Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Cell Reports

Volumn 13, Issue 3, 2015, Pages 479-488

  Kugel, Sita ^a   Feldman, Jessica L ^d   Klein, Mark A ^d   Silberman, Dafne M ^f   Sebastián, Carlos ^a   Mermel, Craig ^a,c   Dobersch, Stephanie ^e   Clark, Abbe R ^a   Getz, Gad ^a,c   Denu, John M ^d   Mostoslavsky, Raul ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^f Centre de Estudios Farmacologicos y Botanicos   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; SIRTUIN 6; SIRT6 PROTEIN, HUMAN; SIRTUIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GEL ELECTROPHORESIS; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTONE ACETYLATION; HUMAN; IMMUNOFLUORESCENCE; KIDNEY CANCER; MELANOMA; MOUSE; MUTANT; NEOPLASM; NON SMALL CELL LUNG CANCER; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; TUMOR XENOGRAFT; UTERINE CERVIX CANCER; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; GLYCOLYSIS; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CELL LINE; GLYCOLYSIS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS; POINT MUTATION; SIRTUINS;

EID: 84944672660     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.09.022     Document Type: Article

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