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Volumn 3, Issue 4, 2010, Pages 205-216

Atacicept: Targeting B cells in multiple sclerosis

Author keywords

atacicept; B cells; B lymphocytes; immunotherapies; multiple sclerosis; treatment

Indexed keywords

APRIL PROTEIN; ATACICEPT; AUTOANTIBODY; B CELL ACTIVATING FACTOR; PLACEBO; RITUXIMAB;

EID: 77954950402     PISSN: 17562856     EISSN: None     Source Type: Journal    
DOI: 10.1177/1756285610371146     Document Type: Review
Times cited : (109)

References (90)
  • 1
    • 4344624041 scopus 로고    scopus 로고
    • cells in human and murine systemic lupus erythematosus
    • Anolik, J. and Sanz, I. ( 2004) B cells in human and murine systemic lupus erythematosus. Curr Opin Rheumatol 16: 505-512.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 505-512
    • Anolik, J.1    Sanz, I.2
  • 2
    • 0034120945 scopus 로고    scopus 로고
    • The role of B cells and autoantibodies in multiple sclerosis
    • Archelos, J.J., Storch, M.K. and Hartung, H.P. ( 2000) The role of B cells and autoantibodies in multiple sclerosis. Ann Neurol 47: 694-706.
    • (2000) Ann Neurol , vol.47 , pp. 694-706
    • Archelos, J.J.1    Storch, M.K.2    Hartung, H.P.3
  • 4
    • 44849097480 scopus 로고    scopus 로고
    • Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    • Benson, M.J., Dillon, S.R., Castigli, E., Geha, R.S., Xu, S., Lam, K.P. et al. (2008) Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 180: 3655-3659.
    • (2008) J Immunol , vol.180 , pp. 3655-3659
    • Benson, M.J.1    Dillon, S.R.2    Castigli, E.3    Geha, R.S.4    Xu, S.5    Lam, K.P.6
  • 5
    • 70849086174 scopus 로고    scopus 로고
    • FTY 720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system
    • Brinkmann, V. ( 2009) FTY 720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Brit J Pharmacol 158: 1173-1182.
    • (2009) Brit J Pharmacol , vol.158 , pp. 1173-1182
    • Brinkmann, V.1
  • 6
    • 34748825490 scopus 로고    scopus 로고
    • Fingolimod: a novel immunosuppressant for multiple sclerosis
    • Brown, B.A., Kantesaria, P.P. and McDevitt, L.M. ( 2007) Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother 41: 1660-1668.
    • (2007) Ann Pharmacother , vol.41 , pp. 1660-1668
    • Brown, B.A.1    Kantesaria, P.P.2    McDevitt, L.M.3
  • 7
    • 49249090858 scopus 로고    scopus 로고
    • Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept
    • Carbonatto, M., Yu, P., Bertolino, M., Vigna, E., Steidler, S., Fava, L. et al. (2008) Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept. Toxicol Sci 105: 200-210.
    • (2008) Toxicol Sci , vol.105 , pp. 200-210
    • Carbonatto, M.1    Yu, P.2    Bertolino, M.3    Vigna, E.4    Steidler, S.5    Fava, L.6
  • 10
    • 21944448962 scopus 로고    scopus 로고
    • Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis
    • Cepok, S., Rosche, B., Grummel, V., Vogel, F., Zhou, D., Sayn, J. et al. (2005) Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain 128: 1667-1676.
    • (2005) Brain , vol.128 , pp. 1667-1676
    • Cepok, S.1    Rosche, B.2    Grummel, V.3    Vogel, F.4    Zhou, D.5    Sayn, J.6
  • 11
    • 34248639557 scopus 로고    scopus 로고
    • The role of CD4 T cells in the pathogenesis of multiple sclerosis
    • Chitnis, T. ( 2007) The role of CD4 T cells in the pathogenesis of multiple sclerosis. Int Rev Neurobiol 79: 43-72.
