메뉴 건너뛰기




Volumn 3, Issue 1, 2015, Pages 53-66

Animal models for fibrotic liver diseases: What we have, what we need, and what is under development

Author keywords

Animal models; Cell tracking; Fibrosis; Hepatic stellate cell; Liver

Indexed keywords


EID: 84958184486     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2014.00035     Document Type: Review
Times cited : (136)

References (126)
  • 1
    • 79954487874 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Lee UE, Friedman SL. Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol 2011;25:195–206. doi: 10.1016/j.bpg.2011.02.005.
    • (2011) Best Pract Res Clin Gastroenterol , vol.25 , pp. 195-206
    • Lee, UE1    Friedman, SL.2
  • 2
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • Schuppan D, Afdhal NH. Liver cirrhosis. Lancet 2008;371:838–851. doi: 10.1016/S0140-6736(08)60383-9.
    • (2008) Lancet , vol.371 , pp. 838-851
    • Schuppan, D1    Afdhal, NH.2
  • 3
    • 70350077449 scopus 로고    scopus 로고
    • Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies
    • Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology 2009;50:1294–1306. doi: 10.1002/hep.23123.
    • (2009) Hepatology , vol.50 , pp. 1294-1306
    • Popov, Y1    Schuppan, D.2
  • 4
    • 0025320936 scopus 로고
    • Experimental models of hepatic fibrosis: a review
    • Tsukamoto H, Matsuoka M, French SW. Experimental models of hepatic fibrosis: a review. Semin Liver Dis 1990;10:56–65. doi: 10.1055/s-20081040457.
    • (1990) Semin Liver Dis , vol.10 , pp. 56-65
    • Tsukamoto, H1    Matsuoka, M2    French, SW.3
  • 5
    • 77953781386 scopus 로고    scopus 로고
    • A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible
    • Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible. Altern Lab Anim 2010;38:167–182.
    • (2010) Altern Lab Anim , vol.38 , pp. 167-182
    • Hooijmans, CR1    Leenaars, M2    Ritskes-Hoitinga, M.3
  • 6
    • 79954484784 scopus 로고    scopus 로고
    • Animal models for the study of hepatic fibrosis
    • Starkel P, Leclercq IA. Animal models for the study of hepatic fibrosis. Best Pract Res Clin Gastroenterol 2011;25:319–333. doi: 10.1016/j.bpg.2011.02.004.
    • (2011) Best Pract Res Clin Gastroenterol , vol.25 , pp. 319-333
    • Starkel, P1    Leclercq, IA.2
  • 7
    • 84885335829 scopus 로고    scopus 로고
    • Hepatitis C virus infection and related liver disease: the quest for the best animal model
    • Mailly L, Robinet E, Meuleman P, Baumert TF, Zeisel MB. Hepatitis C virus infection and related liver disease: the quest for the best animal model. Front Microbiol 2013;4:213. doi: 10.3389/fmicb.2013.00212.
    • (2013) Front Microbiol , vol.4 , pp. 213
    • Mailly, L1    Robinet, E2    Meuleman, P3    Baumert, TF4    Zeisel, MB.5
  • 8
    • 0029778880 scopus 로고    scopus 로고
    • Nimodipine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis caused by chronic intragastric ethanol exposure in the rat
    • Iimuro Y, Ikejima K, Rose ML, Bradford BU, Thurman RG. Nimodipine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis caused by chronic intragastric ethanol exposure in the rat. Hepatology 1996;24:391–397. doi: 10.1002/hep.510240217.
    • (1996) Hepatology , vol.24 , pp. 391-397
    • Iimuro, Y1    Ikejima, K2    Rose, ML3    Bradford, BU4    Thurman, RG.5
  • 9
    • 84884735611 scopus 로고    scopus 로고
    • Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
    • Liedtke C, Luedde T, Sauerbruch T, Scholten D, Streetz K, Tacke F, et al. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Fibrogenesis Tissue Repair 2013;6:19. doi: 10.1186/1755-1536-6-19.
    • (2013) Fibrogenesis Tissue Repair , vol.6 , pp. 19
    • Liedtke, C1    Luedde, T2    Sauerbruch, T3    Scholten, D4    Streetz, K5    Tacke, F6
  • 11
    • 63449110683 scopus 로고    scopus 로고
    • Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats
    • Regimbeau JM, Fuks D, Kohneh-Shahri N, Terris B, Soubrane O. Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats. World J Gastroenterol. 2008;14:6943–6947. doi: 10.3748/wjg.14.6943.
    • (2008) World J Gastroenterol , vol.14 , pp. 6943-6947
    • Regimbeau, JM1    Fuks, D2    Kohneh-Shahri, N3    Terris, B4    Soubrane, O.5
  • 12
    • 35148842448 scopus 로고    scopus 로고
    • Thirteenweek inhalation toxicity of carbon tetrachloride in rats and mice
    • Nagano K, Umeda Y, Saito M, Nishizawa T, Ikawa N, Arito H, et al. Thirteenweek inhalation toxicity of carbon tetrachloride in rats and mice. J Occup Health 2007;49:249–259. doi: 10.1539/joh.49.249.
    • (2007) J Occup Health , vol.49 , pp. 249-259
    • Nagano, K1    Umeda, Y2    Saito, M3    Nishizawa, T4    Ikawa, N5    Arito, H6
  • 13
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 1997;94:10663–10668. doi: 10.1073/pnas.94.20.10663.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10663-10668
    • Shi, Z1    Wakil, AE2    Rockey, DC.3
  • 14
    • 0036892365 scopus 로고    scopus 로고
    • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15
    • Hillebrandt S, Goos C, Matern S, Lammert F. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology 2002;123:2041–2051. doi: 10.1053/gast.2002.37069.
    • (2002) Gastroenterology , vol.123 , pp. 2041-2051
    • Hillebrandt, S1    Goos, C2    Matern, S3    Lammert, F.4
  • 15
    • 33744939234 scopus 로고    scopus 로고
    • Antifibrotic activity of NK cells in experimental liver injury through killing of activated HSC
    • Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, Bishara T, et al. Antifibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol 2006;45:60–71. doi: 10.1016/j.jhep.2005.12. 025.
