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Volumn 6, Issue JAN, 2016, Pages

Cytokine-defined B cell responses as therapeutic targets in multiple sclerosis

Author keywords

B cell modulation; B cell depletion; B lymphocytes; Cytokine defined responses; Immune modulation; Multiple sclerosis

Indexed keywords

ALEMTUZUMAB; ATACICEPT; CD20 ANTIBODY; FINGOLIMOD; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 35; INTERLEUKIN 6; LYMPHOTOXIN; MITOXANTRONE; NATALIZUMAB; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84958177796     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00626     Document Type: Short Survey
Times cited : (76)

References (140)
  • 1
    • 84933278364 scopus 로고    scopus 로고
    • Antibody-independent functions of B cells: a focus on cytokines
    • Shen P, Fillatreau S. Antibody-independent functions of B cells: a focus on cytokines. Nat Rev Immunol (2015) 15(7):441-51. doi: 10.1038/nri3857
    • (2015) Nat Rev Immunol , vol.15 , Issue.7 , pp. 441-451
    • Shen, P.1    Fillatreau, S.2
  • 2
    • 0031748566 scopus 로고    scopus 로고
    • Multiple sclerosis: in situ evidence for antibody-and complement-mediated demyelination
    • Storch MK, Piddlesden S, Haltia M, Iivanainen M, Morgan P, Lassmann H. Multiple sclerosis: in situ evidence for antibody-and complement-mediated demyelination. Ann Neurol (1998) 43(4):465-71. doi:10.1002/ana.410430409
    • (1998) Ann Neurol , vol.43 , Issue.4 , pp. 465-471
    • Storch, M.K.1    Piddlesden, S.2    Haltia, M.3    Iivanainen, M.4    Morgan, P.5    Lassmann, H.6
  • 3
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med (1999) 5(2):170-5. doi:10.1038/5532
    • (1999) Nat Med , vol.5 , Issue.2 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 4
    • 0032839687 scopus 로고    scopus 로고
    • Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation
    • Raine CS, Cannella B, Hauser SL, Genain CP. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann Neurol (1999) 46(2):144-60. doi:10.1002/1531-8249(199908)46:2<144::AID-ANA3>3.0.CO;2-K
    • (1999) Ann Neurol , vol.46 , Issue.2 , pp. 144-160
    • Raine, C.S.1    Cannella, B.2    Hauser, S.L.3    Genain, C.P.4
  • 5
    • 0021811854 scopus 로고
    • Immunoglobulin G, A, and M-clonal restriction in multiple sclerosis cerebrospinal fluid and serum-analysis by two-dimensional electrophoresis
    • Walsh MJ, Tourtellotte WW, Roman J, Dreyer W. Immunoglobulin G, A, and M-clonal restriction in multiple sclerosis cerebrospinal fluid and serum-analysis by two-dimensional electrophoresis. Clin Immunol Immunopathol (1985) 35(3):313-27. doi:10.1016/0090-1229(85)90092-3
    • (1985) Clin Immunol Immunopathol , vol.35 , Issue.3 , pp. 313-327
    • Walsh, M.J.1    Tourtellotte, W.W.2    Roman, J.3    Dreyer, W.4
  • 6
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med (2008) 358(7):676-88. doi:10.1056/NEJMoa0706383
    • (2008) N Engl J Med , vol.358 , Issue.7 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3    Vollmer, T.4    Antel, J.5    Fox, R.J.6
  • 7
    • 41849116363 scopus 로고    scopus 로고
    • Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial
    • Bar-Or A, Calabresi PA, Arnold D, Markowitz C, Shafer S, Kasper LH, et al. Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol (2008) 63(3):395-400. doi:10.1002/ana.21363
    • (2008) Ann Neurol , vol.63 , Issue.3 , pp. 395-400
    • Bar-Or, A.1    Calabresi, P.A.2    Arnold, D.3    Markowitz, C.4    Shafer, S.5    Kasper, L.H.6
  • 8
    • 81555202418 scopus 로고    scopus 로고
    • Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial
    • Kappos L, Li D, Calabresi PA, O'Connor P, Bar-Or A, Barkhof F, et al. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet (2011) 378(9805):1779-87. doi:10.1016/S0140-6736(11)61649-8
    • (2011) Lancet , vol.378 , Issue.9805 , pp. 1779-1787
    • Kappos, L.1    Li, D.2    Calabresi, P.A.3    O'Connor, P.4    Bar-Or, A.5    Barkhof, F.6
  • 9
    • 84895734917 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: a phase 2 study
    • Sorensen PS, Lisby S, Grove R, Derosier F, Shackelford S, Havrdova E, et al. Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: a phase 2 study. Neurology (2014) 82(7):573-81. doi:10.1212/WNL.0000000000000125
    • (2014) Neurology , vol.82 , Issue.7 , pp. 573-581
    • Sorensen, P.S.1    Lisby, S.2    Grove, R.3    Derosier, F.4    Shackelford, S.5    Havrdova, E.6
  • 10
    • 84945967457 scopus 로고    scopus 로고
    • The MIRROR Study: a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study to investigate the safety and MRI efficacy of subcutaneous ofatumumab in subjects with relapsing-remitting multiple sclerosis (RRMS)
    • Bar-Or A, Grove RA, Austin DJ, Tolson JM, VanMeter SA, Lewis E, et al. The MIRROR Study: a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study to investigate the safety and MRI efficacy of subcutaneous ofatumumab in subjects with relapsing-remitting multiple sclerosis (RRMS). Neurology (2014) 82(10 Suppl):S23.006.
    • (2014) Neurology , vol.82 , Issue.10
    • Bar-Or, A.1    Grove, R.A.2    Austin, D.J.3    Tolson, J.M.4    VanMeter, S.A.5    Lewis, E.6
  • 11
    • 77951757865 scopus 로고    scopus 로고
    • Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
    • Bar-Or A, Fawaz L, Fan B, Darlington PJ, Rieger A, Ghorayeb C, et al. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol (2010) 67(4):452-61. doi:10.1002/ana.21939
    • (2010) Ann Neurol , vol.67 , Issue.4 , pp. 452-461
    • Bar-Or, A.1    Fawaz, L.2    Fan, B.3    Darlington, P.J.4    Rieger, A.5    Ghorayeb, C.6
  • 12
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol (2010) 10(3):170-81. doi:10.1038/nri2711
    • (2010) Nat Rev Immunol , vol.10 , Issue.3 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 15
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest (2008) 118(10):3420-30. doi:10.1172/JCI36030
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3420-3430
    • Matsushita, T.1    Yanaba, K.2    Bouaziz, J.D.3    Fujimoto, M.4    Tedder, T.F.5
  • 16
    • 84868619716 scopus 로고    scopus 로고
    • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
    • Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature (2012) 491(7423):264-8. doi:10.1038/nature11501
    • (2012) Nature , vol.491 , Issue.7423 , pp. 264-268
    • Yoshizaki, A.1    Miyagaki, T.2    DiLillo, D.J.3    Matsushita, T.4    Horikawa, M.5    Kountikov, E.I.6
  • 17
    • 84918559452 scopus 로고    scopus 로고
    • Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation
    • Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, et al. Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity (2014) 41(6):1040-51. doi:10.1016/j.immuni.2014.10.016
    • (2014) Immunity , vol.41 , Issue.6 , pp. 1040-1051
    • Matsumoto, M.1    Baba, A.2    Yokota, T.3    Nishikawa, H.4    Ohkawa, Y.5    Kayama, H.6
  • 18
    • 84918498099 scopus 로고    scopus 로고
    • Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production
    • Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, et al. Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production. Nat Med (2014) 20(11):1334-9. doi:10.1038/nm.3680
    • (2014) Nat Med , vol.20 , Issue.11 , pp. 1334-1339
    • Rosser, E.C.1    Oleinika, K.2    Tonon, S.3    Doyle, R.4    Bosma, A.5    Carter, N.A.6
  • 19
    • 1542514778 scopus 로고    scopus 로고
    • Distinct profiles of human B cell effector cytokines: a role in immune regulation?
    • Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol (2004) 172(6):3422-7. doi:10.4049/jimmunol.172.6.3422
    • (2004) J Immunol , vol.172 , Issue.6 , pp. 3422-3427
    • Duddy, M.E.1    Alter, A.2    Bar-Or, A.3
  • 20
    • 74649083783 scopus 로고    scopus 로고
    • CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
    • Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity (2010) 32(1):129-40. doi:10.1016/j.immuni.2009.11.009
    • (2010) Immunity , vol.32 , Issue.1 , pp. 129-140
    • Blair, P.A.1    Norena, L.Y.2    Flores-Borja, F.3    Rawlings, D.J.4    Isenberg, D.A.5    Ehrenstein, M.R.6
  • 21
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood (2011) 117(2):530-41. doi:10.1182/blood-2010-07-294249
    • (2011) Blood , vol.117 , Issue.2 , pp. 530-541
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3    Dilillo, D.J.4    Yanaba, K.5    Venturi, G.M.6
  • 22
    • 44349188750 scopus 로고    scopus 로고
    • B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators
    • Rieger A, Bar-Or A. B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators. Nat Rev Immunol (2008) 8(6):486-7. doi:10.1038/nri2315-c1
    • (2008) Nat Rev Immunol , vol.8 , Issue.6 , pp. 486-487
    • Rieger, A.1    Bar-Or, A.2
  • 23
    • 84907465818 scopus 로고    scopus 로고
    • A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis
    • Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, et al. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. PLoS One (2014) 9(8):e105421. doi:10.1371/journal.pone.0105421
    • (2014) PLoS One , vol.9 , Issue.8
    • Miyazaki, Y.1    Li, R.2    Rezk, A.3    Misirliyan, H.4    Moore, C.5    Farooqi, N.6
  • 24
    • 34248230257 scopus 로고    scopus 로고
    • Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis
    • Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, et al. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol (2007) 178(10):6092-9. doi:10.4049/jimmunol.178.10.6092
    • (2007) J Immunol , vol.178 , Issue.10 , pp. 6092-6099
    • Duddy, M.1    Niino, M.2    Adatia, F.3    Hebert, S.4    Freedman, M.5    Atkins, H.6
  • 25
    • 33847679709 scopus 로고    scopus 로고
    • Association between parasite infection and immune responses in multiple sclerosis
    • Correale J, Farez M. Association between parasite infection and immune responses in multiple sclerosis. Ann Neurol (2007) 61(2):97-108. doi:10.1002/ana.21067
    • (2007) Ann Neurol , vol.61 , Issue.2 , pp. 97-108
    • Correale, J.1    Farez, M.2
  • 26
    • 84864124859 scopus 로고    scopus 로고
    • IL-12 family cytokines: immunological playmakers
    • Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol (2012) 13(8):722-8. doi:10.1038/ni.2366
    • (2012) Nat Immunol , vol.13 , Issue.8 , pp. 722-728
    • Vignali, D.A.1    Kuchroo, V.K.2
  • 27
    • 0030067819 scopus 로고    scopus 로고
    • A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    • Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, KieffE, et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol (1996) 70(2):1143-53.
    • (1996) J Virol , vol.70 , Issue.2 , pp. 1143-1153
    • Devergne, O.1    Hummel, M.2    Koeppen, H.3    Le Beau, M.M.4    Nathanson, E.C.5    Kieff, E.6
  • 28
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 450(7169):566-9. doi:10.1038/nature06306
    • (2007) Nature , vol.450 , Issue.7169 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5    Vignali, K.M.6
  • 29
    • 75149158969 scopus 로고    scopus 로고
    • Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC
    • Seyerl M, Kirchberger S, Majdic O, Seipelt J, Jindra C, Schrauf C, et al. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol (2010) 40(2):321-9. doi:10.1002/eji.200939527
    • (2010) Eur J Immunol , vol.40 , Issue.2 , pp. 321-329
    • Seyerl, M.1    Kirchberger, S.2    Majdic, O.3    Seipelt, J.4    Jindra, C.5    Schrauf, C.6
  • 30
    • 79959572627 scopus 로고    scopus 로고
    • Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance
    • Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA. Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol (2011) 186(12):6661-6. doi:10.4049/jimmunol.1100315
    • (2011) J Immunol , vol.186 , Issue.12 , pp. 6661-6666
    • Chaturvedi, V.1    Collison, L.W.2    Guy, C.S.3    Workman, C.J.4    Vignali, D.A.5
  • 31
    • 84897027520 scopus 로고    scopus 로고
    • IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
    • Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, et al. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature (2014) 507(7492):366-70. doi:10.1038/nature12979
    • (2014) Nature , vol.507 , Issue.7492 , pp. 366-370
    • Shen, P.1    Roch, T.2    Lampropoulou, V.3    O'Connor, R.A.4    Stervbo, U.5    Hilgenberg, E.6
  • 32
    • 84902078796 scopus 로고    scopus 로고
    • Interleukin-35 induces regulatory B cells that suppress autoimmune disease
    • Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV, et al. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med (2014) 20(6):633-41. doi:10.1038/nm.3554
    • (2014) Nat Med , vol.20 , Issue.6 , pp. 633-641
    • Wang, R.X.1    Yu, C.R.2    Dambuza, I.M.3    Mahdi, R.M.4    Dolinska, M.B.5    Sergeev, Y.V.6
  • 33
    • 0029808482 scopus 로고    scopus 로고
    • Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection
    • Caver TE, O'Sullivan FX, Gold LI, Gresham HD. Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection. J Clin Invest (1996) 98(11):2496-506. doi:10.1172/JCI119068
    • (1996) J Clin Invest , vol.98 , Issue.11 , pp. 2496-2506
    • Caver, T.E.1    O'Sullivan, F.X.2    Gold, L.I.3    Gresham, H.D.4
  • 34
    • 0037606009 scopus 로고    scopus 로고
    • B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-1
    • Parekh VV, Prasad DVR, Banerjee PP, Joshi BN, Kumar A, Mishra GC. B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-1. J Immunol (2003) 170(12):5897-911. doi:10.4049/jimmunol.170.12.5897
    • (2003) J Immunol , vol.170 , Issue.12 , pp. 5897-5911
    • Parekh, V.V.1    Prasad, D.V.R.2    Banerjee, P.P.3    Joshi, B.N.4    Kumar, A.5    Mishra, G.C.6
  • 35
    • 84901823579 scopus 로고    scopus 로고
    • TGF-beta-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
    • Lee KM, Stott RT, Zhao G, SooHoo J, Xiong W, Lian MM, et al. TGF-beta-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance. Eur J Immunol (2014) 44(6):1728-36. doi:10.1002/eji.201344062
    • (2014) Eur J Immunol , vol.44 , Issue.6 , pp. 1728-1736
    • Lee, K.M.1    Stott, R.T.2    Zhao, G.3    SooHoo, J.4    Xiong, W.5    Lian, M.M.6
  • 36
    • 33750626239 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation
    • Jahrsdorfer B, Blackwell SE, Wooldridge JE, Huang J, Andreski MW, Jacobus LS, et al. B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood (2006) 108(8):2712-9. doi:10.1182/blood-2006-03-014001
    • (2006) Blood , vol.108 , Issue.8 , pp. 2712-2719
    • Jahrsdorfer, B.1    Blackwell, S.E.2    Wooldridge, J.E.3    Huang, J.4    Andreski, M.W.5    Jacobus, L.S.6
  • 37
    • 68149099548 scopus 로고    scopus 로고
    • Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21
    • Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol (2009) 183(3):1838-45. doi:10.4049/jimmunol.0901066
    • (2009) J Immunol , vol.183 , Issue.3 , pp. 1838-1845
    • Hagn, M.1    Schwesinger, E.2    Ebel, V.3    Sontheimer, K.4    Maier, J.5    Beyer, T.6
  • 38
    • 77954122576 scopus 로고    scopus 로고
    • CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B
    • Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, Beyer T, et al. CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B. Eur J Immunol (2010) 40(7):2060-9. doi:10.1002/eji.200940113
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 2060-2069
    • Hagn, M.1    Ebel, V.2    Sontheimer, K.3    Schwesinger, E.4    Lunov, O.5    Beyer, T.6
  • 39
    • 84859947465 scopus 로고    scopus 로고
    • Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help
    • Hagn M, Sontheimer K, Dahlke K, Brueggemann S, Kaltenmeier C, Beyer T, et al. Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help. Immunol Cell Biol (2012) 90(4):457-67. doi:10.1038/icb.2011.64
    • (2012) Immunol Cell Biol , vol.90 , Issue.4 , pp. 457-467
    • Hagn, M.1    Sontheimer, K.2    Dahlke, K.3    Brueggemann, S.4    Kaltenmeier, C.5    Beyer, T.6
  • 40
    • 38549102077 scopus 로고    scopus 로고
    • TNF-mediated inflammatory disease
    • Bradley JR. TNF-mediated inflammatory disease. J Pathol (2008) 214(2):149-60. doi:10.1002/path.2287
    • (2008) J Pathol , vol.214 , Issue.2 , pp. 149-160
    • Bradley, J.R.1
  • 41
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    • Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol (2001) 19:163-96. doi:10.1146/annurev.immunol.19.1.163
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 42
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol (2014) 14(5):329-42. doi:10.1038/nri3661
    • (2014) Nat Rev Immunol , vol.14 , Issue.5 , pp. 329-342
    • Neurath, M.F.1
  • 43
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • Arnason BGW, Jacobs G, Hanlon M, Harding B, Noronha ABC, Auty A, et al. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology (1999) 53(3):457-65. doi:10.1212/WNL.53.3.457
    • (1999) Neurology , vol.53 , Issue.3 , pp. 457-465
    • Arnason, B.G.W.1    Jacobs, G.2    Hanlon, M.3    Harding, B.4    Noronha, A.B.C.5    Auty, A.6
  • 44
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: from basic science to medicine-40 years in immunology
    • Kishimoto T. Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol (2005) 23:1-21. doi:10.1146/annurev.immunol.23.021704.115806
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 45
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441(7090):235-8. doi:10.1038/nature04753
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 46
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol (2010) 40(7):1830-5. doi:10.1002/eji.201040391
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 47
    • 57449112782 scopus 로고    scopus 로고
    • IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    • Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 105(47):18460-5. doi:10.1073/pnas.0809850105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.47 , pp. 18460-18465
    • Korn, T.1    Mitsdoerffer, M.2    Croxford, A.L.3    Awasthi, A.4    Dardalhon, V.A.5    Galileos, G.6
  • 48
    • 84874099546 scopus 로고    scopus 로고
    • In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling
    • Schneider A, Long SA, Cerosaletti K, Ni CT, Samuels P, Kita M, et al. In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci Transl Med (2013) 5(170):170ra15. doi:10.1126/scitranslmed.3004970
    • (2013) Sci Transl Med , vol.5 , Issue.170
    • Schneider, A.1    Long, S.A.2    Cerosaletti, K.3    Ni, C.T.4    Samuels, P.5    Kita, M.6
  • 49
    • 84899124414 scopus 로고    scopus 로고
    • Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol (2014) 15(5):423-30. doi:10.1038/ni.2865
    • (2014) Nat Immunol , vol.15 , Issue.5 , pp. 423-430
    • Mauer, J.1    Chaurasia, B.2    Goldau, J.3    Vogt, M.C.4    Ruud, J.5    Nguyen, K.D.6
  • 50
    • 84863803849 scopus 로고    scopus 로고
    • B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells
    • Barr TA, Shen P, Brown S, Lampropoulou V, Roch T, Lawrie S, et al. B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. J Exp Med (2012) 209(5):1001-10. doi:10.1084/jem.20111675
    • (2012) J Exp Med , vol.209 , Issue.5 , pp. 1001-1010
    • Barr, T.A.1    Shen, P.2    Brown, S.3    Lampropoulou, V.4    Roch, T.5    Lawrie, S.6
  • 51
    • 84890819172 scopus 로고    scopus 로고
    • MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
    • MolnarfiN, Schulze-TopphoffU, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med (2013) 210(13):2921-37. doi:10.1084/jem.20130699
    • (2013) J Exp Med , vol.210 , Issue.13 , pp. 2921-2937
    • Molnarfi, N.1    Schulze-Topphoff, U.2    Weber, M.S.3    Patarroyo, J.C.4    Prod'homme, T.5    Varrin-Doyer, M.6
  • 52
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma A, Koka R, Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol (2006) 24:657-79. doi:10.1146/annurev.immunol.24.021605.090727
    • (2006) Annu Rev Immunol , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 53
    • 77549084952 scopus 로고    scopus 로고
    • Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
    • Gomez-Nicola D, Spagnolo A, Guaza C, Nieto-Sampedro M. Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Exp Neurol (2010) 222(2):235-42. doi:10.1016/j.expneurol.2009.12.034
    • (2010) Exp Neurol , vol.222 , Issue.2 , pp. 235-242
    • Gomez-Nicola, D.1    Spagnolo, A.2    Guaza, C.3    Nieto-Sampedro, M.4
  • 54
    • 84867911546 scopus 로고    scopus 로고
    • The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes
    • Pandiyan P, Yang XP, Saravanamuthu SS, Zheng L, Ishihara S, O'Shea JJ, et al. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. J Immunol (2012) 189(9):4237-46. doi:10.4049/jimmunol.1201476
    • (2012) J Immunol , vol.189 , Issue.9 , pp. 4237-4246
    • Pandiyan, P.1    Yang, X.P.2    Saravanamuthu, S.S.3    Zheng, L.4    Ishihara, S.5    O'Shea, J.J.6
  • 55
    • 84916879284 scopus 로고    scopus 로고
    • IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells
    • Yu P, Bamford RN, Waldmann TA. IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. Eur J Immunol (2014) 44(11):3330-41. doi:10.1002/eji.201444675
    • (2014) Eur J Immunol , vol.44 , Issue.11 , pp. 3330-3341
    • Yu, P.1    Bamford, R.N.2    Waldmann, T.A.3
  • 56
    • 0036293507 scopus 로고    scopus 로고
    • Increased levels of IL-15 mRNA in relapsing-remitting multiple sclerosis attacks
    • Blanco-Jerez C, Plaza JF, Masjuan J, Orensanz LM, Alvarez-Cermeno JC. Increased levels of IL-15 mRNA in relapsing-remitting multiple sclerosis attacks. J Neuroimmunol (2002) 128(1-2):90-4. doi:10.1016/S0165-5728(02)00146-7
    • (2002) J Neuroimmunol , vol.128 , Issue.1-2 , pp. 90-94
    • Blanco-Jerez, C.1    Plaza, J.F.2    Masjuan, J.3    Orensanz, L.M.4    Alvarez-Cermeno, J.C.5
  • 57
    • 30944440017 scopus 로고    scopus 로고
    • IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis
    • Rentzos M, Cambouri C, Rombos A, Nikolaou C, Anagnostouli M, Tsoutsou A, et al. IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis. J Neurol Sci (2006) 241(1-2):25-9. doi:10.1016/j.jns.2005.10.003
    • (2006) J Neurol Sci , vol.241 , Issue.1-2 , pp. 25-29
    • Rentzos, M.1    Cambouri, C.2    Rombos, A.3    Nikolaou, C.4    Anagnostouli, M.5    Tsoutsou, A.6
  • 58
    • 78650650984 scopus 로고    scopus 로고
    • Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis
    • Saikali P, Antel JP, Pittet CL, Newcombe J, Arbour N. Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis. J Immunol (2010) 185(10):5693-703. doi:10.4049/jimmunol.1002188
