메뉴 건너뛰기




Volumn 1802, Issue 1, 2010, Pages 92-99

Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

Author keywords

Cerebral ischemia; Mitochondria; Neuronal death; PIDD; Reactive oxygen species; SOD1

Indexed keywords

APOPTOSIS INDUCING FACTOR; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; GLUTATHIONE PEROXIDASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN P53; PUMA PROTEIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

EID: 71849093751     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2009.09.002     Document Type: Review
Times cited : (319)

References (103)
  • 1
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
    • Boveris A., and Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134 (1973) 707-716
    • (1973) Biochem. J. , vol.134 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 2
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • 10.1097/00004647-200101000-00002
    • Chan P.H. Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21 (2001) 2-14 10.1097/00004647-200101000-00002
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 3
    • 0028280865 scopus 로고
    • Oxygen radicals in focal cerebral ischemia
    • Chan P.H. Oxygen radicals in focal cerebral ischemia. Brain Pathol. 4 (1994) 59-65
    • (1994) Brain Pathol. , vol.4 , pp. 59-65
    • Chan, P.H.1
  • 4
    • 0033963704 scopus 로고    scopus 로고
    • Oxidative stress and gene regulation
    • Allen R.G., and Tresini M. Oxidative stress and gene regulation. Free Radic. Biol. Med. 28 (2000) 463-499
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 463-499
    • Allen, R.G.1    Tresini, M.2
  • 5
    • 0033818354 scopus 로고    scopus 로고
    • Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-β1
    • Thannickal V.J., Day R.M., Klinz S.G., Bastien M.C., Larios J.M., and Fanburg B.L. Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-β1. FASEB J. 14 (2000) 1741-1748
    • (2000) FASEB J. , vol.14 , pp. 1741-1748
    • Thannickal, V.J.1    Day, R.M.2    Klinz, S.G.3    Bastien, M.C.4    Larios, J.M.5    Fanburg, B.L.6
  • 7
    • 0032740245 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthesis: biological functions and pathophysiology
    • Bredt D.S. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic. Res. 31 (1999) 577-596
    • (1999) Free Radic. Res. , vol.31 , pp. 577-596
    • Bredt, D.S.1
  • 8
    • 0033510014 scopus 로고    scopus 로고
    • Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases
    • 10.1097/00004647-199904000-00001
    • Fiskum G., Murphy A.N., and Beal M.F. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J. Cereb. Blood Flow Metab. 19 (1999) 351-369 10.1097/00004647-199904000-00001
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 351-369
    • Fiskum, G.1    Murphy, A.N.2    Beal, M.F.3
  • 9
    • 0033386202 scopus 로고    scopus 로고
    • Mitochondria in neurodegeneration: bioenergetic function in cell life and death
    • 10.1097/00004647-199903000-00001
    • Murphy A.N., Fiskum G., and Beal M.F. Mitochondria in neurodegeneration: bioenergetic function in cell life and death. J. Cereb. Blood Flow Metab. 19 (1999) 231-245 10.1097/00004647-199903000-00001
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 231-245
    • Murphy, A.N.1    Fiskum, G.2    Beal, M.F.3
  • 10
    • 0018348794 scopus 로고
    • Direct observation of a free radical interaction between vitamin E and vitamin C
    • 10.1038/278737a0
    • Packer J.E., Slater T.F., and Willson R.L. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 278 (1979) 737-738 10.1038/278737a0
    • (1979) Nature , vol.278 , pp. 737-738
    • Packer, J.E.1    Slater, T.F.2    Willson, R.L.3
  • 11
    • 0019842691 scopus 로고
    • Cell damage in the brain: a speculative synthesis
    • Siesjö B.K. Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metab. 1 (1981) 155-185
    • (1981) J. Cereb. Blood Flow Metab. , vol.1 , pp. 155-185
    • Siesjö, B.K.1
  • 12
    • 0019948247 scopus 로고
    • Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids and energy metabolites in rat brain
    • Yoshida S., Abe K., Busto R., Watson B.D., Kogure K., and Ginsberg M.D. Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids and energy metabolites in rat brain. Brain Res. 245 (1982) 307-316
    • (1982) Brain Res. , vol.245 , pp. 307-316
    • Yoshida, S.1    Abe, K.2    Busto, R.3    Watson, B.D.4    Kogure, K.5    Ginsberg, M.D.6
  • 13
    • 0030008052 scopus 로고    scopus 로고
    • Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
    • Bindokas V.P., Jordán J., Lee C.C., and Miller R.J. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci. 16 (1996) 1324-1336
    • (1996) J. Neurosci. , vol.16 , pp. 1324-1336
    • Bindokas, V.P.1    Jordán, J.2    Lee, C.C.3    Miller, R.J.4
  • 14
    • 0030761155 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells
    • Budd S.L., Castilho R.F., and Nicholls D.G. Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells. FEBS Lett. 415 (1997) 21-24