    • (2007) Int Rev Neurobiol , vol.79 , pp. 43-72
    • Chitnis, T.1
  • 12
    • 26444578414 scopus 로고    scopus 로고
    • Mechanisms of action for treatments in multiple sclerosis: does a heterogeneous disease demand a multi-targeted therapeutic approach
    • Chofflon, M. ( 2005) Mechanisms of action for treatments in multiple sclerosis: does a heterogeneous disease demand a multi-targeted therapeutic approach ? BioDrugs 19: 299-308.
    • (2005) BioDrugs , vol.19 , pp. 299-308
    • Chofflon, M.1
  • 13
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • Chun, J. and Hartung, H.-P. ( 2010) Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol 33: 91-101.
    • (2010) Clin Neuropharmacol , vol.33 , pp. 91-101
    • Chun, J.1    Hartung, H.-P.2
  • 14
    • 76149140914 scopus 로고    scopus 로고
    • (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen, J.A., Barkhoff, F., Comi, G., Hartung, H.P., Katri, O.B., Montalban, X. et al. (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 362: 402-415.
    • N Engl J Med , vol.362 , pp. 402-415
    • Cohen, J.A.1    Barkhoff, F.2    Comi, G.3    Hartung, H.P.4    Katri, O.B.5    Montalban, X.6
  • 16
    • 3342884206 scopus 로고    scopus 로고
    • Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    • Corcione, A., Casazza, S., Ferretti, E., Giunti, D., Zappia, E., Pistorio, A. et al. (2004) Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci U S A 101: 11064-11069.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11064-11069
    • Corcione, A.1    Casazza, S.2    Ferretti, E.3    Giunti, D.4    Zappia, E.5    Pistorio, A.6
  • 17
    • 33746565387 scopus 로고    scopus 로고
    • Emerging monoclonal antibody therapies for multiple sclerosis
    • Cree, B. ( 2006) Emerging monoclonal antibody therapies for multiple sclerosis. Neurologist 12: 171-178.
    • (2006) Neurologist , vol.12 , pp. 171-178
    • Cree, B.1
  • 18
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross, A.H., Stark, J.L., Lauber, J., Ramsbottom, M.J. and Lyons, J.A. ( 2006) Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 180: 63-70.
    • (2006) J Neuroimmunol , vol.180 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.A.5
  • 19
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
    • Dall'Era, M., Chakravarty, E., Wallace, D., Genovese, M., Weisman, M., Kavanaugh, A. et al. (2007) Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum 56: 4142-4150.
    • (2007) Arthritis Rheum , vol.56 , pp. 4142-4150
    • Dall'Era, M.1    Chakravarty, E.2    Wallace, D.3    Genovese, M.4    Weisman, M.5    Kavanaugh, A.6
  • 20
    • 33646814688 scopus 로고    scopus 로고
    • The role of CD4+ T-cells in the development of MS
    • Delgado, S. and Sheremata, W.A. ( 2006) The role of CD4+ T-cells in the development of MS. Neurol Res 28: 245-249.
    • (2006) Neurol Res , vol.28 , pp. 245-249
    • Delgado, S.1    Sheremata, W.A.2
  • 21
    • 33644755600 scopus 로고    scopus 로고
    • An APRIL to remember: novel TNF ligands as therapeutic targets
    • Dillon, S.R., Gross, J.A., Ansell, S.M. and Novak, A.J. ( 2006) An APRIL to remember: novel TNF ligands as therapeutic targets. Nat Rev Drug Discov 5: 235-246.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 235-246
    • Dillon, S.R.1    Gross, J.A.2    Ansell, S.M.3    Novak, A.J.4
  • 22
    • 0034596831 scopus 로고    scopus 로고
    • Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
    • Do, R.K., Hatada, E., Lee, H., Tourigny, M.R., Hilbert, D., Chen-Kiang, S. et al. (2000) Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J Exp Med 192: 953-964.
