Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence

Cancer Science

Volumn 106, Issue 5, 2015, Pages 559-566

  Feng, Xin Xia ^a   Luo, Jing ^b   Liu, Mei ^a   Yan, Wei ^a   Zhou, Zhen Zhen ^a   Xia, Yu Jia ^a   Tu, Wei ^a   Li, Pei Yuan ^a   Feng, Zuo Hua ^b   Tian, De An ^a  

^a Tongji Hospital   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cellular senescence; SIRT6; TGF 1; Tumor cells; Tumorigenicity

Indexed keywords

HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P16; PROTEIN P21; REACTIVE OXYGEN METABOLITE; SIRTUIN 6; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; HYPOCHLOROUS ACID; SIRT6 PROTEIN, HUMAN; SIRTUIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOIKIS; APOPTOSIS; ARTICLE; CARCINOGENICITY; CARCINOMA CELL; CELL AGING; CONTROLLED STUDY; ENZYME ACTIVATION; GLYCOLYSIS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DRUG EFFECTS; DRUG SCREENING; GENETICS; LIVER TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANOIKIS; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELL LINE, TUMOR; GLYCOLYSIS; HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE, NUDE; SIRTUINS; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84929703622     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12632     Document Type: Article

References (31)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
2. Dasari A, Bartholomew JN, Volonte D, Galbiati F. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res 2006; 66: 10805-14.
3. Volonte D, Liu Z, Musille PM et al. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Mol Biol Cell 2013; 24: 1852-62.
4. Supanji, Shimomachi M, Hasan MZ, Kawaichi M, Oka C. HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res 2013; 112: 79-92.
5. Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology 2010; 52: 966-74.
6. Massagué J. G1 cell-cycle control and cancer. Nature 2004; 432: 298-306.
7. 2/HOCl-mediated induction of metastatic phenotype of hepatocellular carcinoma cells by enhancing TGF-β1 signaling. PLoS One 2013; 8: e79857.
8. Li YW, Qiu SJ, Fan J et al. Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol 2011; 54: 497-505.
9. Zhou SL, Dai Z, Zhou ZJ et al. Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma. Hepatology 2012; 56: 2242-54.
10. Xu Q, Ma P, Hu C et al. Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. PLoS One 2012; 7: e41862.
11. Ohta K, Haraguchi N, Kano Y et al. Depletion of JARID1B induces cellular senescence in human colorectal cancer. Int J Oncol 2013; 42: 1212-8.
12. Minagawa S, Araya J, Numata T et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2011; 300: L391-401.
13. Marquardt JU, Fischer K, Baus K et al. SIRT6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology 2013; 58: 1054-64.
14. Lefort K, Brooks Y, Ostano P et al. A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J 2013; 32: 2248-63.
15. Sebastian C, Zwaans BMM, Silberman DM et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151: 1185-99.
16. Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-7.
17. Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 2011; 10: 3153-8.
18. Zhong L, D'Urso A, Toiber D et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140: 280-93.
19. Zhong L, Mostoslavsky R. SIRT6: a master epigenetic gatekeeper of glucose metabolism. Transcription 2010; 1: 17-21.
20. Hsu CC, Wang CH, Wu LC et al. Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells. Biochim Biophys Acta 2013; 1830: 4743-51.
21. Liu D, Liu J, Lin B et al. Lewis y regulate cell cycle related factors in ovarian carcinoma cell RMG-I in vitro via ERK and Akt signaling pathways. Int J Mol Sci 2012; 13: 828-39.
22. Watanabe T, Hiasa Y, Tokumoto Y et al. Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection. PLoS One 2013; 8: e67750.
23. Min L, Ji Y, Bakiri L et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol 2012; 14: 1203-11.
24. Wu Y, Zhang X, Salmon M, Lin X, Zehner ZE. TGFβ1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members. Biochim Biophys Acta 2007; 1773: 427-39.
25. Funaba M, Ikeda T, Murakami M et al. Transcriptional regulation of mouse mast cell protease-7 by TGF-β. Biochim Biophys Acta 2006; 1759: 166-70.
26. 2 enhances TGF-β1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways. PLoS One 2013; 8: e65906.
27. Spallarossa P, Altieri P, Barisione C et al. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells. PLoS One 2010; 5: e15583.
28. Kawahara TL, Michishita E, Adler AS et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136: 62-74.
29. Wu CA, Chao Y, Shiah SG, Lin WW. Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase. Biochim Biophys Acta 2013; 1833: 1147-56.
30. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33.
31. Kim MC, Cui FJ, Kim Y. Hydrogen peroxide promotes epithelial to mesenchymal transition and stemness in human malignant mesothelioma cells. Asian Pac J Cancer Prev 2013; 14: 3625-30.