    • (1997) FEBS Lett. , vol.415 , pp. 21-24
    • Budd, S.L.1    Castilho, R.F.2    Nicholls, D.G.3
  • 15
    • 17644394600 scopus 로고    scopus 로고
    • Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence
    • 10.1073/pnas.0501719102
    • Zhao H., Joseph J., Fales H.M., Sokoloski E.A., Levine R.L., Vasquez-Vivar J., and Kalyanaraman B. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5727-5732 10.1073/pnas.0501719102
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5727-5732
    • Zhao, H.1    Joseph, J.2    Fales, H.M.3    Sokoloski, E.A.4    Levine, R.L.5    Vasquez-Vivar, J.6    Kalyanaraman, B.7
  • 16
    • 0038368985 scopus 로고    scopus 로고
    • Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide
    • 10.1016/S0891-5849(03)00142-4
    • Zhao H., Kalivendi S., Zhang H., Joseph J., Nithipatikom K., Vásquez-Vivar J., and Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 34 (2003) 1359-1368 10.1016/S0891-5849(03)00142-4
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 1359-1368
    • Zhao, H.1    Kalivendi, S.2    Zhang, H.3    Joseph, J.4    Nithipatikom, K.5    Vásquez-Vivar, J.6    Kalyanaraman, B.7
  • 17
    • 0036192957 scopus 로고    scopus 로고
    • Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice. Implications for the production and role of superoxide radicals
    • 10.1161/hs0302.103745
    • Kim G.W., Kondo T., Noshita N., and Chan P.H. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice. Implications for the production and role of superoxide radicals. Stroke 33 (2002) 809-815 10.1161/hs0302.103745
    • (2002) Stroke , vol.33 , pp. 809-815
    • Kim, G.W.1    Kondo, T.2    Noshita, N.3    Chan, P.H.4
  • 18
    • 60549117084 scopus 로고    scopus 로고
    • Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia
    • 10.1161/STROKEAHA.108.524447
    • Niizuma K., Endo H., Nito C., Myer D.J., and Chan P.H. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke 40 (2009) 618-625 10.1161/STROKEAHA.108.524447
    • (2009) Stroke , vol.40 , pp. 618-625
    • Niizuma, K.1    Endo, H.2    Nito, C.3    Myer, D.J.4    Chan, P.H.5
  • 19
    • 33947518569 scopus 로고    scopus 로고
    • Reduced oxidative stress promotes NF-κB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors
    • 10.1038/sj.jcbfm.9600379
    • Song Y.S., Lee Y.-S., Narasimhan P., and Chan P.H. Reduced oxidative stress promotes NF-κB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors. J. Cereb. Blood Flow Metab. 27 (2007) 764-775 10.1038/sj.jcbfm.9600379
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 764-775
    • Song, Y.S.1    Lee, Y.-S.2    Narasimhan, P.3    Chan, P.H.4
  • 20
    • 25144457115 scopus 로고    scopus 로고
    • Oxidative stress transiently decreases the IKK complex (IKKα, β, and γ), an upstream component of NF-κB signaling, after transient focal cerebral ischemia in mice
    • 10.1038/sj.jcbfm.9600123
    • Song Y.S., Lee Y.-S., and Chan P.H. Oxidative stress transiently decreases the IKK complex (IKKα, β, and γ), an upstream component of NF-κB signaling, after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 25 (2005) 1301-1311 10.1038/sj.jcbfm.9600123
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1301-1311
    • Song, Y.S.1    Lee, Y.-S.2    Chan, P.H.3
  • 22
    • 0036138386 scopus 로고    scopus 로고
    • Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation
    • Sugawara T., Noshita N., Lewén A., Gasche Y., Ferrand-Drake M., Fujimura M., Morita-Fujimura Y., and Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 22 (2002) 209-217
    • (2002) J. Neurosci. , vol.22 , pp. 209-217
    • Sugawara, T.1    Noshita, N.2    Lewén, A.3    Gasche, Y.4    Ferrand-Drake, M.5    Fujimura, M.6    Morita-Fujimura, Y.7    Chan, P.H.8
  • 23
    • 0026345023 scopus 로고
    • Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase
    • Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., and Chan P.H. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 11158-11162
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 11158-11162
    • Kinouchi, H.1    Epstein, C.J.2    Mizui, T.3    Carlson, E.4    Chen, S.F.5    Chan, P.H.6
  • 24
    • 0029858401 scopus 로고    scopus 로고
    • Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia
    • 10.1097/00004647-199611000-00009
    • Kamii H., Mikawa S., Murakami K., Kinouchi H., Yoshimoto T., Reola L., Carlson E., Epstein C.J., and Chan P.H. Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16 (1996) 1153-1157 10.1097/00004647-199611000-00009
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , pp. 1153-1157
    • Kamii, H.1    Mikawa, S.2    Murakami, K.3    Kinouchi, H.4    Yoshimoto, T.5    Reola, L.6    Carlson, E.7    Epstein, C.J.8    Chan, P.H.9
  • 25
    • 0032531916 scopus 로고    scopus 로고
    • Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion
    • Chan P.H., Kawase M., Murakami K., Chen S.F., Li Y., Calagui B., Reola L., Carlson E., and Epstein C.J. Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J. Neurosci. 18 (1998) 8292-8299
