Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Biochemical Pharmacology

Volumn 92, Issue 2, 2014, Pages 389-402

  Banerjee, Monimoy ^a   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

CYP3A4; Drug metabolism; MDR1; Metolazone; PXR

Indexed keywords

AMINO ACID; BENDROFLUMETHIAZIDE; BENZTHIAZIDE; BUMETANIDE; CHLOROTHIAZIDE; CYCLOTHIAZIDE; CYTOCHROME P450 3A4; HYDROCHLOROTHIAZIDE; HYDROFLUMETHIAZIDE; INDAPAMIDE; METOLAZONE; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; RIFAMPICIN; STEROID RECEPTOR COACTIVATOR 1; TRICHLORMETHIAZIDE; XIPAMIDE; CYTOCHROME P450 3A; CYTOCHROME P450 3A INDUCER; DIURETIC AGENT; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; PROTEIN BINDING; STEROID RECEPTOR; THIAZIDE DIURETIC AGENT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LINE; CONTROLLED STUDY; DRUG BINDING; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SCREENING; ENZYME INDUCTION; FOOD AND DRUG ADMINISTRATION; GENE ACTIVITY; HEK293 CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTESTINE CELL; LIVER CELL; LUCIFERASE ASSAY; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR BINDING ASSAY; STRUCTURE ACTIVITY RELATION; TWO HYBRID SYSTEM; BIOSYNTHESIS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

CELL SURVIVAL; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 CYP3A INDUCERS; DIURETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HEP G2 CELLS; HUMANS; METOLAZONE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN BINDING; RECEPTORS, STEROID; THIAZIDES;

EID: 84908319281     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.08.025     Document Type: Article

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