ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Stohr R ^a   Mavilio, M ^a   Marino, A ^a   Casagrande, V ^a   Kappel, B ^a   Mollmann J ^b   Menghini, R ^a   Melino, G ^a,c   Federici, M ^a,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; ITCH PROTEIN, MOUSE; SIRT6 PROTEIN, MOUSE; SIRTUIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ATHEROSCLEROSIS; BLOOD; BONE MARROW TRANSPLANTATION; DEFICIENCY; DISEASE MODEL; FATTY LIVER; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER; MACROPHAGE; METABOLISM; MITOCHONDRION; MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; UBIQUITINATION;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; CHOLESTEROL; DISEASE MODELS, ANIMAL; FATTY LIVER; INFLAMMATION; LIPID METABOLISM; LIVER; MACROPHAGES; MICE; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATION-REDUCTION; SIRTUINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84925003003     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09023     Document Type: Article

References (18)

1. Libby, P. Inflammation in atherosclerosis. Nature 420, 868-874, doi:10.1038/nature01323 (2002).
2. Lusis, A. J. Atherosclerosis. Nature 407, 233-241, doi:10.1038/35025203 (2000).
3. Libby, P., Ridker, P. M. & Hansson, G. K. Progress and challenges in translating the biology of atherosclerosis. Nature 473, 317-325, doi:10.1038/nature10146 (2011).
4. Mantovani, A., Garlanda, C. & Locati, M. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arteriosclerosis, thrombosis, and vascular biology 29, 1419-1423, doi:10.1161/ATVBAHA.108.180497 (2009).
5. Moore, K. J., Sheedy, F. J. & Fisher, E. A. Macrophages in atherosclerosis: a dynamic balance. Nature reviews. Immunology 13, 709-721, doi:10.1038/nri3520 (2013).
6. Perry, W. L. et al. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nature genetics 18, 143-146, doi:10.1038/ng0298-143 (1998).
7. Rossi, M. et al. The ubiquitin-protein ligase Itch regulates p73 stability. The EMBO journal 24, 836-848, doi:10.1038/sj.emboj.7600444 (2005).
8. Marino, A. et al. ITCH deficiency protects from diet-induced obesity. Diabetes 63, 550-561, doi:10.2337/db13-0802 (2014).
9. Xu, X. et al.Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell metabolism 18, 816-830, doi:10.1016/j.cmet.2013.11.001 (2013).
10. Irisawa, M., Inoue, J., Ozawa, N., Mori, K. & Sato, R. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. The Journal of biological chemistry 284, 28995-29004, doi:10.1074/jbc.M109.041376 (2009).
11. Elhanati, S. et al. Multiple regulatory layers of SREBP1/2 by SIRT6. Cell reports 4, 905-912, doi:10.1016/j.celrep.2013.08.006 (2013).
12. Martinez-Clemente, M. et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 52, 1980-1991, doi:10.1002/hep.23928 (2010).
13. Ito, K. et al. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nature medicine 18, 1350-1358, doi:10.1038/nm.2882 (2012).
14. Carracedo, A. et al. A metabolic prosurvival role for PML in breast cancer. The Journal of clinical investigation 122, 3088-3100, doi:10.1172/JCI62129 (2012).
15. Biddinger, S. B. et al. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes 54, 1314-1323 (2005).
16. Miao, J. et al.Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. Journal of lipid research 55, 659-667, doi:10.1194/jlr.M043711 (2014).
17. Van Rooyen, D. M. et al. Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology 141, 1393-1403, 1403 e1391-1395, doi:10.1053/j.gastro.2011.06.040 (2011).
18. Samuel, V. T. et al.Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. The Journal of biological chemistry 279, 32345-32353, doi:10.1074/jbc.M313478200 (2004).