Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: Mechanisms of action and implications

Journal of Nutrition

Volumn 139, Issue 1, 2009, Pages 1-4

  Kennedy, Arion ^a   Martinez, Kristina ^a   Chuang, Chia Chi ^a   Lapoint, Kathy ^a   Mcintosh, Michael ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CERAMIDE; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OLEIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN KINASE C THETA; SATURATED FATTY ACID; UNSATURATED FATTY ACID;

ADIPOSE TISSUE; CELL INTERACTION; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; FOOD INTAKE; GLUCOSE OXIDATION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; METABOLIC SYNDROME X; MYOTUBE; NEUTROPHIL; NONHUMAN; OBESITY; REVIEW; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; FATTY ACIDS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; OBESITY;

EID: 58649096801     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.098269     Document Type: Review

References (59)

1. WHO. Obesity and overweight; 2006 [cited 2008 May 8]. Available from: www.who.int/mediacentre/factsheets/fs311/en/index.html.
2. Cañete R, Gil-Campos M, Aguilera CM, Gil A. Development of insulin resistance and its relation to diet in the obese child. Eur J Nutr. 2007;46:181-7.
3. USDA, Agricultural Research Service. USDA National Nutrient Database for Standard Reference. Release 21. 2008;20:SR20.
4. USDA, Agricultural Research Service. 2007b; [cited 2008 May 8].Nutrient intakes from food: mean amounts consumed per individual, one day, 2003-2004. Available from: www.ars.usda.gov/ba/bhnrc/fsrg.
5. Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans. 2008;36:348-52.
6. Galgani JE, Uauy RD, Aguirre CA, Diaz EO. Effect of the dietary Fat quality on insulin sensitivity. Br J Nutr. 2008;100:471-9.
7. Johnson L, Mander A, Jones L, Emmett P, Jebb S. Energy-dense, low-fiber, high-fat dietary pattern is associated with increased fatness in childhood. Am J Clin Nutr. 2008;87:846-54.
8. Lundman P, Boquist S, Samnegåird A, Bennermo M, Held C, Ericsson CG, Silveira A, Hamsten A, Tornvall PA. high-fat meal is accompanied by increased plasma interleukin-6 concentrations. Nutr Metab Cardio-vasc Dis. 2007;17:195-202.
9. Kien CL, Bunn JY, Ugrasbul F. Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr. 2005; 82:320-6.
10. Risérus U. Fatty acids and insulin sensitivity. Curr Opin Clin Nutr Metab Care. 2008;11:100-5.
11. Lago F, Dieguez C, Gomez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol. 2007;3:716-24.
12. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9:367-77.
13. Bays HE, Gonzalez-Campoy JM, Bray GA, Kitabchi AE, Bergman DA, Schorr AB, Rodbard HW, Henry RR. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther. 2008;6: 343-68.
14. Elagazar-Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high fat feeding. J Lipid Res. 2008; 49:1894-903.
15. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796-808.
16. Strissel K, Stancheva Z, Miyoshi H, Perfield JW II, DeFuria J, Jick Z, Greenberg AS, Obin MS. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007;56:2910-8.
17. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang
18. Fortier M, Greenberg AS, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46:2347-55.
19. Takahashi K, Yamaguchi S, Shimoyama T, Seki H, Miyokawa K, Katsuta H, Tanaka T, Yoshimoto K, Ohno H, et al. JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. Am J Physiol Endocrinol Metab. 2008;294:E898-909.
20. Guo W, Wong S, Xie W, Lei T, Luo Z. Palmitate modulates ntracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. Am J Physiol Endocrinol Metab. 2007;293:E576-86.
21. Ajuwon KM, Spurlock ME. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr. 2005;135:1841-6.
22. Bradley RL, Fisher FF, Maratos-Flier E. Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring). 2008;16:938-44.
23. Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y. Attenuation of obesity-induced inflammation in C3H/HeJ mice carrying a Toll-like receptor4 mutation. Biochem Biophys Res Commun. 2007;354:45-9.
24. Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, Kotani H, Yamaoka S, Miyake K, et al. Role of toll-like receptor4/NFkB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 2007;27:84-91.
25. Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun. 2006;346:739-45.
26. Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH. Saturated fatty acid activates but polyun-saturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem. 2004;279:16971-9.