    • (2000) J Exp Med , vol.192 , pp. 953-964
    • Do, R.K.1    Hatada, E.2    Lee, H.3    Tourigny, M.R.4    Hilbert, D.5    Chen-Kiang, S.6
  • 26
    • 51849148443 scopus 로고    scopus 로고
    • Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I / II randomized, blinded, placebo-controlled, dose-ranging study
    • Genovese, M.C., Kaine, J.L., Lowenstein, M.B., Del Giudice, J., Baldassare, A., Schechtman, J. et al. (2008) Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I / II randomized, blinded, placebo-controlled, dose-ranging study. Arthritis Rheum 58: 2652-2661.
    • (2008) Arthritis Rheum , vol.58 , pp. 2652-2661
    • Genovese, M.C.1    Kaine, J.L.2    Lowenstein, M.B.3    Del Giudice, J.4    Baldassare, A.5    Schechtman, J.6
  • 28
    • 17944375043 scopus 로고    scopus 로고
    • TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS
    • Gross, J.A., Dillon, S.R., Mudri, S., Johnston, J., Littau, A., Roque, R. et al. (2001) TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity 15: 289-302.
    • (2001) Immunity , vol.15 , pp. 289-302
    • Gross, J.A.1    Dillon, S.R.2    Mudri, S.3    Johnston, J.4    Littau, A.5    Roque, R.6
  • 29
    • 17344380531 scopus 로고    scopus 로고
    • TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
    • Gross, J.A., Johnston, J., Mudri, S., Enselman, R., Dillon, S.R., Madden, K. et al. (2000) TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404: 995-999.
    • (2000) Nature , vol.404 , pp. 995-999
    • Gross, J.A.1    Johnston, J.2    Mudri, S.3    Enselman, R.4    Dillon, S.R.5    Madden, K.6
  • 30
    • 77949424680 scopus 로고    scopus 로고
    • Ebers, G.E. and Ramagopalan S.V. (2010) Environmental factors and their timing in adult-onset multiple sclerosis
    • Handel, A.E., Giovannono G., Ebers, G.E. and Ramagopalan S.V. (2010) Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol 6: 156-166.
    • Nat Rev Neurol , vol.6 , pp. 156-166
    • Handel, A.E.1    Giovannono, G.2
  • 31
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser, S.L., Waubant, E., Arnold, D.L., Vollmer, T., Antel, J., Fox, R.J. et al. (2008) B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 358: 676-688.
    • (2008) N Engl J Med , vol.358 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3    Vollmer, T.4    Antel, J.5    Fox, R.J.6
  • 32
    • 41649114547 scopus 로고    scopus 로고
    • B-cell targeted treatment for multiple sclerosis: mechanism of action and clinical data
    • (Suppl
    • Hawker, K. ( 2008) B-cell targeted treatment for multiple sclerosis: mechanism of action and clinical data. Curr Opin Neurol 21(Suppl 1): S19-S25.
    • (2008) Curr Opin Neurol , vol.21 , Issue.1 , pp. S19-S25
    • Hawker, K.1
  • 33
    • 73949142045 scopus 로고    scopus 로고
    • The evaluation of atacicept on protective immunity in the mouse streptococcal host resistance model (abstract 1934)
    • Heffernan, J., Burleson, F., Roque, R., Waggie, K., Carbonatto, M., Ponce, R. et al. (2008) The evaluation of atacicept on protective immunity in the mouse streptococcal host resistance model (abstract 1934). Toxicologist 102: 398.
    • (2008) Toxicologist , vol.102 , pp. 398
    • Heffernan, J.1    Burleson, F.2    Roque, R.3    Waggie, K.4    Carbonatto, M.5    Ponce, R.6
  • 34
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • Hemmer, B., Archelos, J.J. and Hartung, H.P. ( 2002) New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 3: 291-301.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.P.3
  • 35
    • 36148952124 scopus 로고    scopus 로고
    • Toward the development of rational therapies in multiple sclerosis: what is on the horizon
    • Hemmer, B. and Hartung, H.P. ( 2007) Toward the development of rational therapies in multiple sclerosis: what is on the horizon? Ann Neurol 62: 314-326.
