메뉴 건너뛰기




Volumn 219, Issue , 2014, Pages 187-203

Arrestin interaction with E3 Ubiquitin ligases and deubiquitinases: Functional and therapeutic implications

Author keywords

Beta arrestin; Deubiquitinase; Endocytosis; G protein coupled receptor; Lysosomes; Ubiquitin

Indexed keywords

BETA ARRESTIN 1; BETA ARRESTIN 2; BORTEZOMIB; DEUBIQUITINASE; G PROTEIN COUPLED RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; ADAPTOR PROTEIN; BETA ARRESTIN;

EID: 84958527704     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-41199-1_10     Document Type: Article
Times cited : (15)

References (88)
  • 1
    • 79955588728 scopus 로고    scopus 로고
    • Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination
    • Ahmed MR, Zhan X, Song X, Kook S, Gurevich VV, Gurevich EV (2011) Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination. Biochemistry 50:3749-3763
    • (2011) Biochemistry , vol.50 , pp. 3749-3763
    • Ahmed, M.R.1    Zhan, X.2    Song, X.3    Kook, S.4    Gurevich, V.V.5    Gurevich, E.V.6
  • 2
    • 84875509748 scopus 로고    scopus 로고
    • Minireview: Ubiquitination-regulated G protein-coupled receptor signaling and trafficking
    • Alonso V, Friedman PA (2013) Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking. Mol Endocrinol 27:558-572
    • (2013) Mol Endocrinol , vol.27 , pp. 558-572
    • Alonso, V.1    Friedman, P.A.2
  • 5
    • 67649556158 scopus 로고    scopus 로고
    • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization
    • Berthouze M, Venkataramanan V, Li Y, Shenoy SK (2009) The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J 28:1684-1696
    • (2009) EMBO J , vol.28 , pp. 1684-1696
    • Berthouze, M.1    Venkataramanan, V.2    Li, Y.3    Shenoy, S.K.4
  • 6
    • 37549035071 scopus 로고    scopus 로고
    • Arrestin-2 interacts with the ubiquitinprotein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4
    • Bhandari D, Trejo J, Benovic JL, Marchese A (2007) Arrestin-2 interacts with the ubiquitinprotein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem 282:36971-36979
    • (2007) J Biol Chem , vol.282 , pp. 36971-36979
    • Bhandari, D.1    Trejo, J.2    Benovic, J.L.3    Marchese, A.4
  • 7
    • 77951230331 scopus 로고    scopus 로고
    • Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
    • Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 285:7805-7817
    • (2010) J Biol Chem , vol.285 , pp. 7805-7817
    • Busillo, J.M.1    Armando, S.2    Sengupta, R.3    Meucci, O.4    Bouvier, M.5    Benovic, J.L.6
  • 8
    • 84863338304 scopus 로고    scopus 로고
    • Ubiquitination in signaling to and activation of IKK
    • Chen ZJ (2012) Ubiquitination in signaling to and activation of IKK. Immunol Rev 246:95-106
    • (2012) Immunol Rev , vol.246 , pp. 95-106
    • Chen, Z.J.1
  • 9
    • 0036209874 scopus 로고    scopus 로고
    • Endocytosis of G protein-coupled receptors: Roles of G protein-coupled receptor kinases and beta-arrestin proteins
    • Claing A, Laporte SA, Caron MG, Lefkowitz RJ (2002) Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 66:61-79
    • (2002) Prog Neurobiol , vol.66 , pp. 61-79
    • Claing, A.1    Laporte, S.A.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 10
    • 79955765995 scopus 로고    scopus 로고
    • Temporal profiling of orexin receptorarrestin-ubiquitin complexes reveals differences between receptor subtypes
    • Dalrymple MB, Jaeger WC, Eidne KA, Pfleger KD (2011) Temporal profiling of orexin receptorarrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem 286:16726-16733
    • (2011) J Biol Chem , vol.286 , pp. 16726-16733
    • Dalrymple, M.B.1    Jaeger, W.C.2    Eidne, K.A.3    Pfleger, K.D.4
  • 13
    • 57349129484 scopus 로고    scopus 로고
    • Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