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 5693-5703
    • Saikali, P.1    Antel, J.P.2    Pittet, C.L.3    Newcombe, J.4    Arbour, N.5
  • 59
    • 80054774245 scopus 로고    scopus 로고
    • B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients
    • Schneider R, Mohebiany AN, Ifergan I, Beauseigle D, Duquette P, Prat A, et al. B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. J Immunol (2011) 187(8):4119-28. doi:10.4049/jimmunol.1100885
    • (2011) J Immunol , vol.187 , Issue.8 , pp. 4119-4128
    • Schneider, R.1    Mohebiany, A.N.2    Ifergan, I.3    Beauseigle, D.4    Duquette, P.5    Prat, A.6
  • 60
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol (2008) 8(7):533-44. doi:10.1038/nri2356
    • (2008) Nat Rev Immunol , vol.8 , Issue.7 , pp. 533-544
    • Hamilton, J.A.1
  • 61
    • 0035476518 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    • McQualter JL, Darwiche R, Ewing C, Onuki M, Kay TW, Hamilton JA, et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J Exp Med (2001) 194(7):873-82. doi:10.1084/jem.194.7.873
    • (2001) J Exp Med , vol.194 , Issue.7 , pp. 873-882
    • McQualter, J.L.1    Darwiche, R.2    Ewing, C.3    Onuki, M.4    Kay, T.W.5    Hamilton, J.A.6
  • 62
    • 33846018916 scopus 로고    scopus 로고
    • GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    • Ponomarev ED, Shriver LP, Maresz K, Pedras-Vasconcelos J, Verthelyi D, Dittel BN. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J Immunol (2007) 178(1):39-48. doi:10.4049/jimmunol.178.1.39
    • (2007) J Immunol , vol.178 , Issue.1 , pp. 39-48
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Pedras-Vasconcelos, J.4    Verthelyi, D.5    Dittel, B.N.6
  • 63
    • 79956116032 scopus 로고    scopus 로고
    • RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, et al. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol (2011) 12(6):560-7. doi:10.1038/ni.2027
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 560-567
    • Codarri, L.1    Gyulveszi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6
  • 64
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF
    • El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF. Nat Immunol (2011) 12(6):568-75. doi:10.1038/ni.2031
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6
  • 65
    • 84923369912 scopus 로고    scopus 로고
    • Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells
    • Hartmann FJ, Khademi M, Aram J, Ammann S, Kockum I, Constantinescu C, et al. Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells. Nat Commun (2014) 5:5056. doi:10.1038/ncomms6056
    • (2014) Nat Commun , vol.5 , pp. 5056
    • Hartmann, F.J.1    Khademi, M.2    Aram, J.3    Ammann, S.4    Kockum, I.5    Constantinescu, C.6
  • 66
    • 84903783415 scopus 로고    scopus 로고
    • IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells
    • Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, et al. IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci Transl Med (2014) 6(241):241ra80. doi:10.1126/scitranslmed.3008706
    • (2014) Sci Transl Med , vol.6 , Issue.241
    • Noster, R.1    Riedel, R.2    Mashreghi, M.F.3    Radbruch, H.4    Harms, L.5    Haftmann, C.6
  • 67
    • 84929649614 scopus 로고    scopus 로고
    • Expression of GM-CSF in T cells is increased in multiple sclerosis and suppressed by IFN-beta therapy
    • Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, et al. Expression of GM-CSF in T cells is increased in multiple sclerosis and suppressed by IFN-beta therapy. J Immunol (2015) 194(11):5085-93. doi:10.4049/jimmunol.1403243
    • (2015) J Immunol , vol.194 , Issue.11 , pp. 5085-5093
    • Rasouli, J.1    Ciric, B.2    Imitola, J.3    Gonnella, P.4    Hwang, D.5    Mahajan, K.6
  • 68
    • 84876787121 scopus 로고    scopus 로고
    • Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
    • Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature (2013) 496(7446):518-22. doi:10.1038/nature11868
    • (2013) Nature , vol.496 , Issue.7446 , pp. 518-522
    • Kleinewietfeld, M.1    Manzel, A.2    Titze, J.3    Kvakan, H.4    Yosef, N.5    Linker, R.A.6
  • 69
    • 84856655455 scopus 로고    scopus 로고
    • Innate response activator B cells protect against microbial sepsis
    • Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, et al. Innate response activator B cells protect against microbial sepsis. Science (2012) 335(6068):597-601. doi:10.1126/science.1215173
    • (2012) Science , vol.335 , Issue.6068 , pp. 597-601
    • Rauch, P.J.1    Chudnovskiy, A.2    Robbins, C.S.3    Weber, G.F.4    Etzrodt, M.5    Hilgendorf, I.6
  • 70
    • 84901775867 scopus 로고    scopus 로고
    • Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
    • Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, et al. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med (2014) 211(6):1243-56. doi:10.1084/jem.20131471
    • (2014) J Exp Med , vol.211 , Issue.6 , pp. 1243-1256
    • Weber, G.F.1    Chousterman, B.G.2    Hilgendorf, I.3    Robbins, C.S.4    Theurl, I.5    Gerhardt, L.M.6
  • 71
    • 84899075437 scopus 로고    scopus 로고
    • Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity
    • Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation (2014) 129(16):1677-87. doi:10.1161/CIRCULATIONAHA.113.006381
    • (2014) Circulation , vol.129 , Issue.16 , pp. 1677-1687
    • Hilgendorf, I.1    Theurl, I.2    Gerhardt, L.M.3    Robbins, C.S.4    Weber, G.F.5    Gonen, A.6
  • 72
    • 84945538148 scopus 로고    scopus 로고
    • Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy
    • Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, et al. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Sci Transl Med (2015) 7(310):310ra166. doi:10.1126/scitranslmed.aab4176
    • (2015) Sci Transl Med , vol.7 , Issue.310
    • Li, R.1    Rezk, A.2    Miyazaki, Y.3    Hilgenberg, E.4    Touil, H.5    Shen, P.6
  • 73
    • 0023425428 scopus 로고
    • Oligoclonal IgG bands in cerebrospinal fluid. Principles for demonstration and interpretation based on findings in 1114 neurological patients
    • Kostulas VK, Link H, Lefvert AK. Oligoclonal IgG bands in cerebrospinal fluid. Principles for demonstration and interpretation based on findings in 1114 neurological patients. Arch Neurol (1987) 44(10):1041-4. doi:10.1001/archneur.1987.00520220043014
    • (1987) Arch Neurol , vol.44 , Issue.10 , pp. 1041-1044
    • Kostulas, V.K.1    Link, H.2    Lefvert, A.K.3
  • 74
    • 0031957306 scopus 로고    scopus 로고
    • Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's lymphoma
    • Scott SD. Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's lymphoma. Cancer Pract (1998) 6(3):195-7. doi:10.1046/j.1523-5394.1998.006003195.x
    • (1998) Cancer Pract , vol.6 , Issue.3 , pp. 195-197
    • Scott, S.D.1
  • 75
    • 33745263037 scopus 로고    scopus 로고
    • Rituximab, an anti-cd20 monoclonal antibody: history and mechanism of action
    • Pescovitz MD. Rituximab, an anti-cd20 monoclonal antibody: history and mechanism of action. Am J Transplant (2006) 6(5 Pt 1):859-66. doi:10.1111/j.1600-6143.2006.01288.x
    • (2006) Am J Transplant , vol.6 , Issue.5 , pp. 859-866
    • Pescovitz, M.D.1
  • 76
    • 84882260238 scopus 로고    scopus 로고
    • Mechanisms of action of CD20 antibodies
    • Boross P, Leusen JH. Mechanisms of action of CD20 antibodies. Am J Cancer Res (2012) 2(6):676-90.
