SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury

Journal of Biological Chemistry

Volumn 291, Issue 4, 2016, Pages 1957-1973

  Novgorodov, Sergei A ^b   Riley, Christopher L ^a   Keffler, Jarryd A ^b   Yu, Jin ^b   Kindy, Mark S ^a   Macklin, Wendy B ^c   Lombard, David B ^d   Gudz, Tatyana I ^a,b  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; BIOCHEMISTRY; BIOSYNTHESIS; BRAIN; CERAMIDES; ELECTRON TRANSPORT PROPERTIES; ENZYME ACTIVITY; ENZYMES;

BRAIN ISCHEMIA; CERAMIDE SYNTHASE; ELECTRON TRANSPORT CHAIN; IMMUNOPRECIPITATIONS; MITOCHONDRIAL DYSFUNCTION; OUTER MEMBRANE; PROTEIN CARBONYLS; REACTIVE OXYGEN SPECIES;

MITOCHONDRIA;

CERAMIDE SYNTHASE; CERAMIDE SYNTHASE 1; CERAMIDE SYNTHASE 2; CERAMIDE SYNTHASE 4; CERAMIDE SYNTHASE 6; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 3; SYNTHETASE; UNCLASSIFIED DRUG; CERAMIDE; CERS1 PROTEIN, MOUSE; CERS2 PROTEIN, MOUSE; CERS6 PROTEIN, MOUSE; MEMBRANE PROTEIN; SIRT3 PROTEIN, MOUSE; SPHINGOSINE ACYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CELL PERMEABILIZATION; CONTROLLED STUDY; DEACYLATION; DISEASE ACTIVITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON TRANSPORT; ENZYME ACTIVITY; GENE; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPERFUSION INJURY; SIRTUIN 3 GENE; ANIMAL; APOPTOSIS; BRAIN INJURY; C57BL MOUSE; ENZYMOLOGY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOPHYSIOLOGY;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CERAMIDES; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE STRESS; SIRTUIN 3; SPHINGOSINE N-ACYLTRANSFERASE;

EID: 84959016829     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.668228     Document Type: Article

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