-
1
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576, 2007.
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
2
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
3
-
-
7044229778
-
Primary liver cancer: Worldwide incidence and trends
-
Bosch FX, Ribes J, Díaz M and Cléries R: Primary liver cancer: worldwide incidence and trends. Gastroenterology 127 (5 Suppl 1): S5-S16, 2004.
-
(2004)
Gastroenterology
, vol.127
, Issue.5 SUPPL. 1
-
-
Bosch, F.X.1
Ribes, J.2
Díaz, M.3
Cléries, R.4
-
6
-
-
79953002209
-
A multicenter retrospective study on clinical characteristics, treatment patterns, and outcome in elderly patients with hepatocellular carcinoma
-
Kozyreva ON, Chi D, Clark JW, et al: A multicenter retrospective study on clinical characteristics, treatment patterns, and outcome in elderly patients with hepatocellular carcinoma. Oncologist 16: 310-318, 2011.
-
(2011)
Oncologist
, vol.16
, pp. 310-318
-
-
Kozyreva, O.N.1
Chi, D.2
Clark, J.W.3
-
7
-
-
33751113602
-
Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
-
Haigis MC and Guarente LP: Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 20: 2913-2921, 2006.
-
(2006)
Genes Dev
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
8
-
-
62449178216
-
The critical role of the class III histone deacetylase SIRT1 in cancer
-
Liu T, Liu PY and Marshall GM: The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res 69: 1702-1705, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 1702-1705
-
-
Liu, T.1
Liu, P.Y.2
Marshall, G.M.3
-
10
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, et al: SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464: 121-125, 2010.
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
-
11
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
-
Finley LW, Carracedo A, Lee J, et al: SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell 19: 416-428, 2011.
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
-
12
-
-
79953799195
-
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer
-
Alhazzazi TY, Kamarajan P, Joo N, et al: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer 117: 1670-1678, 2011.
-
(2011)
Cancer
, vol.117
, pp. 1670-1678
-
-
Alhazzazi, T.Y.1
Kamarajan, P.2
Joo, N.3
-
13
-
-
84862689176
-
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation
-
Zhang YY and Zhou LM: Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation. Biochem Biophys Res Commun 423: 26-31, 2012.
-
(2012)
Biochem Biophys Res Commun
, vol.423
, pp. 26-31
-
-
Zhang, Y.Y.1
Zhou, L.M.2
-
14
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong L, D'Urso A, Toiber D, et al: The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140: 280-293, 2010.
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D'Urso, A.2
Toiber, D.3
-
15
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao Z, Hine C, Tian X, et al: SIRT6 promotes DNA repair under stress by activating PARP1. Science 332: 1443-1446, 2011.
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
-
16
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi A, Weinert BT, Choudhary C and Jackson SP: Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329: 1348-1353, 2010.
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
17
-
-
84869082071
-
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
-
Min L, Ji Y, Bakiri L, et al: Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol 14: 1203-1211, 2012.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1203-1211
-
-
Min, L.1
Ji, Y.2
Bakiri, L.3
-
18
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastián C, Zwaans BM, Silberman DM, et al: The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151: 1185-1199, 2012.
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastián, C.1
Zwaans, B.M.2
Silberman, D.M.3
-
19
-
-
84870363221
-
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
-
Bauer I, Grozio A, Lasigliè D, et al: The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J Biol Chem 287: 40924-40937, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 40924-40937
-
-
Bauer, I.1
Grozio, A.2
Lasigliè, D.3
-
20
-
-
84878550317
-
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
-
Khongkow M, Olmos Y, Gong C, et al: SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis 34: 1476-1486, 2013.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1476-1486
-
-
Khongkow, M.1
Olmos, Y.2
Gong, C.3
-
21
-
-
84863012215
-
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
-
Wang P, Guan YF, Du H, Zhai QW, Su DF and Miao CY: Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy 8: 77-87, 2012.
-
(2012)
Autophagy
, vol.8
, pp. 77-87
-
-
Wang, P.1
Guan, Y.F.2
Du, H.3
Zhai, Q.W.4
Su, D.F.5
Miao, C.Y.6
-
22
-
-
84867033830
-
Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production
-
Filippi BM, Yang CS, Tang C and Lam TK: Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. Cell Metab 16: 500-510, 2012.
-
(2012)
Cell Metab
, vol.16
, pp. 500-510
-
-
Filippi, B.M.1
Yang, C.S.2
Tang, C.3
Lam, T.K.4
-
23
-
-
58449109119
-
Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide
-
Wang P, Xu TY, Guan YF, Su DF, Fan GR and Miao CY: Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc Res 81: 370-380, 2009.
