Effects of mechanical loading on intervertebral disc metabolism in vivo

Journal of Bone and Joint Surgery

Volumn 88, Issue SUPPL. 2, 2006, Pages 41-46

  Iatridis, James C ^a   MacLean, Jeffrey J ^b   Roughley, Peter J ^b   Alini, Mauro ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGEN; ENZYME; MESSENGER RNA; PROTEIN; PROTEOGLYCAN;

ADAPTATION; AGING; BACKACHE; BIOMECHANICS; CELL METABOLISM; CONFERENCE PAPER; DISEASE ASSOCIATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; IN VIVO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MECHANOTRANSDUCTION; MODEL; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RNA TRANSCRIPTION;

EID: 33645562103     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.E.01407     Document Type: Conference Paper

References (10)

1. Stokes IA, Iatridis JC. Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization. Spine. 2004;29:2724-32.
2. Adams MA, Bogduk M, Burton K, Dolan P. The biomechanics of back pain. New York: Churchill Livingstone; 2002.
3. Battié MC, Videman T, Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine. 2004;29:2679-90.
4. Lotz JC. Animal models of intervertebral disc degeneration: lessons learned. Spine. 2004;29:2742-50.
5. Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine. 1999;24:996-1002.
6. Roughley PJ. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine. 2004;29:2691-9.
7. Maclean JJ, Lee CR, Alini M, Iatridis JC. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. J Orthop Res. 2004;22:1193-200.
8. MacLean JJ, Lee CR, Grad S, Ito K, Alini M, Iatridis JC. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo. Spine. 2003;28:973-81.
9. MacLean JJ, Lee CR, Alini M, Iatridis JC. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. J Orthop Res. 2005;23:1120-7.
10. Stokes IA, Iatridis JC. Biomechanics of the spine. In: Mow VC, Huiskes R, editors. Basic orthopaedic biomechanics and mechano-biology. 3rd ed. New York: Lippincott Williams and Wilkins; 2005. p 529-62.