspase-3 activity. Blood, 96, 4002-4003.
-
(2000)
Blood
, vol.96
, pp. 4002-4003
-
-
Banks, D.P.1
-
65
-
-
0034789355
-
Cancer gene therapy using a survivin mutant adenovirus
-
Mesri, M. et al. (2001) Cancer gene therapy using a survivin mutant adenovirus. J. Clin. Invest., 108, 981-990.
-
(2001)
J. Clin. Invest
, vol.108
, pp. 981-990
-
-
Mesri, M.1
-
66
-
-
0031984247
-
Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation
-
Adida, C. et al. (1998) Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am. J. Pathol., 152, 43-49.
-
(1998)
Am. J. Pathol
, vol.152
, pp. 43-49
-
-
Adida, C.1
-
67
-
-
0030746636
-
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
-
Ambrosini, G. et al. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med., 3, 917-921.
-
(1997)
Nat. Med
, vol.3
, pp. 917-921
-
-
Ambrosini, G.1
-
68
-
-
0032403126
-
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
-
Tamm, I. et al. (1998) IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res., 58, 5315-5320.
-
(1998)
Cancer Res
, vol.58
, pp. 5315-5320
-
-
Tamm, I.1
-
69
-
-
0032735232
-
Survivin apoptosis: an interloper between cell death and cell proliferation in cancer
-
Altieri, D.C. et al. (1999) Survivin apoptosis: an interloper between cell death and cell proliferation in cancer. Lab. Invest., 79, 1327-1333.
-
(1999)
Lab. Invest
, vol.79
, pp. 1327-1333
-
-
Altieri, D.C.1
-
70
-
-
84938125432
-
Putative tumor suppression function of SIRT6 in endometrial cancer
-
Fukuda, T. et al. (2015) Putative tumor suppression function of SIRT6 in endometrial cancer. FEBS Lett., 589, 2274-2281.
-
(2015)
FEBS Lett
, vol.589
, pp. 2274-2281
-
-
Fukuda, T.1
-
71
-
-
84869082071
-
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
-
Min, L. et al. (2012) Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat. Cell Biol., 14, 1203-1211.
-
(2012)
Nat. Cell Biol
, vol.14
, pp. 1203-1211
-
-
Min, L.1
-
72
-
-
84942246592
-
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression
-
Zhang, J. et al. (2015) The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression. Eur. Rev. Med. Pharmacol. Sci., 19, 818-824.
-
(2015)
Eur. Rev. Med. Pharmacol. Sci
, vol.19
, pp. 818-824
-
-
Zhang, J.1
-
73
-
-
77955952841
-
Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma
-
Jung, S.G. et al. (2010) Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma. Cancer Sci., 101, 1977-1983.
-
(2010)
Cancer Sci
, vol.101
, pp. 1977-1983
-
-
Jung, S.G.1
-
74
-
-
84897999764
-
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma
-
Chen, X. et al. (2014) The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma. Biochem. Biophys. Res. Commun., 446, 364-369.
-
(2014)
Biochem. Biophys. Res. Commun
, vol.446
, pp. 364-369
-
-
Chen, X.1
-
75
-
-
0036223676
-
The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms
-
Makeyev, A.V. et al. (2002) The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA, 8, 265-278.
-
(2002)
RNA
, vol.8
, pp. 265-278
-
-
Makeyev, A.V.1
-
76
-
-
84883223984
-
Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
-
Marquardt, J.U. et al. (2013) Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology, 58, 1054-1064.
-
(2013)
Hepatology
, vol.58
, pp. 1054-1064
-
-
Marquardt, J.U.1
-
77
-
-
84893861526
-
Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal-regulated kinase signaling pathway
-
Zhang, Z.G. et al. (2014) Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal-regulated kinase signaling pathway. Mol. Med. Rep., 9, 882-888.
-
(2014)
Mol. Med. Rep
, vol.9
, pp. 882-888
-
-
Zhang, Z.G.1
-
78
-
-
84906962868
-
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer
-
Han, Z. et al. (2014) Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer. Int. J. Clin. Exp. Pathol., 7, 4774-4781.
-
(2014)
Int. J. Clin. Exp. Pathol
, vol.7
, pp. 4774-4781
-
-
Han, Z.1
-
79
-
-
84907274151
-
Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells
-
Cai, Y. et al. (2014) Radiosensitization effect of overexpression of adenovirus-mediated SIRT6 on A549 non-small cell lung cancer cells. Asian Pac. J. Cancer Prev., 15, 7297-7301.
-
(2014)
Asian Pac. J. Cancer Prev
, vol.15
, pp. 7297-7301
-
-
Cai, Y.1
-
80
-
-
84912120802
-
Twist-1 up-regulation in carcinoma correlates to poor survival
-
Wushou, A. et al. (2014) Twist-1 up-regulation in carcinoma correlates to poor survival. Int. J. Mol. Sci., 15, 21621-21630.
