-
1
-
-
79955588728
-
Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination
-
Ahmed MR, Zhan X, Song X, Kook S, Gurevich VV, Gurevich EV (2011) Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination. Biochemistry 50:3749-3763
-
(2011)
Biochemistry
, vol.50
, pp. 3749-3763
-
-
Ahmed, M.R.1
Zhan, X.2
Song, X.3
Kook, S.4
Gurevich, V.V.5
Gurevich, E.V.6
-
2
-
-
84875509748
-
Minireview: Ubiquitination-regulated G protein-coupled receptor signaling and trafficking
-
Alonso V, Friedman PA (2013) Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking. Mol Endocrinol 27:558-572
-
(2013)
Mol Endocrinol
, vol.27
, pp. 558-572
-
-
Alonso, V.1
Friedman, P.A.2
-
4
-
-
84867025125
-
Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family
-
Becuwe M, Herrador A, Haguenauer-Tsapis R, Vincent O, Leon S (2012) Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family. Biochem Res Int 2012:242764
-
(2012)
Biochem Res Int 2012
, pp. 242764
-
-
Becuwe, M.1
Herrador, A.2
Haguenauer-Tsapis, R.3
Vincent, O.4
Leon, S.5
-
5
-
-
67649556158
-
The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization
-
Berthouze M, Venkataramanan V, Li Y, Shenoy SK (2009) The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J 28:1684-1696
-
(2009)
EMBO J
, vol.28
, pp. 1684-1696
-
-
Berthouze, M.1
Venkataramanan, V.2
Li, Y.3
Shenoy, S.K.4
-
6
-
-
37549035071
-
Arrestin-2 interacts with the ubiquitinprotein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4
-
Bhandari D, Trejo J, Benovic JL, Marchese A (2007) Arrestin-2 interacts with the ubiquitinprotein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem 282:36971-36979
-
(2007)
J Biol Chem
, vol.282
, pp. 36971-36979
-
-
Bhandari, D.1
Trejo, J.2
Benovic, J.L.3
Marchese, A.4
-
7
-
-
77951230331
-
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
-
Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 285:7805-7817
-
(2010)
J Biol Chem
, vol.285
, pp. 7805-7817
-
-
Busillo, J.M.1
Armando, S.2
Sengupta, R.3
Meucci, O.4
Bouvier, M.5
Benovic, J.L.6
-
8
-
-
84863338304
-
Ubiquitination in signaling to and activation of IKK
-
Chen ZJ (2012) Ubiquitination in signaling to and activation of IKK. Immunol Rev 246:95-106
-
(2012)
Immunol Rev
, vol.246
, pp. 95-106
-
-
Chen, Z.J.1
-
9
-
-
0036209874
-
Endocytosis of G protein-coupled receptors: Roles of G protein-coupled receptor kinases and beta-arrestin proteins
-
Claing A, Laporte SA, Caron MG, Lefkowitz RJ (2002) Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 66:61-79
-
(2002)
Prog Neurobiol
, vol.66
, pp. 61-79
-
-
Claing, A.1
Laporte, S.A.2
Caron, M.G.3
Lefkowitz, R.J.4
-
10
-
-
79955765995
-
Temporal profiling of orexin receptorarrestin-ubiquitin complexes reveals differences between receptor subtypes
-
Dalrymple MB, Jaeger WC, Eidne KA, Pfleger KD (2011) Temporal profiling of orexin receptorarrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem 286:16726-16733
-
(2011)
J Biol Chem
, vol.286
, pp. 16726-16733
-
-
Dalrymple, M.B.1
Jaeger, W.C.2
Eidne, K.A.3
Pfleger, K.D.4
-
11
-
-
0036168984
-
The RING domain of Mdm2 can inhibit cell proliferation
-
Dang J, Kuo ML, Eischen CM, Stepanova L, Sherr CJ, Roussel MF (2002) The RING domain of Mdm2 can inhibit cell proliferation. Cancer Res 62:1222-1230
-
(2002)
Cancer Res
, vol.62
, pp. 1222-1230
-
-
Dang, J.1
Kuo, M.L.2
Eischen, C.M.3
Stepanova, L.4
Sherr, C.J.5
Roussel, M.F.6
-
12
-
-
20144389192
-
Assay for ubiquitin ligase activity: High-throughput screen for inhibitors of HDM2
-
Davydov IV, Woods D, Safiran YJ, Oberoi P, Fearnhead HO, Fang S, Jensen JP, Weissman AM, Kenten JH, Vousden KH (2004) Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2. J Biomol Screen 9:695-703