    • (1998) J. Neurosci. , vol.18 , pp. 8292-8299
    • Chan, P.H.1    Kawase, M.2    Murakami, K.3    Chen, S.F.4    Li, Y.5    Calagui, B.6    Reola, L.7    Carlson, E.8    Epstein, C.J.9
  • 26
    • 0030794929 scopus 로고    scopus 로고
    • Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice [Erratum: Stroke 28:2573, 1997]
    • Murakami K., Kondo T., Epstein C.J., and Chan P.H. Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice [Erratum: Stroke 28:2573, 1997]. Stroke 28 (1997) 1797-1804
    • (1997) Stroke , vol.28 , pp. 1797-1804
    • Murakami, K.1    Kondo, T.2    Epstein, C.J.3    Chan, P.H.4
  • 27
    • 0038313084 scopus 로고    scopus 로고
    • Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice
    • 10.1161/01.STR.0000072986.46924.F4
    • Noshita N., Sugawara T., Lewén A., Hayashi T., and Chan P.H. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke 34 (2003) 1513-1518 10.1161/01.STR.0000072986.46924.F4
    • (2003) Stroke , vol.34 , pp. 1513-1518
    • Noshita, N.1    Sugawara, T.2    Lewén, A.3    Hayashi, T.4    Chan, P.H.5
  • 28
    • 33751331389 scopus 로고    scopus 로고
    • Activation of the Akt/GSK3β signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats
    • 10.1038/sj.jcbfm.9600303
    • Endo H., Nito C., Kamada H., Nishi T., and Chan P.H. Activation of the Akt/GSK3β signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 26 (2006) 1479-1489 10.1038/sj.jcbfm.9600303
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1479-1489
    • Endo, H.1    Nito, C.2    Kamada, H.3    Nishi, T.4    Chan, P.H.5
  • 29
    • 0037107185 scopus 로고    scopus 로고
    • Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice
    • Noshita N., Sugawara T., Hayashi T., Lewén A., Omar G., and Chan P.H. Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J. Neurosci. 22 (2002) 7923-7930
    • (2002) J. Neurosci. , vol.22 , pp. 7923-7930
    • Noshita, N.1    Sugawara, T.2    Hayashi, T.3    Lewén, A.4    Omar, G.5    Chan, P.H.6
  • 30
    • 52549132911 scopus 로고    scopus 로고
    • 2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion
    • 10.1038/jcbfm.2008.60
    • 2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion. J. Cereb. Blood Flow Metab. 28 (2008) 1686-1696 10.1038/jcbfm.2008.60
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1686-1696
    • Nito, C.1    Kamada, H.2    Endo, H.3    Niizuma, K.4    Myer, D.J.5    Chan, P.H.6
  • 31
    • 12844268203 scopus 로고    scopus 로고
    • Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress
    • 10.1038/sj.jcbfm.9600028
    • Saito A., Hayashi T., Okuno S., Nishi T., and Chan P.H. Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J. Cereb. Blood Flow Metab. 25 (2005) 267-280 10.1038/sj.jcbfm.9600028
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 267-280
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 32
    • 0035122043 scopus 로고    scopus 로고
    • SOD1 down-regulates NF-κB and c-myc expression in mice after transient focal cerebral ischemia
    • 10.1097/00004647-200102000-00008
    • Huang C.-Y., Fujimura M., Noshita N., Chang Y.-Y., and Chan P.H. SOD1 down-regulates NF-κB and c-myc expression in mice after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 21 (2001) 163-173 10.1097/00004647-200102000-00008
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 163-173
    • Huang, C.-Y.1    Fujimura, M.2    Noshita, N.3    Chang, Y.-Y.4    Chan, P.H.5
  • 33
    • 0037335444 scopus 로고    scopus 로고
    • Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway
    • Saito A., Hayashi T., Okuno S., Ferrand-Drake M., and Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J. Neurosci. 23 (2003) 1710-1718
    • (2003) J. Neurosci. , vol.23 , pp. 1710-1718
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Ferrand-Drake, M.4    Chan, P.H.5
  • 35
    • 0031304166 scopus 로고    scopus 로고
    • Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice
    • Kondo T., Reaume A.G., Huang T.-T., Murakami K., Carlson E., Chen S., Scott R.W., Epstein C.J., and Chan P.H. Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice. Acta Neurochir. Suppl. 70 (1997) 62-64
    • (1997) Acta Neurochir. Suppl. , vol.70 , pp. 62-64
    • Kondo, T.1    Reaume, A.G.2    Huang, T.-T.3    Murakami, K.4    Carlson, E.5    Chen, S.6    Scott, R.W.7    Epstein, C.J.8    Chan, P.H.9
  • 36
    • 0141869839 scopus 로고    scopus 로고
    • Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
    • Kim G.W., Gasche Y., Grzeschik S., Copin J.-C., Maier C.M., and Chan P.H. Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?. J. Neurosci. 23 (2003) 8733-8742
    • (2003) J. Neurosci. , vol.23 , pp. 8733-8742
    • Kim, G.W.1    Gasche, Y.2    Grzeschik, S.3    Copin, J.-C.4    Maier, C.M.5    Chan, P.H.6
  • 37
    • 0032883894 scopus 로고    scopus 로고
    • Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency
    • Kawase M., Murakami K., Fujimura M., Morita-Fujimura Y., Gasche Y., Kondo T., Scott R.W., and Chan P.H. Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke 30 (1999) 1962-1968