    • (2012) Am J Cancer Res , vol.2 , Issue.6 , pp. 676-690
    • Boross, P.1    Leusen, J.H.2
  • 77
    • 26444598492 scopus 로고    scopus 로고
    • Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis
    • Stuve O, Cepok S, Elias B, Saleh A, Hartung HP, Hemmer B, et al. Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch Neurol (2005) 62(10):1620-3. doi:10.1001/archneur.62.10.1620
    • (2005) Arch Neurol , vol.62 , Issue.10 , pp. 1620-1623
    • Stuve, O.1    Cepok, S.2    Elias, B.3    Saleh, A.4    Hartung, H.P.5    Hemmer, B.6
  • 78
    • 13444274684 scopus 로고    scopus 로고
    • Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis
    • Monson NL, Cravens PD, Frohman EM, Hawker K, Racke MK. Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis. Arch Neurol (2005) 62(2):258-64. doi:10.1001/archneur.62.2.258
    • (2005) Arch Neurol , vol.62 , Issue.2 , pp. 258-264
    • Monson, N.L.1    Cravens, P.D.2    Frohman, E.M.3    Hawker, K.4    Racke, M.K.5
  • 79
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol (2006) 180(1-2):63-70. doi:10.1016/j.jneuroim.2006.06.029
    • (2006) J Neuroimmunol , vol.180 , Issue.1-2 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.A.5
  • 80
    • 51649091745 scopus 로고    scopus 로고
    • Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab
    • Stasi R, Cooper N, Del Poeta G, Stipa E, Laura Evangelista M, Abruzzese E, et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood (2008) 112(4):1147-50. doi:10.1182/blood-2007-12-129262
    • (2008) Blood , vol.112 , Issue.4 , pp. 1147-1150
    • Stasi, R.1    Cooper, N.2    Del Poeta, G.3    Stipa, E.4    Laura Evangelista, M.5    Abruzzese, E.6
  • 81
    • 84904266641 scopus 로고    scopus 로고
    • Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients
    • Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, et al. Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients. J Immunol (2014) 193(2):580-6. doi:10.4049/jimmunol.1400118
    • (2014) J Immunol , vol.193 , Issue.2 , pp. 580-586
    • Palanichamy, A.1    Jahn, S.2    Nickles, D.3    Derstine, M.4    Abounasr, A.5    Hauser, S.L.6
  • 82
    • 73249115641 scopus 로고    scopus 로고
    • Depletion of functionally active CD20+ T cells by rituximab treatment
    • Wilk E, Witte T, Marquardt N, Horvath T, Kalippke K, Scholz K, et al. Depletion of functionally active CD20+ T cells by rituximab treatment. Arthritis Rheum (2009) 60(12):3563-71. doi:10.1002/art.24998
    • (2009) Arthritis Rheum , vol.60 , Issue.12 , pp. 3563-3571
    • Wilk, E.1    Witte, T.2    Marquardt, N.3    Horvath, T.4    Kalippke, K.5    Scholz, K.6
  • 83
    • 84896548324 scopus 로고    scopus 로고
    • In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses
    • Bankoti J, Apeltsin L, Hauser SL, Allen S, Albertolle ME, Witkowska HE, et al. In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses. Ann Neurol (2014) 75(2):266-76. doi:10.1002/ana.24088
    • (2014) Ann Neurol , vol.75 , Issue.2 , pp. 266-276
    • Bankoti, J.1    Apeltsin, L.2    Hauser, S.L.3    Allen, S.4    Albertolle, M.E.5    Witkowska, H.E.6
  • 84
    • 84905988500 scopus 로고    scopus 로고
    • Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis
    • Palanichamy A, Apeltsin L, Kuo TC, Sirota M, Wang S, Pitts SJ, et al. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci Transl Med (2014) 6(248):248ra106. doi:10.1126/scitranslmed.3008930
    • (2014) Sci Transl Med , vol.6 , Issue.248
    • Palanichamy, A.1    Apeltsin, L.2    Kuo, T.C.3    Sirota, M.4    Wang, S.5    Pitts, S.J.6
  • 85
    • 84905967681 scopus 로고    scopus 로고
    • B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
    • Stern JNH, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Sci Transl Med (2014) 6(248):248ra107. doi:10.1126/scitranslmed.3008879
    • (2014) Sci Transl Med , vol.6 , Issue.248
    • Stern, J.N.H.1    Yaari, G.2    Vander Heiden, J.A.3    Church, G.4    Donahue, W.F.5    Hintzen, R.Q.6
  • 87
    • 84908546527 scopus 로고    scopus 로고
    • Peripheral B cell depletion and central proinflammatory cytokine reduction following repeated intrathecal administration of rituximab in progressive multiple sclerosis
    • Studer V, Rossi S, Motta C, Buttari F, Centonze D. Peripheral B cell depletion and central proinflammatory cytokine reduction following repeated intrathecal administration of rituximab in progressive multiple sclerosis. J Neuroimmunol (2014) 276(1-2):229-31. doi:10.1016/j.jneuroim.2014.08.617
    • (2014) J Neuroimmunol , vol.276 , Issue.1-2 , pp. 229-231
    • Studer, V.1    Rossi, S.2    Motta, C.3    Buttari, F.4    Centonze, D.5
  • 88
    • 70449418132 scopus 로고    scopus 로고
    • Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial
    • Hawker K, O'Connor P, Freedman MS, Calabresi PA, Antel J, Simon J, et al. Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol (2009) 66(4):460-71. doi:10.1002/ana.21867
    • (2009) Ann Neurol , vol.66 , Issue.4 , pp. 460-471
    • Hawker, K.1    O'Connor, P.2    Freedman, M.S.3    Calabresi, P.A.4    Antel, J.5    Simon, J.6
  • 89
    • 84964962399 scopus 로고    scopus 로고
    • Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis-results of the placebo-controlled, double-blind, phase III ORATORIO Study
    • Montalban X, Hemmer B, Rammohan B, Giovannoni G, de Seze J, Bar-Or A. Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis-results of the placebo-controlled, double-blind, phase III ORATORIO Study. Mult Scler J (2015) 21(S11):780-808. doi:10.1177/1352458515604791
    • (2015) Mult Scler J , vol.21 , pp. 780-808
    • Montalban, X.1    Hemmer, B.2    Rammohan, B.3    Giovannoni, G.4    de Seze, J.5    Bar-Or, A.6
  • 90
    • 0038692705 scopus 로고    scopus 로고
    • BAFF and APRIL: a tutorial on B cell survival
    • Mackay F, Schneider P, Rennert P, Browning J. BAFF and APRIL: a tutorial on B cell survival. Annu Rev Immunol (2003) 21:231-64. doi:10.1146/annurev.immunol.21.120601.141152
    • (2003) Annu Rev Immunol , vol.21 , pp. 231-264
    • Mackay, F.1    Schneider, P.2    Rennert, P.3    Browning, J.4
  • 91
    • 0942298590 scopus 로고    scopus 로고
    • Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival
    • Novak AJ, Darce JR, Arendt BK, Harder B, Henderson K, Kindsvogel W, et al. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood (2004) 103(2):689-94. doi:10.1182/blood-2003-06-2043
    • (2004) Blood , vol.103 , Issue.2 , pp. 689-694
    • Novak, A.J.1    Darce, J.R.2    Arendt, B.K.3    Harder, B.4    Henderson, K.5    Kindsvogel, W.6
  • 92
    • 0347285357 scopus 로고    scopus 로고
    • BCMA is essential for the survival of long-lived bone marrow plasma cells
    • O'Connor BP, Raman VS, Erickson LD, Cook WJ, Weaver LK, Ahonen C, et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med (2004) 199(1):91-8. doi:10.1084/jem.20031330
    • (2004) J Exp Med , vol.199 , Issue.1 , pp. 91-98
