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Volumn 34, Issue , 2016, Pages 1-7

Role of lipids in the metabolism and activation of immune cells

Author keywords

Fatty acids; Inflammation; Macrophages; Oxysterols; T lymphocytes

Indexed keywords

CHOLESTEROL; CONJUGATED LINOLEIC ACID; LIPID; OXYSTEROL; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN;

EID: 84961159913     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.11.002     Document Type: Review
Times cited : (173)

References (86)
  • 1
    • 84907991703 scopus 로고    scopus 로고
    • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
    • Kratz M., Coats B.R., Hisert K.B., Hagman D., Mutskov V., Peris E., et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab 2014, 20:614-625.
    • (2014) Cell Metab , vol.20 , pp. 614-625
    • Kratz, M.1    Coats, B.R.2    Hisert, K.B.3    Hagman, D.4    Mutskov, V.5    Peris, E.6
  • 2
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 2010, 11:889-896.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 3
    • 80051873375 scopus 로고    scopus 로고
    • CD8(+) T cells: foot soldiers of the immune system
    • Zhang N., Bevan M.J. CD8(+) T cells: foot soldiers of the immune system. Immunity 2011, 35:161-168.
    • (2011) Immunity , vol.35 , pp. 161-168
    • Zhang, N.1    Bevan, M.J.2
  • 4
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010, 28:445-489.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 5
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A., Rudra D., Treuting P., Samstein R.M., Liang Y., Kas A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009, 326:986-991.
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 7
    • 84887462082 scopus 로고    scopus 로고
    • Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation
    • Stewart C.A., Metheny H., Iida N., Smith L., Hanson M., Steinhagen F., et al. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest 2013, 123:4859-4874.
    • (2013) J Clin Invest , vol.123 , pp. 4859-4874
    • Stewart, C.A.1    Metheny, H.2    Iida, N.3    Smith, L.4    Hanson, M.5    Steinhagen, F.6
  • 8
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz S.Z., Lu L.F., Rudensky A.Y. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012, 30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 9
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007, 117:175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 10
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: time for reassessment
    • Martinez F.O., Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime Rep 2014, 6:13.
    • (2014) F1000prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 11
    • 77957367098 scopus 로고    scopus 로고
    • Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice
    • Kinoshita M., Uchida T., Sato A., Nakashima M., Nakashima H., Shono S., et al. Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol 2010, 53:903-910.
    • (2010) J Hepatol , vol.53 , pp. 903-910
    • Kinoshita, M.1    Uchida, T.2    Sato, A.3    Nakashima, M.4    Nakashima, H.5    Shono, S.6
  • 12
    • 84903625203 scopus 로고    scopus 로고
    • Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
    • Zigmond E., Samia-Grinberg S., Pasmanik-Chor M., Brazowski E., Shibolet O., Halpern Z., et al. Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury. J Immunol 2014, 193:344-353.
    • (2014) J Immunol , vol.193 , pp. 344-353
    • Zigmond, E.1    Samia-Grinberg, S.2    Pasmanik-Chor, M.3    Brazowski, E.4    Shibolet, O.5    Halpern, Z.6
  • 13
    • 77951146612 scopus 로고    scopus 로고
    • C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • Obstfeld A.E., Sugaru E., Thearle M., Francisco A.M., Gayet C., Ginsberg H.N., et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 2010, 59:916-925.
    • (2010) Diabetes , vol.59 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3    Francisco, A.M.4    Gayet, C.5    Ginsberg, H.N.6
  • 14
    • 84898789996 scopus 로고    scopus 로고
    • Macrophage heterogeneity in liver injury and fibrosis
    • Tacke F., Zimmermann H.W. Macrophage heterogeneity in liver injury and fibrosis. J Hepatol 2014, 60:1090-1096.
