The cytokine and chemokine expression profile of nucleus pulposus cells: Implications for degeneration and regeneration of the intervertebral disc

Arthritis Research and Therapy

Volumn 15, Issue 6, 2013, Pages

  Phillips, Kate L E ^a   Chiverton, Neil ^b   Michael, Anthony L R ^b   Cole, Ashley A ^b   Breakwell, Lee M ^b   Haddock, Gail ^a   Bunning, Rowena A D ^a   Cross, Alison K ^a   Le Maitre, Christine L ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; COMPLEMENTARY DNA; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FRACTALKINE; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 16; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; MESSENGER RNA; TRANSCRIPTOME;

ADULT; ARTICLE; CELL INFILTRATION; CYTOKINE PRODUCTION; GENE; GENE EXPRESSION PROFILING; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; MAJOR CLINICAL STUDY; MIDDLE AGED; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; YOUNG ADULT; AGED; BIOSYNTHESIS; DNA MICROARRAY; FEMALE; IMMUNOLOGY; INTERVERTEBRAL DISK; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION;

ADULT; AGED; CHEMOKINES; CYTOKINES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REGENERATION; RNA, MESSENGER; TRANSCRIPTOME; YOUNG ADULT;

EID: 84889802479     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4408     Document Type: Article

References (56)