    • O'Connor, B.P.1    Raman, V.S.2    Erickson, L.D.3    Cook, W.J.4    Weaver, L.K.5    Ahonen, C.6
  • 93
    • 33644755600 scopus 로고    scopus 로고
    • An APRIL to remember: novel TNF ligands as therapeutic targets
    • Dillon SR, Gross JA, Ansell SM, Novak AJ. An APRIL to remember: novel TNF ligands as therapeutic targets. Nat Rev Drug Discov (2006) 5(3):235-46. doi:10.1038/nrd1982
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.3 , pp. 235-246
    • Dillon, S.R.1    Gross, J.A.2    Ansell, S.M.3    Novak, A.J.4
  • 94
    • 33747837100 scopus 로고    scopus 로고
    • BAFF APRIL and their receptors: structure, function and signaling
    • Bossen C, Schneider P. BAFF APRIL and their receptors: structure, function and signaling. Semin Immunol (2006) 18(5):263-75. doi:10.1016/j.smim.2006.04.006
    • (2006) Semin Immunol , vol.18 , Issue.5 , pp. 263-275
    • Bossen, C.1    Schneider, P.2
  • 95
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • Lai Kwan Lam Q, King Hung Ko O, Zheng BJ, Lu L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc Natl Acad Sci U S A (2008) 105(39):14993-8. doi:10.1073/pnas.0806044105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.39 , pp. 14993-14998
    • Lai Kwan Lam, Q.1    King Hung Ko, O.2    Zheng, B.J.3    Lu, L.4
  • 96
    • 3042569128 scopus 로고    scopus 로고
    • Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis
    • Thangarajh M, Gomes A, Masterman T, Hillert J, Hjelmstrom P. Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J Neuroimmunol (2004) 152(1-2):183-90. doi:10.1016/j.jneuroim.2004.03.017
    • (2004) J Neuroimmunol , vol.152 , Issue.1-2 , pp. 183-190
    • Thangarajh, M.1    Gomes, A.2    Masterman, T.3    Hillert, J.4    Hjelmstrom, P.5
  • 97
    • 20244384231 scopus 로고    scopus 로고
    • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    • Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu CM, et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med (2005) 201(2):195-200. doi:10.1084/jem.20041674
    • (2005) J Exp Med , vol.201 , Issue.2 , pp. 195-200
    • Krumbholz, M.1    Theil, D.2    Derfuss, T.3    Rosenwald, A.4    Schrader, F.5    Monoranu, C.M.6
  • 98
    • 77953341196 scopus 로고    scopus 로고
    • Changes in B-and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis
    • Piccio L, Naismith RT, Trinkaus K, Klein RS, Parks BJ, Lyons JA, et al. Changes in B-and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis. Arch Neurol (2010) 67(6):707-14. doi:10.1001/archneurol.2010.99
    • (2010) Arch Neurol , vol.67 , Issue.6 , pp. 707-714
    • Piccio, L.1    Naismith, R.T.2    Trinkaus, K.3    Klein, R.S.4    Parks, B.J.5    Lyons, J.A.6
  • 100
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
    • Dall'Era M, Chakravarty E, Wallace D, Genovese M, Weisman M, Kavanaugh A, et al. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum (2007) 56(12):4142-50. doi:10.1002/art.23047
    • (2007) Arthritis Rheum , vol.56 , Issue.12 , pp. 4142-4150
    • Dall'Era, M.1    Chakravarty, E.2    Wallace, D.3    Genovese, M.4    Weisman, M.5    Kavanaugh, A.6
  • 101
    • 77954950402 scopus 로고    scopus 로고
    • Atacicept: targeting B cells in multiple sclerosis
    • Hartung HP, Kieseier BC. Atacicept: targeting B cells in multiple sclerosis. Ther Adv Neurol Disord (2010) 3(4):205-16. doi:10.1177/1756285610371146
    • (2010) Ther Adv Neurol Disord , vol.3 , Issue.4 , pp. 205-216
    • Hartung, H.P.1    Kieseier, B.C.2
  • 102
    • 79959856423 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial
    • van Vollenhoven RF, Kinnman N, Vincent E, Wax S, Bathon J. Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum (2011) 63(7):1782-92. doi:10.1002/art.30372
    • (2011) Arthritis Rheum , vol.63 , Issue.7 , pp. 1782-1792
    • van Vollenhoven, R.F.1    Kinnman, N.2    Vincent, E.3    Wax, S.4    Bathon, J.5
  • 103
    • 84896070550 scopus 로고    scopus 로고
    • Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trial
    • Kappos L, Hartung HP, Freedman MS, Boyko A, Radu EW, Mikol DD, et al. Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trial. Lancet Neurol (2014) 13(4):353-63. doi:10.1016/S1474-4422(14)70028-6
    • (2014) Lancet Neurol , vol.13 , Issue.4 , pp. 353-363
    • Kappos, L.1    Hartung, H.P.2    Freedman, M.S.3    Boyko, A.4    Radu, E.W.5    Mikol, D.D.6
  • 104
    • 84945242898 scopus 로고    scopus 로고
    • Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)
    • Isenberg D, Gordon C, Licu D, Copt S, Rossi CP, Wofsy D. Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial). Ann Rheum Dis (2014) 74(11):2006-15. doi:10.1136/annrheumdis-2013-205067
    • (2014) Ann Rheum Dis , vol.74 , Issue.11 , pp. 2006-2015
    • Isenberg, D.1    Gordon, C.2    Licu, D.3    Copt, S.4    Rossi, C.P.5    Wofsy, D.6
  • 105
    • 84926408540 scopus 로고    scopus 로고
    • ATON: results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis
    • Sergott RC, Bennett JL, Rieckmann P, Montalban X, Mikol D, Freudensprung U, et al. ATON: results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis. J Neurol Sci (2015) 351(1-2):174-8. doi:10.1016/j.jns.2015.02.019
    • (2015) J Neurol Sci , vol.351 , Issue.1-2 , pp. 174-178
    • Sergott, R.C.1    Bennett, J.L.2    Rieckmann, P.3    Montalban, X.4    Mikol, D.5    Freudensprung, U.6
  • 106
    • 84899536973 scopus 로고    scopus 로고
    • BAFF suppresses IL-15 expression in B cells
    • Ma N, Xing C, Xiao H, He Y, Han G, Chen G, et al. BAFF suppresses IL-15 expression in B cells. J Immunol (2014) 192(9):4192-201. doi:10.4049/jimmunol.1302132
    • (2014) J Immunol , vol.192 , Issue.9 , pp. 4192-4201
    • Ma, N.1    Xing, C.2    Xiao, H.3    He, Y.4    Han, G.5    Chen, G.6
  • 107
    • 0030973198 scopus 로고    scopus 로고
    • Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy
    • Genc K, Dona DL, Reder AT. Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J Clin Invest (1997) 99(11):2664-71. doi:10.1172/JCI119455
    • (1997) J Clin Invest , vol.99 , Issue.11 , pp. 2664-2671
    • Genc, K.1    Dona, D.L.2    Reder, A.T.3
  • 108
    • 84924362998 scopus 로고    scopus 로고
    • IFN-beta treatment requires B cells for efficacy in neuroautoimmunity
    • Schubert RD, Hu Y, Kumar G, Szeto S, Abraham P, Winderl J, et al. IFN-beta treatment requires B cells for efficacy in neuroautoimmunity. J Immunol (2015) 194(5):2110-6. doi:10.4049/jimmunol.1402029
    • (2015) J Immunol , vol.194 , Issue.5 , pp. 2110-2116
    • Schubert, R.D.1    Hu, Y.2    Kumar, G.3    Szeto, S.4    Abraham, P.5    Winderl, J.6
  • 109
    • 79954997896 scopus 로고    scopus 로고
    • B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis
    • Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, et al. B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis. J Immunol (2011) 186(7):4518-26. doi:10.4049/jimmunol.1000271