    • Decaillot FM, Rozenfeld R, Gupta A, Devi LA (2008) Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci USA 105:16045-16050
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16045-16050
    • Decaillot, F.M.1    Rozenfeld, R.2    Gupta, A.3    Devi, L.A.4
  • 14
    • 0033279836 scopus 로고    scopus 로고
    • SCF and Cullin/Ring H2-based ubiquitin ligases
    • Deshaies RJ (1999) SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 15:435-467
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 435-467
    • Deshaies, R.J.1
  • 15
    • 79960382104 scopus 로고    scopus 로고
    • Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology
    • DeWire SM, Violin JD (2011) Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circ Res 109:205-216
    • (2011) Circ Res , vol.109 , pp. 205-216
    • Dewire, S.M.1    Violin, J.D.2
  • 18
    • 84866855674 scopus 로고    scopus 로고
    • Ubiquitination of G protein-coupled receptors: Functional implications and drug discovery
    • Dores MR, Trejo J (2012) Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol 82:563-570
    • (2012) Mol Pharmacol , vol.82 , pp. 563-570
    • Dores, M.R.1    Trejo, J.2
  • 19
    • 77449103325 scopus 로고    scopus 로고
    • Therapeutic strategies within the ubiquitin proteasome system
    • Eldridge AG, O'Brien T (2010) Therapeutic strategies within the ubiquitin proteasome system. Cell Death Differ 17:4-13
    • (2010) Cell Death Differ , vol.17 , pp. 4-13
    • Eldridge, A.G.1    O'Brien, T.2
  • 20
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING fingerdependent ubiquitin protein ligase for itself and p53
    • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (2000) Mdm2 is a RING fingerdependent ubiquitin protein ligase for itself and p53. J Biol Chem 275:8945-8951
    • (2000) J Biol Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 21
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
    • Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1-24
    • (2001) Pharmacol Rev , vol.53 , pp. 1-24
    • Ferguson, S.S.1
  • 22
    • 73949084919 scopus 로고    scopus 로고
    • A Arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
    • doi:10.1126/scitranslmed.3000071
    • Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM (2009) A Arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 1(1):1ra1. doi:10.1126/scitranslmed.3000071
    • (2009) Sci Transl Med , vol.1 , Issue.1
    • Gesty-Palmer, D.1    Flannery, P.2    Yuan, L.3    Corsino, L.4    Spurney, R.5    Lefkowitz, R.J.6    Luttrell, L.M.7
  • 23
    • 21644463635 scopus 로고    scopus 로고
    • Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
    • Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 280:24412-24419
    • (2005) J Biol Chem , vol.280 , pp. 24412-24419
    • Girnita, L.1    Shenoy, S.K.2    Sehat, B.3    Vasilcanu, R.4    Girnita, A.5    Lefkowitz, R.J.6    Larsson, O.7
  • 26
    • 80052416572 scopus 로고    scopus 로고
    • Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation
    • Groer CE, Schmid CL, Jaeger AM, Bohn LM (2011) Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. J Biol Chem 286:31731-31741
    • (2011) J Biol Chem , vol.286 , pp. 31731-31741
    • Groer, C.E.1    Schmid, C.L.2    Jaeger, A.M.3    Bohn, L.M.4
  • 27
    • 33646414189 scopus 로고    scopus 로고
    • The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
    • Gurevich VV, Gurevich EV (2006) The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110:465-502
    • (2006) Pharmacol Ther , vol.110 , pp. 465-502
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 28
    • 77955487306 scopus 로고    scopus 로고
    • Custom-designed proteins as novel therapeutic tools? the case of arrestins
    • Gurevich VV, Gurevich EV (2010) Custom-designed proteins as novel therapeutic tools? The case of arrestins. Expert Rev Mol Med 12:e13.
