Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 10, 2013, Pages 1765-1775

  Nevzorova, Yulia A ^a   Hu, Wei ^a   Cubero, Francisco J ^a   Haas, Ute ^a   Freimuth, Julia ^a,b   Tacke, Frank ^a   Trautwein, Christian ^a   Liedtke, Christian ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell cycle; Hepatic stellate cell activation; Hepatocellular carcinoma; Liver fibrosis; Myofibroblast

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CARBON TETRACHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; UPREGULATION; WILD TYPE;

Α-SMA; ALPHA-SMOOTH-MUSCLE-ACTIN; CARBON TETRACHLORIDE; CCL(4); CELL CYCLE; HCC; HEPATIC STELLATE CELL ACTIVATION; HEPATIC STELLATE CELLS; HEPATOCELLULAR CARCINOMA; HSC; LIVER FIBROSIS; MYOFIBROBLAST; NON-PARENCHYMAL CELLS; NPC; PCNA; PROLIFERATING CELL NUCLEAR ANTIGEN; QPCR; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; WILDTYPE; WT;

ANIMALS; HEPATIC STELLATE CELLS; HEPATOCYTES; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION;

MUS;

EID: 84879808762     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.06.001     Document Type: Article

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