1. Liebscher T, Haefeli M, Wuertz K, Nerlich AG, Boos N. Age-related variation in cell density of human lumbar intervertebral disc. Spine 2011, 36:153-159. 10.1097/BRS.0b013e3181cd588c, 20671592.
2. Walmsley R. The development and growth of the intervertebral disc. Edinb Med Journal 1953, 60:341-364.
3. Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander A, Poole R, Aebi M, Alini M. The human lumbar intervertebral disc - evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996, 98:996-1003. 10.1172/JCI118884, 507515, 8770872.
4. Adams M, Hutton W. Gradual disk prolapse. Spine 1985, 10:524-531. 10.1097/00007632-198507000-00006, 4081867.
5. Johnson W, Roberts S. Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. J Anat 2003, 203:605-612. 10.1046/j.1469-7580.2003.00249.x, 1571197, 14686696.
6. Roberts S, Evans EH, Kletsas D, Jaffray DC, Eisenstein SM. Senescence in human intervertebral discs. Eur Spine J 2006, 15:S312-S316. 10.1007/s00586-006-0126-8, 2335374, 16773379.
7. Gruber HE, Norton HJ, Ingram JA, Hanley EN. The SOX9 transcription factor in the human disc: Decreased immunolocalization with age and disc degeneration. Spine 2005, 30:625-630. 10.1097/01.brs.0000155420.01444.c6, 15770176.
8. Rutges JPHJ, Duit RA, Kummer JA, Oner FC, van Rijen MH, Verbout AJ, Castelein RM, Dhert WJA, Creemers LB. Hypertrophic differentiation and calcification degeneration. Osteoarthritis Cartilage 2010, 18:1487-1495. 10.1016/j.joca.2010.08.006, 20723612.
9. Weiler C, Nerlich AG, Zipperer J, Bachmeier BE, Boos N. SSE award competition in basic science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J 2002, 2002:308-320.
10. Park J, Chang H, Kim K. Expression of fas ligand and apoptosis of disc cells in herniated lumbar disc tissue. Spine 2001, 26:618-621. 10.1097/00007632-200103150-00011, 11246372.
11. Wang H, Liu H, Zheng Z, Zhang K, Wang T, Sribastav S, Liu W, Liu T. Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc. Apoptosis 2011, 16:990-1003. 10.1007/s10495-011-0644-7, 21879322.
12. Weiler C, Nerlich AG, Bachmeier BE, Boos N. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005, 30:44-53. 10.1097/01.brs.0000174529.07959.c0, 15626980.
13. Bachmeier BE, Nerlich AG, Weiler C, Paesold G, Jochum M, Boos N. Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. Ann NY Acad Sci 2007, 1096:44-54. 10.1196/annals.1397.069, 17405915.
14. Ahn SH, Cho YW, Ahn MW, Jang SH, Sohn YK, Kim HS. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine 2002, 27:911-917. 10.1097/00007632-200205010-00005, 11979160.
15. Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005, 7:R732-R745. 10.1186/ar1732, 1175026, 15987475.
16. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 beta and TNF alpha expression profile. Arthritis Res Ther 2007, 9:R77. 10.1186/ar2275, 2206382, 17688691.
17. Hoyland JA, Le Maitre C, Freemont AJ. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology 2008, 47:809-814. 10.1093/rheumatology/ken056, 18397957.
18. Millward-Sadler SJ, Costello PW, Freemont AJ, Hoyland JA. Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 2009, 11:R65. 10.1186/ar2693, 2714110, 19435506.
19. Studer RK, Vo N, Sowa G, Ondeck C, Kang J. Human nucleus pulposus cells react to IL-6: Independent actions and amplification of response to IL-1 and TNF-alpha. Spine (Phila Pa 1976) 2011, 36:593-599. 10.1097/BRS.0b013e3181da38d5, 21178846.
20. Adams MA, Hutton WC. Prolapsed intervertebral disc; A hyperflexion injury. Spine 1982, 7:184-191. 10.1097/00007632-198205000-00002, 7112236.
21. Adams M, Freeman B, Morrison H, Nelson I, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine 2000, 25:1625-1636. 10.1097/00007632-200007010-00005, 10870137.
22. Lama P, Le Maitre CL, Dolan P, Tarlton JF, Harding IJ, Adams MA. Do intervertebral discs degenerate before they herniate, or after?. Bone Joint J 2013, 95-B:1127-1133. 10.1302/0301-620X.95B8.31660, 23908431.
23. Key JA. Intervertebral disc lesions are the most common cause of low back pain with or without sciatica. Ann Surg 1945, 121:534-539. 10.1097/00000658-194504000-00013, 1618126, 17858591.
24. Teplick J, Haskin M. Spontaneous regression of herniated nucleus pulposus. Am J Neuroradiol 1985, 6:331-335.
25. Keskil S, Ayberk G, Evliyaoglu C, Kizartici T, Yucel E, Anbarci H. Spontaneous resolution of " protruded" lumbar discs. Minim Invasive Neurosurg 2004, 47:226-229. 10.1055/s-2004-818517, 15346319.
26. Kawaguchi S, Yamashita T, Katahira G, Yokozawa H, Torigoe T, Sato N. Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages. Spine 2002, 27:1511-1516. 10.1097/00007632-200207150-00006, 12131709.
27. Kanerva A, Kommonen B, Gronblad M, Tolonen J, Habtemariam A, Virri J, Karaharju E. Inflammatory cells in experimental intervertebral disc injury. Spine 1997, 22:2711-2715. 10.1097/00007632-199712010-00002, 9431603.
28. Habtemariam A, Gronblad M, Virri J, Seitsalo S, Karaharju E. A comparative immunohistochemical study of inflammatory cells in acute-stage and chronic-stage disc herniations. Spine 1998, 23:2159-2165. 10.1097/00007632-199810150-00003, 9802155.
29. Kobayashi S, Meir A, Kokubo Y, Uchida K, Takeno K, Miyazaki T, Yayama T, Kubota M, Nomura E, Mwaka E, Baba H. Ultrastructural analysis on lumbar disc herniation using surgical specimens role of neovascularization and macrophages in hernias. Spine 2009, 34:655-662. 10.1097/BRS.0b013e31819c9d5b, 19333096.