    • (1999) Stroke , vol.30 , pp. 1962-1968
    • Kawase, M.1    Murakami, K.2    Fujimura, M.3    Morita-Fujimura, Y.4    Gasche, Y.5    Kondo, T.6    Scott, R.W.7    Chan, P.H.8
  • 38
    • 17344371804 scopus 로고    scopus 로고
    • Mattson, Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller J.N., Kindy M.S., Holtsberg F.W., St D.K., Clair H.-C., Yen A., Germeyer S.M., Steiner A.J., Bruce-Keller J.B., and Hutchins M.P. Mattson, Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18 (1998) 687-697
    • (1998) J. Neurosci. , vol.18 , pp. 687-697
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3    St, D.K.4    Clair, H.-C.5    Yen, A.6    Germeyer, S.M.7    Steiner, A.J.8    Bruce-Keller, J.B.9    Hutchins, M.P.10
  • 39
    • 33744815599 scopus 로고    scopus 로고
    • Evaluating therapeutic targets for reperfusion-related brain hemorrhage
    • 10.1002/ana.20850
    • Maier C.M., Hsieh L., Crandall T., Narasimhan P., and Chan P.H. Evaluating therapeutic targets for reperfusion-related brain hemorrhage. Ann. Neurol. 59 (2006) 929-938 10.1002/ana.20850
    • (2006) Ann. Neurol. , vol.59 , pp. 929-938
    • Maier, C.M.1    Hsieh, L.2    Crandall, T.3    Narasimhan, P.4    Chan, P.H.5
  • 40
    • 0031974368 scopus 로고    scopus 로고
    • Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    • Murakami K., Kondo T., Kawase M., Li Y., Sato S., Chen S.F., and Chan P.H. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18 (1998) 205-213
    • (1998) J. Neurosci. , vol.18 , pp. 205-213
    • Murakami, K.1    Kondo, T.2    Kawase, M.3    Li, Y.4    Sato, S.5    Chen, S.F.6    Chan, P.H.7
  • 41
    • 0033135367 scopus 로고    scopus 로고
    • Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
    • Fujimura M., Morita-Fujimura Y., Kawase M., Copin J.-C., Calagui B., Epstein C.J., and Chan P.H. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19 (1999) 3414-3422
    • (1999) J. Neurosci. , vol.19 , pp. 3414-3422
    • Fujimura, M.1    Morita-Fujimura, Y.2    Kawase, M.3    Copin, J.-C.4    Calagui, B.5    Epstein, C.J.6    Chan, P.H.7
  • 42
    • 0035002886 scopus 로고    scopus 로고
    • Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice
    • 10.1097/00004647-200105000-00010
    • Noshita N., Sugawara T., Fujimura M., Morita-Fujimura Y., and Chan P.H. Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 21 (2001) 557-567 10.1097/00004647-200105000-00010
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 557-567
    • Noshita, N.1    Sugawara, T.2    Fujimura, M.3    Morita-Fujimura, Y.4    Chan, P.H.5
  • 43
    • 0032889085 scopus 로고    scopus 로고
    • Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia
    • Sheng H., Bart R.D., Oury T.D., Pearlstein R.D., Crapo J.D., and Warner D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 88 (1999) 185-191
    • (1999) Neuroscience , vol.88 , pp. 185-191
    • Sheng, H.1    Bart, R.D.2    Oury, T.D.3    Pearlstein, R.D.4    Crapo, J.D.5    Warner, D.S.6
  • 45
    • 0034084291 scopus 로고    scopus 로고
    • Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia
    • 10.1006/exnr.2000.7363
    • Sheng H., Kudo M., Mackensen G.B., Pearlstein R.D., Crapo J.D., and Warner D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Exp. Neurol. 163 (2000) 392-398 10.1006/exnr.2000.7363
    • (2000) Exp. Neurol. , vol.163 , pp. 392-398
    • Sheng, H.1    Kudo, M.2    Mackensen, G.B.3    Pearlstein, R.D.4    Crapo, J.D.5    Warner, D.S.6
  • 46
    • 0033591310 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse
    • Sheng H., Brady T.C., Pearlstein R.D., Crapo J.D., and Warner D.S. Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. Neurosci. Lett. 267 (1999) 13-16
    • (1999) Neurosci. Lett. , vol.267 , pp. 13-16
    • Sheng, H.1    Brady, T.C.2    Pearlstein, R.D.3    Crapo, J.D.4    Warner, D.S.5
  • 47
    • 0032079478 scopus 로고    scopus 로고
    • Production of nitric oxide by mitochondria
    • 10.1074/jbc.273.18.11038
    • Giulivi C., Poderoso J.J., and Boveris A. Production of nitric oxide by mitochondria. J. Biol. Chem. 273 (1998) 11038-11043 10.1074/jbc.273.18.11038
    • (1998) J. Biol. Chem. , vol.273 , pp. 11038-11043
    • Giulivi, C.1    Poderoso, J.J.2    Boveris, A.3
  • 48
    • 0032079851 scopus 로고    scopus 로고
    • Purification and characterization of a nitric-oxide synthase from rat liver mitochondria
    • 10.1074/jbc.273.18.11044
    • T atoyan A., and Giulivi C. Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J. Biol. Chem. 273 (1998) 11044-11048 10.1074/jbc.273.18.11044
    • (1998) J. Biol. Chem. , vol.273 , pp. 11044-11048
    • T atoyan, A.1    Giulivi, C.2
  • 50
    • 34548847438 scopus 로고    scopus 로고
    • Heart mtNOS, a key mediator of oxidative injury in ischemia/reperfusion [Editorial]
    • 10.1016/j.yjmcc.2007.07.053
    • Ignarro L.J. Heart mtNOS, a key mediator of oxidative injury in ischemia/reperfusion [Editorial]. J. Mol. Cell. Cardiol. 43 (2007) 409-410 10.1016/j.yjmcc.2007.07.053
