메뉴 건너뛰기




Volumn 124, Issue 8, 2013, Pages 509-515

Mitochondrial (dys)function and regulation of macrophage cholesterol efflux

Author keywords

Atherosclerosis; ATP binding cassette transporter A1; Liver X receptor; Macrophage cholesterol efflux; Mitochondrial cholesterol trafficking complex; Sterol 27 hydroxylase

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ADENINE NUCLEOTIDE TRANSLOCASE; CELL PROTEIN; CHOLESTANETRIOL 26 MONOOXYGENASE; FAS LIGAND; HIGH DENSITY LIPOPROTEIN; LIVER X RECEPTOR; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL TSPO PROTEIN; OXYSTEROL; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

EID: 84872388657     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120358     Document Type: Article
Times cited : (27)

References (50)
  • 2
    • 84857635776 scopus 로고    scopus 로고
    • Predictive value of different HDL particles for the protection against or risk of coronary heart disease
    • Rye, K-A and Barter, P. J. (2012) Predictive value of different HDL particles for the protection against or risk of coronary heart disease. Biochim. Biophys Acta 1821, 473-480
    • (2012) Biochim. Biophys Acta , vol.1821 , pp. 473-480
    • Rye, K.-A.1    Barter, P.J.2
  • 5
    • 38849114338 scopus 로고    scopus 로고
    • Cholesterol efflux pathways and other potential mechanisms involved in the atheroprotective effect of high density lipoproteins
    • Tall, A. R. (2008) Cholesterol efflux pathways and other potential mechanisms involved in the atheroprotective effect of high density lipoproteins. J. Intern. Med. 263, 256-273
    • (2008) J. Intern. Med. , vol.263 , pp. 256-273
    • Tall, A.R.1
  • 6
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXRα
    • Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R. and Mangelsdorf, D. J. (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 383, 728-731
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 11
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL Receptor
    • Zelcer, N., Hong, C., Boyadjian, R. and Tontonez, P. (2009) LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL Receptor. Science 325, 100-104
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3    Tontonez, P.4
  • 12
    • 33845970925 scopus 로고    scopus 로고
    • Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ
    • Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M. E., Willson, T. M., Rosenfeld, M. G. and Glass, C. K. (2007) Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ. Mol. Cell 25, 57-70
    • (2007) Mol. Cell , vol.25 , pp. 57-70
    • Ghisletti, S.1    Huang, W.2    Ogawa, S.3    Pascual, G.4    Lin, M.E.5    Willson, T.M.6    Rosenfeld, M.G.7    Glass, C.K.8
  • 13
    • 77958057683 scopus 로고    scopus 로고
    • Macrophages, oxysterols and atherosclerosis
    • Shibata, N. and Glass, C. K. (2010) Macrophages, oxysterols and atherosclerosis. Circ. J. 74, 2045-2051
    • (2010) Circ. J. , vol.74 , pp. 2045-2051
    • Shibata, N.1    Glass, C.K.2
  • 15
    • 0033714093 scopus 로고    scopus 로고
    • Cholestenoic acid is a naturally occurring ligand for liver X receptor α
    • Song, C. and Liao, S. (2000) Cholestenoic acid is a naturally occurring ligand for liver X receptor α. Endocrinology 141, 4180-4184
    • (2000) Endocrinology , vol.141 , pp. 4180-4184
    • Song, C.1    Liao, S.2
  • 16
    • 37649021073 scopus 로고    scopus 로고
    • Oxysterols: novel biologic roles for the 21st century