-
(2004)
J Biomol Screen
, vol.9
, pp. 695-703
-
-
Davydov, I.V.1
Woods, D.2
Safiran, Y.J.3
Oberoi, P.4
Fearnhead, H.O.5
Fang, S.6
Jensen, J.P.7
Weissman, A.M.8
Kenten, J.H.9
Vousden, K.H.10
-
14
-
-
0033279836
-
SCF and Cullin/Ring H2-based ubiquitin ligases
-
Deshaies RJ (1999) SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 15:435-467
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
15
-
-
79960382104
-
Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology
-
DeWire SM, Violin JD (2011) Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circ Res 109:205-216
-
(2011)
Circ Res
, vol.109
, pp. 205-216
-
-
Dewire, S.M.1
Violin, J.D.2
-
17
-
-
44849117014
-
Beta-arrestin-mediated signaling regulates protein synthesis
-
DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ (2008) Beta-arrestin-mediated signaling regulates protein synthesis. J Biol Chem 283:10611-10620
-
(2008)
J Biol Chem
, vol.283
, pp. 10611-10620
-
-
Dewire, S.M.1
Kim, J.2
Whalen, E.J.3
Ahn, S.4
Chen, M.5
Lefkowitz, R.J.6
-
18
-
-
84866855674
-
Ubiquitination of G protein-coupled receptors: Functional implications and drug discovery
-
Dores MR, Trejo J (2012) Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol 82:563-570
-
(2012)
Mol Pharmacol
, vol.82
, pp. 563-570
-
-
Dores, M.R.1
Trejo, J.2
-
19
-
-
77449103325
-
Therapeutic strategies within the ubiquitin proteasome system
-
Eldridge AG, O'Brien T (2010) Therapeutic strategies within the ubiquitin proteasome system. Cell Death Differ 17:4-13
-
(2010)
Cell Death Differ
, vol.17
, pp. 4-13
-
-
Eldridge, A.G.1
O'Brien, T.2
-
20
-
-
0034708458
-
Mdm2 is a RING fingerdependent ubiquitin protein ligase for itself and p53
-
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (2000) Mdm2 is a RING fingerdependent ubiquitin protein ligase for itself and p53. J Biol Chem 275:8945-8951
-
(2000)
J Biol Chem
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
21
-
-
0035101820
-
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
-
Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1-24
-
(2001)
Pharmacol Rev
, vol.53
, pp. 1-24
-
-
Ferguson, S.S.1
-
22
-
-
73949084919
-
A Arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
-
doi:10.1126/scitranslmed.3000071
-
Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM (2009) A Arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 1(1):1ra1. doi:10.1126/scitranslmed.3000071
-
(2009)
Sci Transl Med
, vol.1
, Issue.1
-
-
Gesty-Palmer, D.1
Flannery, P.2
Yuan, L.3
Corsino, L.4
Spurney, R.5
Lefkowitz, R.J.6
Luttrell, L.M.7
-
23
-
-
21644463635
-
Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
-
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 280:24412-24419
-
(2005)
J Biol Chem
, vol.280
, pp. 24412-24419
-
-
Girnita, L.1
Shenoy, S.K.2
Sehat, B.3
Vasilcanu, R.4
Girnita, A.5
Lefkowitz, R.J.6
Larsson, O.7
-
24
-
-
13944274061
-
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
-
Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF (2005) Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem 48:909-912
-
(2005)
J Med Chem
, vol.48
, pp. 909-912
-
-
Grasberger, B.L.1
Lu, T.2
Schubert, C.3
Parks, D.J.4
Carver, T.E.5
Koblish, H.K.6
Cummings, M.D.7
Lafrance, L.V.8
Milkiewicz, K.L.9
Calvo, R.R.10
Maguire, D.11
Lattanze, J.12
Franks, C.F.13
Zhao, S.14
Ramachandren, K.15
Bylebyl, G.R.16
Zhang, M.17
Manthey, C.L.18
Petrella, E.C.19
Pantoliano, M.W.20
Deckman, I.C.21
Spurlino, J.C.22
Maroney, A.C.23
Tomczuk, B.E.24
Molloy, C.J.25
Bone, R.F.26
more..
