β-arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth Factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 24412-24419

  Girnita, Leonard ^a   Shenoy, Sudha K ^c   Sehat, Bita ^a   Vasilcanu, Radu ^a   Girnita, Ada ^a   Lefkowitz, Robert J ^b,c   Larsson, Olle ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; GENETIC ENGINEERING; GROWTH KINETICS; MOLECULAR BIOLOGY; PHYSIOLOGY; TUMORS;

AGING; CANCER CELLS; CELL GROWTH; RECEPTORS;

BIOCHEMISTRY;

ADAPTOR PROTEIN; BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; G PROTEIN COUPLED RECEPTOR; ISOPROTEIN; ONCOPROTEIN; PROTEIN MDM2; SOMATOMEDIN C RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER; CANCER CELL; CELL GROWTH; CELL LINE; CELL STRAIN P6; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; MELANOMA CELL; MOUSE; NONHUMAN; POLYUBIQUITINATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR DOWN REGULATION; UBIQUITINATION;

ANIMALS; ARRESTINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOPRECIPITATION; LIGANDS; MICE; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTOR, IGF TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION; UBIQUITIN;

EID: 21644463635     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501129200     Document Type: Article

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