-
(2009)
Cardiovasc Res
, vol.81
, pp. 370-380
-
-
Wang, P.1
Xu, T.Y.2
Guan, Y.F.3
Su, D.F.4
Fan, G.R.5
Miao, C.Y.6
-
24
-
-
78649297219
-
Autophagy as a trigger for cell death: Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
-
Nezis IP, Shravage BV, Sagona AP, Johansen T, Baehrecke EH and Stenmark H: Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Autophagy 6: 1214-1215, 2010.
-
(2010)
Autophagy
, vol.6
, pp. 1214-1215
-
-
Nezis, I.P.1
Shravage, B.V.2
Sagona, A.P.3
Johansen, T.4
Baehrecke, E.H.5
Stenmark, H.6
-
25
-
-
80053198889
-
Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats
-
Wang P, Tian WW, Song J, Guan YF and Miao CY: Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats. CNS Neurosci Ther 17: 327-332, 2011.
-
(2011)
CNS Neurosci Ther
, vol.17
, pp. 327-332
-
-
Wang, P.1
Tian, W.W.2
Song, J.3
Guan, Y.F.4
Miao, C.Y.5
-
26
-
-
79952537492
-
Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway
-
Wang P, Xu TY, Guan YF, et al: Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 69: 360-374, 2011.
-
(2011)
Ann Neurol
, vol.69
, pp. 360-374
-
-
Wang, P.1
Xu, T.Y.2
Guan, Y.F.3
-
27
-
-
79957945033
-
Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass-and obesity-associated (FTO) downregulation during energy restriction
-
Wang P, Yang FJ, Du H, et al: Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass-and obesity-associated (FTO) downregulation during energy restriction. Mol Med 17: 523-532, 2011.
-
(2011)
Mol Med
, vol.17
, pp. 523-532
-
-
Wang, P.1
Yang, F.J.2
Du, H.3
-
28
-
-
84860561281
-
Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
-
Wang P, Zhang RY, Song J, et al: Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 61: 1051-1061, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 1051-1061
-
-
Wang, P.1
Zhang, R.Y.2
Song, J.3
-
29
-
-
84867895307
-
Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western diet
-
Devarajan A, Grijalva VR, Bourquard N, et al: Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/-mice on a Western diet. Mol Genet Metab 107: 416-427, 2012.
-
(2012)
Mol Genet Metab
, vol.107
, pp. 416-427
-
-
Devarajan, A.1
Grijalva, V.R.2
Bourquard, N.3
-
30
-
-
80052970243
-
Molecular markers of endometrial carcinoma detected in uterine aspirates
-
Colas E, Perez C, Cabrera S, et al: Molecular markers of endometrial carcinoma detected in uterine aspirates. Int J Cancer 129: 2435-2444, 2011.
-
(2011)
Int J Cancer
, vol.129
, pp. 2435-2444
-
-
Colas, E.1
Perez, C.2
Cabrera, S.3
-
31
-
-
84878721346
-
Altered expression of SIRT gene family in head and neck squamous cell carcinoma
-
Lai CC, Lin PM, Lin SF, et al: Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol 34: 1847-1854, 2013.
-
(2013)
Tumour Biol
, vol.34
, pp. 1847-1854
-
-
Lai, C.C.1
Lin, P.M.2
Lin, S.F.3
-
32
-
-
80052908853
-
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
-
Van Meter M, Mao Z, Gorbunova V and Seluanov A: SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10: 3153-3158, 2011.
-
(2011)
Cell Cycle
, vol.10
, pp. 3153-3158
-
-
Van Meter, M.1
Mao, Z.2
Gorbunova, V.3
Seluanov, A.4
-
33
-
-
33747792064
-
MAPK signalling: ERK5 versus ERK1/2
-
Nishimoto S and Nishida E: MAPK signalling: ERK5 versus ERK1/2. EMBO Rep 7: 782-786, 2006.
-
(2006)
EMBO Rep
, vol.7
, pp. 782-786
-
-
Nishimoto, S.1
Nishida, E.2
-
34
-
-
1442335098
-
Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma
-
Wiesenauer CA, Yip-Schneider MT, Wang Y and Schmidt CM: Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg 198: 410-421, 2004.
-
(2004)
J Am Coll Surg
, vol.198
, pp. 410-421
-
-
Wiesenauer, C.A.1
Yip-Schneider, M.T.2
Wang, Y.3
Schmidt, C.M.4
-
35
-
-
45549096918
-
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
-
Li Y, Xu W, McBurney MW and Longo VD: SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8: 38-48, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 38-48
-
-
Li, Y.1
Xu, W.2
McBurney, M.W.3
Longo, V.D.4
-
36
-
-
84865318675
-
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
-
Zhao Y, Luo P, Guo Q, et al: Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Exp Neurol 237: 489-498, 2012.
-
(2012)
Exp Neurol
, vol.237
, pp. 489-498
-
-
Zhao, Y.1
Luo, P.2
Guo, Q.3
|