E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

Oncotarget

Volumn 6, Issue 13, 2015, Pages 11252-11263

  Wu, Minghui ^a   Seto, Edward ^a   Zhang, Jingsong ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

E2F1; Glycolysis; HDAC1; Metabolism; SIRT6

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; HISTONE DEACETYLASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; SIRTUIN 6; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1; TRICHOSTATIN A; E2F1 PROTEIN, HUMAN; HDAC1 PROTEIN, HUMAN; HISTONE DEACETYLASE INHIBITOR; SIRT6 PROTEIN, HUMAN; SIRTUIN;

ARTICLE; BINDING SITE; BLADDER CANCER CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; DEACETYLATION; DNA BINDING; DOWN REGULATION; E2F1 GENE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE TRANSPORT; GLYCOLYSIS; HYPOXIA; PROMOTER REGION; PROSTATE CANCER CELL LINE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIRT6 GENE; TRANSCRIPTION TERMINATION; UPREGULATION; CELL HYPOXIA; CELL PROLIFERATION; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; MUTATION; PATHOLOGY; PROSTATIC NEOPLASMS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE; URINARY BLADDER NEOPLASMS;

BINDING SITES; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; LACTIC ACID; MALE; MUTATION; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIRTUINS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; URINARY BLADDER NEOPLASMS;

EID: 84929628771     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3594     Document Type: Article

References (23)

1. Engelmann D, Pützer BM. The dark side of E2F1: in transit beyond apoptosis. Cancer Res. 2012; 72(3): 571-575.
2. Blanchet E, Annicotte JS, Lagarrigue S, Aguilar V, Clapé C, Chavey C, Fritz V, Casas F, Apparailly F, Auwerx J, Fajas L.E2F transcription factor-1 regulates oxidative metabolism. Nat Cell Biol. 2011; 13 (9): 1146-1152.
3. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, et al. The histone deacetylase SIRT6 regulates glucose homeostasis via Hif1α. Cell. 2010; 140 (2): 280-293.
4. Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, SchneiderJI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural SIRTuin 6 (SIRT6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci USA. 2010; 107 (50): 21790-21794.
5. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011, 144(5):646-674.
6. Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, Vazquez-Ortiz G, Jeong WI, Park O, Ki SH, Gao B, Deng CX. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010; 12 (3): 224-236.
7. Crowe DL, Nguyen DC, Tsang KJ, Kyo S. E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res. 2001; 29(13): 2789-2794.
8. Davis JN, Wojno KJ, Daignault S, Hofer MD, Kuefer R, Rubin MA, Day ML. Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. Cancer Res. 2006; 66(24): 11897-11906.
9. Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu. E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. Oncogene. 2006; 25 (2): 230-239.
10. Valdez CD, Davis JN, Odeh HM, Layfield TL, Cousineau CS, Berton TR, Johnson DG, Wojno KJ, Day ML. Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One. 2011; 6(9): e25187.
11. LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, Gerald WL. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res; 2002;62:4499-4506.
12. Lee JS, Leem SH, Lee SY, Kim SC, Park ES, Kim SB, Kim SK, Kim YJ, Kim WJ, Chu IS. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. J Clin Oncol. 2010; 28 (16):2660-2670.
13. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006; 124(2): 315-329.
14. Kaidi A, Weinert BT, Choudhary C, Jackson SP. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science. 2010; 329 (5997):1348-1353.
15. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V.SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011; 332 (6036):1443-1446.
16. Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF. SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span. Cell. 2009; 136 (1): 62-74.
17. Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012; 151 (6): 1185-1199.
18. Wu M, Wang X, McGregor N, Pienta KJ, Zhang J. Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia. Mol Pharmacol. 2014; 85(6): 866-876.
19. Martínez-Balbás MA1, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J. 2000; 19(4): 662-671.
20. Hsieh MC, Das D, Sambandam N, Zhang MQ, Nahlé Z. Regulation of the PDK4 isozyme by the Rb-E2F1 complex. J Biol Chem. 2008; 283(41): 27410-27417.
21. Palomer X, álvarez-Guardia D, Davidson MM, Chan TO, Feldman AM, Vázquez-Carrera M. The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells. PLoS One. 2011; 6(5): e19724.
22. Minghui Wu, Shohreh Iravani Dickinson, Xue Wang, Jingsong Zhang. Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder. International Journal of Clinical and Experimental Pathology. 2014; 7(10):6504-6513.
23. Bailey KM, Wojtkowiak JW, Cornnell HH, Ribeiro MC, Balagurunathan Y, Hashim AI, Gillies RJ. Mechanisms of buffer therapy resistance. Neoplasia. 2014; 16(4): 354-364.