Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding

Biochemical Pharmacology

Volumn 104, Issue , 2016, Pages 131-138

  Banerjee, Monimoy ^a   Chai, Sergio C ^a   Wu, Jing ^a   Robbins, Delira ^a   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

CYP3A4; PXR; SAR; Transcriptional regulation; Xenobiotic receptor

Indexed keywords

CYTOCHROME P450 3A4; PREGNANE X RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; TRYPTOPHAN; TRYPTOPHAN 299; UNCLASSIFIED DRUG; ALANINE; BISPHOSPHONIC ACID DERIVATIVE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; FLUORINATED HYDROCARBON; LIGAND; LUCIFERASE; PROTEIN BINDING; SR 12813; STEROID RECEPTOR; SULFONAMIDE; TO-901317;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSIENT TRANSFECTION; AGONISTS; BINDING SITE; BIOLOGY; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; HEP-G2 CELL LINE; METABOLISM; MUTATION; PROTEIN CONFORMATION; TWO HYBRID SYSTEM; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; BINDING SITES; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP3A; DIPHOSPHONATES; EPITHELIAL CELLS; HEP G2 CELLS; HUMANS; HYDROCARBONS, FLUORINATED; LIGANDS; LUCIFERASES; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, STEROID; SULFONAMIDES; TRANSFECTION; TRYPTOPHAN; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84959326766     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.02.009     Document Type: Article

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