    • (2006) J Hepatol , vol.45 , pp. 60-71
    • Melhem, A1    Muhanna, N2    Bishara, A3    Alvarez, CE4    Ilan, Y5    Bishara, T6
  • 16
    • 4444269015 scopus 로고    scopus 로고
    • Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid
    • Reif S, Aeed H, Shilo Y, Reich R, Kloog Y, Kweon YO, et al. Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. J Hepatol 2004;41:235–241. doi: 10.1016/j.jhep.2004.04. 010.
    • (2004) J Hepatol , vol.41 , pp. 235-241
    • Reif, S1    Aeed, H2    Shilo, Y3    Reich, R4    Kloog, Y5    Kweon, YO6
  • 17
    • 54949116520 scopus 로고    scopus 로고
    • Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice
    • Salguero PR, Roderfeld M, Hemmann S, Rath T, Atanasova S, Tschuschner A, et al. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 2008;88:1192–1203. doi: 10.1038/labinvest.2008.91.
    • (2008) Lab Invest , vol.88 , pp. 1192-1203
    • Salguero, PR1    Roderfeld, M2    Hemmann, S3    Rath, T4    Atanasova, S5    Tschuschner, A6
  • 18
    • 0036105275 scopus 로고    scopus 로고
    • Reproducible production of thioacetamideinduced macronodular cirrhosis in the rat with no mortality
    • Li X, Benjamin IS, Alexander B. Reproducible production of thioacetamideinduced macronodular cirrhosis in the rat with no mortality. J Hepatol 2002; 36:488–493. doi: 10.1016/S0168-8278(02)00011-9.
    • (2002) J Hepatol , vol.36 , pp. 488-493
    • Li, X1    Benjamin, IS2    Alexander, B.3
  • 19
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538–549. doi: 10.1172/JCI1018.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, JP1    Benyon, RC2    Pickering, J3    McCullen, M4    Northrop, M5    Pawley, S6
  • 20
    • 3042818975 scopus 로고    scopus 로고
    • Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma
    • Yeh CN, Maitra A, Lee KF, Jan YY, Chen MF. Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma. Carcinogenesis 2004;25:631–636. doi: 10.1093/carcin/bgh037.
    • (2004) Carcinogenesis , vol.25 , pp. 631-636
    • Yeh, CN1    Maitra, A2    Lee, KF3    Jan, YY4    Chen, MF.5
  • 21
    • 0000657045 scopus 로고    scopus 로고
    • Endotoxins enhance hepatocarcinogenesis induced by oral intake of thioacetamide in rats
    • Yang JM, Han DW, Xie CM, Liang QC, Zhao YC, Ma XH. Endotoxins enhance hepatocarcinogenesis induced by oral intake of thioacetamide in rats. World J Gastroenterol 1998;4:128–132.
    • (1998) World J Gastroenterol , vol.4 , pp. 128-132
    • Yang, JM1    Han, DW2    Xie, CM3    Liang, QC4    Zhao, YC5    Ma, XH.6
  • 22
    • 41249102034 scopus 로고    scopus 로고
    • Experimental models of hepatocellular carcinoma
    • Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM. Experimental models of hepatocellular carcinoma. J Hepatol 2008;48:858–879. doi: 10.1016/j.jhep.2008.01.008.
    • (2008) J Hepatol , vol.48 , pp. 858-879
    • Newell, P1    Villanueva, A2    Friedman, SL3    Koike, K4    Llovet, JM.5
  • 23
    • 0035793126 scopus 로고    scopus 로고
    • Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen
    • George J, Rao KR, Stern R, Chandrakasan G. Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology 2001;156: 129–138. doi: 10.1016/S0300-483X(00)00352-8.
    • (2001) Toxicology , vol.156 , pp. 129-138
    • George, J1    Rao, KR2    Stern, R3    Chandrakasan, G.4
  • 24
    • 0014506726 scopus 로고
    • The sex-dependent difference in the development of liver tumors in mice administered dimethylnitrosamine
    • Vesselinovitch SD. The sex-dependent difference in the development of liver tumors in mice administered dimethylnitrosamine. Cancer Res 1969; 29:1024–1027.
    • (1969) Cancer Res , vol.29 , pp. 1024-1027
    • Vesselinovitch, SD.1
  • 25
    • 84904736948 scopus 로고    scopus 로고
    • The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
    • Xu J, Liu X, Koyama Y, Wang P, Lan T, Kim IG, et al. The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. Front Pharmacol 2014;5:167. doi: 10.3389/fphar.2014.00167.
    • (2014) Front Pharmacol , vol.5 , pp. 167
    • Xu, J1    Liu, X2    Koyama, Y3    Wang, P4    Lan, T5    Kim, IG6
  • 26
    • 0242690397 scopus 로고    scopus 로고
    • Intrapulmonary vascular dilatation and nitric oxide in hypoxemic rats with chronic bile duct ligation
    • Zhang XJ, Katsuta Y, Akimoto T, Ohsuga M, Aramaki T, Takano T. Intrapulmonary vascular dilatation and nitric oxide in hypoxemic rats with chronic bile duct ligation. J Hepatol 2003;39:724–730. doi: 10.1016/S01 68-8278(03)00430-6.
    • (2003) J Hepatol , vol.39 , pp. 724-730
    • Zhang, XJ1    Katsuta, Y2    Akimoto, T3    Ohsuga, M4    Aramaki, T5    Takano, T.6
  • 27
    • 0002298061 scopus 로고
    • Morphologic and functional changes in the livers of rats after ligation or excision of the common bile duct
    • Symeonidis A, Trams EG. Morphologic and functional changes in the livers of rats after ligation or excision of the common bile duct. Am J Pathol 1957; 33:13–27.
    • (1957) Am J Pathol , vol.33 , pp. 13-27
    • Symeonidis, A1    Trams, EG.2
  • 28
    • 0021238490 scopus 로고
    • Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat
    • Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984;65:305– 311.
    • (1984) Br J Exp Pathol , vol.65 , pp. 305-311
    • Kountouras, J1    Billing, BH2    Scheuer, PJ.3
  • 29
    • 34547423958 scopus 로고    scopus 로고
    • Sodium retention and ascites formation in a cholestatic mice model: role of aldosterone and mineralocorticoid receptor?
    • Ackermann D, Mordasini D, Cheval L, Imbert-Teboul M, Vogt B, Doucet A. Sodium retention and ascites formation in a cholestatic mice model: role of aldosterone and mineralocorticoid receptor? Hepatology 2007;46:173– 179. doi: 10.1002/hep.21699.