    • Javitt, N. B. (2008) Oxysterols: novel biologic roles for the 21st century. Steroids 73, 149-157
    • (2008) Steroids , vol.73 , pp. 149-157
    • Javitt, N.B.1
  • 17
    • 33845587711 scopus 로고    scopus 로고
    • Enzymatic reduction of oxysterols impairs LXR signalling in cultured cells and the livers of mice
    • Chen, W., Chen, G., Head, D. L., Mangelsdorf, D. J. and Russell, D. W. (2007) Enzymatic reduction of oxysterols impairs LXR signalling in cultured cells and the livers of mice. Cell Metab. 5, 73-79
    • (2007) Cell Metab , vol.5 , pp. 73-79
    • Chen, W.1    Chen, G.2    Head, D.L.3    Mangelsdorf, D.J.4    Russell, D.W.5
  • 18
    • 0035914330 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    • Fu, X., Menke, G., Chen, Y., Zhou, G., Macnaul, K. L., Wright, S.D., Sparrow, C. P. and Lund, E. G. (2001) 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem. 276, 38373-38387
    • (2001) J. Biol. Chem. , vol.276 , pp. 38373-38387
    • Fu, X.1    Menke, G.2    Chen, Y.3    Zhou, G.4    Macnaul, K.L.5    Wright, S.D.6    Sparrow, C.P.7    Lund, E.G.8
  • 19
    • 0038175529 scopus 로고    scopus 로고
    • Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux
    • Escher, G., Krozowski, Z., Croft, K. D. and Sviridov, D. (2003) Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. J. Biol. Chem. 278, 11015-11019
    • (2003) J. Biol. Chem. , vol.278 , pp. 11015-11019
    • Escher, G.1    Krozowski, Z.2    Croft, K.D.3    Sviridov, D.4
  • 20
    • 4444337443 scopus 로고    scopus 로고
    • Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signalling in macrophages
    • Szanto, A., Benko, S., Szatmari, I., Balint, B. L., Furtos, I., Ruhl, R., Molnar, S., Csiba, L., Garuti, R., Calandra, S. et al. (2004) Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signalling in macrophages. Mol. Cell. Biol. 24, 8154-8166
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8154-8166
    • Szanto, A.1    Benko, S.2    Szatmari, I.3    Balint, B.L.4    Furtos, I.5    Ruhl, R.6    Molnar, S.7    Csiba, L.8    Garuti, R.9    Calandra, S.10
  • 21
    • 77949394551 scopus 로고    scopus 로고
    • FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages
    • Blorn, T., Back, N., Mutka, A. L., Bittman, R., Li, Z., de Lera, A., Kovanen, P. T., Diczfalusy, U. and Ikonen, E. (2010) FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ. Res. 106, 720-729
    • (2010) Circ. Res. , vol.106 , pp. 720-729
    • Blorn, T.1    Back, N.2    Mutka, A.L.3    Bittman, R.4    Li, Z.5    de Lera, A.6    Kovanen, P.T.7    Diczfalusy, U.8    Ikonen, E.9
  • 22
    • 27644447883 scopus 로고    scopus 로고
    • Oxidized LDL downregulates ATP binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor
    • Zhu, Y., Liao, H., Xie, X., Yuan, Y., Lee, T. S., Wang, N., Wang, X., Shyy, J. Y. and Stemerman, M. B. (2005) Oxidized LDL downregulates ATP binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor. Cardiovasc. Res. 68, 425-432
    • (2005) Cardiovasc. Res. , vol.68 , pp. 425-432
    • Zhu, Y.1    Liao, H.2    Xie, X.3    Yuan, Y.4    Lee, T.S.5    Wang, N.6    Wang, X.7    Shyy, J.Y.8    Stemerman, M.B.9
  • 24
    • 33846886738 scopus 로고    scopus 로고
    • PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine
    • Li, T., Chen, W. and Chiang, J. Y. (2007) PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J. Lipid Res. 48, 373-384
    • (2007) J. Lipid Res. , vol.48 , pp. 373-384
    • Li, T.1    Chen, W.2    Chiang, J.Y.3
