메뉴 건너뛰기




Volumn 24, Issue 3, 2016, Pages 398-408

Aging and age related stresses: A senescence mechanism of intervertebral disc degeneration

Author keywords

Aging; Cellular senescence; Intervertebral disc; Microenvironment

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P21; PROTEIN P53;

EID: 84958153660     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.09.019     Document Type: Review
Times cited : (376)

References (112)
  • 1
    • 84891163628 scopus 로고    scopus 로고
    • Role of cytokines in intervertebral disc degeneration: pain and disc content
    • Risbud M.V., Shapiro I.M. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 2014, 10(1):44-56.
    • (2014) Nat Rev Rheumatol , vol.10 , Issue.1 , pp. 44-56
    • Risbud, M.V.1    Shapiro, I.M.2
  • 2
    • 84926420130 scopus 로고    scopus 로고
    • Stem cell therapy for intervertebral disc regeneration: obstacles and solutions
    • Sakai D., Andersson G.B. Stem cell therapy for intervertebral disc regeneration: obstacles and solutions. Nat Rev Rheumatol 2015, 11(4):243-256.
    • (2015) Nat Rev Rheumatol , vol.11 , Issue.4 , pp. 243-256
    • Sakai, D.1    Andersson, G.B.2
  • 3
    • 33750537050 scopus 로고    scopus 로고
    • Microendoscopic discectomy for lumbar disc herniation: surgical technique and outcome in 873 consecutive cases
    • Wu X., Zhuang S., Mao Z., Chen H. Microendoscopic discectomy for lumbar disc herniation: surgical technique and outcome in 873 consecutive cases. Spine (Phila Pa 1976) 2006, 31(23):2689-2694.
    • (2006) Spine (Phila Pa 1976) , vol.31 , Issue.23 , pp. 2689-2694
    • Wu, X.1    Zhuang, S.2    Mao, Z.3    Chen, H.4
  • 4
    • 38649132004 scopus 로고    scopus 로고
    • Surgical results of anterior corpectomy in the aged patients with cervical myelopathy
    • Lu J., Wu X., Li Y., Kong X. Surgical results of anterior corpectomy in the aged patients with cervical myelopathy. Eur Spine J 2008, 17(1):129-135.
    • (2008) Eur Spine J , vol.17 , Issue.1 , pp. 129-135
    • Lu, J.1    Wu, X.2    Li, Y.3    Kong, X.4
  • 5
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    • Vos T., Flaxman A.D., Naghavi M., Lozano R., Michaud C., Ezzati M., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380(9859):2163-2196.
    • (2012) Lancet , vol.380 , Issue.9859 , pp. 2163-2196
    • Vos, T.1    Flaxman, A.D.2    Naghavi, M.3    Lozano, R.4    Michaud, C.5    Ezzati, M.6
  • 6
    • 84908087752 scopus 로고    scopus 로고
    • Intervertebral disc regeneration: do nutrients lead the way
    • Huang Y.C., Urban J.P., Luk K.D. Intervertebral disc regeneration: do nutrients lead the way. Nat Rev Rheumatol 2014, 10(9):561-566.
    • (2014) Nat Rev Rheumatol , vol.10 , Issue.9 , pp. 561-566
    • Huang, Y.C.1    Urban, J.P.2    Luk, K.D.3
  • 7
    • 84926415990 scopus 로고    scopus 로고
    • Gene therapy approaches to regenerating the musculoskeletal system
    • Evans C.H., Huard J. Gene therapy approaches to regenerating the musculoskeletal system. Nat Rev Rheumatol 2015, 11(4):234-242.
    • (2015) Nat Rev Rheumatol , vol.11 , Issue.4 , pp. 234-242
    • Evans, C.H.1    Huard, J.2
  • 8
    • 78650866043 scopus 로고    scopus 로고
    • Degeneration and regeneration of the intervertebral disc: lessons from development
    • Smith L.J., Nerurkar N.L., Choi K.S., Harfe B.D., Elliott D.M. Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech 2011, 4(1):31-41.
    • (2011) Dis Model Mech , vol.4 , Issue.1 , pp. 31-41
    • Smith, L.J.1    Nerurkar, N.L.2    Choi, K.S.3    Harfe, B.D.4    Elliott, D.M.5
  • 9
    • 84862855802 scopus 로고    scopus 로고
    • Ex vivo observation of human intervertebral disc tissue and cells isolated from degenerated intervertebral discs
    • Ciapetti G., Granchi D., Devescovi V., Leonardi E., Greggi T., Di S.M., et al. Ex vivo observation of human intervertebral disc tissue and cells isolated from degenerated intervertebral discs. Eur Spine J 2012, 21(Suppl 1):S10-S19.
    • (2012) Eur Spine J , vol.21 , pp. S10-S19
    • Ciapetti, G.1    Granchi, D.2    Devescovi, V.3    Leonardi, E.4    Greggi, T.5    Di, S.M.6
  • 10
    • 0036216444 scopus 로고    scopus 로고
    • Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs
    • Sive J.I., Baird P., Jeziorsk M., Watkins A., Hoyland J.A., Freemont A.J. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 2002, 55(2):91-97.
    • (2002) Mol Pathol , vol.55 , Issue.2 , pp. 91-97
    • Sive, J.I.1    Baird, P.2    Jeziorsk, M.3    Watkins, A.4    Hoyland, J.A.5    Freemont, A.J.6
  • 11
    • 33845360165 scopus 로고    scopus 로고
    • Programmed cell death in intervertebral disc degeneration
    • Zhao C.Q., Jiang L.S., Dai L.Y. Programmed cell death in intervertebral disc degeneration. Apoptosis 2006, 11(12):2079-2088.
    • (2006) Apoptosis , vol.11 , Issue.12 , pp. 2079-2088
    • Zhao, C.Q.1    Jiang, L.S.2    Dai, L.Y.3
  • 12
    • 0035890099 scopus 로고    scopus 로고
    • Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells
    • Okuda S., Myoui A., Ariga K., Nakase T., Yonenobu K., Yoshikawa H. Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine (Phila Pa 1976) 2001, 26(22):2421-2426.
    • (2001) Spine (Phila Pa 1976) , vol.26 , Issue.22 , pp. 2421-2426
    • Okuda, S.1    Myoui, A.2    Ariga, K.3    Nakase, T.4    Yonenobu, K.5    Yoshikawa, H.6
  • 13
    • 0037218780 scopus 로고    scopus 로고
    • Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs
    • Matsunaga S., Nagano S., Onishi T., Morimoto N., Suzuki S., Komiya S. Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs. J Neurosurg 2003, 98(1 Suppl):63-67.