    • (2007) Hepatology , vol.46 , pp. 173-179
    • Ackermann, D1    Mordasini, D2    Cheval, L3    Imbert-Teboul, M4    Vogt, B5    Doucet, A.6
  • 30
    • 0017239520 scopus 로고
    • A quantitative assessment of the structural changes the rat’s liver following obstruction of the common bile duct
    • Johnstone JM, Lee EG. A quantitative assessment of the structural changes the rat’s liver following obstruction of the common bile duct. Br J Exp Pathol 1976;57:85–94.
    • (1976) Br J Exp Pathol , vol.57 , pp. 85-94
    • Johnstone, JM1    Lee, EG.2
  • 32
    • 43549120265 scopus 로고    scopus 로고
    • Characterization of time-related changes after experimental bile duct ligation
    • Georgiev P, Jochum W, Heinrich S, Jang JH, Nocito A, Dahm F, et al. Characterization of time-related changes after experimental bile duct ligation. Br J Surg 2008;95:646–656. doi: 10.1002/bjs.6050.
    • (2008) Br J Surg , vol.95 , pp. 646-656
    • Georgiev, P1    Jochum, W2    Heinrich, S3    Jang, JH4    Nocito, A5    Dahm, F6
  • 33
    • 0025607869 scopus 로고
    • Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat
    • Abdel-Aziz G, Lebeau G, Rescan PY, Clement B, Rissel M, Deugnier Y, et al. Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat. Am J Pathol. 1990;137:1333–1342.
    • (1990) Am J Pathol , vol.137 , pp. 1333-1342
    • Abdel-Aziz, G1    Lebeau, G2    Rescan, PY3    Clement, B4    Rissel, M5    Deugnier, Y6
  • 34
    • 0031027703 scopus 로고    scopus 로고
    • Hepatic stellate cells (Ito cells) but not collagen IV may partly be responsible for lower portal pressure after reversing secondary biliary cirrhosis in the rat
    • Zimmermann H, Fellay M, Zimmermann A. Hepatic stellate cells (Ito cells) but not collagen IV may partly be responsible for lower portal pressure after reversing secondary biliary cirrhosis in the rat. J Hepatol 1997;26:158– 166. doi: 10.1016/S0168-8278(97)80022-0.
    • (1997) J Hepatol , vol.26 , pp. 158-166
    • Zimmermann, H1    Fellay, M2    Zimmermann, A.3
  • 35
    • 47649116115 scopus 로고    scopus 로고
    • Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation
    • Geerts AM, Vanheule E, Praet M, Van VH, De VM, Colle I. Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation. Int J Exp Pathol 2008;89: 251–263. doi: 10.1111/j.1365-2613.2008.00597.x.
    • (2008) Int J Exp Pathol , vol.89 , pp. 251-263
    • Geerts, AM1    Vanheule, E2    Praet, M3    Van, VH4    De, VM5    Colle, I.6
  • 36
    • 67649205149 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: management of cholestatic liver diseases
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver, Beuers U, Boberg KM, Chapman RW, Chazouillères O, Invernizzi P. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol 2009;51: 237–267. doi: 10.1016/j.jhep.2009.04.009.
    • (2009) J Hepatol , vol.51 , pp. 237-267
    • Beuers, U1    Boberg, KM2    Chapman, RW3    Chazouillères, O4    Invernizzi, P.5
  • 37
    • 84883150093 scopus 로고    scopus 로고
    • Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
    • Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology 2013;145:521–536. doi: 10.1053/j.gastro.2013.06. 052.
    • (2013) Gastroenterology , vol.145 , pp. 521-536
    • Eaton, JE1    Talwalkar, JA2    Lazaridis, KN3    Gores, GJ4    Lindor, KD.5
  • 38
    • 84901234765 scopus 로고    scopus 로고
    • Characterization of animal models for primary sclerosing cholangitis (PSC)
    • Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, et al. Characterization of animal models for primary sclerosing cholangitis (PSC). J Hepatol 2014;60:1290–1303. doi: 10.1016/j.jhep.2014.02.006.
    • (2014) J Hepatol , vol.60 , pp. 1290-1303
    • Fickert, P1    Pollheimer, MJ2    Beuers, U3    Lackner, C4    Hirschfield, G5    Housset, C6
  • 39
    • 0028028436 scopus 로고
    • Mice with homozygous disruption of the mdr2 Pglycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis
    • Mauad TH, van Nieuwkerk CM, Dingemans KP, Smit JJ, Schinkel AH, Notenboom RG, et al. Mice with homozygous disruption of the mdr2 Pglycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. Am J Pathol 1994; 145:1237–1245.
    • (1994) Am J Pathol , vol.145 , pp. 1237-1245
    • Mauad, TH1    van Nieuwkerk, CM2    Dingemans, KP3    Smit, JJ4    Schinkel, AH5    Notenboom, RG6
  • 40
    • 1442355466 scopus 로고    scopus 로고
    • Spontaneous cholecysto-and hepatolithiasis in Mdr2-/-mice: a model for low phospholipid-associated cholelithiasis
    • Lammert F, Wang DQ, Hillebrandt S, Geier A, Fickert P, Trauner M, et al. Spontaneous cholecysto-and hepatolithiasis in Mdr2-/-mice: a model for low phospholipid-associated cholelithiasis. Hepatology 2004;39:117–128. doi: 10.1002/hep.20022.
    • (2004) Hepatology , vol.39 , pp. 117-128
    • Lammert, F1    Wang, DQ2    Hillebrandt, S3    Geier, A4    Fickert, P5    Trauner, M6
  • 41
    • 0035045719 scopus 로고    scopus 로고
    • The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood
    • Jacquemin E, De Vree JM, Cresteil D, Sokal EM, Sturm E, Dumont M, et al. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. Gastroenterology 2001;120:1448– 1458. doi: 10.1053/gast.2001.23984.
    • (2001) Gastroenterology , vol.120 , pp. 1448-1458
    • Jacquemin, E1    De Vree, JM2    Cresteil, D3    Sokal, EM4    Sturm, E5    Dumont, M6
  • 42
  • 43
    • 84856693038 scopus 로고    scopus 로고
    • Approaches to the pathogenesis of primary biliary cirrhosis through animal models
    • Concepcion AR, Medina JF. Approaches to the pathogenesis of primary biliary cirrhosis through animal models. Clin Res Hepatol Gastroenterol 2012;36:21–28. doi: 10.1016/j.clinre.2011.07.007.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 21-28
    • Concepcion, AR1    Medina, JF.2
  • 44
    • 33947703541 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: what we know and what we want to know about human PBC and spontaneous PBC mouse models
    • Ueno Y, Moritoki Y, Shimosegawa T, Gershwin ME. Primary biliary cirrhosis: what we know and what we want to know about human PBC and spontaneous PBC mouse models. J Gastroenterol 2007;42:189–195. doi: 10.1007/s00535-007-2019-y.