    • (2014) J Hepatol , vol.60 , pp. 1090-1096
    • Tacke, F.1    Zimmermann, H.W.2
  • 15
    • 71149117471 scopus 로고    scopus 로고
    • Immature myeloid cells induced by a high-fat diet contribute to liver inflammation
    • Deng Z.B., Liu Y., Liu C., Xiang X., Wang J., Cheng Z., et al. Immature myeloid cells induced by a high-fat diet contribute to liver inflammation. Hepatology 2009, 50:1412-1420.
    • (2009) Hepatology , vol.50 , pp. 1412-1420
    • Deng, Z.B.1    Liu, Y.2    Liu, C.3    Xiang, X.4    Wang, J.5    Cheng, Z.6
  • 16
    • 33747358360 scopus 로고    scopus 로고
    • Migratory fate and differentiation of blood monocyte subsets
    • Tacke F., Randolph G.J. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 2006, 211:609-618.
    • (2006) Immunobiology , vol.211 , pp. 609-618
    • Tacke, F.1    Randolph, G.J.2
  • 17
    • 84861029037 scopus 로고    scopus 로고
    • Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery
    • Gui T., Shimokado A., Sun Y., Akasaka T., Muragaki Y. Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. Mediat Inflamm 2012, 2012:693083.
    • (2012) Mediat Inflamm , vol.2012 , pp. 693083
    • Gui, T.1    Shimokado, A.2    Sun, Y.3    Akasaka, T.4    Muragaki, Y.5
  • 18
    • 84886797808 scopus 로고    scopus 로고
    • Macrophages in atherosclerosis: a dynamic balance
    • Moore K.J., Sheedy F.J., Fisher E.A. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 2013, 13:709-721.
    • (2013) Nat Rev Immunol , vol.13 , pp. 709-721
    • Moore, K.J.1    Sheedy, F.J.2    Fisher, E.A.3
  • 21
    • 70350731272 scopus 로고    scopus 로고
    • Mechanisms and consequences of efferocytosis in advanced atherosclerosis
    • Thorp E., Tabas I. Mechanisms and consequences of efferocytosis in advanced atherosclerosis. J Leukoc Biol 2009, 86:1089-1095.
    • (2009) J Leukoc Biol , vol.86 , pp. 1089-1095
    • Thorp, E.1    Tabas, I.2
  • 22
    • 72949116358 scopus 로고    scopus 로고
    • Macrophage death and defective inflammation resolution in atherosclerosis
    • Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 2010, 10:36-46.
    • (2010) Nat Rev Immunol , vol.10 , pp. 36-46
    • Tabas, I.1
  • 23
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S., Chan Y., Paltser G., Truong D., Tsui H., Bahrami J., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009, 15:921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5    Bahrami, J.6
  • 24
    • 74949108521 scopus 로고    scopus 로고
    • Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction
    • Madhur M.S., Lob H.E., McCann L.A., Iwakura Y., Blinder Y., Guzik T.J., et al. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension 2010, 55:500-507.
    • (2010) Hypertension , vol.55 , pp. 500-507
    • Madhur, M.S.1    Lob, H.E.2    McCann, L.A.3    Iwakura, Y.4    Blinder, Y.5    Guzik, T.J.6
  • 25
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 2009, 58:1152-1167.
    • (2009) Gut , vol.58 , pp. 1152-1167
    • Brand, S.1
  • 26
    • 84929650379 scopus 로고    scopus 로고
    • IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation
    • Ye L., Jiang B., Deng J., Du J., Xiong W., Guan Y., et al. IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation. J Immunol 2015, 194:5110-5119.
    • (2015) J Immunol , vol.194 , pp. 5110-5119
    • Ye, L.1    Jiang, B.2    Deng, J.3    Du, J.4    Xiong, W.5    Guan, Y.6
  • 28
    • 84922246659 scopus 로고    scopus 로고
    • Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice
    • Hendrikx T., Jeurissen M.L., Bieghs V., Walenbergh S.M., van Gorp P.J., Verheyen F., et al. Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. J Hepatol 2015, 62:430-436.