    • (2003) J Neurosurg , vol.98 , Issue.1 , pp. 63-67
    • Matsunaga, S.1    Nagano, S.2    Onishi, T.3    Morimoto, N.4    Suzuki, S.5    Komiya, S.6
  • 14
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: from physiology to pathology
    • Munoz-Espin D., Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 2014, 15(7):482-496.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , Issue.7 , pp. 482-496
    • Munoz-Espin, D.1    Serrano, M.2
  • 15
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509(7501):439-446.
    • (2014) Nature , vol.509 , Issue.7501 , pp. 439-446
    • van Deursen, J.M.1
  • 16
    • 84933050555 scopus 로고    scopus 로고
    • Forging a signature of in vivo senescence
    • Sharpless N.E., Sherr C.J. Forging a signature of in vivo senescence. Nat Rev Cancer 2015, 15(7):397-408.
    • (2015) Nat Rev Cancer , vol.15 , Issue.7 , pp. 397-408
    • Sharpless, N.E.1    Sherr, C.J.2
  • 18
    • 67651083411 scopus 로고    scopus 로고
    • Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
    • Kim K.W., Chung H.N., Ha K.Y., Lee J.S., Kim Y.Y. Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs. Spine J 2009, 9(8):658-666.
    • (2009) Spine J , vol.9 , Issue.8 , pp. 658-666
    • Kim, K.W.1    Chung, H.N.2    Ha, K.Y.3    Lee, J.S.4    Kim, Y.Y.5
  • 19
    • 33846652876 scopus 로고    scopus 로고
    • Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs
    • Gruber H.E., Ingram J.A., Norton H.J., Hanley E.N. Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine (Phila Pa 1976) 2007, 32(3):321-327.
    • (2007) Spine (Phila Pa 1976) , vol.32 , Issue.3 , pp. 321-327
    • Gruber, H.E.1    Ingram, J.A.2    Norton, H.J.3    Hanley, E.N.4
  • 20
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120(4):513-522.
    • (2005) Cell , vol.120 , Issue.4 , pp. 513-522
    • Campisi, J.1
  • 21
    • 77954563804 scopus 로고    scopus 로고
    • Senescent cells as a source of inflammatory factors for tumor progression
    • Davalos A.R., Coppe J.P., Campisi J., Desprez P.Y. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 2010, 29(2):273-283.
    • (2010) Cancer Metastasis Rev , vol.29 , Issue.2 , pp. 273-283
    • Davalos, A.R.1    Coppe, J.P.2    Campisi, J.3    Desprez, P.Y.4
  • 22
    • 67749114451 scopus 로고    scopus 로고
    • Senescent cells in the intervertebral disc: numbers and mechanisms
    • Kletsas D. Senescent cells in the intervertebral disc: numbers and mechanisms. Spine J 2009, 9(8):677-678.
    • (2009) Spine J , vol.9 , Issue.8 , pp. 677-678
    • Kletsas, D.1
  • 23
    • 67650383738 scopus 로고    scopus 로고
    • Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
    • Loeser R.F. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage 2009, 17(8):971-979.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.8 , pp. 971-979
    • Loeser, R.F.1
  • 24
    • 34249788140 scopus 로고    scopus 로고
    • Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
    • Le M.C.L., Freemont A.J., Hoyland J.A. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 2007, 9(3):R45.
    • (2007) Arthritis Res Ther , vol.9 , Issue.3 , pp. R45
    • Le, M.C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 25
    • 59749099570 scopus 로고    scopus 로고
    • IGF-1 rescues human intervertebral annulus cells from in vitro stress-induced premature senescence
    • Gruber H.E., Hoelscher G.L., Ingram J.A., Bethea S., Hanley E.N. IGF-1 rescues human intervertebral annulus cells from in vitro stress-induced premature senescence. Growth Factors 2008, 26(4):220-225.
    • (2008) Growth Factors , vol.26 , Issue.4 , pp. 220-225
    • Gruber, H.E.1    Hoelscher, G.L.2    Ingram, J.A.3    Bethea, S.4    Hanley, E.N.5
  • 26
    • 77957688083 scopus 로고    scopus 로고
    • Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression
    • Hiyama A., Sakai D., Risbud M.V., Tanaka M., Arai F., Abe K., et al. Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum 2010, 62(10):3036-3047.
    • (2010) Arthritis Rheum , vol.62 , Issue.10 , pp. 3036-3047
    • Hiyama, A.1    Sakai, D.2    Risbud, M.V.3    Tanaka, M.4    Arai, F.5    Abe, K.6
  • 27
    • 63649096684 scopus 로고    scopus 로고
    • Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus
    • Gruber H.E., Ingram J.A., Davis D.E., Hanley E.N. Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus. Spine J 2009, 9(3):210-215.
    • (2009) Spine J , vol.9 , Issue.3 , pp. 210-215
    • Gruber, H.E.1    Ingram, J.A.2    Davis, D.E.3    Hanley, E.N.4
  • 28
    • 84894451272 scopus 로고    scopus 로고
    • In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes
    • Jeong S.W., Lee J.S., Kim K.W. In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes. Spine J 2014, 14(3):499-504.
    • (2014) Spine J , vol.14 , Issue.3 , pp. 499-504
    • Jeong, S.W.1    Lee, J.S.2    Kim, K.W.3
  • 29
    • 50549099313 scopus 로고    scopus 로고
    • Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
    • Heathfield S.K., Le M.C.L., Hoyland J.A. Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration. Arthritis Res Ther 2008, 10(4):R87.
    • (2008) Arthritis Res Ther , vol.10 , Issue.4 , pp. R87
    • Heathfield, S.K.1    Le, M.C.L.2    Hoyland, J.A.3
  • 30
    • 0034753182 scopus 로고    scopus 로고
    • Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation
    • Johnson W.E., Eisenstein S.M., Roberts S. Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect Tissue Res 2001, 42(3):197-207.
    • (2001) Connect Tissue Res , vol.42 , Issue.3 , pp. 197-207
    • Johnson, W.E.1    Eisenstein, S.M.2    Roberts, S.3
  • 31
    • 70450270932 scopus 로고    scopus 로고
    • Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining
    • Sharp C.A., Roberts S., Evans H., Brown S.J. Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining. Eur Spine J 2009, 18(11):1587-1594.