    • (2007) J Gastroenterol , vol.42 , pp. 189-195
    • Ueno, Y1    Moritoki, Y2    Shimosegawa, T3    Gershwin, ME.4
  • 45
    • 79952223723 scopus 로고    scopus 로고
    • Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis
    • Wu SJ, Yang YH, Tsuneyama K, Leung PS, Illarionov P, Gershwin ME, et al. Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis. Hepatology 2011;53:915–925. doi: 10.1002/hep.24113.
    • (2011) Hepatology , vol.53 , pp. 915-925
    • Wu, SJ1    Yang, YH2    Tsuneyama, K3    Leung, PS4    Illarionov, P5    Gershwin, ME6
  • 46
    • 43049094474 scopus 로고    scopus 로고
    • Ae2a,bdeficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis
    • Salas JT, Banales JM, Sarvide S, Recalde S, Ferrer A, Uriarte I, et al. Ae2a,bdeficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology 2008;134:1482– 1493. doi: 10.1053/j.gastro.2008.02.020.
    • (2008) Gastroenterology , vol.134 , pp. 1482-1493
    • Salas, JT1    Banales, JM2    Sarvide, S3    Recalde, S4    Ferrer, A5    Uriarte, I6
  • 47
    • 77952075414 scopus 로고    scopus 로고
    • Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis
    • Plum W, Tschaharganeh DF, Kroy DC, Corsten E, Erschfeld S, Dierssen U, et al. Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis. Am J Pathol. 2010;176:2236–2246. doi: 10.2353/ajpath.2010.090469.
    • (2010) Am J Pathol , vol.176 , pp. 2236-2246
    • Plum, W1    Tschaharganeh, DF2    Kroy, DC3    Corsten, E4    Erschfeld, S5    Dierssen, U6
  • 48
    • 0028897071 scopus 로고
    • 1-naphthylisothiocyanate-induced elevation of biliary glutathione
    • Jean PA, Bailie MB, Roth RA. 1-naphthylisothiocyanate-induced elevation of biliary glutathione. Biochem Pharmacol 1995;49:197–202. doi: 10.1016/0006-2952(94)00469-2.
    • (1995) Biochem Pharmacol , vol.49 , pp. 197-202
    • Jean, PA1    Bailie, MB2    Roth, RA.3
  • 49
    • 0035813010 scopus 로고    scopus 로고
    • Role of MRP2 and GSH in intrahepatic cycling of toxins
    • Dietrich CG, Ottenhoff R, de Waart DR, Oude Elferink RP. Role of MRP2 and GSH in intrahepatic cycling of toxins. Toxicology 2001;167:73–81. doi: 10.1016/S0300-483X(01)00459-0.
    • (2001) Toxicology , vol.167 , pp. 73-81
    • Dietrich, CG1    Ottenhoff, R2    de Waart, DR3    Oude Elferink, RP.4
  • 50
    • 0033976032 scopus 로고    scopus 로고
    • Progressive development of a Th1-type hepatic cytokine profile in rats with experimental cholangitis
    • Tjandra K, Sharkey KA, Swain MG. Progressive development of a Th1-type hepatic cytokine profile in rats with experimental cholangitis. Hepatology 2000;31:280–290. doi: 10.1002/hep.510310204.
    • (2000) Hepatology , vol.31 , pp. 280-290
    • Tjandra, K1    Sharkey, KA2    Swain, MG.3
  • 51
    • 78650189268 scopus 로고    scopus 로고
    • The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis
    • Sullivan BP, Weinreb PH, Violette SM, Luyendyk JP. The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol 2010;177:2837–2849. doi: 10.2353/ajpath.2010. 100425.
    • (2010) Am J Pathol , vol.177 , pp. 2837-2849
    • Sullivan, BP1    Weinreb, PH2    Violette, SM3    Luyendyk, JP.4
  • 53
    • 84907948517 scopus 로고    scopus 로고
    • Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis
    • Yuksel M, Laukens D, Heindryckx F, Van VH, Geerts A, Wong FS, et al. Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. Int J Exp Pathol 2014;95:309–320. doi: 10.1111/iep.12090.
    • (2014) Int J Exp Pathol , vol.95 , pp. 309-320
    • Yuksel, M1    Laukens, D2    Heindryckx, F3    Van, VH4    Geerts, A5    Wong, FS6
  • 55
    • 77955266159 scopus 로고    scopus 로고
    • Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis
    • e3
    • Zierden M, Kuhnen E, Odenthal M, Dienes HP. Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis. Gastroenterology 2010;139:975–986.e3. doi: 10.1053/j.gastro.2010.05.075.
    • (2010) Gastroenterology , vol.139 , pp. 975-986
    • Zierden, M1    Kuhnen, E2    Odenthal, M3    Dienes, HP.4
  • 56
    • 45149109642 scopus 로고    scopus 로고
    • Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
    • Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, et al. Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection. J Exp Med 2008;205:1409–1422. doi: 10.1084/jem.20071859.
    • (2008) J Exp Med , vol.205 , pp. 1409-1422
    • Holdener, M1    Hintermann, E2    Bayer, M3    Rhode, A4    Rodrigo, E5    Hintereder, G6
  • 58
    • 33746310348 scopus 로고    scopus 로고
    • A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis
    • Bartley PB, Ramm GA, Jones MK, Ruddell RG, Li Y, McManus DP. A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis. Int J Parasitol 2006;36:993– 1001. doi: 10.1016/j.ijpara.2006.04.015.
    • (2006) Int J Parasitol , vol.36 , pp. 993-1001
    • Bartley, PB1    Ramm, GA2    Jones, MK3    Ruddell, RG4    Li, Y5    McManus, DP.6
  • 59
    • 0013989779 scopus 로고
    • Chronic liver injury induced by immunologic reactions. Cirrhosis following immunization with heterologous sera
    • Paronetto F, Popper H. Chronic liver injury induced by immunologic reactions. Cirrhosis following immunization with heterologous sera. Am J Pathol 1966;49:1087–1101.
