Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 18, 2012, Pages 7055-7060

  Zheng, Huiyuan ^a   Worrall, Claire ^a   Shen, Hongchang ^a,e   Issad, Tarik ^b   Seregard, Stefan ^c   Girnita, Ada ^a,d   Girnita, Leonard ^a  

^a Karolinska Krankenhaus   (Sweden)

^b INSTITUT COCHIN   (France)

^c ST ERIK S EYE HOSPITAL   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e SHANDONG UNIVERSITY   (China)

Author keywords

Biasing; Cancer; Ubiquitination

Indexed keywords

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOPRECIPITATION; MOUSE; MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; ARRESTINS; BASE SEQUENCE; CELL LINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-PROTEIN-COUPLED RECEPTOR KINASE 2; G-PROTEIN-COUPLED RECEPTOR KINASES; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; SERINE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84860789159     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118359109     Document Type: Article

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