    • (2015) J Hepatol , vol.62 , pp. 430-436
    • Hendrikx, T.1    Jeurissen, M.L.2    Bieghs, V.3    Walenbergh, S.M.4    van Gorp, P.J.5    Verheyen, F.6
  • 29
    • 0032890337 scopus 로고    scopus 로고
    • Oxysterols and atherosclerosis
    • Brown A.J., Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999, 142:1-28.
    • (1999) Atherosclerosis , vol.142 , pp. 1-28
    • Brown, A.J.1    Jessup, W.2
  • 30
    • 84904043004 scopus 로고    scopus 로고
    • The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha
    • Umetani M., Ghosh P., Ishikawa T., Umetani J., Ahmed M., Mineo C., et al. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 2014, 20:172-182.
    • (2014) Cell Metab , vol.20 , pp. 172-182
    • Umetani, M.1    Ghosh, P.2    Ishikawa, T.3    Umetani, J.4    Ahmed, M.5    Mineo, C.6
  • 31
    • 84867031028 scopus 로고    scopus 로고
    • Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
    • Spann N.J., Garmire L.X., McDonald J.G., Myers D.S., Milne S.B., Shibata N., et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 2012, 151:138-152.
    • (2012) Cell , vol.151 , pp. 138-152
    • Spann, N.J.1    Garmire, L.X.2    McDonald, J.G.3    Myers, D.S.4    Milne, S.B.5    Shibata, N.6
  • 32
    • 66549124438 scopus 로고    scopus 로고
    • Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line
    • Rodriguez-Acebes S., de la Cueva P., Fernandez-Hernando C., Ferruelo A.J., Lasuncion M.A., Rawson R.B., et al. Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J 2009, 420:305-315.
    • (2009) Biochem J , vol.420 , pp. 305-315
    • Rodriguez-Acebes, S.1    de la Cueva, P.2    Fernandez-Hernando, C.3    Ferruelo, A.J.4    Lasuncion, M.A.5    Rawson, R.B.6
  • 33
    • 33748792007 scopus 로고    scopus 로고
    • Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
    • Yang C., McDonald J.G., Patel A., Zhang Y., Umetani M., Xu F., et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem 2006, 281:27816-27826.
    • (2006) J Biol Chem , vol.281 , pp. 27816-27826
    • Yang, C.1    McDonald, J.G.2    Patel, A.3    Zhang, Y.4    Umetani, M.5    Xu, F.6
  • 34
    • 84913617157 scopus 로고    scopus 로고
    • Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells
    • Casella C., Miller D.H., Lynch K., Brodsky A.S. Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. Gynecol Oncol 2014, 135:333-341.
    • (2014) Gynecol Oncol , vol.135 , pp. 333-341
    • Casella, C.1    Miller, D.H.2    Lynch, K.3    Brodsky, A.S.4
  • 35
    • 84872388657 scopus 로고    scopus 로고
    • Mitochondrial (dys)function and regulation of macrophage cholesterol efflux
    • Allen A.M., Taylor J.M., Graham A. Mitochondrial (dys)function and regulation of macrophage cholesterol efflux. Clin Sci 2013, 124:509-515.
    • (2013) Clin Sci , vol.124 , pp. 509-515
    • Allen, A.M.1    Taylor, J.M.2    Graham, A.3
  • 36
    • 84906309038 scopus 로고    scopus 로고
    • Oxysterols are agonist ligands of RORgammat and drive Th17 cell differentiation
    • Soroosh P., Wu J., Xue X., Song J., Sutton S.W., Sablad M., et al. Oxysterols are agonist ligands of RORgammat and drive Th17 cell differentiation. Proc Natl Acad Sci U S A 2014, 111:12163-12168.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 12163-12168
    • Soroosh, P.1    Wu, J.2    Xue, X.3    Song, J.4    Sutton, S.W.5    Sablad, M.6
  • 38
    • 45249122276 scopus 로고    scopus 로고
    • Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
    • Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans 2008, 36:348-352.