30. Bertram H, Kroeber M, Wang H, Unglaub F, Guehring T, Carstens C, Richter W. Matrix-assisted cell transfer for intervertebral disc cell therapy. Biochem Biophys Res Commun 2005, 331:1185-1192. 10.1016/j.bbrc.2005.04.034, 15883001.
31. Steck E, Bertram H, Abel R, Chen B, Winter A, Richter W. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 2005, 23:403-411. 10.1634/stemcells.2004-0107, 15749935.
32. Le Maitre CL, Baird P, Freemont AJ, Hoyland JA. An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis Res Ther 2009, 11:R20. 10.1186/ar2611, 2688252, 19210770.
33. Nomura T, Mochida J, Okuma M, Nishimura K, Sakabe K. Nucleus pulposus allograft retards intervertebral disc degeneration. Clin Orthop 2001, 389:94-101.
34. Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T. Transplantation of mesenchymal stem cells embedded in atelocollagen((R)) gel to the intervertebral disc: a potential therapeutic model for disc degeneration. Biomaterials 2003, 24:3531-3541. 10.1016/S0142-9612(03)00222-9, 12809782.
35. Yang Z, Huang CC, Candiotti KA, Zeng X, Yuan T, Li J, Yu H, Abdi S. Sox-9 facilitates differentiation of adipose tissue-derived stem cells into a chondrocyte-like phenotype in vitro. J Orthop Res 2011, 29:1291-1297. 10.1002/jor.21336, 21400575.
36. Lee S, Moon CS, Sul D, Lee J, Bae M, Hong Y, Lee M, Choi S, Derby R, Kim B, Kim J, Yoon J, Wolfer L, Kim J, Wang J, Hwang S, Lee S. Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clin Biochem 2009, 42:1504-1511. 10.1016/j.clinbiochem.2009.06.017, 19563795.
37. Wang J, Tian Y, Phillips KLE, Chiverton N, Haddock G, Bunning RAD, Cross AK, Shapiro IM, LeMaitre CL, Risbud MV. TNF-α and IL-1β dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis Rheum 2013, 65:832-842. 10.1002/art.37819, 23233369.
38. Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L, Bullock R, Isaacs RE, Brown C, Richardson WJ. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum 2010, 62:1974-1982. 2917579, 20222111.
39. Roberts S, Evans H, Trivedi J, Menage J. Histology and pathology of the human intervertebral disc. J Bone Joint Surg Am 2006, 88A:10-14.
40. Phillips KLE, Jordan-Mahy N, Nicklin MHN, LeMaitre CL. Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration. Ann Rheum Dis 2013, 72:1860-1867. 10.1136/annrheumdis-2012-202266, 23396662.
41. Pockert AJ, Richardson SM, Le Maitre CL, Lyon M, Deakin JA, Buttle DJ, Freemont AJ, Hoyland JA. Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum 2009, 60:482-491. 10.1002/art.24291, 19180493.
42. Kawaguchi S, Yamashita T, Yokogushi K, Murakami T, Ohwada O, Sato N. Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral discs. Spine 2001, 26:1209-1214. 10.1097/00007632-200106010-00008, 11389385.
43. Bobechko WP, Hirsch C. Auto-immune response to nucleus pulposus in the rabbit. J Bone Joint Surg Br 1965, 47:574-580.
44. Marshall L, Trethewie E, Curtain C. Chemical radiculitis - clinical, physiological and immunological study. Clin Orthop 1977, 129:61-67.
45. Satoh K, Konno S, Nishiyama K, Olmarker K, Kikuchi S. Presence and distribution of antigen-antibody complexes in the herniated nucleus pulposus. Spine 1999, 24:1980-1984. 10.1097/00007632-199910010-00003, 10528371.
46. Geiss A, Larsson K, Rydevik B, Takahashi I, Olmarker K. Autoimmune properties of nucleus pulposus - an experimental study in pigs. Spine 2007, 32:168-173. 10.1097/01.brs.0000251651.61844.2d, 17224810.
47. Geiss A, Larsson K, Junevik K, Rydevik B, Olmarker K. Autologous nucleus pulposus primes T cells to develop into interleukin-4-producing effector cells: an experimental study on the autoimmune properties of nucleus pulposus. J Orthop Res 2009, 27:97-103. 10.1002/jor.20691, 18634006.
48. Hassler O. The human intervertebral disc. A micro-angiographical study on its vascular supply at various ages. Acta Orthop Scand 1969, 40:765-772. 10.3109/17453676908989540, 5394000.
49. Guinto F, Hashim H, Stumer M. CT demonstration of disk regression after conservative therapy. Am J Neuroradiol 1984, 5:632-633.
50. Mazzetti E, Magagnoli G, Paoletti S, Uguccioni M, Olivotto E, Vitellozzi R, Cattini L, Facchini A, Borzi R. A role for chemokines in the induction of chondrocyte phenotype modulation. Arthritis Rheum 2004, 50:112-122. 10.1002/art.11474, 14730607.
51. Merz D, Liu R, Johnson K, Terkeltaub R. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003, 171:4406-4415.
52. Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, Terek R, Chen Q. Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation. Dev Biol 2010, 341:236-245. 10.1016/j.ydbio.2010.02.033, 2862458, 20206617.
53. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, Lotz M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 2001, 44:1633-1643. 10.1002/1529-0131(200107)44:7<1633::AID-ART286>3.0.CO;2-Z, 11465714.
54. Yuan GH, Masuko-Hongo K, Sakata M, Tsuruha JI, Onuma H, Nakamura H, Aoki H, Kato T, Nishioka K. The role of C-C chemokines and their receptors in osteoarthritis. Arthritis Rheum 2001, 44:1056-1070. 10.1002/1529-0131(200105)44:5<1056::AID-ANR186>3.0.CO;2-U, 11352237.
55. Borzi R, Mazzetti I, Magagnoli G, Paoletti S, Uguccioni M, Gatti R, Orlandini G, Cattini L, Facchini A. Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes. Arthritis Rheum 2002, 46:3201-3211. 10.1002/art.10650, 12483724.
56. Wei L, Sun X, Kanbe K, Wang Z, Sun C, Terek R, Chen Q. Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1. J Rheumatol 2006, 33:1818-1826.