    • (2009) Eur Spine J , vol.18 , Issue.11 , pp. 1587-1594
    • Sharp, C.A.1    Roberts, S.2    Evans, H.3    Brown, S.J.4
  • 32
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I., Weinberg R.A. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005, 37(5):961-976.
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.5 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 33
    • 84889565689 scopus 로고    scopus 로고
    • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    • Storer M., Mas A., Robert-Moreno A., Pecoraro M., Ortells M.C., Di G.V., et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 2013, 155(5):1119-1130.
    • (2013) Cell , vol.155 , Issue.5 , pp. 1119-1130
    • Storer, M.1    Mas, A.2    Robert-Moreno, A.3    Pecoraro, M.4    Ortells, M.C.5    Di, G.V.6
  • 34
    • 28844502298 scopus 로고    scopus 로고
    • Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat
    • Gruber H.E., Ashraf N., Kilburn J., Williams C., Norton H.J., Gordon B.E., et al. Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. Spine (Phila Pa 1976) 2005, 30(23):2593-2600.
    • (2005) Spine (Phila Pa 1976) , vol.30 , Issue.23 , pp. 2593-2600
    • Gruber, H.E.1    Ashraf, N.2    Kilburn, J.3    Williams, C.4    Norton, H.J.5    Gordon, B.E.6
  • 35
    • 84902659050 scopus 로고    scopus 로고
    • Significance of hypoxia in the physiological function of intervertebral disc cells
    • Chen J.W., Li B., Yang Y.H., Jiang S.D., Jiang L.S. Significance of hypoxia in the physiological function of intervertebral disc cells. Crit Rev Eukaryot Gene Expr 2014, 24(3):193-204.
    • (2014) Crit Rev Eukaryot Gene Expr , vol.24 , Issue.3 , pp. 193-204
    • Chen, J.W.1    Li, B.2    Yang, Y.H.3    Jiang, S.D.4    Jiang, L.S.5
  • 36
    • 33748756124 scopus 로고    scopus 로고
    • TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
    • Tsai T.T., Danielson K.G., Guttapalli A., Oguz E., Albert T.J., Shapiro I.M., et al. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. J Biol Chem 2006, 281(35):25416-25424.
    • (2006) J Biol Chem , vol.281 , Issue.35 , pp. 25416-25424
    • Tsai, T.T.1    Danielson, K.G.2    Guttapalli, A.3    Oguz, E.4    Albert, T.J.5    Shapiro, I.M.6
  • 37
    • 38749098170 scopus 로고    scopus 로고
    • Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling
    • Uchiyama Y., Cheng C.C., Danielson K.G., Mochida J., Albert T.J., Shapiro I.M., et al. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. J Bone Miner Res 2007, 22(12):1996-2006.
    • (2007) J Bone Miner Res , vol.22 , Issue.12 , pp. 1996-2006
    • Uchiyama, Y.1    Cheng, C.C.2    Danielson, K.G.3    Mochida, J.4    Albert, T.J.5    Shapiro, I.M.6
  • 38
    • 33645562103 scopus 로고    scopus 로고
    • Effects of mechanical loading on intervertebral disc metabolism in vivo
    • Iatridis J.C., MacLean J.J., Roughley P.J., Alini M. Effects of mechanical loading on intervertebral disc metabolism in vivo. J Bone Joint Surg Am 2006, 88(Suppl 2):41-46.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 41-46
    • Iatridis, J.C.1    MacLean, J.J.2    Roughley, P.J.3    Alini, M.4
  • 39
    • 78149283241 scopus 로고    scopus 로고
    • Leg amputation accelerates senescence of rat lumbar intervertebral discs
    • Xing Q.J., Liang Q.Q., Bian Q., Ding D.F., Cui X.J., Shi Q., et al. Leg amputation accelerates senescence of rat lumbar intervertebral discs. Spine (Phila Pa 1976) 2010, 35(23):E1253-E1261.
    • (2010) Spine (Phila Pa 1976) , vol.35 , Issue.23 , pp. E1253-E1261
    • Xing, Q.J.1    Liang, Q.Q.2    Bian, Q.3    Ding, D.F.4    Cui, X.J.5    Shi, Q.6
  • 40
    • 84883871280 scopus 로고    scopus 로고
    • Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development
    • Purmessur D., Guterl C.C., Cho S.K., Cornejo M.C., Lam Y.W., Ballif B.A., et al. Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development. Arthritis Res Ther 2013, 15(5):R122.
    • (2013) Arthritis Res Ther , vol.15 , Issue.5 , pp. R122
    • Purmessur, D.1    Guterl, C.C.2    Cho, S.K.3    Cornejo, M.C.4    Lam, Y.W.5    Ballif, B.A.6
  • 41
    • 84958115255 scopus 로고    scopus 로고
    • SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model
    • Xia X., Guo J., Lu F., Jiang J. SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model. Spine (Phila Pa 1976) 2015, 40(9):E515-E524.
    • (2015) Spine (Phila Pa 1976) , vol.40 , Issue.9 , pp. E515-E524
    • Xia, X.1    Guo, J.2    Lu, F.3    Jiang, J.4
  • 42
    • 84908664978 scopus 로고    scopus 로고
    • Oxidative stress participates in age-related changes in rat lumbar intervertebral discs
    • Hou G., Lu H., Chen M., Yao H., Zhao H. Oxidative stress participates in age-related changes in rat lumbar intervertebral discs. Arch Gerontol Geriatr 2014, 59(3):665-669.
    • (2014) Arch Gerontol Geriatr , vol.59 , Issue.3 , pp. 665-669
    • Hou, G.1    Lu, H.2    Chen, M.3    Yao, H.4    Zhao, H.5
  • 43
    • 84878203794 scopus 로고    scopus 로고
    • Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration
    • Nasto L.A., Robinson A.R., Ngo K., Clauson C.L., Dong Q., St C.C., et al. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res 2013, 31(7):1150-1157.
    • (2013) J Orthop Res , vol.31 , Issue.7 , pp. 1150-1157
    • Nasto, L.A.1    Robinson, A.R.2    Ngo, K.3    Clauson, C.L.4    Dong, Q.5    St, C.C.6
  • 44
    • 84904559661 scopus 로고    scopus 로고
    • Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress
    • Park J.S., Park J.B., Park I.J., Park E.Y. Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress. Int Orthop 2014, 38(6):1311-1320.