-
(2014)
Int. J. Mol. Sci
, vol.15
, pp. 21621-21630
-
-
Wushou, A.1
-
81
-
-
84940052405
-
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer
-
Azuma, Y. et al. (2015) SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer. J. Surg. Oncol., 112, 231-237.
-
(2015)
J. Surg. Oncol
, vol.112
, pp. 231-237
-
-
Azuma, Y.1
-
82
-
-
84927130669
-
Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway
-
Kim, E.J. et al. (2015) Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway. J. Biol. Chem., 290, 9604-9613.
-
(2015)
J. Biol. Chem
, vol.290
, pp. 9604-9613
-
-
Kim, E.J.1
-
83
-
-
84908128033
-
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer
-
Ming, M. et al. (2014) SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res., 74, 5925-5933.
-
(2014)
Cancer Res
, vol.74
, pp. 5925-5933
-
-
Ming, M.1
-
84
-
-
84890570698
-
Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics
-
Liu, Y. et al. (2013) Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics. Protein Cell, 4, 702-710.
-
(2013)
Protein Cell
, vol.4
, pp. 702-710
-
-
Liu, Y.1
-
85
-
-
84889609373
-
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
-
Piao, J. et al. (2013) Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci. Rep., 3, 3022.
-
(2013)
Sci. Rep
, vol.3
, pp. 3022
-
-
Piao, J.1
-
86
-
-
84922181550
-
Balancing the innate immune system in tumor development
-
Hagerling, C. et al. (2014) Balancing the innate immune system in tumor development. Trends Cell Biol, 25, 214-220.
-
(2014)
Trends Cell Biol
, vol.25
, pp. 214-220
-
-
Hagerling, C.1
-
87
-
-
84870363221
-
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
-
Bauer, I. et al. (2012) The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J. Biol. Chem., 287, 40924-40937.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 40924-40937
-
-
Bauer, I.1
-
88
-
-
79960952144
-
IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
-
Fernando, R.I. et al. (2011) IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res., 71, 5296-5306.
-
(2011)
Cancer Res
, vol.71
, pp. 5296-5306
-
-
Fernando, R.I.1
-
89
-
-
33845524008
-
TNF-alpha in promotion and progression of cancer
-
Balkwill, F. (2006) TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev., 25, 409-416.
-
(2006)
Cancer Metastasis Rev
, vol.25
, pp. 409-416
-
-
Balkwill, F.1
-
90
-
-
59649117804
-
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
-
Van Gool, F. et al. (2009) Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat. Med., 15, 206-210.
-
(2009)
Nat. Med
, vol.15
, pp. 206-210
-
-
Van Gool, F.1
-
91
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
-
Kawahara, T.L. et al. (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell, 136, 62-74.
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
-
92
-
-
33750432183
-
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
-
Bassères, D.S. et al. (2006) Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene, 25, 6817-6830.
-
(2006)
Oncogene
, vol.25
, pp. 6817-6830
-
-
Bassères, D.S.1
-
93
-
-
65549113750
-
CBP/p300-mediated acetylation of histone H3 on lysine 56
-
Das, C. et al. (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature, 459, 113-117.
-
(2009)
Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
-
94
-
-
84890979013
-
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation
-
Lin, Z. et al. (2013) USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. Cell Rep., 5, 1639-1649.
-
(2013)
Cell Rep
, vol.5
, pp. 1639-1649
-
-
Lin, Z.1
-
95
-
-
84907560467
-
The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth
-
Zhang, J. et al. (2014) The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth. Biochem. Biophys. Res. Commun., 452, 575-580.
-
(2014)
Biochem. Biophys. Res. Commun
, vol.452
, pp. 575-580
-
-
Zhang, J.1
-
96
-
-
84929703622
-
Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
-
Feng, X.X. et al. (2015) Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence. Cancer Sci., 106, 559-566.
-
(2015)
Cancer Sci
, vol.106
, pp. 559-566
-
-
Feng, X.X.1
-
97
-
-
84882451168
-
A miR-34a-SIRT6 axis in the squamous cell differentiation network
-
Lefort, K. et al. (2013) A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J., 32, 2248-2263.
-
(2013)
EMBO J
, vol.32
, pp. 2248-2263
-
-
Lefort, K.1
-
98
-
-
84908141001
-
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer
-
Wang, D. et al. (2014) The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. DNA Cell Biol., 33, 581-590.
-
(2014)
DNA Cell Biol
, vol.33
, pp. 581-590
-
-
Wang, D.1
-
99
-
-
84878550317
-
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
-
Khongkow, M. et al. (2013) SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis, 34, 1476-1486.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1476-1486
-
-
Khongkow, M.1
-
100
-
-
84925729166
-
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
-
Thirumurthi, U. et al. (2014) MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci. Signal., 7, ra71.