    • (2011) J Immunol , vol.186 , Issue.7 , pp. 4518-4526
    • Ramgolam, V.S.1    Sha, Y.2    Marcus, K.L.3    Choudhary, N.4    Troiani, L.5    Chopra, M.6
  • 110
    • 84919386274 scopus 로고    scopus 로고
    • The effect of glatiramer acetate therapy on functional properties of B cells from patients with relapsing-remitting multiple sclerosis
    • Ireland SJ, Guzman AA, O'Brien DE, Hughes S, Greenberg B, Flores A, et al. The effect of glatiramer acetate therapy on functional properties of B cells from patients with relapsing-remitting multiple sclerosis. JAMA Neurol (2014) 71(11):1421-8. doi:10.1001/jamaneurol.2014.1472
    • (2014) JAMA Neurol , vol.71 , Issue.11 , pp. 1421-1428
    • Ireland, S.J.1    Guzman, A.A.2    O'Brien, D.E.3    Hughes, S.4    Greenberg, B.5    Flores, A.6
  • 111
    • 80053421148 scopus 로고    scopus 로고
    • Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production
    • Hedegaard CJ, Sellebjerg F, Krakauer M, Hesse D, Bendtzen K, Nielsen CH. Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production. Mult Scler (2011) 17(5):567-77. doi:10.1177/1352458510393771
    • (2011) Mult Scler , vol.17 , Issue.5 , pp. 567-577
    • Hedegaard, C.J.1    Sellebjerg, F.2    Krakauer, M.3    Hesse, D.4    Bendtzen, K.5    Nielsen, C.H.6
  • 112
    • 77249142775 scopus 로고    scopus 로고
    • Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis
    • Begum-Haque S, Sharma A, Christy M, Lentini T, Ochoa-Reparaz J, Fayed IF, et al. Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 219(1-2):47-53. doi:10.1016/j.jneuroim.2009.11.016
    • (2010) J Neuroimmunol , vol.219 , Issue.1-2 , pp. 47-53
    • Begum-Haque, S.1    Sharma, A.2    Christy, M.3    Lentini, T.4    Ochoa-Reparaz, J.5    Fayed, I.F.6
  • 113
    • 33646347357 scopus 로고    scopus 로고
    • Natalizumab effects on immune cell responses in multiple sclerosis
    • Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, et al. Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol (2006) 59(5):748-54. doi:10.1002/ana.20859
    • (2006) Ann Neurol , vol.59 , Issue.5 , pp. 748-754
    • Niino, M.1    Bodner, C.2    Simard, M.L.3    Alatab, S.4    Gano, D.5    Kim, H.J.6
  • 114
    • 84859512094 scopus 로고    scopus 로고
    • Natalizumab treatment perturbs memory-and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis
    • Planas R, Jelcic I, Schippling S, Martin R, Sospedra M. Natalizumab treatment perturbs memory-and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis. Eur J Immunol (2012) 42(3):790-8. doi:10.1002/eji.201142108
    • (2012) Eur J Immunol , vol.42 , Issue.3 , pp. 790-798
    • Planas, R.1    Jelcic, I.2    Schippling, S.3    Martin, R.4    Sospedra, M.5
  • 115
    • 84985914372 scopus 로고    scopus 로고
    • Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF
    • Warnke C, Stettner M, Lehmensiek V, Dehmel T, Mausberg AK, von Geldern G, et al. Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF. Mult Scler (2015) 21(8):1036-44. doi:10.1177/1352458514556296
    • (2015) Mult Scler , vol.21 , Issue.8 , pp. 1036-1044
    • Warnke, C.1    Stettner, M.2    Lehmensiek, V.3    Dehmel, T.4    Mausberg, A.K.5    von Geldern, G.6
  • 116
    • 79954611536 scopus 로고    scopus 로고
    • Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
    • Kowarik MC, Pellkofer HL, Cepok S, Korn T, Kumpfel T, Buck D, et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology (2011) 76(14):1214-21. doi:10.1212/WNL.0b013e3182143564
    • (2011) Neurology , vol.76 , Issue.14 , pp. 1214-1221
    • Kowarik, M.C.1    Pellkofer, H.L.2    Cepok, S.3    Korn, T.4    Kumpfel, T.5    Buck, D.6
  • 117
    • 84895742456 scopus 로고    scopus 로고
    • Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations
    • Miyazaki Y, Niino M, Fukazawa T, Takahashi E, Nonaka T, Amino I, et al. Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations. Clin Immunol (2014) 151(2):127-35. doi:10.1016/j.clim.2014.02.001
    • (2014) Clin Immunol , vol.151 , Issue.2 , pp. 127-135
    • Miyazaki, Y.1    Niino, M.2    Fukazawa, T.3    Takahashi, E.4    Nonaka, T.5    Amino, I.6
  • 118
    • 84909992655 scopus 로고    scopus 로고
    • Differential effects of fingolimod on B-cell populations in multiple sclerosis
    • Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, et al. Differential effects of fingolimod on B-cell populations in multiple sclerosis. Mult Scler (2014) 20(10):1371-80. doi:10.1177/1352458514523496
    • (2014) Mult Scler , vol.20 , Issue.10 , pp. 1371-1380
    • Nakamura, M.1    Matsuoka, T.2    Chihara, N.3    Miyake, S.4    Sato, W.5    Araki, M.6
  • 119
    • 84910003086 scopus 로고    scopus 로고
    • Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study
    • Claes N, Dhaeze T, Fraussen J, Broux B, Van Wijmeersch B, Stinissen P, et al. Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study. PLoS One (2014) 9(10):e111115. doi:10.1371/journal.pone.0111115
    • (2014) PLoS One , vol.9 , Issue.10
    • Claes, N.1    Dhaeze, T.2    Fraussen, J.3    Broux, B.4    Van Wijmeersch, B.5    Stinissen, P.6
  • 121
    • 0021049053 scopus 로고
    • Mitoxantrone (novantrone) as single agent and in combination chemotherapy in the treatment of advanced breast cancer
    • Smith IE, Stuart-Harris R, Pavlidis N, Bozek T. Mitoxantrone (novantrone) as single agent and in combination chemotherapy in the treatment of advanced breast cancer. Cancer Treat Rev (1983) 10(Suppl B):37-40. doi:10.1016/0305-7372(83)90020-8
    • (1983) Cancer Treat Rev , vol.10 , pp. 37-40
    • Smith, I.E.1    Stuart-Harris, R.2    Pavlidis, N.3    Bozek, T.4
  • 123
    • 84863200586 scopus 로고    scopus 로고
    • B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naive B cells
    • Heidt S, Hester J, Shankar S, Friend PJ, Wood KJ. B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naive B cells. Am J Transplant (2012) 12(7):1784-92. doi:10.1111/j.1600-6143.2012.04012.x
    • (2012) Am J Transplant , vol.12 , Issue.7 , pp. 1784-1792
    • Heidt, S.1    Hester, J.2    Shankar, S.3    Friend, P.J.4    Wood, K.J.5
  • 125
    • 84937436086 scopus 로고    scopus 로고
    • Effects of dimethyl fumarate on lymphocyte subsets
    • Berkovich R, Weiner LP. Effects of dimethyl fumarate on lymphocyte subsets. Mult Scler Relat Disord (2015) 4(4):339-41. doi:10.1016/j.msard.2015.06.002
    • (2015) Mult Scler Relat Disord , vol.4 , Issue.4 , pp. 339-341
    • Berkovich, R.1    Weiner, L.P.2
  • 126
    • 0028340163 scopus 로고
    • Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells-specificity and promiscuity
    • Fridkis-Hareli M, Teitelbaum D, Gurevich E, Pecht I, Brautbar C, Kwon OJ, et al. Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells-specificity and promiscuity. Proc Natl Acad Sci U S A (1994) 91(11):4872-6. doi:10.1073/pnas.91.11.4872
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.11 , pp. 4872-4876