    • (2014) Int Orthop , vol.38 , Issue.6 , pp. 1311-1320
    • Park, J.S.1    Park, J.B.2    Park, I.J.3    Park, E.Y.4
  • 45
    • 84875214991 scopus 로고    scopus 로고
    • Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: implications for diabetic intervertebral disc degeneration
    • Jiang L., Zhang X., Zheng X., Ru A., Ni X., Wu Y., et al. Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: implications for diabetic intervertebral disc degeneration. J Orthop Res 2013, 31(5):692-702.
    • (2013) J Orthop Res , vol.31 , Issue.5 , pp. 692-702
    • Jiang, L.1    Zhang, X.2    Zheng, X.3    Ru, A.4    Ni, X.5    Wu, Y.6
  • 47
    • 84894425812 scopus 로고    scopus 로고
    • Investigating the role of DNA damage in tobacco smoking-induced spine degeneration
    • Nasto L.A., Ngo K., Leme A.S., Robinson A.R., Dong Q., Roughley P., et al. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. Spine J 2014, 14(3):416-423.
    • (2014) Spine J , vol.14 , Issue.3 , pp. 416-423
    • Nasto, L.A.1    Ngo, K.2    Leme, A.S.3    Robinson, A.R.4    Dong, Q.5    Roughley, P.6
  • 48
    • 84860442850 scopus 로고    scopus 로고
    • The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study
    • Samartzis D., Karppinen J., Chan D., Luk K.D., Cheung K.M. The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study. Arthritis Rheum 2012, 64(5):1488-1496.
    • (2012) Arthritis Rheum , vol.64 , Issue.5 , pp. 1488-1496
    • Samartzis, D.1    Karppinen, J.2    Chan, D.3    Luk, K.D.4    Cheung, K.M.5
  • 49
    • 34548506785 scopus 로고    scopus 로고
    • Heritability of low back pain and the role of disc degeneration
    • Battie M.C., Videman T., Levalahti E., Gill K., Kaprio J. Heritability of low back pain and the role of disc degeneration. Pain 2007, 131(3):272-280.
    • (2007) Pain , vol.131 , Issue.3 , pp. 272-280
    • Battie, M.C.1    Videman, T.2    Levalahti, E.3    Gill, K.4    Kaprio, J.5
  • 50
    • 39049091805 scopus 로고    scopus 로고
    • Telomerase, senescence and ageing
    • Shawi M., Autexier C. Telomerase, senescence and ageing. Mech Ageing Dev 2008, 129(1-2):3-10.
    • (2008) Mech Ageing Dev , vol.129 , Issue.1-2 , pp. 3-10
    • Shawi, M.1    Autexier, C.2
  • 51
    • 14844362721 scopus 로고    scopus 로고
    • ISSLS prize winner: a study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs
    • Rajasekaran S., Babu J.N., Arun R., Armstrong B.R., Shetty A.P., Murugan S. ISSLS prize winner: a study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine (Phila Pa 1976) 2004, 29(23):2654-2667.
    • (2004) Spine (Phila Pa 1976) , vol.29 , Issue.23 , pp. 2654-2667
    • Rajasekaran, S.1    Babu, J.N.2    Arun, R.3    Armstrong, B.R.4    Shetty, A.P.5    Murugan, S.6
  • 52
    • 80053183939 scopus 로고    scopus 로고
    • Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites
    • Grunhagen T., Shirazi-Adl A., Fairbank J.C., Urban J.P. Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin North Am 2011, 42(4):465-477.
    • (2011) Orthop Clin North Am , vol.42 , Issue.4 , pp. 465-477
    • Grunhagen, T.1    Shirazi-Adl, A.2    Fairbank, J.C.3    Urban, J.P.4
  • 53
    • 33646010313 scopus 로고    scopus 로고
    • Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment
    • Risbud M.V., Guttapalli A., Stokes D.G., Hawkins D., Danielson K.G., Schaer T.P., et al. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem 2006, 98(1):152-159.
    • (2006) J Cell Biochem , vol.98 , Issue.1 , pp. 152-159
    • Risbud, M.V.1    Guttapalli, A.2    Stokes, D.G.3    Hawkins, D.4    Danielson, K.G.5    Schaer, T.P.6
  • 54
    • 84856160786 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
    • Fujita N., Chiba K., Shapiro I.M., Risbud M.V. HIF-1alpha and HIF-2alpha degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res 2012, 27(2):401-412.
    • (2012) J Bone Miner Res , vol.27 , Issue.2 , pp. 401-412
    • Fujita, N.1    Chiba, K.2    Shapiro, I.M.3    Risbud, M.V.4
  • 55
    • 44249119586 scopus 로고    scopus 로고
    • The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease
    • Johnson W.E., Stephan S., Roberts S. The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease. Arthritis Res Ther 2008, 10(2):R46.
    • (2008) Arthritis Res Ther , vol.10 , Issue.2 , pp. R46
    • Johnson, W.E.1    Stephan, S.2    Roberts, S.3
  • 57
    • 14844350606 scopus 로고    scopus 로고
    • Growth factors and treatment of intervertebral disc degeneration
    • Masuda K., Oegema T.R., An H.S. Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976) 2004, 29(23):2757-2769.
    • (2004) Spine (Phila Pa 1976) , vol.29 , Issue.23 , pp. 2757-2769
    • Masuda, K.1    Oegema, T.R.2    An, H.S.3
  • 58
    • 0029049874 scopus 로고
    • Effect of disk maturation on diffusion of low-molecular-weight gadolinium complexes: an experimental study in rabbits
    • Ibrahim M.A., Haughton V.M., Hyde J.S. Effect of disk maturation on diffusion of low-molecular-weight gadolinium complexes: an experimental study in rabbits. AJNR Am J Neuroradiol 1995, 16(6):1307-1311.
    • (1995) AJNR Am J Neuroradiol , vol.16 , Issue.6 , pp. 1307-1311
    • Ibrahim, M.A.1    Haughton, V.M.2    Hyde, J.S.3
  • 61
    • 4844225379 scopus 로고    scopus 로고
    • Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression
    • Maclean J.J., Lee C.R., Alini M., Iatridis J.C. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. J Orthop Res 2004, 22(6):1193-1200.
    • (2004) J Orthop Res , vol.22 , Issue.6 , pp. 1193-1200
    • Maclean, J.J.1    Lee, C.R.2    Alini, M.3    Iatridis, J.C.4
  • 62
    • 0742269711 scopus 로고    scopus 로고
    • Biological response of the intervertebral disc to dynamic loading
    • Walsh A.J., Lotz J.C. Biological response of the intervertebral disc to dynamic loading. J Biomech 2004, 37(3):329-337.