    • (2007) Ann Neurol , vol.62 , pp. 314-326
    • Hemmer, B.1    Hartung, H.P.2
  • 36
    • 33947182607 scopus 로고    scopus 로고
    • Revised criteria for neuromyelitis optica - a new diagnostic standard
    • Hemmer, B. and Stüve, O. ( 2007) Revised criteria for neuromyelitis optica - a new diagnostic standard? Nat Clin Pract Neurol 3: 132-133.
    • (2007) Nat Clin Pract Neurol , vol.3 , pp. 132-133
    • Hemmer, B.1    Stüve, O.2
  • 37
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
    • (Suppl
    • Hohlfeld, R. and Wekerle, H. ( 2004) Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci U S A 101(Suppl 2): 14599-14606.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.2 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 38
    • 0035092524 scopus 로고    scopus 로고
    • The ups and downs of multiple sclerosis therapeutics
    • Hohlfeld, R. and Wiendl, H. ( 2001) The ups and downs of multiple sclerosis therapeutics. Ann Neurol 49: 281-284.
    • (2001) Ann Neurol , vol.49 , pp. 281-284
    • Hohlfeld, R.1    Wiendl, H.2
  • 39
    • 0037097665 scopus 로고    scopus 로고
    • Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    • Hsu, B.L., Harless, S.M., Lindsley, R.C., Hilbert, D.M. and Cancro, M.P. ( 2002) Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 168: 5993-5996.
    • (2002) J Immunol , vol.168 , pp. 5993-5996
    • Hsu, B.L.1    Harless, S.M.2    Lindsley, R.C.3    Hilbert, D.M.4    Cancro, M.P.5
  • 40
    • 33748997648 scopus 로고    scopus 로고
    • A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses
    • Huntington, N.D., Tomioka, R., Clavarino, C., Chow, A.M., Liñares, D., Maña, P. et al. (2006) A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int Immunol 18: 1473-1485.
    • (2006) Int Immunol , vol.18 , pp. 1473-1485
    • Huntington, N.D.1    Tomioka, R.2    Clavarino, C.3    Chow, A.M.4    Liñares, D.5    Maña, P.6
  • 41
    • 16244423682 scopus 로고    scopus 로고
    • The role of BAFF in immune function and implications for autoimmunity
    • Kalled, S.L. ( 2005) The role of BAFF in immune function and implications for autoimmunity. Immunol Rev 204: 43-54.
    • (2005) Immunol Rev , vol.204 , pp. 43-54
    • Kalled, S.L.1
  • 42
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?
    • Kerschensteiner, M., Gallmeier, E., Behrens, L., Leal, V.V., Misgeld, T., Klinkert, W.E. et al. (1999) Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189: 865-870.
    • (1999) J Exp Med , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3    Leal, V.V.4    Misgeld, T.5    Klinkert, W.E.6
  • 43
    • 33749528961 scopus 로고    scopus 로고
    • Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis
    • Kolln, J., Ren, H.M., Da, R.R., Zhang, Y., Spillner, E., Olek, M. et al. (2006) Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol 177: 5652-5658.
    • (2006) J Immunol , vol.177 , pp. 5652-5658
    • Kolln, J.1    Ren, H.M.2    Da, R.R.3    Zhang, Y.4    Spillner, E.5    Olek, M.6
  • 44
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek, B., Storch, M.K., Weissert, R., Wallstroem, E., Stefferl, A., Olsson, T. et al. (2000) Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 157: 267-276.
    • (2000) Am J Pathol , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6
  • 45
    • 30344446249 scopus 로고    scopus 로고
    • Chemokines in multiple sclerosis: CXCL 12 and CXCL 13 up-regulation is differentially linked to CNS immune cell recruitment
    • Krumbholz, M., Theil, D., Cepok, S., Hemmer, B., Kivisäkk, P., Ransohoff, R.M. et al. (2006) Chemokines in multiple sclerosis: CXCL 12 and CXCL 13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 129: 200-211.