    • Fridkis-Hareli, M.1    Teitelbaum, D.2    Gurevich, E.3    Pecht, I.4    Brautbar, C.5    Kwon, O.J.6
  • 127
    • 84939568140 scopus 로고    scopus 로고
    • Longitudinal assessment of immuno-metabolic parameters in multiple sclerosis patients during treatment with glatiramer acetate
    • Carrieri PB, Carbone F, Perna F, Bruzzese D, La Rocca C, Galgani M, et al. Longitudinal assessment of immuno-metabolic parameters in multiple sclerosis patients during treatment with glatiramer acetate. Metabolism (2015) 64(9):1112-21. doi:10.1016/j.metabol.2015.05.001
    • (2015) Metabolism , vol.64 , Issue.9 , pp. 1112-1121
    • Carrieri, P.B.1    Carbone, F.2    Perna, F.3    Bruzzese, D.4    La Rocca, C.5    Galgani, M.6
  • 128
    • 84901979227 scopus 로고    scopus 로고
    • B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients
    • Rovituso D, Heller S, Schroeter M, Kleinschnitz C, Kuerten S. B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients. J Neuroimmunol (2014) 272(1-2):86-90. doi:10.1016/j.jneuroim.2014.04.008
    • (2014) J Neuroimmunol , vol.272 , Issue.1-2 , pp. 86-90
    • Rovituso, D.1    Heller, S.2    Schroeter, M.3    Kleinschnitz, C.4    Kuerten, S.5
  • 129
    • 84926672427 scopus 로고    scopus 로고
    • Hematopoietic mobilization: potential biomarker of response to natalizumab in multiple sclerosis
    • Mattoscio M, Nicholas R, Sormani MP, Malik O, Lee JS, Waldman AD, et al. Hematopoietic mobilization: potential biomarker of response to natalizumab in multiple sclerosis. Neurology (2015) 84(14):1473-82. doi:10.1212/WNL.0000000000001454
    • (2015) Neurology , vol.84 , Issue.14 , pp. 1473-1482
    • Mattoscio, M.1    Nicholas, R.2    Sormani, M.P.3    Malik, O.4    Lee, J.S.5    Waldman, A.D.6
  • 130
    • 55449137632 scopus 로고    scopus 로고
    • Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis
    • Krumbholz M, Meinl I, Kumpfel T, Hohlfeld R, Meinl E. Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology (2008) 71(17):1350-4. doi:10.1212/01.wnl.0000327671.91357.96
    • (2008) Neurology , vol.71 , Issue.17 , pp. 1350-1354
    • Krumbholz, M.1    Meinl, I.2    Kumpfel, T.3    Hohlfeld, R.4    Meinl, E.5
  • 131
    • 0022481289 scopus 로고
    • Mitoxantrone affects topoisomerase activities in human breast cancer cells
    • Crespi MD, Ivanier SE, Genovese J, Baldi A. Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem Biophys Res Commun (1986) 136(2):521-8. doi:10.1016/0006-291X(86)90471-7
    • (1986) Biochem Biophys Res Commun , vol.136 , Issue.2 , pp. 521-528
    • Crespi, M.D.1    Ivanier, S.E.2    Genovese, J.3    Baldi, A.4
  • 132
    • 84863110271 scopus 로고    scopus 로고
    • Mitoxantrone induces natural killer cell maturation in patients with secondary progressive multiple sclerosis
    • Chanvillard C, Millward JM, Lozano M, Hamann I, Paul F, Zipp F, et al. Mitoxantrone induces natural killer cell maturation in patients with secondary progressive multiple sclerosis. PLoS One (2012) 7(6):e39625. doi:10.1371/journal.pone.0039625
    • (2012) PLoS One , vol.7 , Issue.6
    • Chanvillard, C.1    Millward, J.M.2    Lozano, M.3    Hamann, I.4    Paul, F.5    Zipp, F.6
  • 133
    • 84893301493 scopus 로고    scopus 로고
    • BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety
    • Fox RJ, Kita M, Cohan SL, Henson LJ, Zambrano J, Scannevin RH, et al. BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety. Curr Med Res Opin (2014) 30(2):251-62. doi:10.1185/03007995.2013.849236
    • (2014) Curr Med Res Opin , vol.30 , Issue.2 , pp. 251-262
    • Fox, R.J.1    Kita, M.2    Cohan, S.L.3    Henson, L.J.4    Zambrano, J.5    Scannevin, R.H.6
  • 134
    • 84899856893 scopus 로고    scopus 로고
    • Teriflunomide and its mechanism of action in multiple sclerosis
    • Bar-Or A, Pachner A, Menguy-Vacheron F, Kaplan J, Wiendl H. Teriflunomide and its mechanism of action in multiple sclerosis. Drugs (2014) 74(6):659-74. doi:10.1007/s40265-014-0212-x
    • (2014) Drugs , vol.74 , Issue.6 , pp. 659-674
    • Bar-Or, A.1    Pachner, A.2    Menguy-Vacheron, F.3    Kaplan, J.4    Wiendl, H.5
  • 135
    • 84884580887 scopus 로고    scopus 로고
    • Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis
    • Bar-Or A, Freedman MS, Kremenchutzky M, Menguy-Vacheron F, Bauer D, Jodl S, et al. Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis. Neurology (2013) 81(6):552-8. doi:10.1212/WNL.0b013e31829e6fbf
    • (2013) Neurology , vol.81 , Issue.6 , pp. 552-558
    • Bar-Or, A.1    Freedman, M.S.2    Kremenchutzky, M.3    Menguy-Vacheron, F.4    Bauer, D.5    Jodl, S.6
  • 136
    • 84956584286 scopus 로고    scopus 로고
    • Randomized study of teriflunomide effects on immune responses to neoantigen and recall antigens
    • Bar-Or A, Wiendl H, Miller B, Benamor M, Truffinet P, Church M, et al. Randomized study of teriflunomide effects on immune responses to neoantigen and recall antigens. Neurol Neuroimmunol Neuroinflamm (2015) 2(2):e70. doi:10.1212/NXI.0000000000000070
    • (2015) Neurol Neuroimmunol Neuroinflamm , vol.2 , Issue.2
    • Bar-Or, A.1    Wiendl, H.2    Miller, B.3    Benamor, M.4    Truffinet, P.5    Church, M.6
  • 137
    • 77249114139 scopus 로고    scopus 로고
    • B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis
    • Thompson SA, Jones JL, Cox AL, Compston DA, Coles AJ. B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis. J Clin Immunol (2010) 30(1):99-105. doi:10.1007/s10875-009-9327-3
    • (2010) J Clin Immunol , vol.30 , Issue.1 , pp. 99-105
    • Thompson, S.A.1    Jones, J.L.2    Cox, A.L.3    Compston, D.A.4    Coles, A.J.5
  • 138
    • 27944439639 scopus 로고    scopus 로고
    • Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis
    • Cox AL, Thompson SA, Jones JL, Robertson VH, Hale G, Waldmann H, et al. Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis. Eur J Immunol (2005) 35(11):3332-42. doi:10.1002/eji.200535075
    • (2005) Eur J Immunol , vol.35 , Issue.11 , pp. 3332-3342
    • Cox, A.L.1    Thompson, S.A.2    Jones, J.L.3    Robertson, V.H.4    Hale, G.5    Waldmann, H.6
  • 139
    • 84940985056 scopus 로고    scopus 로고
    • Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis
    • Lin YC, Winokur P, Blake A, Wu T, Romm E, Bielekova B. Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis. Ann Clin Transl Neurol (2015) 2(5):445-55. doi:10.1002/acn3.181
    • (2015) Ann Clin Transl Neurol , vol.2 , Issue.5 , pp. 445-455
    • Lin, Y.C.1    Winokur, P.2    Blake, A.3    Wu, T.4    Romm, E.5    Bielekova, B.6
  • 140
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta
    • Wynn D, Kaufman M, Montalban X, Vollmer T, Simon J, Elkins J, et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol (2010) 9(4):381-90. doi:10.1016/S1474-4422(10)70033-8
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3    Vollmer, T.4    Simon, J.5    Elkins, J.6


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