  • 25
    • 58849154028 scopus 로고    scopus 로고
    • Impact of 27-hydroxycholesterol on amyloid β peptide production and ATP-binding cassette transporter expression in primary human neurons
    • Kim, W. S., Chan, S. L., Hill, A. F., Guillemin, G. J. and Garner, B. (2009) Impact of 27-hydroxycholesterol on amyloid β peptide production and ATP-binding cassette transporter expression in primary human neurons. J. Alzheimers Dis. 16, 121-131
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 121-131
    • Kim, W.S.1    Chan, S.L.2    Hill, A.F.3    Guillemin, G.J.4    Garner, B.5
  • 27
    • 80052246894 scopus 로고    scopus 로고
    • Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease
    • Bowden, K. L., Bilbey, N. J., Bilawchuk, L. M., Boadu, E., Sidhu, R., Ory, D. S., Du, H., Chan, T. and Francis, G. A. (2011) Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. J. Biol. Chem. 286, 30624-30635
    • (2011) J. Biol. Chem. , vol.286 , pp. 30624-30635
    • Bowden, K.L.1    Bilbey, N.J.2    Bilawchuk, L.M.3    Boadu, E.4    Sidhu, R.5    Ory, D.S.6    Du, H.7    Chan, T.8    Francis, G.A.9
  • 28
    • 0037073676 scopus 로고    scopus 로고
    • Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes
    • Pandak, W. M., Ren, S., Marques, D., Hall, E., Redford, K., Mallonee, D., Bohdan, P., Heuman, D., Gil, G. and Hylemon, P. (2002) Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. J. Biol. Chem. 277, 48158-48164
    • (2002) J. Biol. Chem. , vol.277 , pp. 48158-48164
    • Pandak, W.M.1    Ren, S.2    Marques, D.3    Hall, E.4    Redford, K.5    Mallonee, D.6    Bohdan, P.7    Heuman, D.8    Gil, G.9    Hylemon, P.10
  • 29
    • 0032892176 scopus 로고    scopus 로고
    • Removal of cholesterol from extrahepatic sources by oxidative mechanisms
    • Bjorkhem, I., Diczfalusy, U. and Lutjohann, D. (1999) Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr. Opin. Lipidol. 10, 161-165
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 161-165
    • Bjorkhem, I.1    Diczfalusy, U.2    Lutjohann, D.3
  • 30
    • 33745606740 scopus 로고    scopus 로고
    • Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene
    • Gallus, G. N., Dotti, M. T. and Federico, A. (2006) Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene. Neurol. Sci. 27, 143-149
    • (2006) Neurol. Sci. , vol.27 , pp. 143-149
    • Gallus, G.N.1    Dotti, M.T.2    Federico, A.3
  • 31
    • 2542562735 scopus 로고    scopus 로고
    • Coronary heart disease in a patient with cerebrotendinus xanthomatosis
    • Valdivielso, P., Calandra, S., Duran, J. C., Garuti, R. and Herrera, E. (2004) Coronary heart disease in a patient with cerebrotendinus xanthomatosis. J. Intern. Med 255, 680-683
    • (2004) J. Intern. Med , vol.255 , pp. 680-683
    • Valdivielso, P.1    Calandra, S.2    Duran, J.C.3    Garuti, R.4    Herrera, E.5
  • 32
    • 84860225393 scopus 로고    scopus 로고
    • Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases
    • Lorbek, G., Lewinsha, M. and Rozman, D. (2012) Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases. FEBS J. 279, 1516-1533
    • (2012) FEBS J , vol.279 , pp. 1516-1533
    • Lorbek, G.1    Lewinsha, M.2    Rozman, D.3
  • 34
    • 0035007094 scopus 로고    scopus 로고
    • Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins
    • Vaya, J., Aviram, M., Mahmood, S., Hayek, T., Grenadir, E., Hoffman, A. and Milo, S. (2001) Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins. Free Radical Res. 34, 485-497