    • (2006) Brain , vol.129 , pp. 200-211
    • Krumbholz, M.1    Theil, D.2    Cepok, S.3    Hemmer, B.4    Kivisäkk, P.5    Ransohoff, R.M.6
  • 46
    • 20244384231 scopus 로고    scopus 로고
    • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    • Krumbholz, M., Theil, D., Derfuss, T., Rosenwald, A., Schrader, F., Monoranu, C.M. et al. (2005) BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 201: 195-200.
    • (2005) J Exp Med , vol.201 , pp. 195-200
    • Krumbholz, M.1    Theil, D.2    Derfuss, T.3    Rosenwald, A.4    Schrader, F.5    Monoranu, C.M.6
  • 47
    • 34248679009 scopus 로고    scopus 로고
    • Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS
    • Lambracht-Washington, D., O'Connor, K.C., Cameron, E.M., Jowdry, A., Ward, E.S., Frohman, E. et al. (2007) Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS. J Neuroimmunol 186: 164-176.
    • (2007) J Neuroimmunol , vol.186 , pp. 164-176
    • Lambracht-Washington, D.1    O'Connor, K.C.2    Cameron, E.M.3    Jowdry, A.4    Ward, E.S.5    Frohman, E.6
  • 48
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: an overview
    • Lassmann, H., Bruck, W. and Lucchinetti, C.F. ( 2007) The immunopathology of multiple sclerosis: an overview. Brain Pathol 17: 210-218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.F.3
  • 49
    • 45249085670 scopus 로고    scopus 로고
    • Rituximab-induced B cell depletion in autoimmune diseases: potential effects on T cells
    • Liossis, S.N. and Sfikakis, P.P. ( 2008) Rituximab-induced B cell depletion in autoimmune diseases: potential effects on T cells. Clin Immunol 127: 280-285.
    • (2008) Clin Immunol , vol.127 , pp. 280-285
    • Liossis, S.N.1    Sfikakis, P.P.2
  • 50
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti, C., Brück, W., Parisi, J., Scheithauer, B., Rodriguez, M., Lassmann, H. et al. (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47: 707-717.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 51
    • 3342921914 scopus 로고    scopus 로고
    • The role of the BAFF / APRIL system in B cell homeostasis and lymphoid cancers
    • MacKay, F. and Tangye, S.G. ( 2004) The role of the BAFF / APRIL system in B cell homeostasis and lymphoid cancers. Curr Opin Pharmacol 4: 347-354.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 347-354
    • MacKay, F.1    Tangye, S.G.2
  • 52
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • MacKay, F., Woodcock, S.A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P. et al. (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 190: 1697-1710.
    • (1999) J Exp Med , vol.190 , pp. 1697-1710
    • MacKay, F.1    Woodcock, S.A.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5    Schneider, P.6
  • 53
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M. et al. (2007) Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130: 1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopolo, M.6
  • 54
    • 8844239964 scopus 로고    scopus 로고
    • Environmental risk factors in multiple sclerosis aetiology
    • Marrie, R.A. ( 2004) Environmental risk factors in multiple sclerosis aetiology. Lancet Neurol 3: 709-718.
    • (2004) Lancet Neurol , vol.3 , pp. 709-718
    • Marrie, R.A.1
  • 55
    • 0034729769 scopus 로고    scopus 로고
    • Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
    • Marsters, S.A., Yan, M., Pitti, R.M., Haas, P.E., Dixit, V.M., Ashkenazi, A. et al. (2000) Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol 10: 785-788.
    • (2000) Curr Biol , vol.10 , pp. 785-788
    • Marsters, S.A.1    Yan, M.2    Pitti, R.M.3    Haas, P.E.4    Dixit, V.M.5    Ashkenazi, A.6
  • 56
    • 33747203086 scopus 로고    scopus 로고
    • Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy
    • Martinez-Gamboa, L., Brezinschek, H.P., Burmester, G.R. and Dorner, T. ( 2006) Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy. Autoimmun Rev 5: 437-442.