    • (2010) Expert Rev Mol Med , vol.12
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 31
    • 84873411358 scopus 로고    scopus 로고
    • Distinct roles for beta-arrestin2 and arrestin-domaincontaining proteins in beta 2) adrenergic receptor trafficking
    • Han SO, Kommaddi RP, Shenoy SK (2013) Distinct roles for beta-arrestin2 and arrestin-domaincontaining proteins in beta(2) adrenergic receptor trafficking. EMBO Rep 14:164-171
    • (2013) EMBO Rep , vol.14 , pp. 164-171
    • Han, S.O.1    Kommaddi, R.P.2    Shenoy, S.K.3
  • 34
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61:3071-3076
    • (2001) Cancer Res. , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6    Anderson, K.C.7
  • 35
    • 84855513161 scopus 로고    scopus 로고
    • Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
    • Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S (2011) Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol 195:1005-1015
    • (2011) J Cell Biol , vol.195 , pp. 1005-1015
    • Hori, K.1    Sen, A.2    Kirchhausen, T.3    Artavanis-Tsakonas, S.4
  • 40
    • 0034266806 scopus 로고    scopus 로고
    • RING finger proteins: Mediators of ubiquitin ligase activity
    • Joazeiro CA, Weissman AM (2000) RING finger proteins: mediators of ubiquitin ligase activity. Cell 102:549-552
    • (2000) Cell , vol.102 , pp. 549-552
    • Joazeiro, C.A.1    Weissman, A.M.2
  • 41
    • 3943099375 scopus 로고    scopus 로고
    • Protein modification by SUMO
    • Johnson ES (2004) Protein modification by SUMO. Annu Rev Biochem 73:355-382
    • (2004) Annu Rev Biochem , vol.73 , pp. 355-382
    • Johnson, E.S.1
  • 42
    • 0035958546 scopus 로고    scopus 로고
    • Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex
    • Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106:145-155
    • (2001) ESCRT-I. Cell , vol.106 , pp. 145-155
    • Katzmann, D.J.1    Babst, M.2    Emr, S.D.3
  • 45
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by beta-arrestins
    • Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signals by beta-arrestins. Science 308:512-517
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 46
    • 67349113489 scopus 로고    scopus 로고
    • Ubiquitin ligase adaptors: Regulators of ubiquitylation and endocytosis of plasma membrane proteins
    • Leon S, Haguenauer-Tsapis R (2009) Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins. Exp Cell Res 315:1574-1583
    • (2009) Exp Cell Res , vol.315 , pp. 1574-1583
    • Leon, S.1    Haguenauer-Tsapis, R.2
  • 47
    • 67650245968 scopus 로고    scopus 로고
    • Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
    • Li X, Baillie GS, Houslay MD (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem 284:16170-16182
    • (2009) J Biol Chem , vol.284 , pp. 16170-16182
    • Li, X.1    Baillie, G.S.2    Houslay, M.D.3
  • 48
    • 80054727295 scopus 로고    scopus 로고
    • Refining efficacy: Allosterism and bias in G protein-coupled receptor signaling
    • Luttrell LM, Kenakin TP (2011) Refining efficacy: allosterism and bias in G protein-coupled receptor signaling. Methods Mol Biol 756:3-35
    • (2011) Methods Mol Biol , vol.756 , pp. 3-35
    • Luttrell, L.M.1    Kenakin, T.P.2
  • 49
    • 0036473397 scopus 로고    scopus 로고
    • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
    • Luttrell LM, Lefkowitz RJ (2002) The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465
    • (2002) J Cell Sci , vol.115 , pp. 455-465
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 50
    • 0242412524 scopus 로고    scopus 로고
    • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination
    • Martin NP, Lefkowitz RJ, Shenoy SK (2003) Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J Biol Chem 278:45954-45959
    • (2003) J Biol Chem , vol.278 , pp. 45954-45959
    • Martin, N.P.1    Lefkowitz, R.J.2    Shenoy, S.K.3
  • 51
    • 84858142724 scopus 로고    scopus 로고
    • HECT and RING finger families of E3 ubiquitin ligases at a glance
    • Metzger MB, Hristova VA, Weissman AM (2012) HECT and RING finger families of E3 ubiquitin ligases at a glance. J Cell Sci 125:531-537
    • (2012) J Cell Sci , vol.125 , pp. 531-537
    • Metzger, M.B.1    Hristova, V.A.2    Weissman, A.M.3
  • 52
    • 20544472067 scopus 로고    scopus 로고
    • Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein
    • Mishra SK, Keyel PA, Edeling MA, Dupin AL, Owen DJ, Traub LM (2005) Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J Biol Chem 280:19270-19280
    • (2005) J Biol Chem , vol.280 , pp. 19270-19280
    • Mishra, S.K.1    Keyel, P.A.2    Edeling, M.A.3    Dupin, A.L.4    Owen, D.J.5    Traub, L.M.6
  • 53
    • 33947314576 scopus 로고    scopus 로고
    • Regulation of receptor trafficking by GRKs and arrestins
    • Moore CA, Milano SK, Benovic JL (2007) Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69:451-482
    • (2007) Annu Rev Physiol , vol.69 , pp. 451-482
    • Moore, C.A.1    Milano, S.K.2    Benovic, J.L.3
  • 54
    • 33846471122 scopus 로고    scopus 로고
    • Proteasome-independent functions of ubiquitin in endocytosis and signaling
    • Mukhopadhyay D, Riezman H (2007) Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315:201-205
    • (2007) Science , vol.315 , pp. 201-205
    • Mukhopadhyay, D.1    Riezman, H.2
  • 61
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seventransmembrane receptors
    • Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seventransmembrane receptors. Nat Rev Drug Discov 9:373-386
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 62
    • 84855901533 scopus 로고    scopus 로고
    • Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors
    • Reiter E, Ahn S, Shukla AK, Lefkowitz RJ (2012) Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 52:179-197
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 179-197
    • Reiter, E.1    Ahn, S.2    Shukla, A.K.3    Lefkowitz, R.J.4
  • 63
    • 67650620318 scopus 로고    scopus 로고
    • Regulation and cellular roles of ubiquitinspecific deubiquitinating enzymes
    • Reyes-Turcu FE, Ventii KH, Wilkinson KD (2009) Regulation and cellular roles of ubiquitinspecific deubiquitinating enzymes. Annu Rev Biochem 78:363-397
    • (2009) Annu Rev Biochem , vol.78 , pp. 363-397
    • Reyes-Turcu, F.E.1    Ventii, K.H.2    Wilkinson, K.D.3
  • 64
    • 33750208522 scopus 로고    scopus 로고
    • Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
    • Salcedo A, Mayor F Jr, Penela P (2006) Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J 25:4752-4762
    • (2006) EMBO J , vol.25 , pp. 4752-4762
    • Salcedo, A.1    Penela, P.2
  • 65
    • 65249100143 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy
    • Shangary S, Wang S (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol 49:223-241
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 223-241
    • Shangary, S.1    Wang, S.2
  • 66
    • 34247573976 scopus 로고    scopus 로고
    • Seven-transmembrane receptors and ubiquitination
    • Shenoy SK (2007) Seven-transmembrane receptors and ubiquitination. Circ Res 100:1142-1154
    • (2007) Circ Res , vol.100 , pp. 1142-1154
    • Shenoy, S.K.1
  • 67
    • 0037737763 scopus 로고    scopus 로고
    • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination
    • Shenoy SK, Lefkowitz RJ (2003) Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 278:14498-14506
    • (2003) J Biol Chem , vol.278 , pp. 14498-14506
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 68
    • 17144364766 scopus 로고    scopus 로고
    • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
    • Shenoy SK, Lefkowitz RJ (2005) Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem 280:15315-15324
    • (2005) J Biol Chem , vol.280 , pp. 15315-15324
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 69
    • 80052038573 scopus 로고    scopus 로고
    • Beta-Arrestin-mediated receptor trafficking and signal transduction
    • Shenoy SK, Lefkowitz RJ (2011) beta-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 32:521-533
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 70
    • 0035834428 scopus 로고    scopus 로고
    • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
    • Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294:1307-1313
    • (2001) Science , vol.294 , pp. 1307-1313
    • Shenoy, S.K.1    McDonald, P.H.2    Kohout, T.A.3    Lefkowitz, R.J.4
  • 72
    • 52049117442 scopus 로고    scopus 로고
    • Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the {beta}2-Adrenergic Receptor
    • Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (2008) Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the {beta}2-Adrenergic Receptor. J Biol Chem 283:22166-22176
    • (2008) J Biol Chem , vol.283 , pp. 22166-22176