    • (1966) Am J Pathol , vol.49 , pp. 1087-1101
    • Paronetto, F1    Popper, H.2
  • 60
    • 27644436818 scopus 로고    scopus 로고
    • Serological and immunohistochemical studies on porcine-serum-induced hepatic fibrosis in rats
    • Baba Y, Saeki K, Onodera T, Doi K. Serological and immunohistochemical studies on porcine-serum-induced hepatic fibrosis in rats. Exp Mol Pathol 2005;79:229–235. doi: 10.1016/j.yexmp.2005.08.007.
    • (2005) Exp Mol Pathol , vol.79 , pp. 229-235
    • Baba, Y1    Saeki, K2    Onodera, T3    Doi, K.4
  • 61
    • 84863967084 scopus 로고    scopus 로고
    • EASL clinical practical guidelines: management of alcoholic liver disease
    • European Association for the Study of Liver
    • European Association for the Study of Liver, Mathurin P, Hadengue A, Bataller R, Addolorato G, Burra P, et al. EASL clinical practical guidelines: management of alcoholic liver disease. J Hepatol 2012;57:399–420. doi: 10.1016/j.jhep.2012.04.004.
    • (2012) J Hepatol , vol.57 , pp. 399-420
    • Mathurin, P1    Hadengue, A2    Bataller, R3    Addolorato, G4    Burra, P5
  • 62
    • 84900821567 scopus 로고    scopus 로고
    • Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges
    • Mathews S, Xu M, Wang H, Bertola A, Gao B. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 2014;306:G819–G823. doi: 10.1152/ajpgi.00041.2014.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , pp. G819-G823
    • Mathews, S1    Xu, M2    Wang, H3    Bertola, A4    Gao, B.5
  • 63
    • 84869089319 scopus 로고    scopus 로고
    • Rodent models of alcoholic liver disease: of mice and men
    • Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH. Rodent models of alcoholic liver disease: of mice and men. Alcohol 2012;46:715–725. doi: 10.1016/j.alcohol.2012.08.004.
    • (2012) Alcohol , vol.46 , pp. 715-725
    • Brandon-Warner, E1    Schrum, LW2    Schmidt, CM3    McKillop, IH.4
  • 64
    • 0013899589 scopus 로고
    • The ultrastructure of fatty liver induced by prolonged ethanol ingestion
    • Iseri OA, Lieber CS, Gottlieb LS. The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol 1966;48:535–555.
    • (1966) Am J Pathol , vol.48 , pp. 535-555
    • Iseri, OA1    Lieber, CS2    Gottlieb, LS.3
  • 65
    • 0020696022 scopus 로고
    • Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat
    • Leo MA, Lieber CS. Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 1983;3:1–11. doi: 10.1002/hep.1840030101.
    • (1983) Hepatology , vol.3 , pp. 1-11
    • Leo, MA1    Lieber, CS.2
  • 66
    • 0028863402 scopus 로고
    • Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis
    • Keegan A, Martini R, Batey R. Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. J Hepatol 1995;23:591– 600. doi: 10.1016/0168-8278(95)80067-0.
    • (1995) J Hepatol , vol.23 , pp. 591-600
    • Keegan, A1    Martini, R2    Batey, R.3
  • 67
    • 0031014487 scopus 로고    scopus 로고
    • Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology
    • Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 1997;25:351–355. doi: 10.1002/hep.510250216.
    • (1997) Hepatology , vol.25 , pp. 351-355
    • Rouach, H1    Fataccioli, V2    Gentil, M3    French, SW4    Morimoto, M5    Nordmann, R.6
  • 68
    • 84875160269 scopus 로고    scopus 로고
    • Mouse model of chronic and binge ethanol feeding (the NIAAA model)
    • Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 2013;8:627–637. doi: 10.1038/nprot.2013.032.
    • (2013) Nat Protoc , vol.8 , pp. 627-637
    • Bertola, A1    Mathews, S2    Ki, SH3    Wang, H4    Gao, B.5
  • 69
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012;142:1592–1609. doi: 10.1053/j.gastro.2012.04.001.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N1    Younossi, Z2    Lavine, JE3    Diehl, AM4    Brunt, EM5    Cusi, K6
  • 70
    • 84904396612 scopus 로고    scopus 로고
    • Experimental models of non-alcoholic fatty liver disease in rats
    • Kucera O, Cervinkova Z. Experimental models of non-alcoholic fatty liver disease in rats. World J Gastroenterol 2014;20:8364–8376. doi: 10.3748/wjg.v20.i26.8364.
    • (2014) World J Gastroenterol , vol.20 , pp. 8364-8376
    • Kucera, O1    Cervinkova, Z.2
  • 71
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 2012;18: 2300–2308. doi: 10.3748/wjg.v18.i19.2300.
    • (2012) World J Gastroenterol , vol.18 , pp. 2300-2308
    • Takahashi, Y1    Soejima, Y2    Fukusato, T.3
  • 72
    • 77950355485 scopus 로고    scopus 로고
    • Characterization of high-fat, dietinduced, non-alcoholic steatohepatitis with fibrosis in rats
    • Xu ZJ, Fan JG, Ding XD, Qiao L, Wang GL. Characterization of high-fat, dietinduced, non-alcoholic steatohepatitis with fibrosis in rats. Dig Dis Sci 2010;55:931–940. doi: 10.1007/s10620-009-0815-3.
    • (2010) Dig Dis Sci , vol.55 , pp. 931-940
    • Xu, ZJ1    Fan, JG2    Ding, XD3    Qiao, L4    Wang, GL.5
  • 73
    • 36348935003 scopus 로고    scopus 로고
    • Lipidinduced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    • Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, Ando H, et al. Lipidinduced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 2007;46:1392–1403. doi: 10.1002/hep.21874.
    • (2007) Hepatology , vol.46 , pp. 1392-1403
    • Matsuzawa, N1    Takamura, T2    Kurita, S3    Misu, H4    Ota, T5    Ando, H6
  • 74
    • 57349137214 scopus 로고    scopus 로고
    • Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    • Tetri LH, Basaranoglu M, Brunt EM, Yerian LM, Neuschwander-Tetri BA. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 2008;295:G987–G995. doi: 10.1152/ajpgi.90272.2008.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , pp. G987-G995
    • Tetri, LH1    Basaranoglu, M2    Brunt, EM3    Yerian, LM4    Neuschwander-Tetri, BA.5
  • 75
    • 0029118256 scopus 로고
    • New insight into the biochemical pathology of liver in choline deficiency
    • Ghoshal AK. New insight into the biochemical pathology of liver in choline deficiency. Crit Rev Biochem Mol Biol 1995;30:263–273. doi: 10.3109/10409239509083487.