    • (2004) J Biomech , vol.37 , Issue.3 , pp. 329-337
    • Walsh, A.J.1    Lotz, J.C.2
  • 63
    • 68849089477 scopus 로고    scopus 로고
    • In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression
    • Wuertz K., Godburn K., MacLean J.J., Barbir A., Donnelly J.S., Roughley P.J., et al. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression. J Orthop Res 2009, 27(9):1235-1242.
    • (2009) J Orthop Res , vol.27 , Issue.9 , pp. 1235-1242
    • Wuertz, K.1    Godburn, K.2    MacLean, J.J.3    Barbir, A.4    Donnelly, J.S.5    Roughley, P.J.6
  • 64
    • 84883161140 scopus 로고    scopus 로고
    • Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor
    • Chan S.C., Walser J., Kappeli P., Shamsollahi M.J., Ferguson S.J., Gantenbein-Ritter B. Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor. PLoS One 2013, 8(8):e72489.
    • (2013) PLoS One , vol.8 , Issue.8
    • Chan, S.C.1    Walser, J.2    Kappeli, P.3    Shamsollahi, M.J.4    Ferguson, S.J.5    Gantenbein-Ritter, B.6
  • 66
    • 0035216307 scopus 로고    scopus 로고
    • Intervertebral disc herniation: studies on a porcine model exposed to highly repetitive flexion/extension motion with compressive force
    • Callaghan J.P., McGill S.M. Intervertebral disc herniation: studies on a porcine model exposed to highly repetitive flexion/extension motion with compressive force. Clin Biomech (Bristol, Avon) 2001, 16(1):28-37.
    • (2001) Clin Biomech (Bristol, Avon) , vol.16 , Issue.1 , pp. 28-37
    • Callaghan, J.P.1    McGill, S.M.2
  • 67
    • 55449106580 scopus 로고    scopus 로고
    • Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine
    • Liang Q.Q., Zhou Q., Zhang M., Hou W., Cui X.J., Li C.G., et al. Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine. Spine (Phila Pa 1976) 2008, 33(19):2052-2058.
    • (2008) Spine (Phila Pa 1976) , vol.33 , Issue.19 , pp. 2052-2058
    • Liang, Q.Q.1    Zhou, Q.2    Zhang, M.3    Hou, W.4    Cui, X.J.5    Li, C.G.6
  • 68
    • 77956911828 scopus 로고    scopus 로고
    • The influence of torsion on disc herniation when combined with flexion
    • Veres S.P., Robertson P.A., Broom N.D. The influence of torsion on disc herniation when combined with flexion. Eur Spine J 2010, 19(9):1468-1478.
    • (2010) Eur Spine J , vol.19 , Issue.9 , pp. 1468-1478
    • Veres, S.P.1    Robertson, P.A.2    Broom, N.D.3
  • 69
    • 27744457462 scopus 로고    scopus 로고
    • The influence of static axial torque in combined loading on intervertebral joint failure mechanics using a porcine model
    • Drake J.D., Aultman C.D., McGill S.M., Callaghan J.P. The influence of static axial torque in combined loading on intervertebral joint failure mechanics using a porcine model. Clin Biomech (Bristol, Avon) 2005, 20(10):1038-1045.
    • (2005) Clin Biomech (Bristol, Avon) , vol.20 , Issue.10 , pp. 1038-1045
    • Drake, J.D.1    Aultman, C.D.2    McGill, S.M.3    Callaghan, J.P.4
  • 70
    • 84902298640 scopus 로고    scopus 로고
    • How healthy discs herniate: a biomechanical and microstructural study investigating the combined effects of compression rate and flexion
    • Wade K.R., Robertson P.A., Thambyah A., Broom N.D. How healthy discs herniate: a biomechanical and microstructural study investigating the combined effects of compression rate and flexion. Spine (Phila Pa 1976) 2014, 39(13):1018-1028.
    • (2014) Spine (Phila Pa 1976) , vol.39 , Issue.13 , pp. 1018-1028
    • Wade, K.R.1    Robertson, P.A.2    Thambyah, A.3    Broom, N.D.4
  • 71
    • 84907855721 scopus 로고    scopus 로고
    • Acute mechanical injury of the human intervertebral disc: link to degeneration and pain
    • discussion 110-1
    • Alkhatib B., Rosenzweig D.H., Krock E., Roughley P.J., Beckman L., Steffen T., et al. Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. Eur Cell Mater 2014, 28:98-110. discussion 110-1.
    • (2014) Eur Cell Mater , vol.28 , pp. 98-110
    • Alkhatib, B.1    Rosenzweig, D.H.2    Krock, E.3    Roughley, P.J.4    Beckman, L.5    Steffen, T.6
  • 72
    • 84892715888 scopus 로고    scopus 로고
    • High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
    • Gawri R., Rosenzweig D.H., Krock E., Ouellet J.A., Stone L.S., Quinn T.M., et al. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Res Ther 2014, 16(1):R21.
    • (2014) Arthritis Res Ther , vol.16 , Issue.1 , pp. R21
    • Gawri, R.1    Rosenzweig, D.H.2    Krock, E.3    Ouellet, J.A.4    Stone, L.S.5    Quinn, T.M.6
  • 73
    • 58249144848 scopus 로고    scopus 로고
    • Inflammatory signaling and cellular senescence
    • Ren J.L., Pan J.S., Lu Y.P., Sun P., Han J. Inflammatory signaling and cellular senescence. Cell Signal 2009, 21(3):378-383.
    • (2009) Cell Signal , vol.21 , Issue.3 , pp. 378-383
    • Ren, J.L.1    Pan, J.S.2    Lu, Y.P.3    Sun, P.4    Han, J.5
  • 74
    • 8644230190 scopus 로고    scopus 로고
    • Degenerative mechanics of the lumbar spine
    • Niosi C.A., Oxland T.R. Degenerative mechanics of the lumbar spine. Spine J 2004, 4(6 Suppl):202S-208S.
    • (2004) Spine J , vol.4 , Issue.6 , pp. 202S-208S
    • Niosi, C.A.1    Oxland, T.R.2
  • 75
    • 81255134289 scopus 로고    scopus 로고
    • Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus
    • Jacobs N.T., Smith L.J., Han W.M., Morelli J., Yoder J.H., Elliott D.M. Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus. J Mech Behav Biomed Mater 2011, 4(8):1611-1619.