-
25
-
-
33846456218
-
An opioid agonist that does not induce mu-opioid receptor-arrestin interactions or receptor internalization
-
Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM (2007) An opioid agonist that does not induce mu-opioid receptor-arrestin interactions or receptor internalization. Mol Pharmacol 71:549-557
-
(2007)
Mol Pharmacol
, vol.71
, pp. 549-557
-
-
Groer, C.E.1
Tidgewell, K.2
Moyer, R.A.3
Harding, W.W.4
Rothman, R.B.5
Prisinzano, T.E.6
Bohn, L.M.7
-
26
-
-
80052416572
-
Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation
-
Groer CE, Schmid CL, Jaeger AM, Bohn LM (2011) Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. J Biol Chem 286:31731-31741
-
(2011)
J Biol Chem
, vol.286
, pp. 31731-31741
-
-
Groer, C.E.1
Schmid, C.L.2
Jaeger, A.M.3
Bohn, L.M.4
-
27
-
-
33646414189
-
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
-
Gurevich VV, Gurevich EV (2006) The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110:465-502
-
(2006)
Pharmacol Ther
, vol.110
, pp. 465-502
-
-
Gurevich, V.V.1
Gurevich, E.V.2
-
28
-
-
77955487306
-
Custom-designed proteins as novel therapeutic tools? the case of arrestins
-
Gurevich VV, Gurevich EV (2010) Custom-designed proteins as novel therapeutic tools? The case of arrestins. Expert Rev Mol Med 12:e13.
-
(2010)
Expert Rev Mol Med
, vol.12
-
-
Gurevich, V.V.1
Gurevich, E.V.2
-
30
-
-
84871997357
-
MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta 2)-adrenergic receptors
-
Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nakamura N, Freedman NJ, Shenoy SK (2012) MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors. J Cell Biol 199:817-830
-
(2012)
J Cell Biol
, vol.199
, pp. 817-830
-
-
Han, S.O.1
Xiao, K.2
Kim, J.3
Wu, J.H.4
Wisler, J.W.5
Nakamura, N.6
Freedman, N.J.7
Shenoy, S.K.8
-
31
-
-
84873411358
-
Distinct roles for beta-arrestin2 and arrestin-domaincontaining proteins in beta 2) adrenergic receptor trafficking
-
Han SO, Kommaddi RP, Shenoy SK (2013) Distinct roles for beta-arrestin2 and arrestin-domaincontaining proteins in beta(2) adrenergic receptor trafficking. EMBO Rep 14:164-171
-
(2013)
EMBO Rep
, vol.14
, pp. 164-171
-
-
Han, S.O.1
Kommaddi, R.P.2
Shenoy, S.K.3
-
32
-
-
80052832196
-
A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1
-
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ (2011) A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature 477:349-353
-
(2011)
Nature
, vol.477
, pp. 349-353
-
-
Hara, M.R.1
Kovacs, J.J.2
Whalen, E.J.3
Rajagopal, S.4
Strachan, R.T.5
Grant, W.6
Towers, A.J.7
Williams, B.8
Lam, C.M.9
Xiao, K.10
Shenoy, S.K.11
Gregory, S.G.12
Ahn, S.13
Duckett, D.R.14
Lefkowitz, R.J.15
-
34
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61:3071-3076
-
(2001)
Cancer Res.