    • (2006) Autoimmun Rev , vol.5 , pp. 437-442
    • Martinez-Gamboa, L.1    Brezinschek, H.P.2    Burmester, G.R.3    Dorner, T.4
  • 57
    • 33646787755 scopus 로고    scopus 로고
    • The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis
    • McDole, J., Johnson, A.J. and Pirko, I. ( 2006) The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis. Neurol Res 28: 256-261.
    • (2006) Neurol Res , vol.28 , pp. 256-261
    • McDole, J.1    Johnson, A.J.2    Pirko, I.3
  • 58
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana, I., Martinic, M.A., Wekerle, H. and Neumann, H. ( 2001) Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am J Pathol 159: 809-815.
    • (2001) Am J Pathol , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 59
    • 34250365790 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers
    • Munafo, A., Priestley, A., Nestorov, I., Visich, J. and Rogge, M. ( 2007) Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers. Eur J Clin Pharmacol 63: 647-656.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 647-656
    • Munafo, A.1    Priestley, A.2    Nestorov, I.3    Visich, J.4    Rogge, M.5
  • 60
    • 40749132997 scopus 로고    scopus 로고
    • Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis
    • Nestorov, I., Munafo, A., Papasouliotis, O. and Visich, J. ( 2008) Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis. J Clin Pharmacol 48: 406-417.
    • (2008) J Clin Pharmacol , vol.48 , pp. 406-417
    • Nestorov, I.1    Munafo, A.2    Papasouliotis, O.3    Visich, J.4
  • 61
    • 73949102012 scopus 로고    scopus 로고
    • (2010) Pharmakokinetics and immunoglobulin response of subcutaneous and intravenous atacicept in patients with systemic lupus erythematosus
    • Nestorov, I., Papasouliotis, O., Pena-Rossi, C. and Munafo, A. (2010) Pharmakokinetics and immunoglobulin response of subcutaneous and intravenous atacicept in patients with systemic lupus erythematosus. J Pharmac Sci 99: 524-538.
    • J Pharmac Sci , vol.99 , pp. 524-538
    • Nestorov, I.1    Papasouliotis, O.2    Pena-Rossi, C.3    Munafo, A.4
  • 63
    • 65149106325 scopus 로고    scopus 로고
    • (2009) An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept on patients with systemic lupus erythematosus
    • Pena-Rossi, C., Nasonov, E., Stanislav, M., Yakusevich, V., Ershova, O., Lomareva, N. et al. (2009) An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept on patients with systemic lupus erythematosus. Lupus 18: 547-555.
    • Lupus , vol.18 , pp. 547-555
    • Pena-Rossi, C.1    Nasonov, E.2    Stanislav, M.3    Yakusevich, V.4    Ershova, O.5    Lomareva, N.6
  • 64
    • 33746301710 scopus 로고    scopus 로고
    • Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis
    • Perini, P., Ranzato, F., Calabrese, M., Battistin, L. and Gallo, P. ( 2006) Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis. J Neurol Neurosurg Psychiatry 77: 953-955.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 953-955
    • Perini, P.1    Ranzato, F.2    Calabrese, M.3    Battistin, L.4    Gallo, P.5
  • 65
    • 33644619154 scopus 로고    scopus 로고
    • The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect
    • Poser, C.M. ( 2006) The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect. Clin Neurol Neurosurg 108: 227-233.
    • (2006) Clin Neurol Neurosurg , vol.108 , pp. 227-233
    • Poser, C.M.1
  • 66
    • 0019469331 scopus 로고
    • Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown
    • Prineas, J.W. and Graham, J.S. ( 1981) Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 10: 149-158.
    • (1981) Ann Neurol , vol.10 , pp. 149-158
    • Prineas, J.W.1    Graham, J.S.2
  • 67
    • 0042809490 scopus 로고    scopus 로고
    • Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis
    • Qin, Y., Duquette, P., Zhang, Y., Olek, M., Da, R.R., Richardson, J. et al. (2003) Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab Invest 83: 1081-1088.
