Identification and characterization of phosphorylation sites within the pregnane X receptor protein

Biochemical Pharmacology

Volumn 87, Issue 2, 2014, Pages 360-370

  Elias, Ayesha ^a   High, Anthony A ^a   Mishra, Ashutosh ^a   Ong, Su Sien ^a   Wu, Jing ^a   Peng, Junmin ^a   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Drug metabolism; Phosphomimetic Mutations; Phosphorylation; PXR

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME P450 3A4; MUTANT PROTEIN; PHOSPHOPROTEIN; PREGNANE X RECEPTOR; SERINE; THREONINE;

ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONSENSUS SEQUENCE; DNA BINDING; DNA RESPONSIVE ELEMENT; FLUORESCENCE MICROSCOPY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE TARGETING; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; LIGAND BINDING; LIQUID CHROMATOGRAPHY; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; TRANSACTIVATION ASSAY; TRANSCRIPTION INITIATION; TUMOR MICROENVIRONMENT; WESTERN BLOTTING;

DRUG METABOLISM; PHOSPHOMIMETIC MUTATIONS.; PHOSPHORYLATION; PXR;

ANIMALS; BINDING SITES; CYCLIN-DEPENDENT KINASE 2; HEK293 CELLS; HEP G2 CELLS; HUMANS; INSECTS; PHOSPHORYLATION; PROTEIN FOLDING; RECEPTORS, STEROID; TRANSCRIPTION, GENETIC;

EID: 84892374149     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.10.015     Document Type: Article

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