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.J.4
Elliott, P.J.5
Adams, J.6
Anderson, K.C.7
-
35
-
-
84855513161
-
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
-
Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S (2011) Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol 195:1005-1015
-
(2011)
J Cell Biol
, vol.195
, pp. 1005-1015
-
-
Hori, K.1
Sen, A.2
Kirchhausen, T.3
Artavanis-Tsakonas, S.4
-
36
-
-
0032741446
-
Structure of an E6AP-UbcH7 complex: Insights into ubiquitination by the E2-E3 enzyme cascade
-
Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP (1999) Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 286:1321-1326
-
(1999)
Science
, vol.286
, pp. 1321-1326
-
-
Huang, L.1
Kinnucan, E.2
Wang, G.3
Beaudenon, S.4
Howley, P.M.5
Huibregtse, J.M.6
Pavletich, N.P.7
-
37
-
-
23344436258
-
WW domains provide a platform for the assembly of multiprotein networks
-
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'Donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T (2005) WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol 25:7092-7106
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7092-7106
-
-
Ingham, R.J.1
Colwill, K.2
Howard, C.3
Dettwiler, S.4
Lim, C.S.5
Yu, J.6
Hersi, K.7
Raaijmakers, J.8
Gish, G.9
Mbamalu, G.10
Taylor, L.11
Yeung, B.12
Vassilovski, G.13
Amin, M.14
Chen, F.15
Matskova, L.16
Winberg, G.17
Ernberg, I.18
Linding, R.19
O'Donnell, P.20
Starostine, A.21
Keller, W.22
Metalnikov, P.23
Stark, C.24
Pawson, T.25
more..
-
38
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G (2004) Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 10:1321-1328
-
(2004)
Nat Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.5
Masucci, M.6
Pramanik, A.7
Selivanova, G.8
-
39
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (2000) The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10:429-439
-
(2000)
Trends Cell Biol
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
Eldridge, A.G.2
Freed, E.3
Furstenthal, L.4
Hsu, J.Y.5
Kaiser, B.K.6
Reimann, J.D.7
-
40
-
-
0034266806
-
RING finger proteins: Mediators of ubiquitin ligase activity
-
Joazeiro CA, Weissman AM (2000) RING finger proteins: mediators of ubiquitin ligase activity. Cell 102:549-552
-
(2000)
Cell
, vol.102
, pp. 549-552
-
-
Joazeiro, C.A.1
Weissman, A.M.2
-
41
-
-
3943099375
-
Protein modification by SUMO
-
Johnson ES (2004) Protein modification by SUMO. Annu Rev Biochem 73:355-382
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 355-382
-
-
Johnson, E.S.1
-
42
-
-
0035958546
-
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex
-
Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106:145-155
-
(2001)
ESCRT-I. Cell
, vol.106
, pp. 145-155
-
-
Katzmann, D.J.1
Babst, M.2
Emr, S.D.3
-
43
-
-
18744406282
-
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
-
Lai Z, Yang T, Kim YB, Sielecki TM, Diamond MA, Strack P, Rolfe M, Caligiuri M, Benfield PA, Auger KR, Copeland RA (2002) Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc Natl Acad Sci USA 99:14734-14739
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14734-14739
-
-
Lai, Z.1
Yang, T.2
Kim, Y.B.3
Sielecki, T.M.4
Diamond, M.A.5
Strack, P.6
Rolfe, M.7
Caligiuri, M.8
Benfield, P.A.9
Auger, K.R.10
Copeland, R.A.11
-
44
-
-
67249152481
-
Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer
-
Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, Benovic JL, Daaka Y (2009) Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci USA 106:9379-9384