    • (2003) Lab Invest , vol.83 , pp. 1081-1088
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3    Olek, M.4    Da, R.R.5    Richardson, J.6
  • 68
    • 84993751469 scopus 로고    scopus 로고
    • (2009) Environmental factors and their timing in adult-onset multiple sclerosis
    • Ramagopalan, S.V., Dyment, D.A. and Ebers, G.C. (2009) Environmental factors and their timing in adult-onset multiple sclerosis. Trends Neurosci 649: 1-8.
    • Trends Neurosci , vol.649 , pp. 1-8
    • Ramagopalan, S.V.1    Dyment, D.A.2    Ebers, G.C.3
  • 69
    • 0037108490 scopus 로고    scopus 로고
    • BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    • Roschke, V., Sosnovtseva, S., Ward, C.D., Hong, J.S., Smith, R., Albert, V. et al. (2002) BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol 169: 4314-4321.
    • (2002) J Immunol , vol.169 , pp. 4314-4321
    • Roschke, V.1    Sosnovtseva, S.2    Ward, C.D.3    Hong, J.S.4    Smith, R.5    Albert, V.6
  • 70
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    • Schneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, J.L., Holler, N. et al. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 189: 1747-1756.
    • (1999) J Exp Med , vol.189 , pp. 1747-1756
    • Schneider, P.1    MacKay, F.2    Steiner, V.3    Hofmann, K.4    Bodmer, J.L.5    Holler, N.6
  • 71
    • 0024976416 scopus 로고
    • Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement
    • Scolding, N.J., Morgan, B.P., Houston, W.A., Linington, C., Campbell, A.K., Compston, D.A. et al. (1989) Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature 339: 620-622.
    • (1989) Nature , vol.339 , pp. 620-622
    • Scolding, N.J.1    Morgan, B.P.2    Houston, W.A.3    Linington, C.4    Campbell, A.K.5    Compston, D.A.6
  • 72
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E. and Aloisi, F. ( 2004) Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 14: 164-174.
    • (2004) Brain Pathol , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 73
    • 0037332043 scopus 로고    scopus 로고
    • Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
    • Seshasayee, D., Valdez, P., Yan, M., Dixit, V.M., Tumas, D., Grewal, I.S. et al. (2003) Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 18: 279-288.
    • (2003) Immunity , vol.18 , pp. 279-288
    • Seshasayee, D.1    Valdez, P.2    Yan, M.3    Dixit, V.M.4    Tumas, D.5    Grewal, I.S.6
  • 74
    • 33746974761 scopus 로고    scopus 로고
    • Therapeutic B cell depletion and regeneration in rheumatoid arthritis: emerging patterns and paradigms
    • Silverman, G.J. ( 2006) Therapeutic B cell depletion and regeneration in rheumatoid arthritis: emerging patterns and paradigms. Arthritis Rheum 54: 2356-2367.
    • (2006) Arthritis Rheum , vol.54 , pp. 2356-2367
    • Silverman, G.J.1
  • 75
    • 35548957360 scopus 로고    scopus 로고
    • Rationale for cytotoxic monoclonal antibodies in MS
    • Simpson, B.S. and Coles, A.J. ( 2007) Rationale for cytotoxic monoclonal antibodies in MS. Int MS J 14: 48-56.
    • (2007) Int MS J , vol.14 , pp. 48-56
    • Simpson, B.S.1    Coles, A.J.2
  • 76
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra, M. and Martin, R. ( 2005) Immunology of multiple sclerosis. Annu Rev Immunol 23: 683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 77
    • 60549116884 scopus 로고    scopus 로고
    • Long-term B lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis
    • Stüve, O., Leussink, V.I., Fröhlich R., Hemmer B., Hartung H.P., Menge T. and Kieseier, B.C. ( 2009) Long-term B lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis. Arch Neurol 66: 259-261.