    • (2007) J. Mol. Cell. Cardiol. , vol.43 , pp. 409-410
    • Ignarro, L.J.1
  • 51
    • 0035893981 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia
    • Lacza Z., Puskar M., Figueroa J.P., Zhang J., Rajapakse N., and Busija D.W. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic. Biol. Med. 31 (2001) 1609-1615
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 1609-1615
    • Lacza, Z.1    Puskar, M.2    Figueroa, J.P.3    Zhang, J.4    Rajapakse, N.5    Busija, D.W.6
  • 52
    • 46349093995 scopus 로고    scopus 로고
    • Brain mitochondrial dysfunction in aging
    • Boveris A., and Navarro A. Brain mitochondrial dysfunction in aging. IUBMB Life 60 (2008) 308-314
    • (2008) IUBMB Life , vol.60 , pp. 308-314
    • Boveris, A.1    Navarro, A.2
  • 54
    • 33845193134 scopus 로고    scopus 로고
    • The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis
    • 10.1128/MCB.01025-06
    • Jiang P., Du W., Heese K., and Wu M. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol. Cell. Biol. 26 (2006) 9071-9082 10.1128/MCB.01025-06
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 9071-9082
    • Jiang, P.1    Du, W.2    Heese, K.3    Wu, M.4
  • 55
    • 33847209168 scopus 로고    scopus 로고
    • Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats
    • 10.1038/sj.jcbfm.9600367
    • Kamada H., Nito C., Endo H., and Chan P.H. Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 27 (2007) 521-533 10.1038/sj.jcbfm.9600367
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 521-533
    • Kamada, H.1    Nito, C.2    Endo, H.3    Chan, P.H.4
  • 56
    • 4544255383 scopus 로고    scopus 로고
    • The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia
    • 10.1523/JNEUROSCI.1745-04.2004
    • Okuno S., Saito A., Hayashi T., and Chan P.H. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J. Neurosci. 24 (2004) 7879-7887 10.1523/JNEUROSCI.1745-04.2004
    • (2004) J. Neurosci. , vol.24 , pp. 7879-7887
    • Okuno, S.1    Saito, A.2    Hayashi, T.3    Chan, P.H.4
  • 58
    • 33747056618 scopus 로고    scopus 로고
    • Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats
    • 10.1523/JNEUROSCI.0897-06.2006
    • Endo H., Kamada H., Nito C., Nishi T., and Chan P.H. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J. Neurosci. 26 (2006) 7974-7983 10.1523/JNEUROSCI.0897-06.2006
    • (2006) J. Neurosci. , vol.26 , pp. 7974-7983
    • Endo, H.1    Kamada, H.2    Nito, C.3    Nishi, T.4    Chan, P.H.5
  • 59
    • 0042477717 scopus 로고    scopus 로고
    • Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
    • 10.1083/jcb.200305149
    • Reimertz C., Kögel D., Rami A., Chittenden T., and Prehn J.H.M. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J. Cell Biol. 162 (2003) 587-597 10.1083/jcb.200305149
    • (2003) J. Cell Biol. , vol.162 , pp. 587-597
    • Reimertz, C.1    Kögel, D.2    Rami, A.3    Chittenden, T.4    Prehn, J.H.M.5
  • 62
    • 0000064578 scopus 로고    scopus 로고
    • Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
    • Gillardon F., Lenz C., Waschke K.F., Krajewski S., Reed J.C., Zimmermann M., and Kuschinsky W. Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Mol. Brain Res. 40 (1996) 254-260
    • (1996) Mol. Brain Res. , vol.40 , pp. 254-260
    • Gillardon, F.1    Lenz, C.2    Waschke, K.F.3    Krajewski, S.4    Reed, J.C.5    Zimmermann, M.6    Kuschinsky, W.7
  • 63
    • 4544298249 scopus 로고    scopus 로고
    • Mitochondrial mechanisms of neural cell apoptosis
    • 10.1111/j.1471-4159.2004.02572.x
    • Polster B.M., and Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90 (2004) 1281-1289 10.1111/j.1471-4159.2004.02572.x
    • (2004) J. Neurochem. , vol.90 , pp. 1281-1289
    • Polster, B.M.1    Fiskum, G.2
  • 64
    • 0031737635 scopus 로고    scopus 로고
    • Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats
    • 10.1097/00004647-199811000-00010
    • Fujimura M., Morita-Fujimura Y., Murakami K., Kawase M., and Chan P.H. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 18 (1998) 1239-1247 10.1097/00004647-199811000-00010
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 1239-1247
    • Fujimura, M.1    Morita-Fujimura, Y.2    Murakami, K.3    Kawase, M.4    Chan, P.H.5
  • 65
    • 34248642353 scopus 로고    scopus 로고
    • Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
    • Sugawara T., Fujimura M., Morita-Fujimura Y., Kawase M., and Chan P.H. Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J. Neurosci. 19 RC39 (1999) 1-6
    • (1999) J. Neurosci. , vol.19 , Issue.RC39 , pp. 1-6
    • Sugawara, T.1    Fujimura, M.2    Morita-Fujimura, Y.3    Kawase, M.4    Chan, P.H.5
  • 66
    • 0042838034 scopus 로고    scopus 로고
    • Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia
    • 10.1097/01.WCB.0000080702.47016.FF
    • Saito A., Hayashi T., Okuno S., Ferrand-Drake M., and Chan P.H. Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 23 (2003) 1010-1019 10.1097/01.WCB.0000080702.47016.FF