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9379-9384
-
-
Lakshmikanthan, V.1
Zou, L.2
Kim, J.I.3
Michal, A.4
Nie, Z.5
Messias, N.C.6
Benovic, J.L.7
Daaka, Y.8
-
45
-
-
17644402459
-
Transduction of receptor signals by beta-arrestins
-
Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signals by beta-arrestins. Science 308:512-517
-
(2005)
Science
, vol.308
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
46
-
-
67349113489
-
Ubiquitin ligase adaptors: Regulators of ubiquitylation and endocytosis of plasma membrane proteins
-
Leon S, Haguenauer-Tsapis R (2009) Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins. Exp Cell Res 315:1574-1583
-
(2009)
Exp Cell Res
, vol.315
, pp. 1574-1583
-
-
Leon, S.1
Haguenauer-Tsapis, R.2
-
47
-
-
67650245968
-
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
-
Li X, Baillie GS, Houslay MD (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem 284:16170-16182
-
(2009)
J Biol Chem
, vol.284
, pp. 16170-16182
-
-
Li, X.1
Baillie, G.S.2
Houslay, M.D.3
-
48
-
-
80054727295
-
Refining efficacy: Allosterism and bias in G protein-coupled receptor signaling
-
Luttrell LM, Kenakin TP (2011) Refining efficacy: allosterism and bias in G protein-coupled receptor signaling. Methods Mol Biol 756:3-35
-
(2011)
Methods Mol Biol
, vol.756
, pp. 3-35
-
-
Luttrell, L.M.1
Kenakin, T.P.2
-
49
-
-
0036473397
-
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
-
Luttrell LM, Lefkowitz RJ (2002) The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465
-
(2002)
J Cell Sci
, vol.115
, pp. 455-465
-
-
Luttrell, L.M.1
Lefkowitz, R.J.2
-
50
-
-
0242412524
-
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination
-
Martin NP, Lefkowitz RJ, Shenoy SK (2003) Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J Biol Chem 278:45954-45959
-
(2003)
J Biol Chem
, vol.278
, pp. 45954-45959
-
-
Martin, N.P.1
Lefkowitz, R.J.2
Shenoy, S.K.3
-
51
-
-
84858142724
-
HECT and RING finger families of E3 ubiquitin ligases at a glance
-
Metzger MB, Hristova VA, Weissman AM (2012) HECT and RING finger families of E3 ubiquitin ligases at a glance. J Cell Sci 125:531-537
-
(2012)
J Cell Sci
, vol.125
, pp. 531-537
-
-
Metzger, M.B.1
Hristova, V.A.2
Weissman, A.M.3
-
52
-
-
20544472067
-
Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein
-
Mishra SK, Keyel PA, Edeling MA, Dupin AL, Owen DJ, Traub LM (2005) Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J Biol Chem 280:19270-19280
-
(2005)
J Biol Chem
, vol.280
, pp. 19270-19280
-
-
Mishra, S.K.1
Keyel, P.A.2
Edeling, M.A.3
Dupin, A.L.4
Owen, D.J.5
Traub, L.M.6
-
53
-
-
33947314576
-
Regulation of receptor trafficking by GRKs and arrestins
-
Moore CA, Milano SK, Benovic JL (2007) Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69:451-482
-
(2007)
Annu Rev Physiol
, vol.69
, pp. 451-482
-
-
Moore, C.A.1
Milano, S.K.2
Benovic, J.L.3
-
54
-
-
33846471122
-
Proteasome-independent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay D, Riezman H (2007) Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315:201-205
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
56
-
-
44349098667
-
Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
-
Nicholson B, Leach CA, Goldenberg SJ, Francis DM, Kodrasov MP, Tian X, Shanks J, Sterner DE, Bernal A, Mattern MR, Wilkinson KD, Butt TR (2008) Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci 17:1035-1043
-
(2008)
Protein Sci
, vol.17
, pp. 1035-1043
-
-
Nicholson, B.1
Leach, C.A.2
Goldenberg, S.J.3
Francis, D.M.4
Kodrasov, M.P.5
Tian, X.6