    • (2008) Biochem Soc Trans , vol.36 , pp. 348-352
    • Cnop, M.1
  • 39
    • 49649089562 scopus 로고    scopus 로고
    • Effect of the dietary fat quality on insulin sensitivity
    • Galgani J.E., Uauy R.D., Aguirre C.A., Diaz E.O. Effect of the dietary fat quality on insulin sensitivity. Br J Nutr 2008, 100:471-479.
    • (2008) Br J Nutr , vol.100 , pp. 471-479
    • Galgani, J.E.1    Uauy, R.D.2    Aguirre, C.A.3    Diaz, E.O.4
  • 40
    • 39449130192 scopus 로고    scopus 로고
    • Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure
    • Kien C.L., Bunn J.Y. Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure. Obesity 2008, 16:29-33.
    • (2008) Obesity , vol.16 , pp. 29-33
    • Kien, C.L.1    Bunn, J.Y.2
  • 41
    • 58649096801 scopus 로고    scopus 로고
    • Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications
    • Kennedy A., Martinez K., Chuang C.C., LaPoint K., McIntosh M. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr 2009, 139:1-4.
    • (2009) J Nutr , vol.139 , pp. 1-4
    • Kennedy, A.1    Martinez, K.2    Chuang, C.C.3    LaPoint, K.4    McIntosh, M.5
  • 42
    • 85027924659 scopus 로고    scopus 로고
    • Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis
    • Anderson E.K., Hill A.A., Hasty A.H. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. Arterioscler Thromb Vasc Biol 2012, 32:1687-1695.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1687-1695
    • Anderson, E.K.1    Hill, A.A.2    Hasty, A.H.3
  • 43
    • 84862669638 scopus 로고    scopus 로고
    • Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
    • Leroux A., Ferrere G., Godie V., Cailleux F., Renoud M.L., Gaudin F., et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol 2012, 57:141-149.
    • (2012) J Hepatol , vol.57 , pp. 141-149
    • Leroux, A.1    Ferrere, G.2    Godie, V.3    Cailleux, F.4    Renoud, M.L.5    Gaudin, F.6
  • 45
    • 84886674980 scopus 로고    scopus 로고
    • Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis
    • Freigang S., Ampenberger F., Weiss A., Kanneganti T.D., Iwakura Y., Hersberger M., et al. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 2013, 14:1045-1053.
    • (2013) Nat Immunol , vol.14 , pp. 1045-1053
    • Freigang, S.1    Ampenberger, F.2    Weiss, A.3    Kanneganti, T.D.4    Iwakura, Y.5    Hersberger, M.6
  • 46
    • 33745194553 scopus 로고    scopus 로고
    • Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation
    • Stentz F.B., Kitabchi A.E. Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation. Biochem Biophys Res Commun 2006, 346:721-726.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 721-726
    • Stentz, F.B.1    Kitabchi, A.E.2
  • 49
    • 84922163095 scopus 로고    scopus 로고
    • Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
    • Park J., Kim M., Kang S.G., Jannasch A.H., Cooper B., Patterson J., et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 2015, 8:80-93.
    • (2015) Mucosal Immunol , vol.8 , pp. 80-93
    • Park, J.1    Kim, M.2    Kang, S.G.3    Jannasch, A.H.4    Cooper, B.5    Patterson, J.6
  • 50
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski K.M., Vieira A.T., Ng A., Kranich J., Sierro F., Yu D., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009, 461:1282-1286.
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3    Kranich, J.4    Sierro, F.5    Yu, D.6
  • 51
    • 84880620577 scopus 로고    scopus 로고
    • Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice
    • 396-406.e1-10
    • Kim M.H., Kang S.G., Park J.H., Yanagisawa M., Kim C.H. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 2013, 145:396-406.e1-10.