    • (2009) Arch Neurol , vol.66 , pp. 259-261
    • Stüve, O.1    Leussink, V.I.2    Fröhlich, R.3    Hemmer, B.4    Hartung, H.P.5    Menge, T.6    Kieseier, B.C.7
  • 78
    • 0036318944 scopus 로고    scopus 로고
    • A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination
    • Svensson, L., Abdul-Majid, K.-B., Bauer, J., Lassmann, H., Harris, R.A., Holmdahl, R. et al. (2002) A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination. Eur J Immunol 32: 1939-1946.
    • (2002) Eur J Immunol , vol.32 , pp. 1939-1946
    • Svensson, L.1    Abdul-Majid, K.-B.2    Bauer, J.3    Lassmann, H.4    Harris, R.A.5    Holmdahl, R.6
  • 79
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
    • Tak, P.P., Thurlings, R.M., Rossier, C., Nestorov, I., Dimic, A., Mircetic, V. et al. (2008) Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum 58: 61-72.
    • (2008) Arthritis Rheum , vol.58 , pp. 61-72
    • Tak, P.P.1    Thurlings, R.M.2    Rossier, C.3    Nestorov, I.4    Dimic, A.5    Mircetic, V.6
  • 80
    • 3042569128 scopus 로고    scopus 로고
    • Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis
    • Thangarajh, M., Gomes, A., Masterman, T., Hillert, J. and Hjelmstrom, P. ( 2004) Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J Neuroimmunol 152: 183-190.
    • (2004) J Neuroimmunol , vol.152 , pp. 183-190
    • Thangarajh, M.1    Gomes, A.2    Masterman, T.3    Hillert, J.4    Hjelmstrom, P.5
  • 81
    • 33845710885 scopus 로고    scopus 로고
    • A proliferation-inducing ligand (APRIL) is expressed by astrocytes and is increased in multiple sclerosis
    • Thangarajh, M., Masterman, T., Hillert, J., Moerk, S. and Jonsson, R. ( 2007) A proliferation-inducing ligand (APRIL) is expressed by astrocytes and is increased in multiple sclerosis. Scand J Immunol 65: 92-98.
    • (2007) Scand J Immunol , vol.65 , pp. 92-98
    • Thangarajh, M.1    Masterman, T.2    Hillert, J.3    Moerk, S.4    Jonsson, R.5
  • 83
    • 0035860466 scopus 로고    scopus 로고
    • BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
    • Thompson, J.S., Bixler, S.A., Qian, F., Vora, K., Scott, M.L., Cachero, T.G. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293: 2108-2111.
    • (2001) Science , vol.293 , pp. 2108-2111
    • Thompson, J.S.1    Bixler, S.A.2    Qian, F.3    Vora, K.4    Scott, M.L.5    Cachero, T.G.6
  • 85
    • 85047691237 scopus 로고    scopus 로고
    • Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
    • Villar, L.M., Sádaba, M.C., Roldán, E., Masjuan, J., González-Porqué, P., Villarrubia, N. et al. (2005) Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J Clin Invest 115: 187-194.
    • (2005) J Clin Invest , vol.115 , pp. 187-194
    • Villar, L.M.1    Sádaba, M.C.2    Roldán, E.3    Masjuan, J.4    González-Porqué, P.5    Villarrubia, N.6
  • 88
  • 89
    • 25444448197 scopus 로고    scopus 로고
    • Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    • Zeyda, M., Poglitsch, M., Geyeregger, R., Smolen, J.S., Zlabinger, G.J., Hörl, W.H. et al. (2005) Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis Rheum 52: 2730-2739.
    • (2005) Arthritis Rheum , vol.52 , pp. 2730-2739
    • Zeyda, M.1    Poglitsch, M.2    Geyeregger, R.3    Smolen, J.S.4    Zlabinger, G.J.5    Hörl, W.H.6
  • 90
    • 42649099687 scopus 로고    scopus 로고
    • B lymphocytes-chief players and therapeutic targets in autoimmune diseases
    • Zouali, M. ( 2008) B lymphocytes-chief players and therapeutic targets in autoimmune diseases. Front Biosci 13: 4852-4861.
    • (2008) Front Biosci , vol.13 , pp. 4852-4861
    • Zouali, M.1


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