Shanks, J.7
Sterner, D.E.8
Bernal, A.9
Mattern, M.R.10
Wilkinson, K.D.11
Butt, T.R.12
-
57
-
-
80051616441
-
Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of betaarrestin
-
Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ (2011) Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of betaarrestin. Sci Signal 4:ra51
-
(2011)
Sci Signal
, vol.4
-
-
Nobles, K.N.1
Xiao, K.2
Ahn, S.3
Shukla, A.K.4
Lam, C.M.5
Rajagopal, S.6
Strachan, R.T.7
Huang, T.Y.8
Bressler, E.A.9
Hara, M.R.10
Shenoy, S.K.11
Gygi, S.P.12
Lefkowitz, R.J.13
-
58
-
-
34848820302
-
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection
-
Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA (2007) Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest 117:2445-2458
-
(2007)
J Clin Invest
, vol.117
, pp. 2445-2458
-
-
Noma, T.1
Lemaire, A.2
Naga Prasad, S.V.3
Barki-Harrington, L.4
Tilley, D.G.5
Chen, J.6
Le Corvoisier, P.7
Violin, J.D.8
Wei, H.9
Lefkowitz, R.J.10
Rockman, H.A.11
-
59
-
-
23044505285
-
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain
-
Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL (2005) Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell 19:297-308
-
(2005)
Mol Cell
, vol.19
, pp. 297-308
-
-
Ogunjimi, A.A.1
Briant, D.J.2
Pece-Barbara, N.3
Le Roy, C.4
Di Guglielmo, G.M.5
Kavsak, P.6
Rasmussen, R.K.7
Seet, B.T.8
Sicheri, F.9
Wrana, J.L.10
-
60
-
-
12344276574
-
Real-time monitoring of ubiquitination in living cells by BRET
-
Perroy J, Pontier S, Charest PG, Aubry M, Bouvier M (2004) Real-time monitoring of ubiquitination in living cells by BRET. Nat Methods 1:203-208
-
(2004)
Nat Methods
, vol.1
, pp. 203-208
-
-
Perroy, J.1
Pontier, S.2
Charest, P.G.3
Aubry, M.4
Bouvier, M.5
-
61
-
-
77951844975
-
Teaching old receptors new tricks: Biasing seventransmembrane receptors
-
Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seventransmembrane receptors. Nat Rev Drug Discov 9:373-386
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 373-386
-
-
Rajagopal, S.1
Rajagopal, K.2
Lefkowitz, R.J.3
-
62
-
-
84855901533
-
Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors
-
Reiter E, Ahn S, Shukla AK, Lefkowitz RJ (2012) Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 52:179-197
-
(2012)
Annu Rev Pharmacol Toxicol
, vol.52
, pp. 179-197
-
-
Reiter, E.1
Ahn, S.2
Shukla, A.K.3
Lefkowitz, R.J.4
-
63
-
-
67650620318
-
Regulation and cellular roles of ubiquitinspecific deubiquitinating enzymes
-
Reyes-Turcu FE, Ventii KH, Wilkinson KD (2009) Regulation and cellular roles of ubiquitinspecific deubiquitinating enzymes. Annu Rev Biochem 78:363-397
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 363-397
-
-
Reyes-Turcu, F.E.1
Ventii, K.H.2
Wilkinson, K.D.3
-
64
-
-
33750208522
-
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
-
Salcedo A, Mayor F Jr, Penela P (2006) Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J 25:4752-4762
-
(2006)
EMBO J
, vol.25
, pp. 4752-4762
-
-
Salcedo, A.1
Penela, P.2
-
65
-
-
65249100143
-
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy
-
Shangary S, Wang S (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol 49:223-241
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 223-241
-
-
Shangary, S.1
Wang, S.2
-
66
-
-
34247573976
-
Seven-transmembrane receptors and ubiquitination
-
Shenoy SK (2007) Seven-transmembrane receptors and ubiquitination. Circ Res 100:1142-1154
-
(2007)
Circ Res
, vol.100
, pp. 1142-1154
-
-
Shenoy, S.K.1
-
67
-
-
0037737763
-
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination
-
Shenoy SK, Lefkowitz RJ (2003) Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 278:14498-14506
-
(2003)
J Biol Chem
, vol.278
, pp. 14498-14506
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
68
-
-
17144364766
-
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
-
Shenoy SK, Lefkowitz RJ (2005) Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem 280:15315-15324
-
(2005)
J Biol Chem
, vol.280
, pp. 15315-15324
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
69
-
-
80052038573
-
Beta-Arrestin-mediated receptor trafficking and signal transduction
-
Shenoy SK, Lefkowitz RJ (2011) beta-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 32:521-533
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 521-533
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
70
-
-
0035834428
-
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
-
Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294:1307-1313
-
(2001)
Science
, vol.294
, pp. 1307-1313
-
-
Shenoy, S.K.1
McDonald, P.H.2
Kohout, T.A.3
Lefkowitz, R.J.4
-
71
-
-
35748944113
-
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
-
Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ (2007) Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem 282:29549-29562
-
(2007)
J Biol Chem
, vol.282
, pp. 29549-29562
-
-
Shenoy, S.K.1
Barak, L.S.2
Xiao, K.3
Ahn, S.4
Berthouze, M.5
Shukla, A.K.6
Luttrell, L.M.7
Lefkowitz, R.J.8
-
72
-
-
52049117442
-
Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the {beta}2-Adrenergic Receptor
-
Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (2008) Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the {beta}2-Adrenergic Receptor. J Biol Chem 283:22166-22176
-
(2008)
J Biol Chem
, vol.283
, pp. 22166-22176
-
-
Shenoy, S.K.1
Xiao, K.2
Venkataramanan, V.3
Snyder, P.M.4
Freedman, N.J.5
Weissman, A.M.6
-
73
-
-
66149116039
-
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
-
Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ (2009) Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci USA 106:6650-6655
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6650-6655
-
-
Shenoy, S.K.1
Modi, A.S.2
Shukla, A.K.3
Xiao, K.4
Berthouze, M.5
Ahn, S.6
Wilkinson, K.D.7
Miller, W.E.8
Lefkowitz, R.J.9
-
74
-
-
77956919285
-
Arresting a transient receptor potential (TRP) channel: Beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
-
Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem 285:30115-30125
-
(2010)
J Biol Chem
, vol.285
, pp. 30115-30125
-
-
Shukla, A.K.1
Kim, J.2
Ahn, S.3
Xiao, K.4
Shenoy, S.K.5
Liedtke, W.6
Lefkowitz, R.J.7
-
75
-
-
80052359992
-
Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling
-
Shukla AK, Xiao K, Lefkowitz RJ (2011) Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci 36:457-469
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 457-469
-
-
Shukla, A.K.1
Xiao, K.2
Lefkowitz, R.J.3
-
76
-
-
78649673808
-
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H + exchanger 1 ubiquitylation, endocytosis, and function
-
Simonin A, Fuster D (2010) Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H + exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem 285:38293-38303
-
(2010)
J Biol Chem
, vol.285
, pp. 38293-38303
-
-
Simonin, A.1
Fuster, D.2
-
77
-
-
0032885416
-
The proteasome inhibitor PS-341 in cancer therapy
-
Teicher BA, Ara G, Herbst R, Palombella VJ, Adams J (1999) The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res. 5: 2638-2645
-
(1999)
Clin Cancer Res.
