IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation

Journal of Immunology

Volumn 194, Issue 11, 2015, Pages 5110-5119

  Ye, Liang ^a,b   Jiang, Bo ^c   Deng, Jun ^d   Du, Jing ^e   Xiong, Wen ^f   Guan, Youfei ^b   Wen, Zhongyang ^a,b   Huang, Kunzhao ^a,b   Huang, Zhong ^a,b  

^a SHENZHEN UNIVERSITY   (China)

^b Shenzhen University Health Science Center   (China)

^c Maoming People's Hospital   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^f E mail: szbloodcenter hotmailcom   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 37; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IL37 PROTEIN, HUMAN; INTERLEUKIN 1; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE; HUMAN; HUMAN CELL; IL 37 GENE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BIOSYNTHESIS; BLOOD; CELL LINE; CYTOLOGY; DBA MOUSE; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; INFLAMMATION; MONONUCLEAR CELL; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; HEK293 CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED DBA; RECOMBINANT PROTEINS; RNA, MESSENGER; SYNOVIAL MEMBRANE; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 84929650379     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401810     Document Type: Article

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