    • (2001) Free Radical Res , vol.34 , pp. 485-497
    • Vaya, J.1    Aviram, M.2    Mahmood, S.3    Hayek, T.4    Grenadir, E.5    Hoffman, A.6    Milo, S.7
  • 35
    • 0034623160 scopus 로고    scopus 로고
    • Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture
    • Brown, A. J., Watt, G. F., Burnett, J. R., Dean, R. T. and Jessup, W. (2000) Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. J. Biol. Chem. 275, 27627-27633
    • (2000) J. Biol. Chem. , vol.275 , pp. 27627-27633
    • Brown, A.J.1    Watt, G.F.2    Burnett, J.R.3    Dean, R.T.4    Jessup, W.5
  • 36
    • 0037044747 scopus 로고    scopus 로고
    • ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages
    • Feng, B. and Tabas, I. (2002) ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. J. Biol. Chem. 277, 43271-43280
    • (2002) J. Biol. Chem. , vol.277 , pp. 43271-43280
    • Feng, B.1    Tabas, I.2
  • 37
    • 33747329092 scopus 로고    scopus 로고
    • Oxysterol mixtures in atheroma-relevant proportions, display synergistic and proapoptotic effects
    • Larsson, D. A., Baird, S., Nyhalah, J. D., Yuan, X. M. and Li, W. (2006) Oxysterol mixtures in atheroma-relevant proportions, display synergistic and proapoptotic effects. Free Radical Biol. Med. 41, 902-910
    • (2006) Free Radical Biol. Med. , vol.41 , pp. 902-910
    • Larsson, D.A.1    Baird, S.2    Nyhalah, J.D.3    Yuan, X.M.4    Li, W.5
  • 38
    • 65549149476 scopus 로고    scopus 로고
    • Regulation of the steroidogenic acute regulatory protein gene expression, present and future perspectives
    • Manna, P. R., Dyson, M. T. and Stocco, D. M. (2009) Regulation of the steroidogenic acute regulatory protein gene expression, present and future perspectives. Mol. Hum. Reprod. 6, 321-333
    • (2009) Mol. Hum. Reprod. , vol.6 , pp. 321-333
    • Manna, P.R.1    Dyson, M.T.2    Stocco, D.M.3
  • 39
    • 67649288976 scopus 로고    scopus 로고
    • Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states
    • Rone, M. B., Fan, J. and Papadopoulos, V. (2009) Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim. Biophys. Acta 179, 646-658
    • (2009) Biochim. Biophys. Acta , vol.179 , pp. 646-658
    • Rone, M.B.1    Fan, J.2    Papadopoulos, V.3
  • 40
    • 62849098368 scopus 로고    scopus 로고
    • Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human (THP-1) macrophages
    • Borthwick, F., Taylor, J. M., Bartholomew, C. and Graham, A. (2009) Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human (THP-1) macrophages. FEBS Lett. 583, 1147-1153
    • (2009) FEBS Lett , vol.583 , pp. 1147-1153
    • Borthwick, F.1    Taylor, J.M.2    Bartholomew, C.3    Graham, A.4
  • 41
    • 77952381631 scopus 로고    scopus 로고
    • Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein A-I
    • Taylor, J. M. W., Borthwick, F., Bartholomew, C. and Graham, A. (2010) Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein A-I. Cardiovasc. Res. 86, 526-534
    • (2010) Cardiovasc. Res. , vol.86 , pp. 526-534
    • Taylor, J.M.W.1    Borthwick, F.2    Bartholomew, C.3    Graham, A.4
  • 42
    • 67349160445 scopus 로고    scopus 로고
    • Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages
    • Ning, Y., Bai, Q., Lu, H., Li, X., Pandak, W. M., Zhao, F., Chen, S., Ren, S. and Yin, L. (2009) Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages. Atherosclerosis 204, 114-120
    • (2009) Atherosclerosis , vol.204 , pp. 114-120