27. Shi H, Kokoeva M, Inouye K, Tzanneli I, Yin H, Flier J. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-25.
28. Davis J, Gabler N, Walker-Daniels J, Spurlock M. TLR-4 deficiency selectively protects against obesity-induced by diets high in saturated fat. Obesity (Silver Spring). 2008;16:1248-55.
29. Reynoso R, Salgado LM, Calderóon V. High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate. Mol Cell Biochem. 2003;246:155-62.
30. Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys. 2003;419:101-9.
31. Fain J, Buehrer B, Tichansky D, Madan A. Regulation of adiponectin release and demonstration of adiponectin mRNA as well as release by the non-fat cells of human omental adipose tissue. Int J Obes (Lond). 2008;32:429-35.
32. Koska J, Stefan N, Permana P, Weyer C, Sonoda M, Bogardus C, Smith S, Joanisse D, Funahashi T, et al. Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoapidonectinemia in obese
33. individuals. Am J Clin Nutr. 2008;87:295-302.
34. Xi L, Qian Z, Zhou C, Sun S. Corcetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes. Br J Pharmacol. 2007;151:610-7.
35. Kim JY, Van de Wall E, Laplant M, Azzara A, Trujillo M. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007;117:2621-37.
36. Laine PS, Schwartz EA, Wang Y, Zhang WY, Karnik SK, Musi N, Reaven PD. Palmitic acid induces IP-10 expression in human macro- phages via NF-kappaB activation. Biochem Biophys Res Commun. 2007;358:150-5.
37. Weatherill AR, Lee JY, Zhao L, Lemay DG, Youn HS, Hwang DH. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic
38. cell functions mediated through TLR4. J Immunol. 2005;174:5390-7.
39. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007;282:35279-92.
40. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006;116:115-24.
41. Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol.
42. 2005;25:2062-8.
43. Permana PA, Menge C, Reaven PD. Macrophage-secreted factors induce adipocyte inflammation and insulin resistance. Biochem Biophys Res Commun. 2006;341:507-14.
44. Lumeng CN, Deyoung M, Saltiel AR. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab. 2007;292:E166-74.
45. Furuhashi M, Fucho R, Gorgun C, Tuncman G, Cao H, Hotamisgligil G. Adipocyte/ macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640-50.
46. Jove M, Planavila A, Laguna JC, Vazquez-Carrera M. Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor κB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells. Endocrinology. 2005;146: 3087-95.
47. Jove M, Planavila A, Sanchez RM, Merlos M, Laguna JC, Vazquez- Carrera M. Palmitate induce tumor necrosis factor-α expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-κB activation. Endocrinology. 2006;147:552-61.
48. Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem. 2004;279:41294-301.
49. Weigert C, Brodbeck K, Staiger H, Kaush C, Machicao F, Haring H, Schleicher E. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteosome-dependent activation of nuclear factor-kB. J Biol Chem. 2004;279: 23942-52.
50. Handschin C, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27:728-35.
51. Coll T, Jove M, Rodriguez-Calvo R, Eyre E, Palomer X, Sanchez RM, Merlos M, Laguna JC, Vazquez-Carrera M. Palmitate-mediated down-regulation of peroxisome proliferator-activated receptor-γ coactivator 1 α in skeletal muscle cells involves MEK1/2 and nuclear factor-κB activation. Diabetes. 2006;55:2779-87.
52. Coll T, Eyre E, Rodriguez-Calvo R, Palomer X, Sanchez RM, Merlos M, Laguna JC, Vazquez-Carrera M. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J BiolChem. 2008;283:11107-16.
53. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, et al. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007;282: 15439-50.
54. Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008;118:2992-3002.
55. Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA. Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem. 2005;280:20148-53.
56. Lee JS, Pinnamaneni S, Eo S, Cho I, Pyo J, Kim C, Sinclair A, Febbraio M, Watt M. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol. 2006;100:1467-74.
57. Dietze-Schroeder D, Sell H, Uhlig M, Koenen MH, Eckel J. Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors. Diabetes. 2005;54:2003-11.
58. Sell H, Dietze-Schroeder D, Kaiser U, Eckel J. Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. Endocrinology. 2006;147:2458-67.
59. Zhou Q, Du J, Hu Z, Walsh K, Wang X. Evidence for adipose-muscle cross-talk: opposing regulation of muscle proteolysis by adiponectin andfatty acids. Endocrinology. 2007;148:5696-705.