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 1010-1019
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Ferrand-Drake, M.4    Chan, P.H.5
  • 67
    • 27744476223 scopus 로고    scopus 로고
    • Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia
    • 10.1523/jneurosci.2818-05.2005
    • Culmsee C., Zhu C., Landshamer S., Becattini B., Wagner E., Pellechia M., Blomgren K., and Plesnila N. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J. Neurosci. 25 (2005) 10262-10272 10.1523/jneurosci.2818-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 10262-10272
    • Culmsee, C.1    Zhu, C.2    Landshamer, S.3    Becattini, B.4    Wagner, E.5    Pellechia, M.6    Blomgren, K.7    Plesnila, N.8
  • 68
    • 22544487228 scopus 로고    scopus 로고
    • Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    • 10.1016/j.neulet.2005.05.058
    • Lee B.I., Lee D.J., Cho K.J., and Kim G.W. Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Neurosci. Lett. 386 (2005) 23-27 10.1016/j.neulet.2005.05.058
    • (2005) Neurosci. Lett. , vol.386 , pp. 23-27
    • Lee, B.I.1    Lee, D.J.2    Cho, K.J.3    Kim, G.W.4
  • 69
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 70
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H., Henzel W.J., Liu X., Lutschg A., and Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90 (1997) 405-413
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 72
    • 0033834275 scopus 로고    scopus 로고
    • Expression of caspases and their substrates in the rat model of focal cerebral ischemia
    • doi:10.1006/nbdi.2000.0310
    • Krupinski J., Lopez E., Marti E., and Ferrer I. Expression of caspases and their substrates in the rat model of focal cerebral ischemia. Neurobiol. Dis. 7 (2000) 332-342 doi:10.1006/nbdi.2000.0310
    • (2000) Neurobiol. Dis. , vol.7 , pp. 332-342
    • Krupinski, J.1    Lopez, E.2    Marti, E.3    Ferrer, I.4
  • 73
    • 67449128454 scopus 로고    scopus 로고
    • Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat
    • 10.1007/s10571-009-9348-8
    • Chaitanya G.V., and Babu P.P. Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Cell. Mol. Neurobiol. 29 (2009) 563-573 10.1007/s10571-009-9348-8
    • (2009) Cell. Mol. Neurobiol. , vol.29 , pp. 563-573
    • Chaitanya, G.V.1    Babu, P.P.2
  • 74
    • 0037384802 scopus 로고    scopus 로고
    • Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra
    • Ferrer I., and Planas A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 62 (2003) 329-339
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 329-339
    • Ferrer, I.1    Planas, A.M.2
  • 77
    • 2442453730 scopus 로고    scopus 로고
    • The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
    • 10.1126/science.1095432
    • Tinel A., and Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304 (2004) 843-846 10.1126/science.1095432
    • (2004) Science , vol.304 , pp. 843-846
    • Tinel, A.1    Tschopp, J.2
  • 78
    • 55849091768 scopus 로고    scopus 로고
    • The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats
    • 10.1073/pnas.0806222105
    • Niizuma K., Endo H., Nito C., Myer D.J., Kim G.S., and Chan P.H. The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 16369-16374 10.1073/pnas.0806222105
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 16369-16374
    • Niizuma, K.1    Endo, H.2    Nito, C.3    Myer, D.J.4    Kim, G.S.5    Chan, P.H.6
  • 79
    • 4344663051 scopus 로고    scopus 로고
    • Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity
    • 10.1038/sj.embor.7400153
    • Robertson J.D., Gogvadze V., Kropotov A., Vakifahmetoglu H., Zhivotovsky B., and Orrenius S. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep. 5 (2004) 643-648 10.1038/sj.embor.7400153
    • (2004) EMBO Rep. , vol.5 , pp. 643-648
    • Robertson, J.D.1    Gogvadze, V.2    Kropotov, A.3    Vakifahmetoglu, H.4    Zhivotovsky, B.5    Orrenius, S.6
  • 80
    • 9644307904 scopus 로고    scopus 로고
    • Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
    • 10.1074/jbc.C400374200
    • Enoksson M., Robertson J.D., Gogvadze V., Bu P., Kropotov A., Zhivotovsky B., and Orrenius S. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J. Biol. Chem. 279 (2004) 49575-49578 10.1074/jbc.C400374200
    • (2004) J. Biol. Chem. , vol.279 , pp. 49575-49578
    • Enoksson, M.1    Robertson, J.D.2    Gogvadze, V.3    Bu, P.4    Kropotov, A.5    Zhivotovsky, B.6    Orrenius, S.7
  • 81
    • 33846219997 scopus 로고    scopus 로고
    • Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
    • doi:10.1038/sj.emboj.7601473
    • Tinel A., Janssens S., Lippens S., Cuenin S., Logette E., Jaccard B., Quadroni M., and Tschopp J. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway. EMBO J. 26 (2007) 197-208 doi:10.1038/sj.emboj.7601473
    • (2007) EMBO J. , vol.26 , pp. 197-208
    • Tinel, A.1    Janssens, S.2    Lippens, S.3    Cuenin, S.4    Logette, E.5    Jaccard, B.6    Quadroni, M.7    Tschopp, J.8
  • 82