    • (2011) J Mech Behav Biomed Mater , vol.4 , Issue.8 , pp. 1611-1619
    • Jacobs, N.T.1    Smith, L.J.2    Han, W.M.3    Morelli, J.4    Yoder, J.H.5    Elliott, D.M.6
  • 76
    • 84872831222 scopus 로고    scopus 로고
    • Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs
    • Nasto L.A., Wang D., Robinson A.R., Clauson C.L., Ngo K., Dong Q., et al. Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mech Ageing Dev 2013, 134(1-2):35-42.
    • (2013) Mech Ageing Dev , vol.134 , Issue.1-2 , pp. 35-42
    • Nasto, L.A.1    Wang, D.2    Robinson, A.R.3    Clauson, C.L.4    Ngo, K.5    Dong, Q.6
  • 77
    • 84918554285 scopus 로고    scopus 로고
    • Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP
    • Johnson Z.I., Shapiro I.M., Risbud M.V. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biol 2014, 40:10-16.
    • (2014) Matrix Biol , vol.40 , pp. 10-16
    • Johnson, Z.I.1    Shapiro, I.M.2    Risbud, M.V.3
  • 78
    • 67650577141 scopus 로고    scopus 로고
    • High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response
    • Mavrogonatou E., Kletsas D. High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response. DNA Repair (Amst) 2009, 8(8):930-943.
    • (2009) DNA Repair (Amst) , vol.8 , Issue.8 , pp. 930-943
    • Mavrogonatou, E.1    Kletsas, D.2
  • 79
    • 58949103806 scopus 로고    scopus 로고
    • Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression
    • Sowa G., Vadala G., Studer R., Kompel J., Iucu C., Georgescu H., et al. Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine (Phila Pa 1976) 2008, 33(17):1821-1828.
    • (2008) Spine (Phila Pa 1976) , vol.33 , Issue.17 , pp. 1821-1828
    • Sowa, G.1    Vadala, G.2    Studer, R.3    Kompel, J.4    Iucu, C.5    Georgescu, H.6
  • 80
    • 43049163718 scopus 로고    scopus 로고
    • Free radicals and senescence
    • Lu T., Finkel T. Free radicals and senescence. Exp Cell Res 2008, 314(9):1918-1922.
    • (2008) Exp Cell Res , vol.314 , Issue.9 , pp. 1918-1922
    • Lu, T.1    Finkel, T.2
  • 81
    • 84888857607 scopus 로고    scopus 로고
    • Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression
    • Ma K.G., Shao Z.W., Yang S.H., Wang J., Wang B.C., Xiong L.M., et al. Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression. Osteoarthritis Cartilage 2013, 21(12):2030-2038.
    • (2013) Osteoarthritis Cartilage , vol.21 , Issue.12 , pp. 2030-2038
    • Ma, K.G.1    Shao, Z.W.2    Yang, S.H.3    Wang, J.4    Wang, B.C.5    Xiong, L.M.6
  • 82
    • 84862793462 scopus 로고    scopus 로고
    • Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells
    • Ding F., Shao Z.W., Yang S.H., Wu Q., Gao F., Xiong L.M. Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells. Apoptosis 2012, 17(6):579-590.
    • (2012) Apoptosis , vol.17 , Issue.6 , pp. 579-590
    • Ding, F.1    Shao, Z.W.2    Yang, S.H.3    Wu, Q.4    Gao, F.5    Xiong, L.M.6
  • 83
    • 84899452308 scopus 로고    scopus 로고
    • Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence
    • Correia-Melo C., Hewitt G., Passos J.F. Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence. Longev Healthspan 2014, 3(1):1.
    • (2014) Longev Healthspan , vol.3 , Issue.1 , pp. 1
    • Correia-Melo, C.1    Hewitt, G.2    Passos, J.F.3
  • 84
    • 84887459924 scopus 로고    scopus 로고
    • Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype
    • McCarthy D.A., Clark R.R., Bartling T.R., Trebak M., Melendez J.A. Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype. J Biol Chem 2013, 288(45):32149-32159.
    • (2013) J Biol Chem , vol.288 , Issue.45 , pp. 32149-32159
    • McCarthy, D.A.1    Clark, R.R.2    Bartling, T.R.3    Trebak, M.4    Melendez, J.A.5
  • 85
    • 84881399206 scopus 로고    scopus 로고
    • A complex secretory program orchestrated by the inflammasome controls paracrine senescence
    • Acosta J.C., Banito A., Wuestefeld T., Georgilis A., Janich P., Morton J.P., et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 2013, 15(8):978-990.
    • (2013) Nat Cell Biol , vol.15 , Issue.8 , pp. 978-990
    • Acosta, J.C.1    Banito, A.2    Wuestefeld, T.3    Georgilis, A.4    Janich, P.5    Morton, J.P.6
  • 86
    • 84887345656 scopus 로고    scopus 로고
    • A complex interaction between Wnt signaling and TNF-alpha in nucleus pulposus cells
    • Hiyama A., Yokoyama K., Nukaga T., Sakai D., Mochida J. A complex interaction between Wnt signaling and TNF-alpha in nucleus pulposus cells. Arthritis Res Ther 2013, 15(6):R189.
    • (2013) Arthritis Res Ther , vol.15 , Issue.6 , pp. R189
    • Hiyama, A.1    Yokoyama, K.2    Nukaga, T.3    Sakai, D.4    Mochida, J.5
  • 87
    • 34248357202 scopus 로고    scopus 로고
    • Microarray analysis of laser capture microdissected-anulus cells from the human intervertebral disc
    • Gruber H.E., Mougeot J.L., Hoelscher G., Ingram J.A., Hanley E.N. Microarray analysis of laser capture microdissected-anulus cells from the human intervertebral disc. Spine (Phila Pa 1976) 2007, 32(11):1181-1187.
    • (2007) Spine (Phila Pa 1976) , vol.32 , Issue.11 , pp. 1181-1187
    • Gruber, H.E.1    Mougeot, J.L.2    Hoelscher, G.3    Ingram, J.A.4    Hanley, E.N.5
  • 88
    • 77649122081 scopus 로고    scopus 로고
    • Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis
    • Gruber H.E., Hoelscher G.L., Ingram J.A., Zinchenko N., Hanley E.N. Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis. BMC Biotechnol 2010, 10:5.