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 263-273
    • Ghoshal, AK.1
  • 76
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004;39:1286–1296. doi: 10.1002/hep.20170.
    • (2004) Hepatology , vol.39 , pp. 1286-1296
    • Ip, E1    Farrell, G2    Hall, P3    Robertson, G4    Leclercq, I.5
  • 77
    • 0344010170 scopus 로고    scopus 로고
    • Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies
    • Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA, Woodburne VE, et al. Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J Gastroenterol Hepatol 2003;18:1272– 1282. doi: 10.1046/j.1440-1746.2003.03198.x.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1272-1282
    • Kirsch, R1    Clarkson, V2    Shephard, EG3    Marais, DA4    Jaffer, MA5    Woodburne, VE6
  • 78
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME, Green RM. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 2004;40:47– 51. doi: 10.1016/j.jhep.2003.09.020.
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, ME1    Green, RM.2
  • 79
    • 33845788135 scopus 로고    scopus 로고
    • Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone
    • Leclercq IA, Lebrun VA, Starkel P, Horsmans YJ. Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest 2007;87:56–65. doi: 10.1038/labinvest.3700489.
    • (2007) Lab Invest , vol.87 , pp. 56-65
    • Leclercq, IA1    Lebrun, VA2    Starkel, P3    Horsmans, YJ.4
  • 80
    • 70349416501 scopus 로고    scopus 로고
    • c-Jun Nterminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice
    • Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, de MS, et al. c-Jun Nterminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 2009;137:1467–1477. doi: 10.1053/j.gastro.2009.06.045.
    • (2009) Gastroenterology , vol.137 , pp. 1467-1477
    • Kodama, Y1    Kisseleva, T2    Iwaisako, K3    Miura, K4    Taura, K5    de, MS6
  • 81
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 2008;23:1635–1648. doi: 10.1111/j.1440-1746.2008.05543.x.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, CZ1    Yeh, MM.2
  • 82
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998;12:3182–3194. doi: 10.1101/gad.12.20.3182.
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I1    Hammer, RE2    Richardson, JA3    Ikemoto, S4    Bashmakov, Y5    Goldstein, JL6
  • 83
    • 33947264902 scopus 로고    scopus 로고
    • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
    • Nakayama H, Otabe S, Ueno T, Hirota N, Yuan X, Fukutani T, et al. Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. Metabolism 2007;56:470–475. doi: 10.1016/j.metabol.2006.11.004.
    • (2007) Metabolism , vol.56 , pp. 470-475
    • Nakayama, H1    Otabe, S2    Ueno, T3    Hirota, N4    Yuan, X5    Fukutani, T6
  • 84
    • 10744222107 scopus 로고    scopus 로고
    • Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
    • Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, et al. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci USA 2004;101:2082– 2087. doi: 10.1073/pnas.0308617100.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2082-2087
    • Stiles, B1    Wang, Y2    Stahl, A3    Bassilian, S4    Lee, WP5    Kim, YJ6
  • 85
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774–1783. doi: 10.1172/JCI20513.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y1    Suzuki, A2    Kataoka, E3    Sasaki, T4    Hamada, K5    Sasaki, J6
  • 86
    • 84886509630 scopus 로고    scopus 로고
    • In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)
    • Kanuri G, Bergheim I. In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD). Int J Mol Sci 2013;14:11963–11980.
    • (2013) Int J Mol Sci , vol.14 , pp. 11963-11980
    • Kanuri, G1    Bergheim, I.2
  • 87
    • 78649560195 scopus 로고    scopus 로고
    • Rosiglitazone attenuates age-and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice
    • Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, et al. Rosiglitazone attenuates age-and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology 2010;52: 2001–2011. doi: 10.1002/hep.23941.
    • (2010) Hepatology , vol.52 , pp. 2001-2011
    • Gupte, AA1    Liu, JZ2    Ren, Y3    Minze, LJ4    Wiles, JR5    Collins, AR6
  • 88
    • 0030981063 scopus 로고    scopus 로고
    • Leptin receptor of Zucker fatty rat performs reduced signal transduction
    • Yamashita T, Murakami T, Iida M, Kuwajima M, Shima K. Leptin receptor of Zucker fatty rat performs reduced signal transduction. Diabetes 1997;46: 1077–1080. doi: 10.2337/diab.46.6.1077.
    • (1997) Diabetes , vol.46 , pp. 1077-1080
    • Yamashita, T1    Murakami, T2    Iida, M3    Kuwajima, M4    Shima, K.5
  • 89
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 1997;94:2557–2562. doi: 10.1073/pnas.94.6.2557.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, SQ1    Lin, HZ2    Lane, MD3    Clemens, M4    Diehl, AM.5
  • 90
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005; 19:136–138.
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M1    Cederbaum, AI2    Nieto, N.3
  • 91
    • 33745651353 scopus 로고    scopus 로고
    • Fat aussie–a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis
    • Arsov T, Silva DG, O’Bryan MK, Sainsbury A, Lee NJ, Kennedy C, et al. Fat aussie–a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol 2006;20:1610– 1622. doi: 10.1210/me.2005-0494.
    • (2006) Mol Endocrinol , vol.20 , pp. 1610-1622
    • Arsov, T1    Silva, DG2    O’Bryan, MK3    Sainsbury, A4    Lee, NJ5    Kennedy, C6
  • 92
    • 33644897826 scopus 로고    scopus 로고
    • Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice
    • Arsov T, Larter CZ, Nolan CJ, Petrovsky N, Goodnow CC, Teoh NC, et al. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Commun 2006;342:1152–1159. doi: 10.1016/j.bbrc.2006.02.032.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 1152-1159
    • Arsov, T1    Larter, CZ2    Nolan, CJ3    Petrovsky, N4    Goodnow, CC5    Teoh, NC6
  • 93
    • 79955554762 scopus 로고    scopus 로고
    • Animal models for the study of liver fibrosis: new insights from knockout mouse models
    • Hayashi H, Sakai T. Animal models for the study of liver fibrosis: new insights from knockout mouse models. Am J Physiol Gastrointest Liver Physiol 2011;300:G729–G738. doi: 10.1152/ajpgi.00013.2011.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G729-G738
    • Hayashi, H1    Sakai, T.2
  • 94
    • 0041347547 scopus 로고    scopus 로고
    • AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4)
    • Kanno K, Tazuma S, Chayama K. AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4). Biochem Biophys Res Commun 2003;308:177–183. doi: 10.1016/S0006-291X(03)01357-3.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 177-183
    • Kanno, K1    Tazuma, S2    Chayama, K.3
  • 95
    • 33746561298 scopus 로고    scopus 로고
    • Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
    • Czochra P, Klopcic B, Meyer E, Herkel J, Garcia-Lazaro JF, Thieringer F, et al. Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J Hepatol 2006;45:419–428. doi: 10.1016/j.jhep.2006.04.010.