    • 0034666684 scopus 로고    scopus 로고
    • Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia
    • 10.1002/1097-4547(20000915)61:6<686::AID-JNR12>3.0.CO;2-7
    • Rosenbaum D.M., Gupta G., D'Amore J., Singh M., Weidenheim K., Zhang H., and Kessler J.A. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia. J. Neurosci. Res. 61 (2000) 686-692 10.1002/1097-4547(20000915)61:6<686::AID-JNR12>3.0.CO;2-7
    • (2000) J. Neurosci. Res. , vol.61 , pp. 686-692
    • Rosenbaum, D.M.1    Gupta, G.2    D'Amore, J.3    Singh, M.4    Weidenheim, K.5    Zhang, H.6    Kessler, J.A.7
  • 83
    • 0035209472 scopus 로고    scopus 로고
    • Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia
    • 10.1097/00004647-200112000-00005
    • Jin K., Graham S.H., Mao X., Nagayama T., Simon R.P., and Greenberg D.A. Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia. J. Cereb. Blood Flow Metab. 21 (2001) 1411-1421 10.1097/00004647-200112000-00005
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1411-1421
    • Jin, K.1    Graham, S.H.2    Mao, X.3    Nagayama, T.4    Simon, R.P.5    Greenberg, D.A.6
  • 84
    • 0027765510 scopus 로고
    • Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia
    • Chan P.H., Kamii H., Yang G., Gafni J., Epstein C.J., Carlson E., and Reola L. Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. NeuroReport 5 (1993) 293-296
    • (1993) NeuroReport , vol.5 , pp. 293-296
    • Chan, P.H.1    Kamii, H.2    Yang, G.3    Gafni, J.4    Epstein, C.J.5    Carlson, E.6    Reola, L.7
  • 85
    • 0028040278 scopus 로고
    • Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia
    • Yang G., Chan P.H., Chen J., Carlson E., Chen S.F., Weinstein P., Epstein C.J., and Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25 (1994) 165-170
    • (1994) Stroke , vol.25 , pp. 165-170
    • Yang, G.1    Chan, P.H.2    Chen, J.3    Carlson, E.4    Chen, S.F.5    Weinstein, P.6    Epstein, C.J.7    Kamii, H.8
  • 86
    • 0028331886 scopus 로고
    • Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase
    • Kamii H., Kinouchi H., Sharp F.R., Koistinaho J., Epstein C.J., and Chan P.H. Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 14 (1994) 478-486
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 478-486
    • Kamii, H.1    Kinouchi, H.2    Sharp, F.R.3    Koistinaho, J.4    Epstein, C.J.5    Chan, P.H.6
  • 87
    • 0028032568 scopus 로고
    • Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice
    • Kamii H., Kinouchi H., Sharp F.R., Epstein C.J., Sagar S.M., and Chan P.H. Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice. Brain Res. 662 (1994) 240-244
    • (1994) Brain Res. , vol.662 , pp. 240-244
    • Kamii, H.1    Kinouchi, H.2    Sharp, F.R.3    Epstein, C.J.4    Sagar, S.M.5    Chan, P.H.6
  • 88
    • 0030597122 scopus 로고    scopus 로고
    • Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia
    • Kondo T., Murakami K., Honkaniemi J., Sharp F.R., Epstein C.J., and Chan P.H. Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia. Brain Res. 737 (1996) 321-326
    • (1996) Brain Res. , vol.737 , pp. 321-326
    • Kondo, T.1    Murakami, K.2    Honkaniemi, J.3    Sharp, F.R.4    Epstein, C.J.5    Chan, P.H.6
  • 89
    • 0032703437 scopus 로고    scopus 로고
    • Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    • Fujimura M., Morita-Fujimura Y., Narasimhan P., Copin J.-C., Kawase M., and Chan P.H. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30 (1999) 2408-2415
    • (1999) Stroke , vol.30 , pp. 2408-2415
    • Fujimura, M.1    Morita-Fujimura, Y.2    Narasimhan, P.3    Copin, J.-C.4    Kawase, M.5    Chan, P.H.6
  • 90
    • 0034655765 scopus 로고    scopus 로고
    • The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
    • Fujimura M., Morita-Fujimura Y., Noshita N., Sugawara T., Kawase M., and Chan P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 20 (2000) 2817-2824
    • (2000) J. Neurosci. , vol.20 , pp. 2817-2824
    • Fujimura, M.1    Morita-Fujimura, Y.2    Noshita, N.3    Sugawara, T.4    Kawase, M.5    Chan, P.H.6
  • 91
    • 0034744739 scopus 로고    scopus 로고
    • Overexpression of copper-zinc superoxide dismutase attenuates acute activation of activator protein-1 after transient focal cerebral ischemia in mice
    • Huang C.-Y., Fujimura M., Chang Y.-Y., and Chan P.H. Overexpression of copper-zinc superoxide dismutase attenuates acute activation of activator protein-1 after transient focal cerebral ischemia in mice. Stroke 32 (2001) 741-747
    • (2001) Stroke , vol.32 , pp. 741-747
    • Huang, C.-Y.1    Fujimura, M.2    Chang, Y.-Y.3    Chan, P.H.4
  • 92
    • 0035910375 scopus 로고    scopus 로고
    • Reduction of copper,zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia
    • Fujimura M., Morita-Fujimura Y., Copin J.-C., Yoshimoto T., and Chan P.H. Reduction of copper,zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia. Brain Res. 889 (2001) 208-213
    • (2001) Brain Res. , vol.889 , pp. 208-213