    • (2013) Gastroenterology , vol.145
    • Kim, M.H.1    Kang, S.G.2    Park, J.H.3    Yanagisawa, M.4    Kim, C.H.5
  • 53
    • 84865086635 scopus 로고    scopus 로고
    • Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA
    • Oliver E., McGillicuddy F.C., Harford K.A., Reynolds C.M., Phillips C.M., Ferguson J.F., et al. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. J Nutr Biochem 2012, 23:1192-1200.
    • (2012) J Nutr Biochem , vol.23 , pp. 1192-1200
    • Oliver, E.1    McGillicuddy, F.C.2    Harford, K.A.3    Reynolds, C.M.4    Phillips, C.M.5    Ferguson, J.F.6
  • 55
    • 84867186758 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
    • Xue B., Yang Z., Wang X., Shi H. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One 2012, 7:e45990.
    • (2012) PLoS One , vol.7
    • Xue, B.1    Yang, Z.2    Wang, X.3    Shi, H.4
  • 57
    • 84901856464 scopus 로고    scopus 로고
    • Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses
    • Draper E., DeCourcey J., Higgins S.C., Canavan M., McEvoy F., Lynch M., et al. Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses. J Nutr Biochem 2014, 25:741-749.
    • (2014) J Nutr Biochem , vol.25 , pp. 741-749
    • Draper, E.1    DeCourcey, J.2    Higgins, S.C.3    Canavan, M.4    McEvoy, F.5    Lynch, M.6
  • 58
    • 34249993498 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids affect lipopolysaccharide-induced maturation of dendritic cells through mitogen-activated protein kinases p38
    • Wang H., Hao Q., Li Q.R., Yan X.W., Ye S., Li Y.S., et al. Omega-3 polyunsaturated fatty acids affect lipopolysaccharide-induced maturation of dendritic cells through mitogen-activated protein kinases p38. Nutrition 2007, 23:474-482.
    • (2007) Nutrition , vol.23 , pp. 474-482
    • Wang, H.1    Hao, Q.2    Li, Q.R.3    Yan, X.W.4    Ye, S.5    Li, Y.S.6
  • 59
    • 70849105973 scopus 로고    scopus 로고
    • Docosahexaenoic acid reduces suppressive and migratory functions of CD4+CD25+ regulatory T-cells
    • Yessoufou A., Ple A., Moutairou K., Hichami A., Khan N.A. Docosahexaenoic acid reduces suppressive and migratory functions of CD4+CD25+ regulatory T-cells. J Lipid Res 2009, 50:2377-2388.
    • (2009) J Lipid Res , vol.50 , pp. 2377-2388
    • Yessoufou, A.1    Ple, A.2    Moutairou, K.3    Hichami, A.4    Khan, N.A.5
  • 60
    • 15444365136 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acids increase T-lymphocyte phospholipid mass and acyl-CoA binding protein expression
    • Collison L.W., Collison R.E., Murphy E.J., Jolly C.A. Dietary n-3 polyunsaturated fatty acids increase T-lymphocyte phospholipid mass and acyl-CoA binding protein expression. Lipids 2005, 40:81-87.
    • (2005) Lipids , vol.40 , pp. 81-87
    • Collison, L.W.1    Collison, R.E.2    Murphy, E.J.3    Jolly, C.A.4
  • 62
    • 23244465860 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells
    • Kim H.J., Vosseler C.A., Weber P.C., Erl W. Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. J Cell Physiol 2005, 204:881-888.
    • (2005) J Cell Physiol , vol.204 , pp. 881-888
    • Kim, H.J.1    Vosseler, C.A.2    Weber, P.C.3    Erl, W.4
  • 63
    • 79955632319 scopus 로고    scopus 로고
    • Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
    • Im S.S., Yousef L., Blaschitz C., Liu J.Z., Edwards R.A., Young S.G., et al. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab 2011, 13:540-549.