    • Shenoy, S.K.1    Xiao, K.2    Venkataramanan, V.3    Snyder, P.M.4    Freedman, N.J.5    Weissman, A.M.6
  • 73
    • 66149116039 scopus 로고    scopus 로고
    • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
    • Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ (2009) Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci USA 106:6650-6655
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6650-6655
    • Shenoy, S.K.1    Modi, A.S.2    Shukla, A.K.3    Xiao, K.4    Berthouze, M.5    Ahn, S.6    Wilkinson, K.D.7    Miller, W.E.8    Lefkowitz, R.J.9
  • 74
    • 77956919285 scopus 로고    scopus 로고
    • Arresting a transient receptor potential (TRP) channel: Beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    • Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem 285:30115-30125
    • (2010) J Biol Chem , vol.285 , pp. 30115-30125
    • Shukla, A.K.1    Kim, J.2    Ahn, S.3    Xiao, K.4    Shenoy, S.K.5    Liedtke, W.6    Lefkowitz, R.J.7
  • 75
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling
    • Shukla AK, Xiao K, Lefkowitz RJ (2011) Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci 36:457-469
    • (2011) Trends Biochem Sci , vol.36 , pp. 457-469
    • Shukla, A.K.1    Xiao, K.2    Lefkowitz, R.J.3
  • 76
    • 78649673808 scopus 로고    scopus 로고
    • Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H + exchanger 1 ubiquitylation, endocytosis, and function
    • Simonin A, Fuster D (2010) Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H + exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem 285:38293-38303
    • (2010) J Biol Chem , vol.285 , pp. 38293-38303
    • Simonin, A.1    Fuster, D.2
  • 79
    • 33845901313 scopus 로고    scopus 로고
    • MDM2 inhibitors for cancer therapy
    • Vassilev LT (2007) MDM2 inhibitors for cancer therapy. Trends Mol Med 13:23-31
    • (2007) Trends Mol Med , vol.13 , pp. 23-31
    • Vassilev, L.T.1
  • 81
    • 84883752677 scopus 로고    scopus 로고
    • GPCR biased ligands as novel heart failure therapeutics
    • doi: 10.1016/j.tcm. 2013.01.002. Epub 2013 Mar 15
    • Iolin JD, Soergel DG, Boerrigter G, Burnett JC, Jr., Lark MW (2013) GPCR biased ligands as novel heart failure therapeutics. Trends Cardiovasc Med 23(7):242-249. doi: 10.1016/j.tcm. 2013.01.002. Epub 2013 Mar 15
    • (2013) Trends Cardiovasc Med , vol.23 , Issue.7 , pp. 242-249
    • Iolin, J.D.1    Soergel, D.G.2    Boerrigter, G.3    Burnett Jr., J.C.4    Lark, M.W.5
  • 82
    • 79952488185 scopus 로고    scopus 로고
    • Therapeutic potential of beta-arrestin-and G protein-biased agonists
    • Whalen EJ, Rajagopal S, Lefkowitz RJ (2011) Therapeutic potential of beta-arrestin-and G protein-biased agonists. Trends Mol Med 17:126-139
    • (2011) Trends Mol Med , vol.17 , pp. 126-139
    • Whalen, E.J.1    Rajagopal, S.2    Lefkowitz, R.J.3
  • 84
    • 79952777210 scopus 로고    scopus 로고
    • Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking
    • Wyatt D, Malik R, Vesecky AC, Marchese A (2011) Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. J Biol Chem 286:3884-3893
    • (2011) J Biol Chem , vol.286 , pp. 3884-3893
    • Wyatt, D.1    Malik, R.2    Vesecky, A.C.3    Marchese, A.4
  • 85
    • 79953296222 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains
    • Xiao K, Shenoy SK (2011) Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. J Biol Chem 286:12785-12795
    • (2011) J Biol Chem , vol.286 , pp. 12785-12795
    • Xiao, K.1    Shenoy, S.K.2
  • 87
    • 84860789159 scopus 로고    scopus 로고
    • Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulinlike growth factor 1 receptor
    • Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L (2012) Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulinlike growth factor 1 receptor. Proc Natl Acad Sci USA 109:7055-7060
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7055-7060
    • Zheng, H.1    Worrall, C.2    Shen, H.3    Issad, T.4    Seregard, S.5    Girnita, A.6    Girnita, L.7
  • 88
    • 67649856866 scopus 로고    scopus 로고
    • Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
    • Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ (2009) Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci USA 106:9649-9654
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9649-9654
    • Zidar, D.A.1    Violin, J.D.2    Whalen, E.J.3    Lefkowitz, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.