    • Fujimura, M.1    Morita-Fujimura, Y.2    Copin, J.-C.3    Yoshimoto, T.4    Chan, P.H.5
  • 93
    • 0038582584 scopus 로고    scopus 로고
    • Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia
    • 10.1016/S0169-328X(03)00062-7
    • Narasimhan P., Fujimura M., Noshita N., and Chan P.H. Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. Mol. Brain Res. 113 (2003) 28-36 10.1016/S0169-328X(03)00062-7
    • (2003) Mol. Brain Res. , vol.113 , pp. 28-36
    • Narasimhan, P.1    Fujimura, M.2    Noshita, N.3    Chan, P.H.4
  • 95
    • 1542300773 scopus 로고    scopus 로고
    • Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia
    • 10.1016/j.nbd.2003.10.005
    • Hayashi T., Saito A., Okuno S., Ferrand-Drake M., Dodd R.L., and Chan P.H. Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia. Neurobiol. Dis. 15 (2004) 229-239 10.1016/j.nbd.2003.10.005
    • (2004) Neurobiol. Dis. , vol.15 , pp. 229-239
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Dodd, R.L.5    Chan, P.H.6
  • 96
    • 4043170492 scopus 로고    scopus 로고
    • Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1
    • 10.1016/j.molbrainres.2004.05.012
    • Saito A., Hayashi T., Okuno S., Nishi T., and Chan P.H. Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1. Mol. Brain Res. 127 (2004) 89-95 10.1016/j.molbrainres.2004.05.012
    • (2004) Mol. Brain Res. , vol.127 , pp. 89-95
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 97
    • 7644237799 scopus 로고    scopus 로고
    • Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia
    • 10.1161/01.STR.0000144653.32853.ed
    • Saito A., Hayashi T., Okuno S., Nishi T., and Chan P.H. Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia. Stroke 35 (2004) 2560-2565 10.1161/01.STR.0000144653.32853.ed
    • (2004) Stroke , vol.35 , pp. 2560-2565
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 98
    • 11844282198 scopus 로고    scopus 로고
    • Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons
    • 10.1038/sj.jcbfm.9600005
    • Hayashi T., Saito A., Okuno S., Ferrand-Drake M., Dodd R.L., and Chan P.H. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons. J. Cereb. Blood Flow Metab. 25 (2005) 41-53 10.1038/sj.jcbfm.9600005
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 41-53
    • Hayashi, T.1    Saito, A.2    Okuno, S.3    Ferrand-Drake, M.4    Dodd, R.L.5    Chan, P.H.6
  • 99
    • 17444427103 scopus 로고    scopus 로고
    • Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia
    • 10.1111/j.1471-4159.2005.03039.x
    • Narasimhan P., Sugawara T., Liu J., Hayashi T., Noshita N., and Chan P.H. Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia. J. Neurochem. 93 (2005) 351-358 10.1111/j.1471-4159.2005.03039.x
    • (2005) J. Neurochem. , vol.93 , pp. 351-358
    • Narasimhan, P.1    Sugawara, T.2    Liu, J.3    Hayashi, T.4    Noshita, N.5    Chan, P.H.6
  • 100
    • 25144494690 scopus 로고    scopus 로고
    • Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1α expression after transient focal cerebral ischemia
    • 10.1038/sj.jcbfm.9600124
    • Nishi T., Maier C.M., Hayashi T., Saito A., and Chan P.H. Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1α expression after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 25 (2005) 1312-1324 10.1038/sj.jcbfm.9600124
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1312-1324
    • Nishi, T.1    Maier, C.M.2    Hayashi, T.3    Saito, A.4    Chan, P.H.5
  • 101
    • 33644858950 scopus 로고    scopus 로고
    • Modulation of proline-rich Akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia
    • 10.1161/01.STR.0000198826.56611.a2
    • Saito A., Hayashi T., Okuno S., Nishi T., and Chan P.H. Modulation of proline-rich Akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke 37 (2006) 513-517 10.1161/01.STR.0000198826.56611.a2
    • (2006) Stroke , vol.37 , pp. 513-517
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 102
    • 33947525763 scopus 로고    scopus 로고
    • Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats. Relation to blood-brain barrier dysfunction
    • 10.1161/01.STR.0000258041.75739.cb
    • Kamada H., Yu F., Nito C., and Chan P.H. Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats. Relation to blood-brain barrier dysfunction. Stroke 38 (2007) 1044-1049 10.1161/01.STR.0000258041.75739.cb
    • (2007) Stroke , vol.38 , pp. 1044-1049
    • Kamada, H.1    Yu, F.2    Nito, C.3    Chan, P.H.4
  • 103
    • 2142772632 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and myeloperoxidase expression. Quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia
    • 10.1161/01.STR.0000125861.55804.f2
    • Maier C.M., Hsieh L., Yu F., Bracci P., and Chan P.H. Matrix metalloproteinase-9 and myeloperoxidase expression. Quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia. Stroke 35 (2004) 1169-1174 10.1161/01.STR.0000125861.55804.f2
    • (2004) Stroke , vol.35 , pp. 1169-1174
    • Maier, C.M.1    Hsieh, L.2    Yu, F.3    Bracci, P.4    Chan, P.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.