Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

Immunology and Cell Biology

Volumn 90, Issue 4, 2012, Pages 457-467

  Hagn, Magdalena ^a   Sontheimer, Kai ^b   Dahlke, Karen ^b   Brueggemann, Sabine ^b   Kaltenmeier, Christof ^b   Beyer, Thamara ^b   Hofmann, Stefanie ^b   Lunov, Oleg ^b   Barth, Thomas Fe ^b   Fabricius, Dorit ^b   Tron, Kyrylo ^b   Nienhaus, Gerd Ulrich ^b,c   Simmet, Thomas ^b   Schrezenmeier, Hubert ^b   Jahrsdörfer, Bernd ^b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF ULM   (Germany)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

B cell; CD40 ligand; IL 21; neoplasm; tumor; virus

Indexed keywords

BREFELDIN A; CD40 LIGAND; GRANZYME B; INTERLEUKIN 21; PERFORIN; T LYMPHOCYTE RECEPTOR;

ACTIVE TRANSPORT; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CANCER CELL; CANCER EPIDEMIOLOGY; CD4+ T LYMPHOCYTE; CELL MATURATION; CELLULAR IMMUNITY; COCULTURE; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC LYMPHOCYTE; ENDOPLASMIC RETICULUM; ENZYME INDUCTION; ENZYME KINETICS; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GOLGI COMPLEX; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOSURVEILLANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

B-LYMPHOCYTES; CD40 LIGAND; CELL DIFFERENTIATION; CELLS, CULTURED; GRANZYMES; HUMANS; IMMUNITY, CELLULAR; INTERLEUKIN-2; INTERLEUKINS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84859947465     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2011.64     Document Type: Article

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