Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans

Science

Volumn 322, Issue 5898, 2008, Pages 110-115

  Deng, Xinzhu ^a   Yin, Xianglei ^a   Allan, Richard ^a   Lu, Diane D ^a   Maurer, Carine W ^b   Haimovitz Friedman, Adriana ^a   Fuks, Zvi ^a   Shaham, Shai ^b   Kolesnick, Richard ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CERAMIDE; CERAMIDE SYNTHASE; SPHINGOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

APOPTOSIS; ENZYME ACTIVITY; MITOCHONDRION; MUTATION; NEMATODE; PROTEIN; RADIATION EXPOSURE; TUMOR;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; ENZYME INACTIVATION; GENE MUTATION; GERM LINE; IONIZING RADIATION; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY;

ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-BINDING PROTEINS; CERAMIDES; GENES, HELMINTH; GERM CELLS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MUTATION; NUCLEAR ENVELOPE; OXIDOREDUCTASES; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION, IONIZING; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

CAENORHABDITIS ELEGANS;

EID: 53349098893     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158111     Document Type: Article

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26. We thank Caenorhabditis Genetics Center and National BioResource Project-Japan for the strains provided; H. R. Horwitz for the anti-CED-4 antibody; Y. Gruenbaum for the anti-Ce-lamin-antibody; M. O. Hengartner for the strain opls219; and S. Davidor, D. Chau, H. Lee, J. Mesicek, and the Molecular Cytology and Genomics Core Laboratory of MSKCC for the technical assistance. This work was supported by grants CA85704 (R.K.), CA105125-03 (A.H.-F.), and 2R01HD42680-06 (S.S.).