-
(2014)
Sci. Signal
, vol.7
-
-
Thirumurthi, U.1
-
101
-
-
84923076498
-
Expression of SIRT2 and SIRT6 in retinoblastoma
-
Orellana, M.E. et al. (2015) Expression of SIRT2 and SIRT6 in retinoblastoma. Ophthalmic Res., 53, 100-108.
-
(2015)
Ophthalmic Res
, vol.53
, pp. 100-108
-
-
Orellana, M.E.1
-
102
-
-
84940179025
-
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
-
Sociali, G. et al. (2015) Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. Eur. J. Med. Chem., 102, 530-539.
-
(2015)
Eur. J. Med. Chem
, vol.102
, pp. 530-539
-
-
Sociali, G.1
-
103
-
-
84918559371
-
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma
-
Lu, C.T. et al. (2014) The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma. Anticancer Res., 34, 7137-7143.
-
(2014)
Anticancer Res
, vol.34
, pp. 7137-7143
-
-
Lu, C.T.1
-
104
-
-
84862804268
-
Histone deacetylase in chronic lymphocytic leukemia
-
Wang, J.C. et al. (2011) Histone deacetylase in chronic lymphocytic leukemia. Oncology, 81, 325-329.
-
(2011)
Oncology
, vol.81
, pp. 325-329
-
-
Wang, J.C.1
-
105
-
-
84942885599
-
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
-
Cagnetta, A. et al. (2015) APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clin. Cancer Res., 21, 3934-3945.
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 3934-3945
-
-
Cagnetta, A.1
-
106
-
-
84944672660
-
Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer
-
Kugel, S. et al. (2015) Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer. Cell Rep, 13, 479-488.
-
(2015)
Cell Rep
, vol.13
, pp. 479-488
-
-
Kugel, S.1
-
107
-
-
84886995308
-
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination
-
Ronnebaum, S.M. et al. (2013) The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. Mol. Cell. Biol., 33, 4461-4472.
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 4461-4472
-
-
Ronnebaum, S.M.1
-
108
-
-
84925003003
-
ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice
-
Stöhr, R. et al. (2015) ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice. Sci. Rep., 5, 9023.
-
(2015)
Sci. Rep
, vol.5
, pp. 9023
-
-
Stöhr, R.1
-
109
-
-
75749132016
-
USP10 regulates p53 localization and stability by deubiquitinating p53
-
Yuan, J. et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell, 140, 384-396.
-
(2010)
Cell
, vol.140
, pp. 384-396
-
-
Yuan, J.1
-
110
-
-
84890215172
-
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
-
Rizza, W. et al. (2014) What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res. Rev., 13, 38-45.
-
(2014)
Ageing Res. Rev
, vol.13
, pp. 38-45
-
-
Rizza, W.1
-
111
-
-
84880068090
-
The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells
-
Sharma, A. et al. (2013) The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J. Biol. Chem., 288, 18439-18447.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 18439-18447
-
-
Sharma, A.1
-
114
-
-
84876717815
-
Rejuvenating sirtuins: the rise of a new family of cancer drug targets
-
Bruzzone, S. et al. (2013) Rejuvenating sirtuins: the rise of a new family of cancer drug targets. Curr. Pharm. Des., 19, 614-623.
-
(2013)
Curr. Pharm. Des
, vol.19
, pp. 614-623
-
-
Bruzzone, S.1
-
115
-
-
84886686038
-
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
-
Feldman, J.L. et al. (2013) Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J. Biol. Chem., 288, 31350-31356.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 31350-31356
-
-
Feldman, J.L.1
-
116
-
-
84871213843
-
Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors
-
Kokkonen, P. et al. (2012) Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors. ACS Med. Chem. Lett., 3, 969-974.
-
(2012)
ACS Med. Chem. Lett
, vol.3
, pp. 969-974
-
-
Kokkonen, P.1
-
117
-
-
84902449175
-
Discovery of novel and selective SIRT6 inhibitors
-
Parenti, M.D. et al. (2014) Discovery of novel and selective SIRT6 inhibitors. J. Med. Chem., 57, 4796-4804.
-
(2014)
J. Med. Chem
, vol.57
, pp. 4796-4804
-
-
Parenti, M.D.1
-
118
-
-
84891848670
-
Small-molecule allosteric activators of sirtuins
-
Sinclair, D.A. et al. (2014) Small-molecule allosteric activators of sirtuins. Annu. Rev. Pharmacol. Toxicol., 54, 363-380.
-
(2014)
Annu. Rev. Pharmacol. Toxicol
, vol.54
, pp. 363-380
-
-
Sinclair, D.A.1
|