    • (2011) Cell Metab , vol.13 , pp. 540-549
    • Im, S.S.1    Yousef, L.2    Blaschitz, C.3    Liu, J.Z.4    Edwards, R.A.5    Young, S.G.6
  • 64
    • 5444235922 scopus 로고    scopus 로고
    • LXR-dependent gene expression is important for macrophage survival and the innate immune response
    • Joseph S.B., Bradley M.N., Castrillo A., Bruhn K.W., Mak P.A., Pei L., et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 2004, 119:299-309.
    • (2004) Cell , vol.119 , pp. 299-309
    • Joseph, S.B.1    Bradley, M.N.2    Castrillo, A.3    Bruhn, K.W.4    Mak, P.A.5    Pei, L.6
  • 65
    • 41749112419 scopus 로고    scopus 로고
    • Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors alpha and gamma and of retinoid X receptors
    • Posokhova E.N., Khoshchenko O.M., Chasovskikh M.I., Pivovarova E.N., Dushkin M.I. Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors alpha and gamma and of retinoid X receptors. Biochem Biokhim 2008, 73:296-304.
    • (2008) Biochem Biokhim , vol.73 , pp. 296-304
    • Posokhova, E.N.1    Khoshchenko, O.M.2    Chasovskikh, M.I.3    Pivovarova, E.N.4    Dushkin, M.I.5
  • 66
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi L., Eigenbrod T., Munoz-Planillo R., Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009, 10:241-247.
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 67
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer N., Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 2006, 116:607-614.
    • (2006) J Clin Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 69
    • 79953177493 scopus 로고    scopus 로고
    • Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
    • Hong C., Walczak R., Dhamko H., Bradley M.N., Marathe C., Boyadjian R., et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res 2011, 52:531-539.
    • (2011) J Lipid Res , vol.52 , pp. 531-539
    • Hong, C.1    Walczak, R.2    Dhamko, H.3    Bradley, M.N.4    Marathe, C.5    Boyadjian, R.6
  • 70
    • 63049122784 scopus 로고    scopus 로고
    • Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    • Ghisletti S., Huang W., Jepsen K., Benner C., Hardiman G., Rosenfeld M.G., et al. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev 2009, 23:681-693.
    • (2009) Genes Dev , vol.23 , pp. 681-693
    • Ghisletti, S.1    Huang, W.2    Jepsen, K.3    Benner, C.4    Hardiman, G.5    Rosenfeld, M.G.6
  • 71
    • 84883181808 scopus 로고    scopus 로고
    • Sterols and oxysterols in immune cell function
    • Spann N.J., Glass C.K. Sterols and oxysterols in immune cell function. Nat Immunol 2013, 14:893-900.
    • (2013) Nat Immunol , vol.14 , pp. 893-900
    • Spann, N.J.1    Glass, C.K.2
  • 72
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011, 13:1016-1023.
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 73
    • 84055190798 scopus 로고    scopus 로고
    • Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
    • Galic S., Fullerton M.D., Schertzer J.D., Sikkema S., Marcinko K., Walkley C.R., et al. Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest 2011, 121:4903-4915.
    • (2011) J Clin Invest , vol.121 , pp. 4903-4915
    • Galic, S.1    Fullerton, M.D.2    Schertzer, J.D.3    Sikkema, S.4    Marcinko, K.5    Walkley, C.R.6
  • 74
    • 84898596957 scopus 로고    scopus 로고
    • Inhibition of macrophage fatty acid beta-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses
    • Namgaladze D., Lips S., Leiker T.J., Murphy R.C., Ekroos K., Ferreiros N., et al. Inhibition of macrophage fatty acid beta-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses. Diabetologia 2014, 57:1067-1077.
    • (2014) Diabetologia , vol.57 , pp. 1067-1077
    • Namgaladze, D.1    Lips, S.2    Leiker, T.J.3    Murphy, R.C.4    Ekroos, K.5    Ferreiros, N.6
  • 75
    • 84872660747 scopus 로고    scopus 로고
    • Immunometabolism of AMPK in insulin resistance and atherosclerosis
    • Fullerton M.D., Steinberg G.R., Schertzer J.D. Immunometabolism of AMPK in insulin resistance and atherosclerosis. Mol Cell Endocrinol 2013, 366:224-234.