    • Ning, Y.1    Bai, Q.2    Lu, H.3    Li, X.4    Pandak, W.M.5    Zhao, F.6    Chen, S.7    Ren, S.8    Yin, L.9
  • 43
    • 67349267332 scopus 로고    scopus 로고
    • StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice
    • Ning, Y., Xu, L., Ren, S., Pandak, W. M., Chen, S. and Yin, L. (2009) StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice. Lipids 44, 511-519
    • (2009) Lipids , vol.44 , pp. 511-519
    • Ning, Y.1    Xu, L.2    Ren, S.3    Pandak, W.M.4    Chen, S.5    Yin, L.6
  • 45
    • 33746084479 scopus 로고    scopus 로고
    • Energized, polarized and actively respiring mitochondria are required for acute Leydig cell steroidogenesis
    • Allen, J. A., Shankara, T., Janus, P., Buck, S., Diemer, T., Hales, K. H. and Hales, D. B. (2006) Energized, polarized and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. Endocrinolology 147, 3924-3935
    • (2006) Endocrinolology , vol.147 , pp. 3924-3935
    • Allen, J.A.1    Shankara, T.2    Janus, P.3    Buck, S.4    Diemer, T.5    Hales, K.H.6    Hales, D.B.7
  • 46
    • 22244442115 scopus 로고    scopus 로고
    • Bacterial endotoxin lipolysaccharide and reactive oxygen species inhibit Leydig cell steroidogenesis via perturbation of mitochondria
    • Allen, J. A., Diemer, T., Janus, P., Hales, K. H. and Hales, D. B. (2004) Bacterial endotoxin lipolysaccharide and reactive oxygen species inhibit Leydig cell steroidogenesis via perturbation of mitochondria. Endocrine 25, 265-278
    • (2004) Endocrine , vol.25 , pp. 265-278
    • Allen, J.A.1    Diemer, T.2    Janus, P.3    Hales, K.H.4    Hales, D.B.5
  • 47
    • 47849100495 scopus 로고    scopus 로고
    • Oxidative-stress induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signalling pathway
    • Abidi, P., Zhang, H., Zaidi, S. M., Shen, W. J., Sucheta, S., Cortez, Y., Han, J. and Azhar, S. (2008) Oxidative-stress induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signalling pathway. J. Endocrinol. 198, 193-207
    • (2008) J. Endocrinol. , vol.198 , pp. 193-207
    • Abidi, P.1    Zhang, H.2    Zaidi, S.M.3    Shen, W.J.4    Sucheta, S.5    Cortez, Y.6    Han, J.7    Azhar, S.8
  • 48
    • 70350621225 scopus 로고    scopus 로고
    • ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation
    • Lee, S. Y., Gong, E. Y., Hong, C. Y., Kim, K. H., Han, J. S., Ryu, J. C., Chae, H. Z., Yun, C. H. and Lee, K. (2009) ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation. Free Radical Biol. Med. 47, 1591-1600
    • (2009) Free Radical Biol. Med. , vol.47 , pp. 1591-1600
    • Lee, S.Y.1    Gong, E.Y.2    Hong, C.Y.3    Kim, K.H.4    Han, J.S.5    Ryu, J.C.6    Chae, H.Z.7    Yun, C.H.8    Lee, K.9
  • 49
    • 77955415606 scopus 로고    scopus 로고
    • Regulation of translocator protein 18kDa (TSPO) expression in health and disease states
    • Batarseh, A. and Papadopoulos, V. (2010) Regulation of translocator protein 18kDa (TSPO) expression in health and disease states. Mol. Cell. Endocrinol. 327, 1-12
    • (2010) Mol. Cell. Endocrinol. , vol.327 , pp. 1-12
    • Batarseh, A.1    Papadopoulos, V.2
  • 50
    • 34547877924 scopus 로고    scopus 로고
    • Mitochondrial medicine: pharmacological targeting of mitochondria in disease
    • Armstrong, J. S. (2007) Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br. J. Pharmacol. 151, 1154-1165
    • (2007) Br. J. Pharmacol. , vol.151 , pp. 1154-1165
    • Armstrong, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.