    • (2010) BMC Biotechnol , vol.10 , pp. 5
    • Gruber, H.E.1    Hoelscher, G.L.2    Ingram, J.A.3    Zinchenko, N.4    Hanley, E.N.5
  • 89
    • 84889802479 scopus 로고    scopus 로고
    • The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc
    • Phillips K.L., Chiverton N., Michael A.L., Cole A.A., Breakwell L.M., Haddock G., et al. The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc. Arthritis Res Ther 2013, 15(6):R213.
    • (2013) Arthritis Res Ther , vol.15 , Issue.6 , pp. R213
    • Phillips, K.L.1    Chiverton, N.2    Michael, A.L.3    Cole, A.A.4    Breakwell, L.M.5    Haddock, G.6
  • 90
    • 84860326883 scopus 로고    scopus 로고
    • Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: a descriptive study in the New Zealand white rabbit
    • Henriksson H.B., Svala E., Skioldebrand E., Lindahl A., Brisby H. Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: a descriptive study in the New Zealand white rabbit. Spine (Phila Pa 1976) 2012, 37(9):722-732.
    • (2012) Spine (Phila Pa 1976) , vol.37 , Issue.9 , pp. 722-732
    • Henriksson, H.B.1    Svala, E.2    Skioldebrand, E.3    Lindahl, A.4    Brisby, H.5
  • 91
    • 84930381177 scopus 로고    scopus 로고
    • Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study
    • Sakai D., Nishimura K., Tanaka M., Nakajima D., Grad S., Alini M., et al. Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study. Spine J 2015, 15(6):1356-1365.
    • (2015) Spine J , vol.15 , Issue.6 , pp. 1356-1365
    • Sakai, D.1    Nishimura, K.2    Tanaka, M.3    Nakajima, D.4    Grad, S.5    Alini, M.6
  • 92
    • 84957849205 scopus 로고    scopus 로고
    • Viability, growth kinetics and stem cell markers of single and clustered cells in human intervertebral discs: implications for regenerative therapies
    • Turner S., Balain B., Caterson B., Morgan C., Roberts S. Viability, growth kinetics and stem cell markers of single and clustered cells in human intervertebral discs: implications for regenerative therapies. Eur Spine J 2014, 23(11):2462-2472.
    • (2014) Eur Spine J , vol.23 , Issue.11 , pp. 2462-2472
    • Turner, S.1    Balain, B.2    Caterson, B.3    Morgan, C.4    Roberts, S.5
  • 93
    • 84930516015 scopus 로고    scopus 로고
    • The inflammatory milieu of the degenerate disc: is mesenchymal stem cell-based therapy for intervertebral disc repair a feasible approach?
    • Krock E., Rosenzweig D.H., Haglund L. The inflammatory milieu of the degenerate disc: is mesenchymal stem cell-based therapy for intervertebral disc repair a feasible approach?. Curr Stem Cell Res Ther 2015, 10(4):317-328.
    • (2015) Curr Stem Cell Res Ther , vol.10 , Issue.4 , pp. 317-328
    • Krock, E.1    Rosenzweig, D.H.2    Haglund, L.3
  • 95
    • 80053100194 scopus 로고    scopus 로고
    • Extending the activities of human nucleus pulposus cells with recombinant adeno-associated virus vector-mediated human telomerase reverse transcriptase gene transfer
    • Wu J., Wang D., Zhang C., Wang C., Zhang Y., Xin H., et al. Extending the activities of human nucleus pulposus cells with recombinant adeno-associated virus vector-mediated human telomerase reverse transcriptase gene transfer. Tissue Eng Part A 2011, 17(19-20):2407-2415.
    • (2011) Tissue Eng Part A , vol.17 , Issue.19-20 , pp. 2407-2415
    • Wu, J.1    Wang, D.2    Zhang, C.3    Wang, C.4    Zhang, Y.5    Xin, H.6
  • 96
    • 84859582048 scopus 로고    scopus 로고
    • Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and cell cycle arrest
    • Liang W., Ye D., Dai L., Shen Y., Xu J. Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and cell cycle arrest. J Cell Biochem 2012, 113(6):2112-2121.
    • (2012) J Cell Biochem , vol.113 , Issue.6 , pp. 2112-2121
    • Liang, W.1    Ye, D.2    Dai, L.3    Shen, Y.4    Xu, J.5
  • 97
    • 84888055764 scopus 로고    scopus 로고
    • Prolonged expansion of human nucleus pulposus cells expressing human telomerase reverse transcriptase mediated by lentiviral vector
    • Wu J., Wang D., Ruan D., He Q., Zhang Y., Wang C., et al. Prolonged expansion of human nucleus pulposus cells expressing human telomerase reverse transcriptase mediated by lentiviral vector. J Orthop Res 2014, 32(1):159-166.
    • (2014) J Orthop Res , vol.32 , Issue.1 , pp. 159-166
    • Wu, J.1    Wang, D.2    Ruan, D.3    He, Q.4    Zhang, Y.5    Wang, C.6
  • 98
    • 58149508954 scopus 로고    scopus 로고
    • Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells
    • Nakai T., Mochida J., Sakai D. Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells. Arthritis Res Ther 2008, 10(6):R140.
    • (2008) Arthritis Res Ther , vol.10 , Issue.6 , pp. R140
    • Nakai, T.1    Mochida, J.2    Sakai, D.3
  • 99
    • 79955047394 scopus 로고    scopus 로고
    • Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells
    • Minagawa S., Araya J., Numata T., Nojiri S., Hara H., Yumino Y., et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2011, 300(3):L391-L401.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , Issue.3 , pp. L391-L401
    • Minagawa, S.1    Araya, J.2    Numata, T.3    Nojiri, S.4    Hara, H.5    Yumino, Y.6
  • 100
    • 79951780686 scopus 로고    scopus 로고
    • The relationship between the Wnt/beta-catenin and TGF-beta/BMP signals in the intervertebral disc cell
    • Hiyama A., Sakai D., Tanaka M., Arai F., Nakajima D., Abe K., et al. The relationship between the Wnt/beta-catenin and TGF-beta/BMP signals in the intervertebral disc cell. J Cell Physiol 2011, 226(5):1139-1148.
    • (2011) J Cell Physiol , vol.226 , Issue.5 , pp. 1139-1148
    • Hiyama, A.1    Sakai, D.2    Tanaka, M.3    Arai, F.4    Nakajima, D.5    Abe, K.6
  • 101
    • 69249124009 scopus 로고    scopus 로고
    • Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway
    • Zhang Y., Herbert B.S., Rajashekhar G., Ingram D.A., Yoder M.C., Clauss M., et al. Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway. FASEB J 2009, 23(5):1358-1365.