    • (2006) J Hepatol , vol.45 , pp. 419-428
    • Czochra, P1    Klopcic, B2    Meyer, E3    Herkel, J4    Garcia-Lazaro, JF5    Thieringer, F6
  • 96
    • 0028953768 scopus 로고
    • Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
    • Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 1995;92:2572–2576. doi: 10.1073/pnas.92.7.2572.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2572-2576
    • Sanderson, N1    Factor, V2    Nagy, P3    Kopp, J4    Kondaiah, P5    Wakefield, L6
  • 97
    • 84879808762 scopus 로고    scopus 로고
    • Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis
    • Nevzorova YA, Hu W, Cubero FJ, Haas U, Freimuth J, Tacke F, et al. Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Biochim Biophys Acta 2013;1832:1765–1775. doi: 10.1016/j.bbadis.2013.06.001.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1765-1775
    • Nevzorova, YA1    Hu, W2    Cubero, FJ3    Haas, U4    Freimuth, J5    Tacke, F6
  • 98
    • 84892904559 scopus 로고    scopus 로고
    • Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration
    • Mannaerts I, Schroyen B, Verhulst S, Van LL, Schuit F, Nyssen M, et al. Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration. PloS One 2013;8:e84071. doi: 10.1371/journal.pone.0084071.
    • (2013) PloS One , vol.8 , pp. e84071
    • Mannaerts, I1    Schroyen, B2    Verhulst, S3    Van, LL4    Schuit, F5    Nyssen, M6
  • 99
    • 34247619364 scopus 로고    scopus 로고
    • Gene expression profiles during hepatic stellate cell activation in culture and in vivo
    • de MS, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, et al. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007;132:1937–1946. doi: 10.1053/j.gastro.2007.02.033.
    • (2007) Gastroenterology , vol.132 , pp. 1937-1946
    • de, MS1    Seki, E2    Uchinami, H3    Kluwe, J4    Zhang, Y5    Brenner, DA6
  • 100
    • 21844465158 scopus 로고    scopus 로고
    • Genomic and functional characterization of stellate cells isolated from human cirrhotic livers
    • Sancho-Bru P, Bataller R, Gasull X, Colmenero J, Khurdayan V, Gual A, et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005;43:272–282. doi: 10.1016/j.jhep.2005.02.035.
    • (2005) J Hepatol , vol.43 , pp. 272-282
    • Sancho-Bru, P1    Bataller, R2    Gasull, X3    Colmenero, J4    Khurdayan, V5    Gual, A6
  • 101
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 2012; 142:938–946. doi: 10.1053/j.gastro.2011.12.044.
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernandez-Gea, V1    Ghiassi-Nejad, Z2    Rozenfeld, R3    Gordon, R4    Fiel, MI5    Yue, Z6
  • 103
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134: 657–667. doi: 10.1016/j.cell.2008.06.049.
    • (2008) Cell , vol.134 , pp. 657-667
    • Krizhanovsky, V1    Yon, M2    Dickins, RA3    Hearn, S4    Simon, J5    Miething, C6
  • 104
    • 84872128525 scopus 로고    scopus 로고
    • A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice
    • Puche JE, Lee YA, Jiao J, Aloman C, Fiel MI, Munoz U, et al. A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice. Hepatology 2013;57:339–350. doi: 10.1002/hep.26053.
    • (2013) Hepatology , vol.57 , pp. 339-350
    • Puche, JE1    Lee, YA2    Jiao, J3    Aloman, C4    Fiel, MI5    Munoz, U6
  • 105
    • 84888339170 scopus 로고    scopus 로고
    • Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
    • Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, et al. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 2013;4:2823. doi: 10.1038/ncomms3823.
    • (2013) Nat Commun , vol.4 , pp. 2823
    • Mederacke, I1    Hsu, CC2    Troeger, JS3    Huebener, P4    Mu, X5    Dapito, DH6
  • 106
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, PenzOsterreicher M, et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010;51:1027–1036. doi: 10.1002/hep.23368.
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, K1    Miura, K2    Iwaisako, K3    Osterreicher, CH4    Kodama, Y5    PenzOsterreicher, M6
  • 107
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, et al. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 2011;53: 1685–1695. doi: 10.1002/hep.24206.
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, AS1    Diaz, R2    Hui, JJ3    Yanger, K4    Zong, Y5    Alpini, G6
  • 108
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134:1655–1669. doi: 10.1053/j.gastro.2008.03.003.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, SL.1
  • 109
    • 84862195154 scopus 로고    scopus 로고
    • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
    • Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci USA 2012;109:9448–9453. doi: 10.1073/pnas.1201840109.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 9448-9453
    • Kisseleva, T1    Cong, M2    Paik, Y3    Scholten, D4    Jiang, C5    Benner, C6
  • 110
    • 0037268098 scopus 로고    scopus 로고
    • Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration
    • Issa R, Zhou X, Trim N, Millward-Sadler H, Krane S, Benyon C, et al. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J 2003;17:47–49.
    • (2003) FASEB J , vol.17 , pp. 47-49
    • Issa, R1    Zhou, X2    Trim, N3    Millward-Sadler, H4    Krane, S5    Benyon, C6
  • 111
    • 84908190503 scopus 로고    scopus 로고
    • CRISPR-mediated direct mutation of cancer genes in the mouse liver
    • Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 2014;514:380–384. doi: 10.1038/nature13589.
