Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis

Human Gene Therapy

Volumn 24, Issue 5, 2013, Pages 508-519

  Narmada, Balakrishnan Chakrapani ^a,b,c   Kang, Yuzhan ^d   Venkatraman, Lakshmi ^b,e   Peng, Qiwen ^c,e   Sakban, Rashidah Binte ^a   Nugraha, Bramasta ^a,b,c   Jiang, Xuan ^f   Bunte, Ralph M ^g   So, Peter T C ^d,e,h   Tucker Kellogg, Lisa ^b,e   Mao, Hai Quan ^f   Yu, Hanry ^a,b,c,d,e,h  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^d SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^e SINGAPORE MIT ALLIANCE   (Singapore)

^f Johns Hopkins University   (United States)

^g DUKE NUS MEDICAL SCHOOL   (Singapore)

^h Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; DIMETHYLNITROSAMINE; LIPOSOME; PLASMID VECTOR; RETINOL; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL CULTURE; CONTROLLED STUDY; ENCAPSULATION; GENE DELIVERY SYSTEM; GENE EXPRESSION; IN VITRO STUDY; LIVER FIBROSIS; LIVER SINUSOID; MALE; NONHUMAN; PLASMID; RAT; STELLATE CELL; TRANSGENICS;

ANIMALS; BILE DUCTS; DIMETHYLNITROSAMINE; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HEPATIC STELLATE CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; LIPOSOMES; LIVER; LIVER CIRRHOSIS; RATS; TRANSGENES;

EID: 84877870673     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2012.158     Document Type: Article

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