    • (2013) Mol Cell Endocrinol , vol.366 , pp. 224-234
    • Fullerton, M.D.1    Steinberg, G.R.2    Schertzer, J.D.3
  • 77
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D., Carling D., Stout R.D., Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 2008, 181:8633-8641.
    • (2008) J Immunol , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 78
    • 84898026759 scopus 로고    scopus 로고
    • Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice
    • Miao H., Ou J., Ma Y., Guo F., Yang Z., Wiggins M., et al. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep 2014, 7:223-235.
    • (2014) Cell Rep , vol.7 , pp. 223-235
    • Miao, H.1    Ou, J.2    Ma, Y.3    Guo, F.4    Yang, Z.5    Wiggins, M.6
  • 79
    • 84895524321 scopus 로고
    • Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?
    • Lawlor K.E., Vince J.E. Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?. Biochim Biophys Acta 1840, 2014:1433-1440.
    • (1840) Biochim Biophys Acta , vol.2014 , pp. 1433-1440
    • Lawlor, K.E.1    Vince, J.E.2
  • 80
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7:11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 81
    • 84876684375 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
    • Kidani Y., Elsaesser H., Hock M.B., Vergnes L., Williams K.J., Argus J.P., et al. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol 2013, 14:489-499.
    • (2013) Nat Immunol , vol.14 , pp. 489-499
    • Kidani, Y.1    Elsaesser, H.2    Hock, M.B.3    Vergnes, L.4    Williams, K.J.5    Argus, J.P.6
  • 82
    • 84873684726 scopus 로고    scopus 로고
    • Metabolic control of the Treg/Th17 axis
    • Barbi J., Pardoll D., Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev 2013, 252:52-77.
    • (2013) Immunol Rev , vol.252 , pp. 52-77
    • Barbi, J.1    Pardoll, D.2    Pan, F.3
  • 83
    • 84897505811 scopus 로고    scopus 로고
    • Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity
    • Lee J., Walsh M.C., Hoehn K.L., James D.E., Wherry E.J., Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol 2014, 192:3190-3199.
    • (2014) J Immunol , vol.192 , pp. 3190-3199
    • Lee, J.1    Walsh, M.C.2    Hoehn, K.L.3    James, D.E.4    Wherry, E.J.5    Choi, Y.6
  • 84
    • 46149098344 scopus 로고    scopus 로고
    • LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    • Bensinger S.J., Bradley M.N., Joseph S.B., Zelcer N., Janssen E.M., Hausner M.A., et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 2008, 134:97-111.
    • (2008) Cell , vol.134 , pp. 97-111
    • Bensinger, S.J.1    Bradley, M.N.2    Joseph, S.B.3    Zelcer, N.4    Janssen, E.M.5    Hausner, M.A.6
  • 85
    • 70350724700 scopus 로고    scopus 로고
    • Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes
    • Geyeregger R., Shehata M., Zeyda M., Kiefer F.W., Stuhlmeier K.M., Porpaczy E., et al. Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes. J Leukoc Biol 2009, 86:1039-1048.
    • (2009) J Leukoc Biol , vol.86 , pp. 1039-1048
    • Geyeregger, R.1    Shehata, M.2    Zeyda, M.3    Kiefer, F.W.4    Stuhlmeier, K.M.5    Porpaczy, E.6
  • 86
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod L., Friedrich C., Nandan A., Freitag J., Hagemann S., Harmrolfs K., et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2014, 20:1327-1333.
    • (2014) Nat Med , vol.20 , pp. 1327-1333
    • Berod, L.1    Friedrich, C.2    Nandan, A.3    Freitag, J.4    Hagemann, S.5    Harmrolfs, K.6


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