    • (2009) FASEB J , vol.23 , Issue.5 , pp. 1358-1365
    • Zhang, Y.1    Herbert, B.S.2    Rajashekhar, G.3    Ingram, D.A.4    Yoder, M.C.5    Clauss, M.6
  • 102
    • 39049119345 scopus 로고    scopus 로고
    • P38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration
    • Studer R.K., Aboka A.M., Gilbertson L.G., Georgescu H., Sowa G., Vo N., et al. p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration. Spine (Phila Pa 1976) 2007, 32(25):2827-2833.
    • (2007) Spine (Phila Pa 1976) , vol.32 , Issue.25 , pp. 2827-2833
    • Studer, R.K.1    Aboka, A.M.2    Gilbertson, L.G.3    Georgescu, H.4    Sowa, G.5    Vo, N.6
  • 103
    • 46449096413 scopus 로고    scopus 로고
    • P38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1
    • Studer R.K., Gilbertson L.G., Georgescu H., Sowa G., Vo N., Kang J.D. p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1. J Orthop Res 2008, 26(7):991-998.
    • (2008) J Orthop Res , vol.26 , Issue.7 , pp. 991-998
    • Studer, R.K.1    Gilbertson, L.G.2    Georgescu, H.3    Sowa, G.4    Vo, N.5    Kang, J.D.6
  • 104
    • 84928243456 scopus 로고    scopus 로고
    • The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
    • Zhu Y., Tchkonia T., Pirtskhalava T., Gower A.C., Ding H., Giorgadze N., et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 2015, 14(4):644-658.
    • (2015) Aging Cell , vol.14 , Issue.4 , pp. 644-658
    • Zhu, Y.1    Tchkonia, T.2    Pirtskhalava, T.3    Gower, A.C.4    Ding, H.5    Giorgadze, N.6
  • 105
    • 84892772553 scopus 로고    scopus 로고
    • The transpedicular approach for the study of intervertebral disc regeneration strategies: in vivo characterization
    • Vadala G., De Strobel F., Bernardini M., Denaro L., D'Avella D., Denaro V. The transpedicular approach for the study of intervertebral disc regeneration strategies: in vivo characterization. Eur Spine J 2013, 22(Suppl 6):S972-S978.
    • (2013) Eur Spine J , vol.22 , pp. S972-S978
    • Vadala, G.1    De Strobel, F.2    Bernardini, M.3    Denaro, L.4    D'Avella, D.5    Denaro, V.6
  • 106
    • 84877855262 scopus 로고    scopus 로고
    • Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes
    • Illien-Junger S., Grosjean F., Laudier D.M., Vlassara H., Striker G.E., Iatridis J.C. Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes. PLoS One 2013, 8(5):e64302.
    • (2013) PLoS One , vol.8 , Issue.5
    • Illien-Junger, S.1    Grosjean, F.2    Laudier, D.M.3    Vlassara, H.4    Striker, G.E.5    Iatridis, J.C.6
  • 107
    • 84861821882 scopus 로고    scopus 로고
    • The impact of discography on the surgical decision in patients with chronic low back pain
    • Berg S., Isberg B., Josephson A., Fallman M. The impact of discography on the surgical decision in patients with chronic low back pain. Spine J 2012, 12(4):283-291.
    • (2012) Spine J , vol.12 , Issue.4 , pp. 283-291
    • Berg, S.1    Isberg, B.2    Josephson, A.3    Fallman, M.4
  • 108
    • 84861946126 scopus 로고    scopus 로고
    • Intradiscal pulsed radiofrequency application following provocative discography for the management of degenerative disc disease and concordant pain: a pilot study
    • Rohof O. Intradiscal pulsed radiofrequency application following provocative discography for the management of degenerative disc disease and concordant pain: a pilot study. Pain Pract 2012, 12(5):342-349.
    • (2012) Pain Pract , vol.12 , Issue.5 , pp. 342-349
    • Rohof, O.1
  • 109
    • 84882973099 scopus 로고    scopus 로고
    • The precision, accuracy and validity of detecting posterior ligamentous complex injuries of the thoracic and lumbar spine: a critical appraisal of the literature
    • van Middendorp J.J., Patel A.A., Schuetz M., Joaquim A.F. The precision, accuracy and validity of detecting posterior ligamentous complex injuries of the thoracic and lumbar spine: a critical appraisal of the literature. Eur Spine J 2013, 22(3):461-474.
    • (2013) Eur Spine J , vol.22 , Issue.3 , pp. 461-474
    • van Middendorp, J.J.1    Patel, A.A.2    Schuetz, M.3    Joaquim, A.F.4
  • 110
    • 84888007595 scopus 로고    scopus 로고
    • Adjacent segment disease in the lumbar spine following different treatment interventions
    • Radcliff K.E., Kepler C.K., Jakoi A., Sidhu G.S., Rihn J., Vaccaro A.R., et al. Adjacent segment disease in the lumbar spine following different treatment interventions. Spine J 2013, 13(10):1339-1349.
    • (2013) Spine J , vol.13 , Issue.10 , pp. 1339-1349
    • Radcliff, K.E.1    Kepler, C.K.2    Jakoi, A.3    Sidhu, G.S.4    Rihn, J.5    Vaccaro, A.R.6
  • 111
    • 84908507230 scopus 로고    scopus 로고
    • Comparison of adjacent segment disease after minimally invasive or open transforaminal lumbar interbody fusion
    • Yee T.J., Terman S.W., La Marca F., Park P. Comparison of adjacent segment disease after minimally invasive or open transforaminal lumbar interbody fusion. J Clin Neurosci 2014, 21(10):1796-1801.
    • (2014) J Clin Neurosci , vol.21 , Issue.10 , pp. 1796-1801
    • Yee, T.J.1    Terman, S.W.2    La Marca, F.3    Park, P.4
  • 112
    • 84926684490 scopus 로고    scopus 로고
    • Circumferential dynamic stabilization of the lumbar spine: a biomechanical analysis
    • Kafer W., Cakir B., Midderhoff S., Reichel H., Wilke H.J. Circumferential dynamic stabilization of the lumbar spine: a biomechanical analysis. Eur Spine J 2014, 23(11):2330-2339.
    • (2014) Eur Spine J , vol.23 , Issue.11 , pp. 2330-2339
    • Kafer, W.1    Cakir, B.2    Midderhoff, S.3    Reichel, H.4    Wilke, H.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.