    • (2014) Nature , vol.514 , pp. 380-384
    • Xue, W1    Chen, S2    Yin, H3    Tammela, T4    Papagiannakopoulos, T5    Joshi, NS6
  • 112
    • 84862683094 scopus 로고    scopus 로고
    • Drug targeting to the diseased liver
    • Poelstra K, Prakash J, Beljaars L. Drug targeting to the diseased liver. J Control Release 2012;161:188–197. doi: 10.1016/j.jconrel.2012.02.011.
    • (2012) J Control Release , vol.161 , pp. 188-197
    • Poelstra, K1    Prakash, J2    Beljaars, L.3
  • 113
    • 41849117310 scopus 로고    scopus 로고
    • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
    • Sato Y, Murase K, Kato J, Kobune M, Sato T, Kawano Y, et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 2008;26:431–442. doi: 10.1038/nbt1396.
    • (2008) Nat Biotechnol , vol.26 , pp. 431-442
    • Sato, Y1    Murase, K2    Kato, J3    Kobune, M4    Sato, T5    Kawano, Y6
  • 114
    • 84877870673 scopus 로고    scopus 로고
    • Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis
    • Narmada BC, Kang Y, Venkatraman L, Peng Q, Sakban RB, Nugraha B, et al. Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis. Hum Gene Ther 2013;24:508– 519. doi: 10.1089/hum.2012.158.
    • (2013) Hum Gene Ther , vol.24 , pp. 508-519
    • Narmada, BC1    Kang, Y2    Venkatraman, L3    Peng, Q4    Sakban, RB5    Nugraha, B6
  • 115
    • 79960718862 scopus 로고    scopus 로고
    • Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice
    • Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K. Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice. Hepatology 2011;54:586–596. doi: 10.1002/hep.24395.
    • (2011) Hepatology , vol.54 , pp. 586-596
    • Bansal, R1    Prakash, J2    Post, E3    Beljaars, L4    Schuppan, D5    Poelstra, K.6
  • 116
    • 84888233058 scopus 로고    scopus 로고
    • Mice with human livers
    • Grompe M, Strom S. Mice with human livers. Gastroenterology 2013;145: 1209–1214. doi: 10.1053/j.gastro.2013.09.009.
    • (2013) Gastroenterology , vol.145 , pp. 1209-1214
    • Grompe, M1    Strom, S.2
  • 117
    • 84880396558 scopus 로고    scopus 로고
    • Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models
    • Bility MT, Li F, Cheng L, Su L. Liver immune-pathogenesis and therapy of human liver tropic virus infection in humanized mouse models. J Gastroenterol Hepatol 2013;28:120–124. doi: 10.1111/jgh.12092.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 120-124
    • Bility, MT1    Li, F2    Cheng, L3    Su, L.4
  • 118
    • 84897420281 scopus 로고    scopus 로고
    • Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages
    • Bility MT, Cheng L, Zhang Z, Luan Y, Li F, Chi L, et al. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS Pathog 2014;10:e1004032. doi: 10.1371/journal.ppat.1004032.
    • (2014) PLoS Pathog , vol.10 , pp. e1004032
    • Bility, MT1    Cheng, L2    Zhang, Z3    Luan, Y4    Li, F5    Chi, L6
  • 119
    • 0027958462 scopus 로고
    • Immunohistochemical study of hepatic fibrosis induced in rats by multiple galactosamine injections
    • Jonker AM, Dijkhuis FW, Hardonk MJ, Moerkerk P, Ten KJ, Grond J. Immunohistochemical study of hepatic fibrosis induced in rats by multiple galactosamine injections. Hepatology 1994;19:775–781. doi: 10.1002/hep.1840190334.
    • (1994) Hepatology , vol.19 , pp. 775-781
    • Jonker, AM1    Dijkhuis, FW2    Hardonk, MJ3    Moerkerk, P4    Ten, KJ5    Grond, J.6
  • 120
    • 84875056271 scopus 로고    scopus 로고
    • An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis
    • Matsumoto M, Hada N, Sakamaki Y, Uno A, Shiga T, Tanaka C, et al. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol 2013;94:93–103. doi: 10.1111/iep.12008.
    • (2013) Int J Exp Pathol , vol.94 , pp. 93-103
    • Matsumoto, M1    Hada, N2    Sakamaki, Y3    Uno, A4    Shiga, T5    Tanaka, C6
  • 121
    • 71549163153 scopus 로고    scopus 로고
    • A novel model of CCl4-induced cirrhosis with ascites in the mouse
    • Domenicali M, Caraceni P, Giannone F, Baldassarre M, Lucchetti G, Quarta C, et al. A novel model of CCl4-induced cirrhosis with ascites in the mouse. J Hepatol 2009;51:991–999. doi: 10.1016/j.jhep.2009.09.008.
    • (2009) J Hepatol , vol.51 , pp. 991-999
    • Domenicali, M1    Caraceni, P2    Giannone, F3    Baldassarre, M4    Lucchetti, G5    Quarta, C6
  • 122
    • 0026512122 scopus 로고
    • Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease
    • Jimenez W, Claria J, Arroyo V, Rodes J. Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease. J Gastroenterol Hepatol 1992;7:90–97. doi: 10.1111/j.1440-1746.1992.tb00940.x.
    • (1992) J Gastroenterol Hepatol , vol.7 , pp. 90-97
    • Jimenez, W1    Claria, J2    Arroyo, V3    Rodes, J.4
  • 124
    • 33744956853 scopus 로고    scopus 로고
    • Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
    • Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem 2006;281:15090–15098. doi: 10.1074/jbc.M600030200.
    • (2006) J Biol Chem , vol.281 , pp. 15090-15098
    • Popov, Y1    Patsenker, E2    Bauer, M3    Niedobitek, E4    Schulze-Krebs, A5    Schuppan, D.6
  • 125
    • 0033913769 scopus 로고    scopus 로고
    • Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1
    • Wang T, Shankar K, Ronis MJ, Mehendale HM. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J Pharmacol Exp Ther 2000;294:473–479.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 473-479
    • Wang, T1    Shankar, K2    Ronis, MJ3    Mehendale, HM.4
  • 126
    • 68849118378 scopus 로고    scopus 로고
    • Experimental mouse models for hepatocellular carcinoma research
    • Heindryckx F, Colle I, Van VH. Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 2009;90:367–386. doi: 10.1111/j.1365-2613.2009.00656.x.
    • (2009) Int J Exp Pathol , vol.90 , pp. 367-386
    • Heindryckx, F1    Colle, I2    Van, VH.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.