Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC

European Journal of Immunology

Volumn 40, Issue 2, 2010, Pages 321-329

  Seyerl, Maria ^a   Kirchberger, Stefanie ^a,b   Majdic, Otto ^a   Seipelt, Joachim ^c   Jindra, Christoph ^a   Schrauf, Catharina ^a   Stöckl, Johannes ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Human rhinovirus; IL 35; Treg

Indexed keywords

ALPHA INTERFERON; CD274 ANTIBODY; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 35; MONOCLONAL ANTIBODY; SIALOADHESIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN RHINOVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; UMBILICAL CORD BLOOD;

ANTIGENS, CD; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DENDRITIC CELLS; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-10; INTERLEUKINS; MEMBRANE GLYCOPROTEINS; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINOVIRUS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 75149158969     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939527     Document Type: Article

References (37)

1. Zinkernagel, R. M., What is missing in immunology to understand immunity? Nat. Immunol. 2000. 1: 181-185.
2. Shevach, E. M., From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006. 25: 195-201.
3. Collison, L. W., Workman, C. J., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R. et al., The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007. 450: 566-569.
4. Collison, L.W., Pillai, M. R., Chaturvedi, V. and Vignali, D. A., Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J. Immunol. 2009. 182: 6121-6128.
5. Niedbala, W., Wei, X. Q., Cai, B., Hueber, A. J., Leung, B. P., McInnes, I. B. and Liew, F. Y., IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol. 2007. 37: 3021-3029.
6. Bardel, E., Larousserie, F., Charlot-Rabiega, P., Coulomb-L'Hermine, A. and Devergne, O., Human CD4+CD25+Foxp3+regulatory T cells do not constitutively express IL-35. J. Immunol. 2008. 181: 6898-6905.
7. Allan, S. E., Song-Zhao, G. X., Abraham, T., McMurchy, A. N. and Levings, M. K., Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur. J. Immunol. 2008. 38: 3282-3289.
8. Sakaguchi, S., Regulatory T cells: key controllers of immunologic selftolerance. Cell 2000. 101: 455-458.
9. Tato, C. M. and Cua, D. J., Alternative lifestyles of T cells. Nat. Immunol. 2008. 9: 1323-1325.
10. Roncarolo, M. G. and Gregori, S., Is FOXP3 a bona fide marker for human regulatory T cells? Eur. J. Immunol. 2008. 38: 925-927.
11. Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E. and Roncarolo, M. G., A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997. 389: 737-742.
12. Kirchberger, S., Majdic, O., Steinberger, P., Bluml, S., Pfistershammer, K., Zlabinger, G., Deszcz, L. et al., Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. J. Immunol. 2005. 175: 1145-1152.
13. Kirchberger, S., Majdic, O. and Stockl, J., Modulation of the immune system by human rhinoviruses. Int. Arch. Allergy Immunol. 2007. 142: 1-10.
14. Shepard, D. A., Heinz, B. A. and Rueckert, R. R., WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14. J. Virol. 1993. 67: 2245-2254.
15. Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G. and Levings, M. K., Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int. Immunol. 2007. 19: 345-354.
16. Levings, M. K., Gregori, S., Tresoldi, E., Cazzaniga, S., Bonini, C. and Roncarolo, M. G., Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+Tr cells. Blood 2005. 105: 1162-1169.
17. Hoffmann, P., Boeld, T. J., Eder, R., Huehn, J., Floess, S., Wieczorek, G., Olek, S. et al., Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur. J. Immunol. 2009. 39: 1088-1097.
18. Tran, D. Q., Ramsey, H. and Shevach, E. M., Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007. 110: 2983-2990.
19. Battaglia, M. and Roncarolo, M. G., The role of cytokines (and not only) in inducing and expanding Tregulatory type 1 cells. Transplantation 2004. 77: S16-S18.
20. Devergne, O., Birkenbach, M. and Kieff, E., Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA 1997. 94: 12041-12046.
21. Collison, L. W. and Vignali, D. A., Interleukin-35: odd one out or part of the family? Immunol. Rev. 2008. 226: 248-262.
22. Ziegler, S. F., FOXP3: not just for regulatory T cells anymore. Eur. J. Immunol. 2007. 37: 21-23.
23. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J. et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
24. Greenwald, R. J., Freeman, G. J. and Sharpe, A. H., The B7 family revisited. Annu. Rev. Immunol. 2005. 23: 515-548.
25. Selenko-Gebauer, N., Majdic, O., Szekeres, A., Hofler, G., Guthann, E., Korthauer, U., Zlabinger, G. et al., B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J. Immunol. 2003. 170: 3637-3644.
26. Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J. and Ahmed, R., Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006. 439: 682-687.
27. Yao, S. and Chen, L., Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade. Trends Mol. Med. 2006. 12: 244-246.
28. Fife, B. T. and Bluestone, J. A., Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol. Rev. 2008. 224: 166-182.
29. Hartnell, A., Steel, J., Turley, H., Jones, M., Jackson, D. G. and Crocker, P. R., Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 2001. 97: 288-296.
30. van den Berg, T. K., Nath, D., Ziltener, H. J., Vestweber, D., Fukuda, M., van Die, I. and Crocker, P. R., Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J. Immunol. 2001. 166: 3637-3640.
31. Rosenstein, Y., Santana, A. and Pedraza-Alva, G., CD43, a molecule with multiple functions. Immunol. Res. 1999. 20: 89-99.
32. Shaw, A. S., FERMing up the synapse. Immunity 2001. 15: 683-686.
33. Daniels, M. A., Hogquist, K. A. and Jameson, S. C., Sweet 'n' sour: the impact of differential glycosylation on T cell responses. Nat. Immunol. 2002. 3: 903-910.
34. Stockl, J., Vetr, H., Majdic, O., Zlabinger, G., Kuechler, E. and Knapp, W., Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10. J. Clin. Invest. 1999. 104: 957-965.
35. Stockl, J., Majdic, O., Kohl, P., Pickl, W. F., Menzel, J. E. and Knapp, W., Leukosialin (CD43)-major histocompatibility class I molecule interactions involved in spontaneous T cell conjugate formation. J. Exp. Med. 1996. 184: 1769-1779.
36. Kirchberger, S., Majdic, O., Bluml, S., Schrauf, C., Leitner, J., Gerner, C., Paster, W. et al., The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells. Blood 2008. 112: 1240-1248.
37. Stockl, J., Majdic, O., Fischer, G., Maurer, D. and Knapp,W., Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL. J. Immunol. 2001. 167: 2724-2733.