, vol.5
, pp. 2638-2645
-
-
Teicher, B.A.1
Ara, G.2
Herbst, R.3
Palombella, V.J.4
Adams, J.5
-
78
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320:1-13
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1-13
-
-
Urban, J.D.1
Clarke, W.P.2
Von Zastrow, M.3
Nichols, D.E.4
Kobilka, B.5
Weinstein, H.6
Javitch, J.A.7
Roth, B.L.8
Christopoulos, A.9
Sexton, P.M.10
Miller, K.J.11
Spedding, M.12
Mailman, R.B.13
-
79
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev LT (2007) MDM2 inhibitors for cancer therapy. Trends Mol Med 13:23-31
-
(2007)
Trends Mol Med
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
80
-
-
0037249354
-
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase
-
Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP (2003) Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell 11:249-259
-
(2003)
Mol Cell
, vol.11
, pp. 249-259
-
-
Verdecia, M.A.1
Joazeiro, C.A.2
Wells, N.J.3
Ferrer, J.L.4
Bowman, M.E.5
Hunter, T.6
Noel, J.P.7
-
81
-
-
84883752677
-
GPCR biased ligands as novel heart failure therapeutics
-
doi: 10.1016/j.tcm. 2013.01.002. Epub 2013 Mar 15
-
Iolin JD, Soergel DG, Boerrigter G, Burnett JC, Jr., Lark MW (2013) GPCR biased ligands as novel heart failure therapeutics. Trends Cardiovasc Med 23(7):242-249. doi: 10.1016/j.tcm. 2013.01.002. Epub 2013 Mar 15
-
(2013)
Trends Cardiovasc Med
, vol.23
, Issue.7
, pp. 242-249
-
-
Iolin, J.D.1
Soergel, D.G.2
Boerrigter, G.3
Burnett Jr., J.C.4
Lark, M.W.5
-
82
-
-
79952488185
-
Therapeutic potential of beta-arrestin-and G protein-biased agonists
-
Whalen EJ, Rajagopal S, Lefkowitz RJ (2011) Therapeutic potential of beta-arrestin-and G protein-biased agonists. Trends Mol Med 17:126-139
-
(2011)
Trends Mol Med
, vol.17
, pp. 126-139
-
-
Whalen, E.J.1
Rajagopal, S.2
Lefkowitz, R.J.3
-
83
-
-
36749094552
-
A unique mechanism of beta-blocker action: Carvedilol stimulates beta-arrestin signaling
-
Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ (2007) A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci USA 104:16657-16662
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 16657-16662
-
-
Wisler, J.W.1
Dewire, S.M.2
Whalen, E.J.3
Violin, J.D.4
Drake, M.T.5
Ahn, S.6
Shenoy, S.K.7
Lefkowitz, R.J.8
-
84
-
-
79952777210
-
Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking
-
Wyatt D, Malik R, Vesecky AC, Marchese A (2011) Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. J Biol Chem 286:3884-3893
-
(2011)
J Biol Chem
, vol.286
, pp. 3884-3893
-
-
Wyatt, D.1
Malik, R.2
Vesecky, A.C.3
Marchese, A.4
-
85
-
-
79953296222
-
Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains
-
Xiao K, Shenoy SK (2011) Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. J Biol Chem 286:12785-12795
-
(2011)
J Biol Chem
, vol.286
, pp. 12785-12795
-
-
Xiao, K.1
Shenoy, S.K.2
-
86
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH (2005) Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7:547-559
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
Ludwig, R.L.2
Jensen, J.P.3
Pierre, S.A.4
Medaglia, M.V.5
Davydov, I.V.6
Safiran, Y.J.7
Oberoi, P.8
Kenten, J.H.9
Phillips, A.C.10
Weissman, A.M.11
Vousden, K.H.12
-
87
-
-
84860789159
-
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulinlike growth factor 1 receptor
-
Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L (2012) Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulinlike growth factor 1 receptor. Proc Natl Acad Sci USA 109:7055-7060
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 7055-7060
-
-
Zheng, H.1
Worrall, C.2
Shen, H.3
Issad, T.4
Seregard, S.5
Girnita, A.6
Girnita, L.7
-
88
-
-
67649856866
-
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
-
Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ (2009) Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci USA 106:9649-9654
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9649-9654
-
-
Zidar, D.A.1
Violin, J.D.2
Whalen, E.J.3
Lefkowitz, R.J.4
|